The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Cysteine depletion induces pancreatic tumor ferroptosis in mice
Open accessAbstract
Ferroptotic cell death and cancer: Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is triggered by high intracellular levels of lipid reactive oxygen species. Pancreatic cancer cells have high levels of reactive oxygen species but manage to avoid ferroptosis by importing extracellular cysteine. Studying mice bearing pancreatic tumors, Badgley et al. found that administration of a drug inhibiting cysteine import induced tumor-selective ferroptosis and inhibited tumor growth. Further work will be required to determine whether this therapeutic strategy will be effective in human pancreatic cancer, a tumor type for which new treatments are urgently needed. Science , this issue p. 85
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Reflecting on recent reports suggesting that depletion of CoA contributes to the induction of ferroptosis by erastin (25, 26)”
From Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction (2022) · cites this paper as [25]
Experimental — accuracy not yet measuredIn the citing paper
“Labile iron can also potentiate cell death via the lipid oxidation process known as “ferroptosis”218”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [218]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Self-citationGSVA: gene set variation analysis for microarray and RNA-Seq data
Hänzelmann, S., Castelo, R., & Guinney, J. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-7 · Cited by 15,440
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citationGenomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621
GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor
Davis, S. R., & Meltzer, P. S. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm254 · Cited by 3,316
Research works printed but not linked: 1
- T. M. Therneau P. M. Grambsch Modeling Survival Data: Extending the Cox Model (Springer 2013).
Cited by
Sorted by citations
Ferroptosis: mechanisms, biology and role in disease
Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,973
Self-citationFerroptosis: molecular mechanisms and health implications
Tang, D., Chen, X., Kang, R., & Kroemer, G. (2020) · Cell Research · doi:10.1038/s41422-020-00441-1 · Cited by 4,495
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
Stockwell, B. R. (2022) · Cell · doi:10.1016/j.cell.2022.06.003 · Cited by 3,211
Self-citationBroadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 3,012
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Koppula, P., Zhuang, L., & Gan, B. (2020) · Protein & Cell · doi:10.1007/s13238-020-00789-5 · Cited by 2,640
Targeting Ferroptosis as a Vulnerability in Cancer
Lei, G., Zhuang, L., & Gan, B. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00459-0 · Cited by 2,252
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
Cancer metabolism: looking forward
Martínez‐Reyes, I., & Chandel, N. S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00378-6 · Cited by 1,877
The role of ROS in tumour development and progression
Cheung, E. C., & Vousden, K. H. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00435-0 · Cited by 1,663
The Cell Biology of Ferroptosis
Dixon, S. J., & Olzmann, J. A. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00703-5 · Cited by 1,596
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321
Self-citationThe Metabolic Underpinnings of Ferroptosis
Zheng, J., & Conrad, M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.011 · Cited by 1,368
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
Tang, R., Xu, J., Zhang, B., Liu, J., Liang, C., Hua, J., Meng, Q., Yu, X., & Shi, S. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00946-7 · Cited by 1,292
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
Fang, X., Ardehali, H., Min, J., & Wang, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00735-4 · Cited by 1,121
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
Gao, W., Wang, Y., Zhou, Y., Wang, X., & Yu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01046-3 · Cited by 1,097
Newton, K., Strasser, A., Kayagaki, N., & Dixit, V. M. (2024) · Cell · doi:10.1016/j.cell.2023.11.044 · Cited by 1,068
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
Zhou, Q., Meng, Y., Li, D., Yao, L., Le, J., Liu, Y., Sun, Y., Zeng, F., Chen, X., & Deng, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01769-5 · Cited by 1,056
