The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Cysteine depletion induces pancreatic tumor ferroptosis in mice
Open accessAbstract
Ferroptotic cell death and cancer: Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is triggered by high intracellular levels of lipid reactive oxygen species. Pancreatic cancer cells have high levels of reactive oxygen species but manage to avoid ferroptosis by importing extracellular cysteine. Studying mice bearing pancreatic tumors, Badgley et al. found that administration of a drug inhibiting cysteine import induced tumor-selective ferroptosis and inhibited tumor growth. Further work will be required to determine whether this therapeutic strategy will be effective in human pancreatic cancer, a tumor type for which new treatments are urgently needed. Science , this issue p. 85
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Reflecting on recent reports suggesting that depletion of CoA contributes to the induction of ferroptosis by erastin (25, 26)”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [25]
Experimental — accuracy not yet measuredIn the citing paper
“Labile iron can also potentiate cell death via the lipid oxidation process known as “ferroptosis”218”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [218]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Self-citationGSVA: gene set variation analysis for microarray and RNA-Seq data
Hänzelmann, S., Castelo, R., & Guinney, J. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-7 · Cited by 15,440
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citationGenomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621
GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor
Davis, S. R., & Meltzer, P. S. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm254 · Cited by 3,316
Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170
Self-citationHingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277
Moffitt, R. A., Marayati, R., Flate, E. L., Volmar, K. E., Loeza, S. G. H., Hoadley, K. A., Rashid, N. U., Williams, L. A., Eaton, S. C., Chung, A. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3398 · Cited by 2,194
EMT and Dissemination Precede Pancreatic Tumor Formation
Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136
Role of Mitochondria in Ferroptosis
Gao, M., Yi, J., Zhu, J., Minikes, A. M., Monian, P., Thompson, C. B., & Jiang, X. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.042 · Cited by 2,120
Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088
Self-citationFerroptosis is an autophagic cell death process
Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., & Jiang, X. (2016) · Cell Research · doi:10.1038/cr.2016.95 · Cited by 1,899
A Model-Based Background Adjustment for Oligonucleotide Expression Arrays
Wu, Z. J., Irizarry, R. A., Gentleman, R. C., Martínez-Murillo, F., & Spencer, F. A. (2004) · Journal of the American Statistical Association · doi:10.1198/016214504000000683 · Cited by 1,717
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
Shimada, K., Skouta, R., Kaplan, A., Yang, W. S., Hayano, M., Dixon, S. J., Brown, L. M., Valenzuela, C. A., Wolpaw, A. J., & Stockwell, B. R. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2079 · Cited by 1,017
Self-citationImidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model
Zhang, Y., Tan, H., Daniels, J. D., Zandkarimi, F., Liu, H., Brown, L. M., Uchida, K., O’Connor, O. A., & Stockwell, B. R. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2019.01.008 · Cited by 739
Self-citationFKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt
Pei, H., Li, L., Fridley, B. L., Jenkins, G. D., Kalari, K. R., Lingle, W., Petersen, G., Lou, Z., & Wang, L. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.016 · Cited by 709
Cramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S. W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4232 · Cited by 549
Self-citationRedox imbalance in cystine/glutamate transporter-deficient mice
Sato, H., Shiiya, A., Kimata, M., Maebara, K., Tamba, M., Sakakura, Y., Makino, N., Sugiyama, F., Yagami, K.-I., Moriguchi, T., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506439200 · Cited by 422
A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Yang, S., He, P., Wang, J., Schetter, A. J., Tang, W., Funamizu, N., Yanaga, K. K., Uwagawa, T., Satoskar, A. R., Gaedcke, J., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2841 · Cited by 403
High-Efficiency FLP and ΦC31 Site-Specific Recombination in Mammalian Cells
Raymond, C. S., & Soriano, P. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000162 · Cited by 385
Carrière, C., Young, A. L., Gunn, J. R., Longnecker, D. S., & Korc, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.03.068 · Cited by 236
Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer
Donahue, T. R., Tran, L. M., Hill, R., Li, Y., Kovochich, A., Calvopina, J. H., Patel, S. G., Wu, N., Hindoyan, A. A., Farrell, J. J., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1539 · Cited by 212
Daher, B., Parks, S. K., Durivault, J., Cormerais, Y., Baidarjad, H., Tambutté, É., Pouysségur, J., & Vučetić, M. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3855 · Cited by 208
Grützmann, R., Pilarsky, C. P., Ammerpohl, O., Lüttges, J., Böhme, A., Sipos, B., Foerder, M., Alldinger, I., Jahnke, B., Schackert, H. K., et al. (2004) · Neoplasia · doi:10.1593/neo.04295 · Cited by 198
Hiraoka, N., Yamazaki–Itoh, R., Ino, Y., Mizuguchi, Y., Yamada, T., Hirohashi, S., & Kanai, Y. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.009 · Cited by 174
Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion
Harris, I. S., Endress, J. E., Coloff, J. L., Selfors, L. M., McBrayer, S. K., Rosenbluth, J. M., Takahashi, N., Dhakal, S., Koduri, V., Oser, M. G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.020 · Cited by 171
RTCGAToolbox: A New Tool for Exporting TCGA Firehose Data
Samur, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106397 · Cited by 161
Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis
Srinivasan, B., Baratashvili, M., van der Zwaag, M., Kanon, B., Colombelli, C., Lambrechts, R. A., Schaap, O., Nollen, E. A. A., Podgoršek, A., Kosec, G., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1906 · Cited by 127
Leu, J. I.-J., Murphy, M. E., & George, D. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821277116 · Cited by 113
Carrière, C., Young, A. L., Gunn, J. R., Longnecker, D. S., & Korc, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027725 · Cited by 77
Rückert, F., Hennig, M. J. P., Petraki, C. D., Wehrum, D., Distler, M., Denz, A., Schroeder, M., Dawelbait, G., Kalthoff, H., Hd, S., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604717 · Cited by 70
Quantification of Murine Pancreatic Tumors by High-Resolution Ultrasound
Sastra, S. A., & Olive, K. P. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-287-2_13 · Cited by 58
Self-citationKshattry, S., Saha, A., Gries, P., Tiziani, S., Stone, E. M., Georgiou, G., & DiGiovanni, J. (2019) · npj Precision Oncology · doi:10.1038/s41698-019-0088-z · Cited by 54
Self-citationEberle-Singh, J. A., Sagalovskiy, I. R., Maurer, H. C., Sastra, S. A., Palermo, C. F., Decker-Farrell, A. R., Kim, M. J., Sheedy, J., Mollin, A., Cao, L., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3281 · Cited by 36
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- T. M. Therneau P. M. Grambsch Modeling Survival Data: Extending the Cox Model (Springer 2013).
