Synapse-specific astrocyte gating of amygdala-related behavior
Open accessAbstract
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A 1 adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A 2A receptor activation. Furthermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression in a fear-conditioning paradigm. Therefore, we conclude that astrocyte activity determines fear responses by selectively regulating specific synapses, which indicates that animal behavior results from the coordinated activity of neurons and astrocytes.
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Chemogenetic activation of astrocytes in relevant circuits can affect memory performance.
“chemogenetic activation of astrocytes in relevant circuits can affect memory performance 7, 80 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [80]
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Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
Tripartite synapses: glia, the unacknowledged partner
Araque, A., Parpura, V., Sanzgiri, R. P., & Haydon, P. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01349-6 · Cited by 2,529 · see citing works
Self-citationTripartite synapses: astrocytes process and control synaptic information
Perea, G., Navarrete, M., & Araque, A. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.05.001 · Cited by 1,820 · see citing works
Self-citationEndogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607 · see citing works
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580 · see citing works
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,529 · see citing works
Long-term potentiation depends on release of d-serine from astrocytes
Henneberger, C., Papouin, T., Oliet, S. H. R., & Rusakov, D. A. (2010) · Nature · doi:10.1038/nature08673 · Cited by 1,389 · see citing works
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308 · see citing works
Self-citationCortical pathways to the mammalian amygdala
McDonald, A. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00003-3 · Cited by 1,303 · see citing works
Amygdala circuitry mediating reversible and bidirectional control of anxiety
Tye, K. M., Prakash, R., Kim, S.-Y., Fenno, L. E., Grosenick, L., Zarabi, H., Thompson, K. R., Gradinaru, V., Ramakrishnan, C., & Deisseroth, K. (2011) · Nature · doi:10.1038/nature09820 · Cited by 1,289 · see citing works
Astrocytic Purinergic Signaling Coordinates Synaptic Networks
Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280 · see citing works
Endocannabinoid Signaling and Synaptic Function
Castillo, P. E., Younts, T. J., Chávez, A. E., & Hashimotodani, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.020 · Cited by 1,126 · see citing works
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,065 · see citing works
Glia-Derived d-Serine Controls NMDA Receptor Activity and Synaptic Memory
Panatier, A., Theodosis, D. T., Mothet, J.-P., Touquet, B., Pollegioni, L., Poulain, D. A., & Oliet, S. H. R. (2006) · Cell · doi:10.1016/j.cell.2006.02.051 · Cited by 934 · see citing works
Encoding of conditioned fear in central amygdala inhibitory circuits
Ciocchi, S., Herry, C., Grenier, F., Wolff, S. B. E., Letzkus, J. J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M. B., et al. (2010) · Nature · doi:10.1038/nature09559 · Cited by 924 · see citing works
Amygdala inhibitory circuits and the control of fear memory
Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., & Lüthi, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.026 · Cited by 878 · see citing works
Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T. G., Haydon, P. G., & Frank, M. G. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.024 · Cited by 877 · see citing works
Imai, Y., Ibata, I., Ito, D., Ohsawa, K., & Kohsaka, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1112 · Cited by 872 · see citing works
Genetic dissection of an amygdala microcircuit that gates conditioned fear
Haubensak, W., Kunwar, P. S., Cai, H., Ciocchi, S., Wall, N. R., Ponnusamy, R., Biag, J., Dong, H.-W., Deisseroth, K., Callaway, E. M., et al. (2010) · Nature · doi:10.1038/nature09553 · Cited by 840 · see citing works
