The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Open accessAbstract
Profiling coronaviruses: Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections. Shrock et al. used a technology known as VirScan to probe the antibody repertoires of hundreds of coronavirus disease 2019 (COVID-19) patients and pre–COVID-19 era controls. They identified hundreds of antibody targets, including several antibody epitopes shared by the mild and severe coronaviruses and many specific to SARS-CoV-2. A machine-learning model accurately classified patients infected with SARS-CoV-2 and guided the design of an assay for rapid SARS-CoV-2 antibody detection. The study also looked at how the antibody response and viral exposure history differ in patients with diverging outcomes, which could inform the production of improved vaccine and antibody therapies. Science , this issue p. eabd4250
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“COVID-19 severity has been linked to the incidence of CMV, a primary pathogen associated with memory inflation, but more work is needed to establish how CMV and other latent viruses of the elderly affect new memory T cell formation, function, and longevity146.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [146]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,959
MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms
Kumar, S., Stecher, G., Li, M., Knyaz, C., & Tamura, K. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy096 · Cited by 37,683
Self-citationA pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
From local explanations to global understanding with explainable AI for trees
Lundberg, S. M., Erion, G., Chen, H., DeGrave, A., Prutkin, J. M., Nair, B., Katz, R., Himmelfarb, J., Bansal, N., & Lee, S.-I. (2020) · Nature Machine Intelligence · doi:10.1038/s42256-019-0138-9 · Cited by 10,551
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · doi:10.1101/2020.02.19.956581 · Cited by 8,586
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
Lan, J., Ge, J., Yu, J., Shan, S., Zhou, H., Fan, S., Zhang, Q., Shi, X., Wang, Q., Zhang, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2180-5 · Cited by 5,983
Origin and evolution of pathogenic coronaviruses
Cui, J., Li, F., & Shi, Z. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0118-9 · Cited by 5,729
Prospects for inferring very large phylogenies by using the neighbor-joining method
Tamura, K., Nei, M., & Kumar, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404206101 · Cited by 5,588
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature · doi:10.1038/s41586-020-2286-9 · Cited by 4,405
Flagged first, then by citations
Research works printed but not linked: 2
- National Center for Biotechnology Information National Library of Medicine Protein database (2004) [cited 29 February 2020]; www.ncbi.nlm.nih.gov/protein/.
- 10.1016/j.cell.2020.02.058 · DOI · Paper page
Cited by
Sorted by citations
SARS-CoV-2 variants, spike mutations and immune escape
Harvey, W. T., Carabelli, A. M., Jackson, B., Gupta, R. K., Thomson, E. C., Harrison, E. M., Ludden, C., Reeve, R., Rambaut, A., COVID-19 Genomics UK (COG-UK) Consortium, et al. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00573-0 · Cited by 3,528
Adaptive immunity to SARS-CoV-2 and COVID-19
Sette, A., & Crotty, S. (2021) · Cell · doi:10.1016/j.cell.2021.01.007 · Cited by 1,860
SARS-CoV-2 evolution during treatment of chronic infection
Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., et al. (2021) · Nature · doi:10.1038/s41586-021-03291-y · Cited by 1,097
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Ng, K. W., Faulkner, N., Cornish, G. H., Rosa, A., Harvey, R., Hussain, S., Ulferts, R., Earl, C., Wrobel, A. G., Benton, D. J., et al. (2020) · Science · doi:10.1126/science.abe1107 · Cited by 886
COVID-19 Neutralizing Antibodies Predict Disease Severity and Survival