Cited by
Sorted by citations
Ferroptosis: mechanisms, biology and role in disease
Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,973
Self-citationFerroptosis: molecular mechanisms and health implications
Tang, D., Chen, X., Kang, R., & Kroemer, G. (2020) · Cell Research · doi:10.1038/s41422-020-00441-1 · Cited by 4,495
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
Stockwell, B. R. (2022) · Cell · doi:10.1016/j.cell.2022.06.003 · Cited by 3,211
Self-citationBroadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 3,012
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Koppula, P., Zhuang, L., & Gan, B. (2020) · Protein & Cell · doi:10.1007/s13238-020-00789-5 · Cited by 2,640
Metadata
- Authors
- Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H.-J., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., Decker, A. R., Sastra, S. A., Palermo, C. F., Andrade, L. R., Sajjakulnukit, P., Zhang, L., Tolstyka, Z. P., Hirschhorn, T., Lamb, C., Liu, T., Gu, W., Seeley, E. S., Stone, E., Georgiou, G., Manor, U., Iuga, A., Wahl, G. M., Stockwell, B. R., Lyssiotis, C. A., & Olive, K. P.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Michigan (US)
- Salk Institute for Biological Studies (US)
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
- Columbia University (US)
- The University of Texas at Austin (US)
- University of California, San Francisco (US)
- Corresponding author
- Kremer, Daniel M.
- Maurer, H. Carlo
- Olive, Kenneth P.
- ORCID
- Badgley, Michael A.
- Kremer, Daniel M.
- Maurer, H. Carlo
- DelGiorno, Kathleen E.
- Lee, Ho-Joon
- Purohit, Vinee
- Sagalovskiy, Irina R.
- Ma, Alice
- Kapilian, Jonathan
- Decker, Amanda R.
- Palermo, Carmine F.
- Andrade, Leonardo R.
- Sajjakulnukit, Peter
- Zhang, Li
- Hirschhorn, Tal
- Lamb, Candice
- Liu, Tong
- Gu, Wei
- Stone, Everett
- Georgiou, George
- Manor, Uri
- Iuga, Alina
- Wahl, Geoffrey M.
- Stockwell, Brent R.
- Lyssiotis, Costas A.
- Olive, Kenneth P.
- Venue
- Science
- Published
- 2020-04-03
- Volume
- 368
- Issue
- 6486
- Pages
- 85-89
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7681911
- OpenAlex
- W3015020891
- Cited by
- 1,294
- References
- 41
- Citations by year
- 2026: 165 · 2025: 206 · 2024: 253 · 2023: 230 · 2022: 210 · 2021: 171 · 2020: 58
- FWCI
- 94.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T32 A009503, F31 CA180738, 1R01CA215607, P30CA013696, U24-DK097153, P01CA087497, CA189623, CA014195, R35 CA197687, Cancer Center Core Grant CA014195, CA197687)
- National Cancer Institute (CA224272, R35CA209896)
- Damon Runyon Cancer Research Foundation (DFS-09-14)
- U.S. Department of Education
- U.S. Department of Defense (W81XWH-17-1-0497)
- Lustgarten Foundation (2011 Innovator Award)
- Sidney Kimmel Foundation for Cancer Research (SKF-16-005)
- Pancreatic Cancer Action Network (13-70-25-LYSS)
- The V Foundation for Cancer Research (V2016-009)
- Waitt Foundation
- Salk Women and Special Science Award
- The Freeberg Foundation (N/A)
- Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- ferroptosis, cysteine depletion, pancreatic cancer, lipid reactive oxygen species, cancer therapy, tumor growth inhibition
- MeSH terms
- Ferroptosis, Animals, Cystathionine gamma-Lyase, Cysteine, Cystine, Humans, Mice, Mutant Strains, Pancreatic Neoplasms, Gene Deletion, Carcinoma, Pancreatic Ductal, Cationic Amino Acid Transporter 1, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