Amygdala Microcircuits Controlling Learned Fear
Duvarci, S., & Pare, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.042 · Cited by 751 · see citing works
Midbrain circuits for defensive behaviour
Tovote, P., Esposito, M. S., Botta, P., Chaudun, F., Fadok, J. P., Marković, M., Wolff, S. B. E., Ramakrishnan, C., Fenno, L. E., Deisseroth, K. A., et al. (2016) · Nature · doi:10.1038/nature17996 · Cited by 739 · see citing works
Astrocytes Potentiate Transmitter Release at Single Hippocampal Synapses
Perea, G., & Araque, A. (2007) · Science · doi:10.1126/science.1144640 · Cited by 727 · see citing works
Self-citationAstrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses
Panatier, A., Vallée, J., Haber, M., Murai, K. K., Lacaille, J.-C., & Robitaille, R. (2011) · Cell · doi:10.1016/j.cell.2011.07.022 · Cited by 650 · see citing works
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
Parri, H. R., Gould, T. M., & Crunelli, V. (2001) · Nature Neuroscience · doi:10.1038/90507 · Cited by 625 · see citing works
Toll-like receptors modulate adult hippocampal neurogenesis
Rolls, A., Shechter, R., London, A., Ziv, Y., Ronen, A., Levy, R., & Schwartz, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1629 · Cited by 620 · see citing works
Endocannabinoids Mediate Neuron-Astrocyte Communication
Navarrete, M., & Araque, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.029 · Cited by 588 · see citing works
Self-citationTopographic organization of neurons in the acoustic thalamus that project to the amygdala
LeDoux, J., Farb, C. R., & Ruggiero, D. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01043.1990 · Cited by 546 · see citing works
Local Ca2+ detection and modulation of synaptic release by astrocytes
Di Castro, M. A., Chuquet, J., Liaudet, N., Bhaukaurally, K., Santello, M., Bouvier, D., Tiret, P., & Volterra, A. (2011) · Nature Neuroscience · doi:10.1038/nn.2929 · Cited by 529 · see citing works
Han, J., Kesner, P., Metna-Laurent, M., Duan, T., Xu, L., Georges, F., Koehl, M., Abrous, D. N., Mendizabal-Zubiaga, J., Grandes, P., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.037 · Cited by 514 · see citing works
Self-citationThe paraventricular thalamus controls a central amygdala fear circuit
Penzo, M. A., Robert, V., Tucciarone, J., De Bundel, D., Wang, M., Van Aelst, L., Darvas, M., Parada, L. F., Palmiter, R. D., He, M., et al. (2015) · Nature · doi:10.1038/nature13978 · Cited by 506 · see citing works
Experience-dependent modification of a central amygdala fear circuit
Li, H., Penzo, M. A., Taniguchi, H., Kopec, C. D., Huang, Z. J., & Li, B. (2013) · Nature Neuroscience · doi:10.1038/nn.3322 · Cited by 497 · see citing works
Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes
Navarrete, M., & Araque, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.043 · Cited by 485 · see citing works
Self-citationAstrocyte Ca2+ signalling: an unexpected complexity
Volterra, A., Liaudet, N., & Savtchouk, I. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3725 · Cited by 446 · see citing works
Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca 2+ Signaling
Agulhon, C., Fiacco, T. A., & McCarthy, K. D. (2010) · Science · doi:10.1126/science.1184821 · Cited by 409 · see citing works
GABAergic network activation of glial cells underlies hippocampal heterosynaptic depression
Serrano, A., Haddjeri, N., Lacaille, J.-C., & Robitaille, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5255-05.2006 · Cited by 398 · see citing works
Kim, K. K., Adelstein, R. S., & Kawamoto, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.052969 · Cited by 398 · see citing works
Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R. (2011) · Science · doi:10.1126/science.1201043 · Cited by 381 · see citing works
Astrocytes regulate cortical state switching in vivo
Poskanzer, K. E., & Yuste, R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520759113 · Cited by 377 · see citing works
Neurons of the lateral and basolateral amygdaloid nuclei: A golgi study in the rat