García-Beltrán, W. F., Lam, E. C., Astudillo, M. G., Yang, D., Miller, T. E., Feldman, J. E., Hauser, B. M., Caradonna, T. M., Clayton, K., Nitido, A. D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.12.015 · Cited by 708
Self-citationPathogenesis of human cytomegalovirus in the immunocompromised host
Griffiths, P. D., & Reeves, M. B. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00582-z · Cited by 615
Tarke, A., Sidney, J., Kidd, C. K., Dan, J. M., Ramirez, S. I., Yu, E. D., Mateus, J., da Silva Antunes, R., Moore, E., Rubiro, P., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100204 · Cited by 540
Natural killer cells in antiviral immunity
Björkström, N. K., Strunz, B., & Ljunggren, H. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00558-3 · Cited by 527
Anderson, E. M., Goodwin, E. C., Verma, A., Arevalo, C. P., Bolton, M. J., Weirick, M. E., Gouma, S., McAllister, C. M., Christensen, S. R., Weaver, J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.010 · Cited by 381
SARS-CoV-2, COVID-19 and the aging immune system
Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic
To, K. K., Sridhar, S., Chiu, K. H., Hung, D. L. L., Li, X., Hung, I. F., Tam, A. R., Chung, T. W., Chan, J. F., Zhang, J., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1898291 · Cited by 359
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Sokal, A., Chappert, P., Barba-Spaeth, G., Roeser, A., Fourati, S., Azzaoui, I., Vandenberghe, A., Fernandez, I., Meola, A., Bouvier-Alias, M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.050 · Cited by 340
Kundu, R., Narean, J. S., Wang, L., Fenn, J., Pillay, T. D., Derqui, N., Conibear, E., Koycheva, A., Davies, M., Tolosa-Wright, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27674-x · Cited by 316
Leveraging artificial intelligence in the fight against infectious diseases
Wong, F. J., de la Fuente‐Núñez, C., & Collins, J. J. (2023) · Science · doi:10.1126/science.adh1114 · Cited by 331
Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., et al. (2021) · Science · doi:10.1126/science.abh1823 · Cited by 293
Antibodies to combat viral infections: development strategies and progress
Pantaleo, G., Correia, B. E., Fenwick, C. W., Joo, V., & Perez, L. H. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00495-3 · Cited by 298
Tubiana, J., Schneidman-Duhovny, D., & Wolfson, H. J. (2022) · Nature Methods · doi:10.1038/s41592-022-01490-7 · Cited by 274
Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant
Edara, V. V., Norwood, C., Floyd, K., Lai, L., Davis-Gardner, M. E., Hudson, W. H., Mantus, G., Nyhoff, L. E., Adelman, M. W., Fineman, R., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.03.009 · Cited by 224
Advances and Utility of the Human Plasma Proteome
Deutsch, E. W., Omenn, G. S., Sun, Z., Maes, M., Pernemalm, M., Palaniappan, K. K., Letunica, N., Vandenbrouck, Y., Brun, V., Tao, S., et al. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00657 · Cited by 246
Self-citationHumoral Responses and Serological Assays in SARS-CoV-2 Infections
Galipeau, Y., Greig, M., Liu, C., Driedger, M., & Langlois, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.610688 · Cited by 247
The development of COVID-19 treatment
Yuan, Y., Jiao, B., Qu, L., Yang, D., & Liu, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125246 · Cited by 271
Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors
Shroff, R. T., Chalasani, P., Wei, R., Pennington, D., Quirk, G., Schoenle, M. V., Peyton, K. L., Uhrlaub, J. L., Ripperger, T. J., Jergović, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01542-z · Cited by 237
Immunological imprinting of the antibody response in COVID-19 patients
Aydillo, T., Rombauts, A., Stadlbauer, D., Aslam, S., Abelenda-Alonso, G., Escalera, A., Amanat, F., Jiang, K., Krammer, F., Carratala, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23977-1 · Cited by 223