Ferroptosis in infection, inflammation, and immunity
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 836
Metabolic reprogramming and epigenetic modifications on the path to cancer
Sun, L., Zhang, H., & Gao, P. (2021) · Protein & Cell · doi:10.1007/s13238-021-00846-7 · Cited by 818
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Liang, D., Feng, Y., Zandkarimi, F., Wang, H., Zhang, Z., Kim, J., Cai, Y., Gu, W. J., Stockwell, B. R., & Jiang, X. (2023) · Cell · doi:10.1016/j.cell.2023.05.003 · Cited by 769
Self-citationEngineering nanomedicine for glutathione depletion-augmented cancer therapy
Xiong, Y., Xiao, C., Li, Z., & Yang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00718h · Cited by 702
Targeting ROS in cancer: rationale and strategies
Glorieux, C., Liu, S., Trachootham, D., & Huang, P. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-00979-4 · Cited by 735
Understanding mechanisms of antioxidant action in health and disease
Halliwell, B. B. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00645-4 · Cited by 709
Cellular degradation systems in ferroptosis
Chen, X., Yu, C., Kang, R., Kroemer, G., & Tang, D. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00728-1 · Cited by 671
Targeting ferroptosis opens new avenues for the development of novel therapeutics
Sun, S., Shen, J., Jiang, J., Wang, F., & Min, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01606-1 · Cited by 674
Lei, G., Zhuang, L., & Gan, B. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.011 · Cited by 635
Amino acid metabolism in health and disease
Ling, Z., Jiang, Y.-F., Ru, J.-N., Lu, J.-H., Ding, B., & Wu, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01569-3 · Cited by 590
Ferroptosis of tumour neutrophils causes immune suppression in cancer
Kim, R., Hashimoto, A., Markosyan, N., Tyurin, V. A., Tyurina, Y. Y., Kar, G., Fu, S., Sehgal, M., Garcia-Gerique, L., Kossenkov, A. V., et al. (2022) · Nature · doi:10.1038/s41586-022-05443-0 · Cited by 568
Targeting glutamine metabolism as a therapeutic strategy for cancer
Jin, J., Byun, J., Choi, Y., & Park, K. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00971-9 · Cited by 605
Characteristics and Biomarkers of Ferroptosis
Chen, X., Comish, P. B., Tang, D., & Kang, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637162 · Cited by 535
Ferroptosis, radiotherapy, and combination therapeutic strategies
Lei, G., Mao, C., Yan, Y., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-021-00841-y · Cited by 539
Koppula, P., Lei, G., Zhang, Y., Yan, Y., Mao, C., Kondiparthi, L., Shi, J., Liu, X., Horbath, A. D., Das, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29905-1 · Cited by 495
The diversified role of mitochondria in ferroptosis in cancer
Liu, Y., Lu, S.-P., Wu, L., Yang, L., Wang, J., & Wang, J. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06045-y · Cited by 486
Li, F., Long, H., Zhou, Z.-W., Luo, H., Xu, S., & Gao, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910292 · Cited by 476
Dai, E., Han, L., Liu, J., Xie, Y., Zeh, H. J., Kang, R., Bai, L., & Tang, D. (2020) · Nature Communications · doi:10.1038/s41467-020-20154-8 · Cited by 440
Identification of essential sites of lipid peroxidation in ferroptosis
von Krusenstiern, A. N., Robson, R. N., Qian, N., Qiu, B., Hu, F., Reznik, E., Smith, N., Zandkarimi, F., Estes, V. M., Dupont, M. M., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-022-01249-3 · Cited by 432
Self-citationZhao, Y., Li, M., Yao, X., Yang, F., Lin, Z., Li, Z., Cai, K., Zhao, Y., & Luo, Z. Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108487 · Cited by 420
Modes of Regulated Cell Death in Cancer
Koren, E., & Fuchs, Y. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0789 · Cited by 388
The metabolic landscape of RAS-driven cancers from biology to therapy
Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis
Kang, Y. P., Mockabee‐Macias, A., Jiang, C., Falzone, A., Prieto-Farigua, N., Stone, E. M., Harris, I. S., & DeNicola, G. M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.007 · Cited by 358
Self-citationFerroptosis in health and disease
Berndt, C., Alborzinia, H., Skafar, V., Ayton, S., Barayeu, U., Bartelt, A., Bayır, H., Bebber, C. M., Birsoy, K., Böttcher, J. P., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103211 · Cited by 372
Self-citationxCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling
Liu, J., Xia, X., & Huang, P. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.021 · Cited by 357