McDonald, A. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120307 · Cited by 371 · see citing works
Synaptic correlates of fear extinction in the amygdala
Amano, T., Ünal, Ç. T., & Paré, D. (2010) · Nature Neuroscience · doi:10.1038/nn.2499 · Cited by 369 · see citing works
Astrocyte signaling controls spike timing–dependent depression at neocortical synapses
Min, R., & Nevian, T. (2012) · Nature Neuroscience · doi:10.1038/nn.3075 · Cited by 361 · see citing works
Cytoarchitecture of the central amygdaloid nucleus of the rat
McDonald, A. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902080409 · Cited by 338 · see citing works
Li, X., Zima, A. V., Sheikh, F., Blatter, L. A., & Chen, J. (2005) · Circulation Research · doi:10.1161/01.res.0000172556.05576.4c · Cited by 333 · see citing works
Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways
Martín, R., Bajo-Grañeras, R., Moratalla, R., Perea, G., & Araque, A. (2015) · Science · doi:10.1126/science.aaa7945 · Cited by 312 · see citing works
Self-citationAraque, A., Martı́n, E. D., Perea, G., Arellano, J. I., & Buño, W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02443.2002 · Cited by 283 · see citing works
Self-citationStructural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions
Pérez‐Alvarez, A., Navarrete, M., Covelo, A., Martín, E. D., & Araque, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2401-14.2014 · Cited by 277 · see citing works
Self-citationRaastad, M., Storm, J. F., & Andersen, P. N. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00114.x · Cited by 250 · see citing works
Glial Biology in Learning and Cognition
Fields, R. D., Araque, A., Johansen-Berg, H., Lim, S.-S., Lynch, G., Nave, K.-A., Nedergaard, M., Perez, R., Sejnowski, T., & Wake, H. (2014) · The Neuroscientist · doi:10.1177/1073858413504465 · Cited by 232 · see citing works
Self-citationHirrlinger, P. G., Scheller, A., Braun, C., Hirrlinger, J., & Kirchhoff, F. (2006) · Glia · doi:10.1002/glia.20342 · Cited by 200 · see citing works
Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking
Scofield, M. D., Boger, H. A., Smith, R. J., Li, H., Haydon, P. G., & Kalivas, P. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.016 · Cited by 197 · see citing works
Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., et al. (2016) · eLife · doi:10.7554/elife.20362 · Cited by 194 · see citing works
Self-citationDo stars govern our actions? Astrocyte involvement in rodent behavior
Oliveira, J. F., Sardinha, V. M., Guerra-Gomes, S., Araque, A., & Sousa, N. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.07.006 · Cited by 189 · see citing works
Self-citationDunwiddie, T. V., & Diao, L. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38968-8 · Cited by 168 · see citing works
Gómez‐Gonzalo, M., Navarrete, M., Perea, G., Covelo, A., Martín‐Fernández, M., Shigemoto, R., Luján, R., & Araque, A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu231 · Cited by 138 · see citing works
Self-citationAstrocytic IP3Rs: Contribution to Ca2+ signalling and hippocampal LTP
Sherwood, M. W., Arizono, M., Hisatsune, C., Bannai, H., Ebisui, E., Sherwood, J. L., Panatier, A., Oliet, S. H. R., & Mikoshiba, K. (2017) · Glia · doi:10.1002/glia.23107 · Cited by 135 · see citing works
Braga, M. F. M., Aroniadou‐Anderjaska, V., Xie, J., & Li, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00442.2003 · Cited by 112 · see citing works
Kamprath, K., Romo-Parra, H., Häring, M., Gaburro, S., Doengi, M., Lutz, B., & Pape, H.-C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.196 · Cited by 86 · see citing works
Lateral regulation of synaptic transmission by astrocytes
Covelo, A., & Araque, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.02.036 · Cited by 86 · see citing works
Self-citationAppaix, F., Girod, S., Boisseau, S., Römer, J., Vial, J., Albrieux, M., Maurin, M., Depaulis, A., Guillemain, I., & van der Sanden, B. P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035169 · Cited by 81 · see citing works
Ramikie, T. S., Nyilas, R., Bluett, R. J., Gamble‐George, J., Hartley, N. D., Mackie, K., Watanabe, M., Katona, I., & Patel, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.012 · Cited by 80 · see citing works
