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Cortical wiring by synapse type–specific control of local protein synthesis
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Abstract
Neurons use local protein synthesis to support their morphological complexity, which requires independent control across multiple subcellular compartments up to the level of individual synapses. We identify a signaling pathway that regulates the local synthesis of proteins required to form excitatory synapses on parvalbumin-expressing (PV + ) interneurons in the mouse cerebral cortex. This process involves regulation of the TSC subunit 2 (Tsc2) by the Erb-B2 receptor tyrosine kinase 4 (ErbB4), which enables local control of messenger RNA {mRNA} translation in a cell type–specific and synapse type–specific manner. Ribosome-associated mRNA profiling reveals a molecular program of synaptic proteins downstream of ErbB4 signaling required to form excitatory inputs on PV + interneurons. Thus, specific connections use local protein synthesis to control synapse formation in the nervous system.
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“Interestingly, Erbb4 was shown to regulate translation of several synaptic proteins, including the pore‐forming AMPAR subunit GluA4 (Bernard et al., 2022).”
From MicroRNA‐138‐5p suppresses excitatory synaptic strength at the cerebellar input layer (2025) · cites this paper as Bernard et al., 2022
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MicroRNA‐138‐5p suppresses excitatory synaptic strength at the cerebellar input layer
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Metadata
- Authors
- Bernard, C., Exposito-Alonso, D., Selten, M., Sanalidou, S., Hanusz-Godoy, A., Aguilera, A., Hamid, F., Oozeer, F., Maeso, P., Allison, L., Russell, M., Fleck, R. A., Rico, B., & Marín, O.
- Affiliations
- Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE1 1UL, UK.
- Centre for Ultrastructural Imaging, King’s College London, London SE1 1UL, UK.
- ORCID
- Venue
- Science
- Published
- 2022-11-25
- Volume
- 378
- Issue
- 6622
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC7618116
- Cited by
- 81
- References
- 13
- Language
- en
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