COVID-19 deaths in Africa: prospective systematic postmortem surveillance study
Mwananyanda, L., Gill, C. J., MacLeod, W., Kwenda, G., Pieciak, R., Mupila, Z., Lapidot, R., Mupeta, F., Forman, L., Ziko, L., et al. (2021) · BMJ · doi:10.1136/bmj.n334 · Cited by 211
Dowell, A. C., Butler, M., Jinks, E., Tut, G., Lancaster, T., Sylla, P., Begum, J., Bruton, R. K., Pearce, H., Verma, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-01089-8 · Cited by 197
The humoral response and antibodies against SARS-CoV-2 infection
Qi, H., Liu, B., Wang, X., & Zhang, L. (2022) · Nature Immunology · doi:10.1038/s41590-022-01248-5 · Cited by 195
Point-of-care COVID-19 diagnostics powered by lateral flow assay
Zhou, Y., Wu, Y., Ding, L., Huang, X., & Xiong, Y. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2021.116452 · Cited by 187
Immunology of SARS-CoV-2 infection in children
Chou, J. S., Thomas, P. G., & Randolph, A. G. (2022) · Nature Immunology · doi:10.1038/s41590-021-01123-9 · Cited by 176
Li, J., & Lillehoj, P. B. (2021) · ACS Sensors · doi:10.1021/acssensors.0c02561 · Cited by 177
Self-citationThe impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses
Murray, S. M., Ansari, M. A., Frater, J., Klenerman, P., Dunachie, S. J., Barnes, E. J., & Ogbe, A. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00809-x · Cited by 173
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
Low, J. S., Jerak, J., Tortorici, M. A., McCallum, M., Pinto, D., Cassotta, A., Foglierini, M., Mele, F., Abdelnabi, R., Weynand, B., et al. (2022) · Science · doi:10.1126/science.abq2679 · Cited by 163
Immunity to SARS‐CoV‐2 induced by infection or vaccination
Dopico, X. C., Ols, S., Loré, K., & Hedestam, G. B. K. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13372 · Cited by 172
Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients
Li, Y., Ma, M., Lei, Q., Wang, F., Hong, W., Lai, D., Hou, H., Xu, Z., Zhang, B., Chen, H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108915 · Cited by 161
Review of Current COVID-19 Diagnostics and Opportunities for Further Development
Mardian, Y., Kosasih, H., Karyana, M., Neal, A., & Lau, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.615099 · Cited by 153
SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants
Tea, F., Stella, A. O., Aggarwal, A., Darley, D. R., Pilli, D., Vitale, D., Merheb, V., Lee, F. X. Z., Cunningham, P., Walker, G. J., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003656 · Cited by 135
Antibody and B cell responses to SARS-CoV-2 infection and vaccination
Röltgen, K., & Boyd, S. D. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.06.009 · Cited by 143
Borriello, F., Poli, V., Shrock, E. L., Spreafico, R., Liu, X., Pishesha, N., Carpenet, C., Chou, J. S., Gioia, M. D., McGrath, M. E., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.009 · Cited by 121
Self-citationRisk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors
Zsichla, L., & Müller, V. (2023) · Viruses · doi:10.3390/v15010175 · Cited by 121
Ryzhikov, A. B., Bogryantseva, M. P., Usova, S. V., Даниленко, Е. Д., Августовна, Н. Е., Pyankov, O. V., Pyankova, O. G., Gudymo, A. S., Боднев, С. А., Сергеевна, О. Г., et al. (2021) · Russian Journal of Infection and Immunity · doi:10.15789/2220-7619-asb-1699 · Cited by 106
Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification
Li, X., Zhu, W., Fan, M., Zhang, J., Peng, Y., Huang, F., Wang, N., He, L., Zhang, L., Holmdahl, R., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.04.001 · Cited by 109
Lin, C.-Y., Wolf, J., Brice, D. C., Sun, Y., Locke, M., Cherry, S., Castellaw, A. H., Wehenkel, M., Crawford, J. C., Zarnitsyna, V. I., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.12.005 · Cited by 103
Peptides for Vaccine Development
Hamley, I. W. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01238 · Cited by 104
