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Structural basis for the docking of mTORC1 on the lysosomal surface

Rogala, Kacper B., Gu, Xin, Kedir, Jibril F., Abu-Remaileh, Monther, Bianchi, Laura F., Bottino, Alexia M. S., Dueholm, Rikke, Niehaus, Anna, Overwijn, Daan, Fils, Ange-Célia Priso, Zhou, Sherry X., Leary, Daniel, Laqtom, Nouf N., Brignole, Edward J., Sabatini, David M.·2019·Science
DOI 10.1126/science.aay0166PMC PMC7176403
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Abstract

Complex regulation: The protein kinase mTORC1 controls cellular growth in response to external signals. In the presence of nutrients, it localizes on the surface of the lysosome, where it is activated. The Raptor domain of mTORC1 binds to a complex comprising the protein Ragulator and a heterodimer of the Rag guanosine triphosphatase, which can adopt four different nucleotide conformations depending on nutrient availability. Rogala et al. determined the structure of the Raptor-Rag-Ragulator complex at 3.2-angstrom resolution by cryo–electron microscopy. The structure shows why Raptor binds only to a specific nucleotide conformation of the Rag heterodimer and suggests a model for how mTORC1 would dock onto the lysosomal surface, which is a key step in its activation. Science , this issue p. 468

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Research works printed but not linked: 63

  1. 10.1073/pnas.1716173114 · DOI
  2. 10.1038/s41556-018-0205-1 · DOI
  3. 10.1038/s41568-018-0074-8 · DOI · Paper page
  4. 10.1038/s42255-019-0038-7 · DOI
  5. 10.1016/j.bbrc.2006.03.220 · DOI
  6. 10.1126/science.1157535 · DOI · Paper page
  7. 10.1038/nature11745 · DOI
  8. 10.1093/genetics/152.3.853 · DOI
  9. 10.1074/jbc.M004389200 · DOI
  10. 10.1016/j.molcel.2017.09.026 · DOI · Paper page
  11. 10.1146/annurev-biochem-062708-134043 · DOI
  12. 10.1126/scisignal.2004112 · DOI · Paper page
  13. 10.1016/j.molcel.2013.09.016 · DOI · Paper page
  14. 10.1073/pnas.1811727115 · DOI
  15. 10.1038/ng.3473 · DOI
  16. 10.1038/s41592-019-0575-8 · DOI
  17. 10.1038/s42003-019-0437-z · DOI
  18. 10.1101/gad.16968011 · DOI · Paper page
  19. 10.3390/biom7030048 · DOI
  20. 10.1093/embo-reports/kvf221 · DOI
  21. 10.1038/emboj.2008.308 · DOI · Paper page
  22. 10.1083/jcb.2.4.179 · DOI
  23. 10.1016/j.mrfmmm.2009.01.001 · DOI
  24. 10.1038/75863 · DOI
  25. 10.1093/embo-reports/kve043 · DOI
  26. 10.7554/eLife.07410 · DOI
  27. K. B. Rogala thesis University of Oxford (2016).
  28. 10.1016/0378-1119(77)90000-2 · DOI
  29. 10.1038/nbt984 · DOI
  30. 10.1016/j.pep.2009.08.010 · DOI
  31. 10.1038/nbt1095 · DOI · Paper page
  32. 10.1016/0022-2836(92)90629-X · DOI
  33. 10.1038/nmeth.1318 · DOI
  34. 10.1002/prot.24364 · DOI
  35. 10.1038/ncomms11529 · DOI
  36. 10.1128/jvi.67.8.4566-4579.1993 · DOI
  37. 10.1017/S1431927603445911 · DOI
  38. 10.1038/nmeth.4193 · DOI
  39. 10.1107/S205225251801463X · DOI
  40. 10.1016/j.jsb.2015.11.003 · DOI
  41. 10.7554/eLife.42166 · DOI
  42. 10.7554/eLife.03665 · DOI
  43. 10.1038/nmeth.4169 · DOI · Paper page
  44. 10.1038/nmeth.4347 · DOI
  45. 10.1002/jcc.20084 · DOI
  46. 10.1107/S0907444910007493 · DOI · Paper page
  47. 10.1107/S2059798318006551 · DOI
  48. 10.1107/S0907444909042073 · DOI · Paper page
  49. 10.1038/nmeth.3541 · DOI · Paper page
  50. 10.1002/pro.3235 · DOI · Paper page
  51. S. J. M. Smith K. Rittinger in GTPase Protocols E. Manser T. Leung Eds. (Humana 2003) pp. 013–024.
  52. 10.1126/science.aao3265 · DOI
  53. 10.1038/nmeth.4067 · DOI
  54. 10.1038/nmeth.4067 · DOI
  55. 10.1063/1.328693 · DOI
  56. 10.1063/1.448118 · DOI
  57. 10.1063/1.464397 · DOI
  58. 10.1038/s41467-017-01567-4 · DOI
  59. 10.1038/celldisc.2017.49 · DOI
  60. 10.1016/j.molcel.2017.10.016 · DOI
  61. 10.1093/bib/bbx108 · DOI · Paper page
  62. 10.1093/nar/gku316 · DOI · Paper page
  63. 10.1107/S2059798318009324 · DOI

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Metadata

Authors
Rogala, K. B., Gu, X., Kedir, J. F., Abu-Remaileh, M., Bianchi, L. F., Bottino, A. M. S., Dueholm, R., Niehaus, A., Overwijn, D., Fils, A.-C. P., Zhou, S. X., Leary, D., Laqtom, N. N., Brignole, E. J., & Sabatini, D. M.
Affiliations
  • Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  • Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  • Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-10-25
Volume
366
Issue
6464
Pages
468-475
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.aay0166
PMC
PMC7176403
Cited by
214
References
15
Language
en
Funders
  • National Institutes of Health (R01 CA103866, R01 CA129105, R37 AI47389, F30 CA236179)
  • U.S. Department of Defense (W81XWH-07-0448)
  • Howard Hughes Medical Institute
  • Charles A. King Trust
  • Koch Institute
  • American Cancer Society
  • Lustgarten Foundation
  • Saudi Aramco Ibn Khaldun Fellowship for Saudi Women
  • Tuberous Sclerosis Association

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CoChat. (2026). Citation check: Structural basis for the docking of mTORC1 on the lysosomal surface. https://app.cochat.ai/papers/10.1126/science.aay0166
The paper
Rogala, K. B., Gu, X., Kedir, J. F., Abu-Remaileh, M., Bianchi, L. F., Bottino, A. M. S., Dueholm, R., Niehaus, A., Overwijn, D., Fils, A.-C. P., Zhou, S. X., Leary, D., Laqtom, N. N., Brignole, E. J., & Sabatini, D. M. (2019). Structural basis for the docking of mTORC1 on the lysosomal surface. Science. https://doi.org/10.1126/science.aay0166