Physiological properties of central amygdala neurons: species differences
Dumont, É. C., Martina, M., Samson, R. D., Drolet, G., & Paré, D. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01879.x · Cited by 78 · see citing works
Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy
Pérez‐Alvarez, A., Araque, A., & Martín, E. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00051 · Cited by 30 · see citing works
Self-citationHagos, L., & Hülsmann, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.08.010 · Cited by 27 · see citing works
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Astrocyte function from information processing to cognition and cognitive impairment
Santello, M., Toni, N., & Volterra, A. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0325-8 · Cited by 737 · see citing works
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement
Adamsky, A., Kol, A., Kreisel, T., Doron, A., Ozeri-Engelhard, N., Melcer, T., Refaeli, R., Horn, H., Regev, L., Groysman, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.002 · Cited by 631 · see citing works
“importance in neuron-astrocyte communication (Agulhon et al., 2008, 2013; Araque et al., 2014; Bonder and McCarthy, 2014; Bull et al., 2014; Chai et al., 2017; Chen et al., 2016; Martin-Fernandez et al., 2017; Scofield et al., 2015; Yang et al., 2015), we chose to express the Gq-coupled designer receptor hM3Dq (Roth,…”
Function and therapeutic value of astrocytes in neurological diseases
Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662 · see citing works
Neural circuit mechanisms of social behavior
Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527 · see citing works
Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
Farhy-Tselnicker, I., & Allen, N. J. (2018) · Neural Development · doi:10.1186/s13064-018-0104-y · Cited by 396 · see citing works
“Increases in astrocyte calcium lead in some cases to the release of transmitter molecules such as glutamate, ATP or GABA, termed gliotransmitters that in turn, modulate astrocyte and neuronal activity [30, 80, 127].”
Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
Corkrum, M., Covelo, A., Lines, J., Bellocchio, L., Pisansky, M., Loke, K., Quintana, R., Rothwell, P. E., Lujan, R., Marsicano, G., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.026 · Cited by 327 · see citing works
“, 2014), our results indicate that the regulation of synaptic transmission in the NAc evoked by dopamine and acute activation with DREADDs is mediated by astrocytic ATP/adenosine signaling, which has also been shown to modulate neurotransmission in other brain regions such as retina, cortex, hippocampal CA1, dentate g…”
BackgroundSelf-citationCell-autonomous clock of astrocytes drives circadian behavior in mammals
Brancaccio, M., Edwards, M. D., Patton, A. P., Smyllie, N. J., Chesham, J. E., Maywood, E. S., & Hastings, M. H. (2019) · Science · doi:10.1126/science.aat4104 · Cited by 331 · see citing works
Diversity and Specificity of Astrocyte–neuron Communication
Durkee, C. A., & Araque, A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.11.010 · Cited by 315 · see citing works
Self-citationBehaviorally consequential astrocytic regulation of neural circuits
Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M. R., Monk, K. R., Hastings, M. H., Haydon, P. G., Rowitch, D. H., Shaham, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.12.008 · Cited by 311 · see citing works
Neuronal activity determines distinct gliotransmitter release from a single astrocyte
Covelo, A., & Araque, A. (2018) · eLife · doi:10.7554/elife.32237 · Cited by 276 · see citing works
Self-citationKol, A., Adamsky, A., Groysman, M., Kreisel, T., London, M., & Goshen, I. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0679-6 · Cited by 283 · see citing works
“Indeed, GFAP::hM4Di mice injected with either saline or CNO during NAPR acquisition showed a marked decrease in exploration following a second exposure to the square environment to which they were exposed 1 day earlier (F(1,12) = 45.”