Cell death in pancreatic cancer: from pathogenesis to therapy
Chen, X., Zeh, H. J., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00486-6 · Cited by 344
Bayır, H., Dixon, S. J., Tyurina, Y. Y., Kellum, J. A., & Kagan, V. E. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00689-x · Cited by 355
The therapeutic potential of targeting regulated non-apoptotic cell death
Hadian, K., & Stockwell, B. R. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00749-8 · Cited by 349
Self-citationMetabolic orchestration of the wound healing response
Eming, S. A., Murray, P. J., & Pearce, E. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.017 · Cited by 326
Emerging mechanisms and targeted therapy of ferroptosis in cancer
Wang, H., Cheng, Y., Mao, C., Liu, S., Xiao, D., Huang, J. X., & Tao, Y. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.022 · Cited by 326
Disulfidptosis: disulfide stress–induced cell death
Liu, X., Zhuang, L., & Gan, B. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.07.009 · Cited by 325
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1
Kong, N., Chen, X., Feng, J., Duan, T., Liu, S., Sun, X., Chen, P., Pan, T. S., Yan, L., Jin, T., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.036 · Cited by 303
The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis
Santana-Codina, N., Gikandi, A., & Mancias, J. D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62026-4_4 · Cited by 329
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
Wang, W., & Zou, W. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.09.006 · Cited by 313
Ferroptosis: principles and significance in health and disease
Chen, F., Kang, R., Tang, D., & Liu, J. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01564-3 · Cited by 341
A guideline on the molecular ecosystem regulating ferroptosis
Dai, E., Chen, X., Linkermann, A., Jiang, X., Kang, R., Kagan, V. E., Bayır, H., Yang, W. S., García‐Sáez, A. J., Ioannou, M. S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01360-8 · Cited by 327
Self-citationSignaling pathways in cancer metabolism: mechanisms and therapeutic targets
You, M., Xie, Z., Zhang, N., Zhang, Y., Xiao, D., Liu, S., Zhuang, W., Li, L., & Tao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01442-3 · Cited by 317
Lu, Y., Zhao, M., Luo, Q.-W., Zhang, Y., Liu, T.-T., Yang, Z., Liao, M., Tu, P., & Zeng, K. (2022) · ACS Nano · doi:10.1021/acsnano.2c01619 · Cited by 296
Self-citationOxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy
Aboelella, N. S., Brandle, C., Kim, T., Ding, Z., & Zhou, G. (2021) · Cancers · doi:10.3390/cancers13050986 · Cited by 303
Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells
Yao, X., Li, W., Fang, D., Xiao, C., Wu, X. W., Li, M., & Luo, Z. Y. (2021) · Advanced Science · doi:10.1002/advs.202100997 · Cited by 292
The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer
Jyotsana, N., Ta, K. T. L., & DelGiorno, K. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.858462 · Cited by 290
Self-citationZhang, Z., Zeng, X., Wu, Y., Liu, Y., Zhang, X., & Song, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.925618 · Cited by 271
Feng, L., Zhao, K., Sun, L., Yin, X., Zhang, J., Liu, C., & Li, B. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03042-7 · Cited by 277
Activation of lysosomal iron triggers ferroptosis in cancer
Cañeque, T., Baron, L., Müller, S., Carmona, A., Colombeau, L., Versini, A., Solier, S., Gaillet, C., Sindikubwabo, F., Sampaio, J. L., et al. (2025) · Nature · doi:10.1038/s41586-025-08974-4 · Cited by 287
Self-citationGPX4-independent ferroptosis—a new strategy in disease’s therapy
Ma, T., Du, J., Zhang, Y., Wang, Y., Wang, B., & Zhang, T. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01212-0 · Cited by 291
FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells
Zeng, Y., Zhuo, Q., Hu, Q., Xu, X., Liu, M., Zhang, Z., Xu, W., Liu, W., Fan, G., Qin, Y., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101807 · Cited by 271
Amino Acid Depletion Therapies: Starving Cancer Cells to Death
Butler, M., van der Meer, L. T., & van Leeuwen, F. N. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.03.003 · Cited by 277
Persister cancer cells: Iron addiction and vulnerability to ferroptosis
Rodriguez, R., Schreiber, S. L., & Conrad, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.12.001 · Cited by 280
Molecular mechanisms of ferroptosis and relevance to inflammation
Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01672-1 · Cited by 273
Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Wang, X., Chen, Y., Wang, X., Tian, H., Wang, Y., Jin, J., Shan, Z., Liu, Y., Cai, Z., Tong, X., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0567 · Cited by 271
Song, X., Liu, J., Kuang, F., Chen, X., Zeh, H. J., Kang, R., Kroemer, G., Xie, Y., & Tang, D. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108767 · Cited by 262
Functional states of myeloid cells in cancer
van Vlerken-Ysla, L. E., Tyurina, Y. Y., Kagan, V. E., & Gabrilovich, D. I. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.009 · Cited by 274
Ferroptosis: when metabolism meets cell death
Zheng, J., & Conrad, M. (2024) · Physiological Reviews · doi:10.1152/physrev.00031.2024 · Cited by 286
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
Kremer, D. M., Nelson, B. S., Lin, L., Yarosz, E. L., Halbrook, C. J., Kerk, S. A., Sajjakulnukit, P., Myers, A. L., Thurston, G., Hou, S. W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24859-2 · Cited by 268
Self-citationWu, C., Liu, Z., Chen, Z., Xu, D., Chen, L., Lin, H., & Shi, J. (2021) · Science Advances · doi:10.1126/sciadv.abj8833 · Cited by 254
Wang, Y., Cheng, H., Wang, T., Zhang, K., Zhang, Y., & Kang, X. (2023) · Cell Proliferation · doi:10.1111/cpr.13448 · Cited by 243
Zhang, Q., Deng, T., Zhang, H., Zuo, D., Zhu, Q., Bai, M., Liu, R., Ning, T., Zhang, L., Yu, Z., et al. (2022) · Advanced Science · doi:10.1002/advs.202203357 · Cited by 234
Self-citationHIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
Singhal, R., Mitta, S. R., Das, N. K., Kerk, S. A., Sajjakulnukit, P., Solanki, S., Andren, A., Kumar, R., Olive, K. P., Banerjee, R., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143691 · Cited by 215
Self-citationCathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Xie, Z., Zhao, M., Yan, C., Kong, W., Lan, F., Narengaowa, Zhao, S., Yang, Q., Bai, Z., Qing, H., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05786-0 · Cited by 217
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond
Mao, C., Wang, M., Zhuang, L., & Gan, B. (2024) · Protein & Cell · doi:10.1093/procel/pwae003 · Cited by 237
Ferroptosis: A flexible constellation of related biochemical mechanisms
Dixon, S. J., & Pratt, D. A. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.03.005 · Cited by 219
ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1
Zhang, T., Sun, L., Hao, Y., Suo, C., Shen, S., Wei, H., Ma, W., Zhang, P., Wang, T., Gu, X., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00299-1 · Cited by 209
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Xiao, Y.-L., Gong, Y., Qi, Y.-J., Shao, Z., & Jiang, Y.-Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01771-x · Cited by 218
Yang, W., Wang, Y., Zhang, C., Huang, Y., Yu, J., Shi, L., Zhang, P., Yin, Y., Li, R., & Tao, K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.865689 · Cited by 210
SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer
Lee, J., & Roh, J. (2022) · Antioxidants · doi:10.3390/antiox11122444 · Cited by 213
Ferroptosis as a potential target for cancer therapy
Chen, Z., Wang, W., Razak, S. R. A., Han, T., Ahmad, N. H., & Li, X. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05930-w · Cited by 223
MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells
Kuang, F., Liu, J., Xie, Y., Tang, D., & Kang, R. (2021) · Cell Chemical Biology · doi:10.1016/j.chembiol.2021.01.006 · Cited by 199
The pleiotropic functions of reactive oxygen species in cancer
Wu, K., Zowalaty, A. E. E., Sayin, V. I., & Papagiannakopoulos, T. Y. (2024) · Nature Cancer · doi:10.1038/s43018-024-00738-9 · Cited by 216
Du, J., Wang, X., Li, Y., Ren, X., Zhou, Y., Hu, W., Zhou, C., Jing, Q., Yang, C., Wang, L., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03996-y · Cited by 199
Role of mitochondrial alterations in human cancer progression and cancer immunity
Wang, S., Tseng, L., & Lee, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00956-w · Cited by 225
Self-citationZheng, X. W., Wang, Q., Zhou, Y., Zhang, D., Geng, Y., Hu, W., Wu, C., Shi, Y., & Jiang, J. (2022) · 癌症：英文版 · doi:10.1002/cac2.12363 · Cited by 196
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
Drijvers, J. M., Gillis, J. E., Muijlwijk, T., Nguyen, T. H., Gaudiano, E. F., Harris, I. S., LaFleur, M. W., Ringel, A. E., Yao, C.-H., Kurmi, K., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0384 · Cited by 191