Dobaño, C., Vidal, M., Santano, R., Jiménez, A., Chi, J., Barrios, D., Ruiz‐Olalla, G., Melero, N. R., Carolis, C., Parras, D., et al. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.01731-20 · Cited by 103
RETRACTED: SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies
Ng, K. W., Faulkner, N., Finsterbusch, K., Wu, M., Harvey, R., Hussain, S., Greco, M., Liu, Y., Kjær, S., Swanton, C., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn3715 · Cited by 100
RetractedMarkers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma
Natarajan, H., Crowley, A. R., Butler, S. E., Xu, S., Weiner, J. A., Bloch, E. M., Littlefield, K. E., Wieland‐Alter, W., Connor, R. I., Wright, P. F., et al. (2021) · mBio · doi:10.1128/mbio.00765-21 · Cited by 99
Self-citationCOVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine
Pereira, N. L., Ahmad, F., Byku, M., Cummins, N. W., Morris, A. A., OWENS, A. T., Tuteja, S., & Cresci, S. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.11.024 · Cited by 93
Immune recall improves antibody durability and breadth to SARS-CoV-2 variants
Chen, Y., Tong, P., Whiteman, N. B., Moghaddam, A. S., Zarghami, M., Zuiani, A., Habibi, S., Gautam, A. K., Keerti, K., Bi, C., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abp8328 · Cited by 89
Self-citationSerology as a Tool to Assess Infectious Disease Landscapes and Guide Public Health Policy
Haselbeck, A., Im, J., Prifti, K., Marks, F., Holm, M., & Zellweger, R. M. (2022) · Pathogens · doi:10.3390/pathogens11070732 · Cited by 91
Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course
Muri, J., Cecchinato, V., Cavalli, A., Shanbhag, A. A., Matkovic, M., Biggiogero, M., Maida, P. A., Moritz, J., Toscano, C., Ghovehoud, E., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01445-w · Cited by 100
Voltammetric-based immunosensor for the detection of SARS-CoV-2 nucleocapsid antigen
Eissa, S., Alhadrami, H. A., Al-Mozaini, M., Hassan, A. M., & Zourob, M. M. (2021) · Microchimica Acta · doi:10.1007/s00604-021-04867-1 · Cited by 89
Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality
Morgenlander, W. R., Henson, S. N., Monaco, D. R., Chen, A., Littlefield, K. E., Bloch, E. M., Fujimura, E., Ruczinski, I., Crowley, A. R., Natarajan, H., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146927 · Cited by 86
Self-citationFielding, C. A., Sabberwal, P., Williamson, J. C., Greenwood, E. J. D., Crozier, T. W. M., Zelek, W. M., Seow, J., Graham, C., Huettner, I., Edgeworth, J. D., et al. (2022) · eLife · doi:10.7554/elife.74489 · Cited by 87
Vogl, T. J., Klompus, S., Leviatan, S., Kalka, I. N., Weinberger, A., Wijmenga, C., Fu, J., Zhernakova, A., Weersma, R. K., & Segal, E. (2021) · Nature Medicine · doi:10.1038/s41591-021-01409-3 · Cited by 83
Role of Peptides in Diagnostics
Pandey, S., Malviya, G., & Dvorakova, M. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168828 · Cited by 85
Why Does the Severity of COVID-19 Differ With Age?
Zimmermann, P., & Curtis, N. C. (2021) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003413 · Cited by 89
Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses
Shrock, E. L., Timms, R. T., Kula, T., Mena, E. L., West, A. P., Guo, R., Lee, I., Cohen, A. A., McKay, L. G. A., Bi, C., et al. (2023) · Science · doi:10.1126/science.adc9498 · Cited by 88
Self-citationThe great escape? SARS-CoV-2 variants evading neutralizing responses
Prévost, J., & Finzi, A. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.010 · Cited by 80
Development and deployment of COVID-19 vaccines for those most vulnerable
Koff, W. C., Schenkelberg, T., Williams, T. M., Baric, R. S., McDermott, A. B., Cameron, C., Cameron, M. J., Frieman, M. B., Neumann, G., Kawaoka, Y., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd1525 · Cited by 80
Molecular mimicry and autoimmunity in the time of COVID-19