BackgroundImproved tools to study astrocytes
Yu, X., Nagai, J., & Khakh, B. S. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0264-8 · Cited by 298 · see citing works
VanRyzin, J. W., Marquardt, A. E., Argue, K. J., Vecchiarelli, H. A., Ashton, S. E., Arambula, S. E., Hill, M. N., & McCarthy, M. M. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.006 · Cited by 272 · see citing works
“, 1999; Amateau and McCarthy, 2002), or MePD astrocytes may perform ‘‘real-time’’ synaptic gating of social information during a play bout (Martin-Fernandez et al., 2017).”
Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory
Robin, L. M., Oliveira da Cruz, J. F., Langlais, V. C., Martin-Fernandez, M., Metna-Laurent, M., Busquets-Garcia, A., Bellocchio, L., Soria-Gomez, E., Papouin, T., Varilh, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.034 · Cited by 262 · see citing works
Self-citationG-Protein-Coupled Receptors in Astrocyte–Neuron Communication
Kofuji, P., & Araque, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.025 · Cited by 237 · see citing works
“The tripartite synapse has now been demonstrated in diverse brain regions and in multiple organisms including humans (Allen, 2014, 2019; Guerra-Gomes et al., 2017; Martin-Fernandez et al., 2017; Navarrete et al., 2013; Santello et al., 2019).”
BackgroundSelf-citationDurkee, C. A., Covelo, A., Lines, J., Kofuji, P., Aguilar, J., & Araque, A. (2019) · Glia · doi:10.1002/glia.23589 · Cited by 224 · see citing works
“…used to specifically activate astrocytes (Adamsky et al., 2018; Agulhon et al., 2013; Bonder & McCarthy, 2014; Bull et al., 2014; Chai et al., 2017; Martin-Fernandez et al., 2017; Scofield et al., 2015), but the Ca2+ dynamics and intracel- lular signaling pathways involved were not fully…”
BackgroundSelf-citationSchiweck, J., Eickholt, B. J., & Murk, K. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00261 · Cited by 223 · see citing works
Neuroimmune signaling in alcohol use disorder
Erickson, E. K., Grantham, E. K., Warden, A. S., & Harris, R. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.007 · Cited by 224 · see citing works
Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior
Guerra‐Gomes, S., Sousa, N., Pinto, L., & Oliveira, J. F. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00427 · Cited by 219 · see citing works
“This redundancy system results in CeM neuronal inhibition with impact in animal behavior (Martin-Fernandez et al., 2017).”
BackgroundInfluentialWahis, J., Baudon, A., Althammer, F., Kerspern, D., Goyon, S., Hagiwara, D., Lefèvre, A., Barteczko, L., Boury‐Jamot, B., Bellanger, B., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00800-0 · Cited by 192 · see citing works
Versatile control of synaptic circuits by astrocytes: where, when and how?
