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Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
Abstract
A complex that inactivates a GTPase keeps the TORC1 pathway in check in times of amino acid deprivation.
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GATOR2 inhibits the activity of GATOR1.
“One of the best described systems for regulating the nucleotide binding status of the Rag GTPases is the activity of the GATOR complexes. GATOR1 functions as a GAP for RagA and RagB, while GATOR2 acts to inhibit the activity of GATOR1 167,168.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [167]
GATOR1 functions as a GAP for RagA and RagB.
“One of the best described systems for regulating the nucleotide binding status of the Rag GTPases is the activity of the GATOR complexes. GATOR1 functions as a GAP for RagA and RagB, while GATOR2 acts to inhibit the activity of GATOR1 167,168.”
From Targeting the biology of aging with mTOR inhibitors (2023) · cites this paper as [167]
Citations
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Metadata
- Authors
- Panchaud, N., Péli-Gulli, M.-P., & De Virgilio, C.
- Affiliations
- Department of Biology, Division of Biochemistry, University of Fribourg, CH-1700 Fribourg, Switzerland.
- Venue
- Science Signaling
- Published
- 2013-05-28
- Volume
- 6
- Issue
- 277
- ISSN
- 1945-0877
- 1937-9145
- Cited by
- 286
- References
- 6
- Language
- en
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