Rojas, M., Herrán, M., Ramı́rez-Santana, C., Leung, P. S. C., Anaya, J.-M., Ridgway, W. M., & Gershwin, M. E. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103070 · Cited by 87
Two-step fitness selection for intra-host variations in SARS-CoV-2
Li, J., Du, P., Yang, L., Zhang, J., Song, C., Chen, D., Song, Y., Ding, N., Hua, M., Han, K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110205 · Cited by 80
Self-citationOne year of SARS-CoV-2 evolution
Wu, A., Wang, L., Zhou, H., Ji, C., Xia, S., Cao, Y., Meng, J., Ding, X. L., Gold, S., Jiang, T., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.017 · Cited by 73
Prahl, M. K., Golan, Y., Cassidy, A. G., Matsui, Y., Li, L., Alvarenga, B. D., Chen, H., Jigmeddagva, U., Lin, C. Y., Gonzalez, V. J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32188-1 · Cited by 78
Poston, D., Weisblum, Y., Wise, H. M., Templeton, K. E., Jenks, S. J., Hatziioannou, T., & Bieniasz, P. D. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1803 · Cited by 78
The landscape of antibody binding in SARS-CoV-2 infection
Heffron, A. S., McIlwain, S. J., Amjadi, M. F., Baker, D. A., Khullar, S., Armbrust, T., Halfmann, P., Kawaoka, Y., Sethi, A. K., Palmenberg, A. C., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001265 · Cited by 78
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
Huang, K.-Y. A., Tan, T. K., Chen, T.-H., Huang, C., Harvey, R., Hussain, S., Chen, C., Harding, A. C., Gilbert‐Jaramillo, J., Liu, X., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009352 · Cited by 67
SARS-CoV-2 spike S2-specific neutralizing antibodies
Li, C., & Chang, S. (2023) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2220582 · Cited by 73
Cross-Reactivity of SARS-CoV Structural Protein Antibodies Against SARS-CoV-2
Bates, T. A., Weinstein, J. B., Farley, S. E., Leier, H. C., Messer, W. B., & Tafesse, F. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.108737 · Cited by 69
Aguilar-Bretones, M., Westerhuis, B. M., Raadsen, M. P., de Bruin, E., Chandler, F. D., Okba, N. M. A., Haagmans, B. L., Langerak, T., Endeman, H., van den Akker, J. P. C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci150613 · Cited by 65
Structural mapping of antibody landscapes to human betacoronavirus spike proteins
Bangaru, S., Antanasijevic, A., Kose, N., Sewall, L. M., Jackson, A. M., Suryadevara, N., Zhan, X., Torres, J. L., Copps, J., de la Peña, A. T., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn2911 · Cited by 65
Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health
Traversi, D., Pulliero, A., Izzotti, A., Franchitti, E., Iacoviello, L., Gianfagna, F., Gialluisi, A., Izzi, B., Agodi, A., Barchitta, M., et al. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11020135 · Cited by 74
Sermet‐Gaudelus, I., Temmam, S., Huon, C., Behillil, S., Gajdos, V., Bigot, T., Lurier, T., Chrétien, D., Backović, M., Delaunay, A., et al. (2021) · Eurosurveillance · doi:10.2807/1560-7917.es.2021.26.13.2001782 · Cited by 70
Immune imprinting and next-generation coronavirus vaccines
Huang, C. Q., Vishwanath, S., Carnell, G., Chan, A. C. Y., & Heeney, J. L. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01505-9 · Cited by 68
Self-citationHolenya, P., Lange, P. J., Reimer, U., Woltersdorf, W. W. W., Panterodt, T., Glas, M., Wasner, M., Eckey, M., Drosch, M., Hollidt, J., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202049101 · Cited by 66
Staquicini, D. I., Tang, F. H. F., Markosian, C., Yao, V. J., Staquicini, F. I., Dodero‐Rojas, E., Contessoto, V. G., Davis, D., O’Brien, P., Habib, N., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2105739118 · Cited by 69
Woudenberg, T., Pelleau, S., Anna, F., Attia, M., Donnadieu, F., Gravet, A., Lohmann, C., Séraphin, H., Guihéneuf, R., Delamare, C., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103495 · Cited by 64