Dallérac, G. M., Zapata, J., & Rouach, N. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0080-6 · Cited by 187 · see citing works
Zhou, Y., Zhu, H., Liu, Z., Chen, X., Su, X., Ma, C., Tian, Z. F., Huang, B. Y., Yan, E., Liu, X., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0524-y · Cited by 162 · see citing works
Kofuji, P., & Araque, A. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-101920-112225 · Cited by 166 · see citing works
Self-citationOe, Y., Wang, X., Patriarchi, T., Konno, A., Ozawa, K., Yahagi, K., Hirai, H., Tsuboi, T., Kitaguchi, T., Tian, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14378-x · Cited by 166 · see citing works
Astrocytes modulate sensory-evoked neuronal network activity
Lines, J., Martín, E. D., Kofuji, P., Aguilar, J., & Araque, A. (2020) · Nature Communications · doi:10.1038/s41467-020-17536-3 · Cited by 159 · see citing works
Self-citationGABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Mederos, S., Sánchez‐Puelles, C., Esparza, J., Valero, M., Ponomarenko, A. A., & Perea, G. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00752-x · Cited by 163 · see citing works
Glia as sculptors of synaptic plasticity
Sancho, L., Contreras, M., & Allen, N. J. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.11.005 · Cited by 152 · see citing works
Astrocyte–Neuron Networks: A Multilane Highway of Signaling for Homeostatic Brain Function
Mederos, S., González-Arias, C., & Perea, G. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00045 · Cited by 146 · see citing works
The role of astrocyte‐mediated plasticity in neural circuit development and function
Perez-Catalan, N. A., Doe, C. Q., & Ackerman, S. D. (2021) · Neural Development · doi:10.1186/s13064-020-00151-9 · Cited by 137 · see citing works
Astrocyte regulation of neural circuit activity and network states
Oliveira, J. F., & Araque, A. (2022) · Glia · doi:10.1002/glia.24178 · Cited by 132 · see citing works
“In line with these observations, the activation of astrocytic Gq GPCR in astrocytes of the centro medial nucleus of the amygdala was sufficient to decrease the neuronal firing rate also in this limbic region via selective potentiation and depression of inhibitory and excitatory inputs, respectively, to this nucleus (M…”
BackgroundResultSelf-citationAstrocyte, a Promising Target for Mood Disorder Interventions
Zhou, X., Xiao, Q., Xie, L., Yang, F., Wang, L., & Tu, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00136 · Cited by 120 · see citing works
Astrocytes integrate and drive action potential firing in inhibitory subnetworks
Deemyad, T., Lüthi, J., & Spruston, N. (2018) · Nature Communications · doi:10.1038/s41467-018-06338-3 · Cited by 125 · see citing works
Functional immune cell–astrocyte interactions
Sanmarco, L. M., Polonio, C. M., Wheeler, M. A., & Quintana, F. J. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202715 · Cited by 126 · see citing works
From Synapses to Circuits, Astrocytes Regulate Behavior
Lyon, K. A., & Allen, N. J. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.786293 · Cited by 117 · see citing works
Navarrete, M., Cuartero, M. I., Palenzuela, R., Draffin, J. E., Konomi, A., Serra, I., Colié, S., Castaño-Castaño, S., Hasan, M. T., Nebreda, Á. R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10830-9 · Cited by 120 · see citing works
Gutiérrez‐Rodrίguez, A., Río, I. B., Puente, N., Gómez‐Urquijo, S., Fontaine, C. J., Huguet, J. E., Elezgarai, I., Ruehle, S., Lutz, B., Robin, L. M., et al. (2018) · Glia · doi:10.1002/glia.23314 · Cited by 119 · see citing works
“…astrocytes through rising calcium in astrocytes that modulates syn- aptic transmission and plasticity (Araque, Castillo, Manzoni, & Tonini, 2017; G omez-Gonzalo et al., 2015; Martin-Fernandez et al., 2017; Navarrete & Araque, 2008, 2010; Navarrete et al., 2013; Navarrete, Diez, & Araque, 2014).”
BackgroundInfluentialSelf-citationGABAergic‐astrocyte signaling: A refinement of inhibitory brain networks
Mederos, S., & Perea, G. (2019) · Glia · doi:10.1002/glia.23644 · Cited by 111 · see citing works
“The boosted inhibition was mediated by ATP/Ado release from astrocytes, and resultant activation of neuronal adenosine A2A receptor (Martin-Fernandez et al., 2017).”
BackgroundInfluentialAstrocytic cAMP modulates memory via synaptic plasticity
Zhou, Z.-W., Okamoto, K., Onodera, J., Hiragi, T., Andoh, M., Ikawa, M., Tanaka, K., Ikegaya, Y., & Koyama, R. (2021) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2016584118 · Cited by 107 · see citing works
“Previous reports have shown that astrocytic gliotransmitters play an important role in memory (3, 8 – 10).”
