Cited by 1,604Environmental Toxicology and EcotoxicologyMicroplastics and Plastic PollutionToxic Organic Pollutants Impact

A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon

Tian, Zhenyu, Zhao, Haoqi, Peter, Katherine T., Gonzalez, Melissa, Wetzel, Jill, Wu, Christopher, Hu, Ximin, Prat, Jasmine +19 more·2021·Science

Abstract

Tire tread particles turn streams toxic: For coho salmon in the U.S. Pacific Northwest, returning to spawn in urban and suburban streams can be deadly. Regular acute mortality events are tied, in particular, to stormwater runoff, but the identity of the causative toxicant(s) has not been known. Starting from leachate from new and aged tire tread wear particles, Tian et al. followed toxic fractions through chromatography steps, eventually isolating a single molecule that could induce acute toxicity at threshold concentrations of ∼1 microgram per liter. The compound, called 6PPD-quinone, is an oxidation product of an additive intended to prevent damage to tire rubber from ozone. Measurements from road runoff and immediate receiving waters show concentrations of 6PPD-quinone high enough to account for the acute toxicity events. Science , this issue p. 185

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Crossref · 10.1126/science.abd6951

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Authors
Tian, Z., Zhao, H., Peter, K. T., Gonzalez, M., Wetzel, J., Wu, C., Hu, X., Prat, J., Mudrock, E., Hettinger, R., Cortina, A. E., Biswas, R. G., Kock, F. V. C., Soong, R., Jenne, A., Du, B., Hou, F., He, H., Lundeen, R., Gilbreath, A., Sutton, R., Scholz, N. L., Davis, J. W., Dodd, M. C., Simpson, A., McIntyre, J. K., & Kolodziej, E. P.
Affiliations
  • Center for Urban Waters (US)
  • University of Washington (US)
  • Washington State University (US)
  • University of Toronto (CA)
  • Department of Chemistry, University of Toronto, Scarborough Campus, 1265 Military Trail, Toronto, ON M1C 1A4, Canada.
  • Southern California Coastal Water Research Project, Costa Mesa, CA 92626, USA.
  • San Francisco Estuary Institute (US)
  • National Oceanic and Atmospheric Administration (US)
  • United States Fish and Wildlife Service (US)
Corresponding author
Kolodziej, Edward P.
Venue
Science
Published
2021-01-08
Volume
371
Issue
6525
Pages
185-189
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W3108318864
Cited by
1,604
References
43
Citations by year
2026: 400 · 2025: 414 · 2024: 321 · 2023: 218 · 2022: 159 · 2021: 90 · 2020: 2
FWCI
47.03
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (1608464, 1803240)
  • U.S. Environmental Protection Agency (01J18101, #DW-014-92437301)
  • Natural Sciences and Engineering Research Council of Canada (ALLRP 549399, RGPIN-2019-04165)
  • Washington State Governors Funds
  • São Paulo Research Foundation (2018/16040-5, 2019/14770-9)
  • Regional Monitoring Program for Water Quality in SF Bay
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
  • Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
6PPD-quinone, coho salmon, acute toxicity, stormwater runoff, urban rivers, leachate, aquatic toxicology, fish mortality
MeSH terms
Animals, Antioxidants, Environmental Exposure, Phenylenediamines, Rubber, Northwestern United States, Benzoquinones, Oncorhynchus kisutch

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