Artificial intelligence in accelerating vaccine development - current and future perspectives
Kaushik, R. K., Kant, R., & Christodoulides, M. (2023) · Frontiers in Bacteriology · doi:10.3389/fbrio.2023.1258159 · Cited by 70
Gattinger, P., Niespodziana, K., Stiasny, K., Sahanic, S., Tulaeva, I., Borochova, K., Dorofeeva, Y., Schlederer, T., Sonnweber, T., Höfer, G., et al. (2021) · Allergy · doi:10.1111/all.15066 · Cited by 64
Immunosenescence and inflamm-ageing in COVID-19
Zinatizadeh, M. R., Zarandi, P. K., Ghiasi, M., Kooshki, H., Mohammadi, M., Amani, J., & Rezaei, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101818 · Cited by 69
Autoantibodies in COVID‐19 correlate with antiviral humoral responses and distinct immune signatures
Taeschler, P., Cervia, C., Zurbuchen, Y., Hasler, S., Pou, C., Tan, Z., Adamo, S., Raeber, M. E., Bächli, E., Rudiger, A., et al. (2022) · Allergy · doi:10.1111/all.15302 · Cited by 64
A novel machine learning method for evaluating the impact of emission sources on ozone formation
Cheng, Y., Huang, X., Peng, Y., Tang, M., Zhu, B., Xia, S.-Y., & He, L. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120685 · Cited by 63
Cerutti, G., Rapp, M., Guo, Y., Bahna, F. A., Bimela, J. S., Reddem, E. R., Yu, J., Wang, P., Liu, L., Huang, Y., et al. (2021) · Structure · doi:10.1016/j.str.2021.05.014 · Cited by 59
Haynes, W. A., Kamath, K., Bozekowski, J. D., Baum, E., Campbell, M., Casanovas‐Massana, A., Daugherty, P. S., Cruz, C. S. D., Dhal, A., Farhadian, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02835-2 · Cited by 60
Fraley, E., LeMaster, C., Geanes, E. S., Banerjee, D., Khanal, S., Grundberg, E., Selvarangan, R., & Bradley, T. (2021) · BMC Medicine · doi:10.1186/s12916-021-02055-9 · Cited by 61
Bellusci, L., Grubbs, G., Zahra, F. T., Forgacs, D., Golding, H., Ross, T. M., & Khurana, S. (2022) · Nature Communications · doi:10.1038/s41467-022-32298-w · Cited by 56
Credle, J. J., Gunn, J., Sangkhapreecha, P., Monaco, D. R., Zheng, X. A., Tsai, H.-J., Wilbon, A., Morgenlander, W. R., Rastegar, A. T., Dong, Y. W., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00925-y · Cited by 72
Self-citationArtificial intelligence-driven biomedical genomics
Guo, K., Wu, M., Soo, Z., Yang, Y. Y., Zhang, Y., Zhang, Q., Lin, H., Grosser, M., Venter, D. J., Zhang, G., et al. (2023) · Knowledge-Based Systems · doi:10.1016/j.knosys.2023.110937 · Cited by 64
Noda, K., Matsuda, K., Yagishita, S., Maeda, K., Akiyama, Y., Terada-Hirashima, J., Matsushita, H., Iwata, S., Yamashita, K., Atarashi, Y., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84387-3 · Cited by 59
Heidepriem, J., Dahlke, C., Kobbe, R., Santer, R., Koch, T., Fathi, A., Seco, B. M. S., Ly, M. L., Schmiedel, S., Schwinge, D., et al. (2021) · Pathogens · doi:10.3390/pathogens10040438 · Cited by 59
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
Youngs, J., Provine, N. M., Lim, N. T. Y., Sharpe, H., Amini, A., Chen, Y., Luo, J. F., Edmans, M. D., Zacharopoulou, P., Chen, W., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009804 · Cited by 57
Self-citationModeling how antibody responses may determine the efficacy of COVID-19 vaccines
Padmanabhan, P., Desikan, R., & Dixit, N. M. (2022) · Nature Computational Science · doi:10.1038/s43588-022-00198-0 · Cited by 57
A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2
Majdoubi, A., Michalski, C., O’Connell, S. E., Dada, S., Narpala, S., Gelinas, J. P., Mehta, D., Cheung, C., Winkler, D. F. H., Basappa, M., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.146316 · Cited by 57
Feldman, J. E., Bals, J., Altomare, C. G., Denis, K. S., Lam, E. C., Hauser, B. M., Ronsard, L., Sangesland, M., Moreno, T. B., Okonkwo, V., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl5842 · Cited by 60