Upadhyayula, P. S., Higgins, D. M. O., Mela, A., Banu, M. A., Dovas, A., Zandkarimi, F., Patel, P. R., Mahajan, A., Humala, N., Nguyen, T. T. T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36630-w · Cited by 195
Self-citationCDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis
Minami, J. K., Morrow, D., Bayley, N. A., Fernandez, E. G., Salinas, J. J., Tse, C., Zhu, H., Su, B., Plawat, R., Jones, A. E., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.05.001 · Cited by 199
Sun, J., Zhou, C., Zhao, Y., Zhang, X.-F., Chen, W., Zhou, Q., Hu, B., Gao, D., Raatz, L., Wang, Z., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101942 · Cited by 190
STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway
Yang, Y., Ma, Y., Li, Q., Ling, Y., Zhou, Y., Chu, K., Xue, L., & Tao, S. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04971-x · Cited by 191
Nicolini, A., & Ferrari, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1353787 · Cited by 209
Liu, X., Zhang, Y., Zhuang, L., Olszewski, K. L., & Gan, B. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.11.010 · Cited by 191
Dietary regulation in health and disease
Wu, Q., Gao, Z., Yu, X., & Wang, P. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01104-w · Cited by 190
Recommendations for robust and reproducible research on ferroptosis
Mishima, E., Nakamura, T., Doll, S. G., Proneth, B., Fedorova, M., Pratt, D. A., Angeli, J. P. F., Dixon, S. J., Wahida, A., & Conrad, M. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00843-2 · Cited by 211
Lei, H., Pei, Z., Jiang, C., & Cheng, L. (2023) · Exploration · doi:10.1002/exp.20220001 · Cited by 181
Cassim, S., Vučetić, M., Ždralević, M., & Pouysségur, J. (2020) · Cancers · doi:10.3390/cancers12051119 · Cited by 183
Metadata
- Authors
- Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H.-J., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., Decker, A. R., Sastra, S. A., Palermo, C. F., Andrade, L. R., Sajjakulnukit, P., Zhang, L., Tolstyka, Z. P., Hirschhorn, T., Lamb, C., Liu, T., Gu, W., Seeley, E. S., Stone, E., Georgiou, G., Manor, U., Iuga, A., Wahl, G. M., Stockwell, B. R., Lyssiotis, C. A., & Olive, K. P.
- Affiliations
- Columbia University Irving Medical Center (US)
- University of Michigan (US)
- Salk Institute for Biological Studies (US)
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
- Columbia University (US)
- The University of Texas at Austin (US)
- University of California, San Francisco (US)
- Corresponding author
- Kremer, Daniel M.
- Maurer, H. Carlo
- Olive, Kenneth P.
- ORCID
- Badgley, Michael A.
- Kremer, Daniel M.
- Maurer, H. Carlo
- DelGiorno, Kathleen E.
- Lee, Ho-Joon
- Purohit, Vinee
- Sagalovskiy, Irina R.
- Ma, Alice
- Kapilian, Jonathan
- Decker, Amanda R.
- Palermo, Carmine F.
- Andrade, Leonardo R.
- Sajjakulnukit, Peter
- Zhang, Li
- Hirschhorn, Tal
- Lamb, Candice
- Liu, Tong
- Gu, Wei
- Stone, Everett
- Georgiou, George
- Manor, Uri
- Iuga, Alina
- Wahl, Geoffrey M.
- Stockwell, Brent R.
- Lyssiotis, Costas A.
- Olive, Kenneth P.
- Venue
- Science
- Published
- 2020-04-03
- Volume
- 368
- Issue
- 6486
- Pages
- 85-89
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7681911
- OpenAlex
- W3015020891
- Cited by
- 1,294
- References
- 41
- Citations by year
- 2026: 165 · 2025: 206 · 2024: 253 · 2023: 230 · 2022: 210 · 2021: 171 · 2020: 58
- FWCI
- 94.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (T32 A009503, F31 CA180738, 1R01CA215607, P30CA013696, U24-DK097153, P01CA087497, CA189623, CA014195, R35 CA197687, Cancer Center Core Grant CA014195, CA197687)
- National Cancer Institute (CA224272, R35CA209896)
- Damon Runyon Cancer Research Foundation (DFS-09-14)
- U.S. Department of Education
- U.S. Department of Defense (W81XWH-17-1-0497)
- Lustgarten Foundation (2011 Innovator Award)
- Sidney Kimmel Foundation for Cancer Research (SKF-16-005)
- Pancreatic Cancer Action Network (13-70-25-LYSS)
- The V Foundation for Cancer Research (V2016-009)
- Waitt Foundation
- Salk Women and Special Science Award
- The Freeberg Foundation (N/A)
- Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- ferroptosis, cysteine depletion, pancreatic cancer, lipid reactive oxygen species, cancer therapy, tumor growth inhibition
- MeSH terms
- Ferroptosis, Animals, Cystathionine gamma-Lyase, Cysteine, Cystine, Humans, Mice, Mutant Strains, Pancreatic Neoplasms, Gene Deletion, Carcinoma, Pancreatic Ductal, Cationic Amino Acid Transporter 1, Cell Line, Tumor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
