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Region-Specific Characteristics of Astrocytes and Microglia: A Possible Involvement in Aging and Diseases

Lee, Jae, Kim, Sung Wook, Kim, Kyong-Tai·2022·Cells
DOI 10.3390/cells11121902PMC PMC9220858
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Abstract

Although different regions of the brain are dedicated to specific functions, the intra- and inter-regional heterogeneity of astrocytes and microglia in these regions has not yet been fully understood. Recently, an advancement in various technologies, such as single-cell RNA sequencing, has allowed for the discovery of astrocytes and microglia with distinct molecular fingerprints and varying functions in the brain. In addition, the regional heterogeneity of astrocytes and microglia exhibits different functions in several situations, such as aging and neurodegenerative diseases. Therefore, investigating the region-specific astrocytes and microglia is important in understanding the overall function of the brain. In this review, we summarize up-to-date research on various intra- and inter-regional heterogeneities of astrocytes and microglia, and provide information on how they can be applied to aging and neurodegenerative diseases.

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Cited by

Sorted by citations

Metadata

Authors
Lee, J., Kim, S. W., & Kim, K.-T.
Affiliations
Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2022-06-12
Volume
11
Issue
12
Pages
1902
ISSN
2073-4409
DOI
10.3390/cells11121902
PMC
PMC9220858
Cited by
34
References
58
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Rural Development Administration of the Republic of Korea (PJ01640202)

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