Self-citationNath, H., Mallick, A., Roy, S., Sukla, S., Basu, K., De, A., & Biswas, S. (2021) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001369 · Cited by 57
Tang, J., Novak, T., Hecker, J., Grubbs, G., Zahra, F. T., Bellusci, L., Pourhashemi, S., Chou, J. S., Moffitt, K. L., Halasa, N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30649-1 · Cited by 55
SARS-CoV-2 accessory proteins reveal distinct serological signatures in children
Hachim, A., Gu, H., Kavian, O., Mori, M., Kwan, M. Y. W., Chan, W. H., Yau, Y. S., Chiu, S. S., Tsang, O. T. Y., Hui, D. S. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30699-5 · Cited by 42
Dugas, M., Grote-Westrick, T., Vollenberg, R., Lorentzen, E. U., Brix, T. J., Schmidt, H., Tepasse, P., & Kühn, J. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.02.085 · Cited by 57
Stražar, M., Park, J., Abelin, J. G., Taylor, H. B., Pedersen, T. K., Plichta, D. R., Brown, E., Eraslan, B., Hung, Y.-M., Ortiz, K., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.009 · Cited by 56
The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends
Geyer, P. E., Hornburg, D., Pernemalm, M., Hauck, S. M., Palaniappan, K. K., Albrecht, V., Dagley, L. F., Moritz, R. L., Yu, X., Edfors, F., et al. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00586 · Cited by 58
Self-citationBriquez, P. S., Rouhani, S. J., Yu, J., Pyzer, A. R., Trujillo, J., Dugan, H. L., Stamper, C. T., Changrob, S., Sperling, A. I., Wilson, P. C., et al. (2022) · Science Advances · doi:10.1126/sciadv.abn3777 · Cited by 55
Off balance: Interferons in COVID-19 lung infections
Akamatsu, M. A., de Castro, J. T., Takano, C. Y., & Ho, P. L. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103642 · Cited by 57
Metadata
- Authors
- Shrock, E., Fujimura, E., Kula, T., Timms, R. T., Lee, I.-H., Leng, Y., Robinson, M. L., Sie, B. M., Li, M. Z., Chen, Y., Logue, J., Zuiani, A., McCulloch, D., Lelis, F. J. N., Henson, S., Monaco, D. R., Travers, M., Habibi, S., Clarke, W. A., Caturegli, P., Laeyendecker, O., Piechocka-Trocha, A., Li, J. Z., Khatri, A., Chu, H. Y., MGH COVID-19 Collection & Processing Team, Villani, A.-C., Kays, K., Goldberg, M. B., Hacohen, N., Filbin, M. R., Yu, X. G., Walker, B. D., Wesemann, D. R., Larman, H. B., Lederer, J. A., Elledge, S. J., Lavin-Parsons, K., Parry, B., Lilley, B., Lodenstein, C., McKaig, B., Charland, N., Khanna, H., Margolin, J., Gonye, A., Gushterova, I., Lasalle, T., Sharma, N., Russo, B. C., Rojas-Lopez, M., Sade-Feldman, M., Manakongtreecheep, K., Tantivit, J., Thomas, M. F., Abayneh, B. A., Allen, P., Antille, D., Armstrong, K., Boyce, S., Braley, J., Branch, K., Broderick, K., Carney, J., Chan, A., Davidson, S., Dougan, M., Drew, D., Elliman, A., Flaherty, K., Flannery, J., Forde, P., Gettings, E., Griffin, A., Grimmel, S., Grinke, K., Hall, K., Healy, M., Henault, D., Holland, G., Kayitesi, C., LaValle, V., Lu, Y., Luthern, S., Marchewka (Schneider), J., Martino, B., McNamara, R., Nambu, C., Nelson, S., Noone, M., Ommerborn, C., Pacheco, L. C., Phan, N., Porto, F. A., Ryan, E., Selleck, K., Slaughenhaupt, S., Sheppard, K. S., Suschana, E., Wilson, V., Alter, G., Balazs, A., Bals, J., Barbash, M., Bartsch, Y., Boucau, J., Chevalier, J., Chowdhury, F., Einkauf, K., Fallon, J., Fedirko, L., Finn, K., Garcia-Broncano, P., Hartana, C., Jiang, C., Kaplonek, P., Karpell, M., Lam, E. C., Lefteri, K., Lian, X., Lichterfeld, M., Lingwood, D., Liu, H., Liu, J., Ly, N., Michell, A., Millstrom, I., Miranda, N., O’Callaghan, C., Osborn, M., Pillai, S., Rassadkina, Y., Reissis, A., Ruzicka, F., Seiger, K., Sessa, L., Sharr, C., Shin, S., Singh, N., Sun, W., Sun, X., Ticheli, H., Trocha-Piechocka, A., Worrall, D., Zhu, A., Daley, G., Golan, D., Heller, H., Sharpe, A., Jilg, N., Rosenthal, A., & Wong, C.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Washington (US)
- National Institutes of Health (US)
- Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.
