Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses
Open accessAbstract
Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.
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STAT3, IRF4, and BATF are additional transcription factors required for IL-17 expression.
“multiple additional transcription factors were shown to be required for the expression of IL-17, including STAT3, IRF4, and BATF”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [18]
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Self-citation
- Authors
- Hirota, K., Turner, J.-E., Villa, M., Duarte, J. H., Demengeot, J., Steinmetz, O. M., & Stockinger, B.
- Affiliations
- National Institute for Medical Research (GB)
- Instituto Gulbenkian de Ciência (PT)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Stockinger, Brigitta
- ORCID
- Venue
- Nature Immunology
- Published
- 2013-03-10
- Volume
- 14
- Issue
- 4
- Pages
- 372-379
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3672955
- OpenAlex
- W2001194497
- Cited by
- 509
- References
- 47
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 39 · 2023: 31 · 2022: 32 · 2021: 40 · 2020: 34 · 2019: 48 · 2018: 44 · 2017: 48 · 2016: 46 · 2015: 38 · 2014: 48 · 2013: 20
- FWCI
- 28.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Chongqing University of Arts and Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- Th17 cells, Peyer's patches, T follicular helper cells, germinal center B cells, IL-17, IL-23, intestinal mucosal immunity, B cell differentiation
- MeSH terms
- Animals, B-Lymphocytes, Female, T-Lymphocytes, Helper-Inducer, Immunoglobulin A, Immunoglobulin A, Secretory, Intestinal Mucosa, Peyer's Patches, Immunoglobulin Class Switching, Mice, Knockout, Germinal Center, Mice, Interleukin-23, Th17 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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