- Massachusetts General Hospital (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Shrock, Ellen
- Fujimura, Eric
- Kula, Tomasz
- Timms, Richard T.
- Elledge, Stephen J.
- ORCID
- Shrock, Ellen
- Fujimura, Eric
- Kula, Tomasz
- Timms, Richard T.
- Lee, I-Hsiu
- Leng, Yumei
- Robinson, Matthew L.
- Sie, Brandon M.
- Li, Mamie Z.
- Chen, Yuezhou
- Logue, Jennifer
- Zuiani, Adam
- McCulloch, Denise
- Lelis, Felipe J. N.
- Henson, Stephanie
- Travers, Meghan
- Habibi, Shaghayegh
- Clarke, William A.
- Caturegli, Patrizio
- Laeyendecker, Oliver
- Piechocka-Trocha, Alicja
- Li, Jonathan Z.
- Khatri, Ashok
- Chu, Helen Y.
- Villani, Alexandra-Chloé
- Goldberg, Marcia B.
- Hacohen, Nir
- Filbin, Michael R.
- Yu, Xu G.
- Walker, Bruce D.
- Wesemann, Duane R.
- Larman, H. Benjamin
- Elledge, Stephen J.
- Parry, Blair
- Lilley, Brendan
- McKaig, Brenna
- Charland, Nicole
- Khanna, Hargun
- Margolin, Justin
- Gonye, Anna
- Gushterova, Irena
- Russo, Brian C.
- Sade-Feldman, Moshe
- Manakongtreecheep, Kasidet
- Tantivit, Jessica
- Thomas, Molly Fisher
- Dougan, Michael
- Flaherty, Keith
- Hall, Kathryn
- Healy, Meg
- Lu, Yuting
- Martino, Brittani
- Phan, Nicole
- Ryan, Edward
- Suschana, Elizabeth
- Alter, Galit
- Balazs, Alejandro
- Bals, Julia
- Bartsch, Yannic
- Boucau, Julie
- Chowdhury, Fatema
- Einkauf, Kevin
- Hartana, Ciputra
- Jiang, Chenyang
- Lam, Evan C.
- Lian, Xiaodong
- Lichterfeld, Mathias
- Lingwood, Daniel
- Liu, Hang
- Michell, Ashlin
- Osborn, Matthew
- Pillai, Shiv
- Rassadkina, Yelizaveta
- Seiger, Kyra
- Sessa, Libera
- Shin, Sally
- Singh, Nishant
- Sun, Weiwei
- Sun, Xiaoming
- Worrall, Daniel
- Zhu, Alex
- Daley, George
- Heller, Howard
- Sharpe, Arlene
- Jilg, Nikolaus
- Venue
- Science
- Published
- 2020-11-27
- Volume
- 370
- Issue
- 6520
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7857405
- OpenAlex
- W3091214020
- Cited by
- 678
- References
- 38
- Citations by year
- 2026: 31 · 2025: 44 · 2024: 67 · 2023: 105 · 2022: 156 · 2021: 236 · 2020: 39
- FWCI
- 17.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AI139538)
- National Cancer Institute (U24)
- MassCPR (No Number)
- U.S. Department of Defense (W81XWH-16-1-0464)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- SARS-CoV-2, COVID-19 pandemic, humoral immune response, cross-reactive antibodies, neutralizing antibodies, spike protein, nucleocapsid protein, ORF1, pre-existing antibodies, disease severity, cytomegalovirus, herpes simplex virus type 1, sex differences in antibody response, hospitalized patients
- MeSH terms
- Seroconversion, COVID-19, SARS-CoV-2, COVID-19 Serological Testing, Antibody Formation, Epitopes, Cross Reactions, Female, Humans, Male, Protein Conformation, Severity of Illness Index, Epitope Mapping, Cryoelectron Microscopy, Antibodies, Neutralizing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review