Astrocyte and neuron cooperation in long-term depression
Durkee, C. A., Kofuji, P., Navarrete, M., & Araque, A. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.07.004 · Cited by 117 · see citing works
Self-citationValence coding in amygdala circuits
Pignatelli, M., & Beyeler, A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.10.010 · Cited by 120 · see citing works
Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors
Li, Y., Li, L., Wu, J., Zhu, Z., Feng, X., Qin, L., Zhu, Y., Sun, L., Liu, Y., Qiu, Z., et al. (2020) · eLife · doi:10.7554/elife.57155 · Cited by 117 · see citing works
Astroglia-specific contributions to the regulation of synapses, cognition and behaviour
Augusto‐Oliveira, M., Arrifano, G. D. P., Takeda, P. Y., Lopes-Araújo, A., Santos-Sacramento, L., Anthony, D. C., Verkhratsky, A., & Lopez, M. E. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.039 · Cited by 107 · see citing works
Luca, C. D., Colangelo, A. M., Virtuoso, A., Alberghina, L., & Papa, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041539 · Cited by 104 · see citing works
“The cannabinoid (CB) system, furthermore, seems to be a signaling pathway by which activated astrocytes release glutamate and enhance the synaptic strength with both short‐term [83] and long‐term plasticity [84].”
BackgroundAstroglia-Derived ATP Modulates CNS Neuronal Circuits
Illés, P., Burnstock, G., & Tang, Y. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.006 · Cited by 104 · see citing works
Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK
Nagai, J., Bellafard, A., Qu, Z., Yu, X., Ollivier, M., Gangwani, M. R., Castro, B. D., Coppola, G., Schumacher, S. M., Golshani, P., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.023 · Cited by 101 · see citing works
“, 2018), and mediates cell-cell communication in some settings in neural circuits of rodents (Adamsky et al., 2018; Iwai et al., 2021; Kofuji and Araque, 2021b; Martin-Fernandez et al., 2017; Mederos et al., 2019; Otsu et al., 2015), fruit flies (Ma et al.”
Melanopsin for precise optogenetic activation of astrocyte‐neuron networks
Mederos, S., Hernández‐Vivanco, A., Ramírez‐Franco, J., Martín‐Fernández, M., Navarrete, M., Yang, A., Boyden, E. S., & Perea, G. (2019) · Glia · doi:10.1002/glia.23580 · Cited by 101 · see citing works
“…for astrocyte-neuron studies revealing the impact of astrocyte signaling in food intake (Chen et al., 2016; Yang, Qi, & Yang, 2015), fear responses (Martin-Fernandez et al., 2017), memory recall (Adamsky et al., 2018), Sara Mederos and Alicia Hernández-Vivanco contributed equally to this work. and…”
BackgroundPurinergic signaling orchestrating neuron-glia communication
Agostinho, P. M., Madeira, D., Dias, L., Simões, A. P., Cunha, R. A., & Canas, P. M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105253 · Cited by 91 · see citing works
Mazaré, N., Oudart, M., Moulard, J., Cheung, G. T. Y., Tortuyaux, R., Mailly, P., Mazaud, D., Bemelmans, A., Boulay, A.-C., Blugeon, C., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108076 · Cited by 90 · see citing works
“Recent studies have shown that astrocytes directly regulate memory formation through their contribution to local synaptic transmission and plasticity via exchange of regulatory signals with synapses (Adamsky et al., 2018; Martin-Fernandez et al., 2017; Santello et al., 2019).”
BackgroundA roadmap to integrate astrocytes into Systems Neuroscience
Kastanenka, K. V., Moreno‐Bote, R., Pittà, M. D., Perea, G., Eraso‐Pichot, A., Masgrau, R., Poskanzer, K. E., & Galea, E. (2019) · Glia · doi:10.1002/glia.23632 · Cited by 83 · see citing works
“…of excitatory and inhibitory neuro-transmission in the amygdala, with a net effect of reduced fear expression in a fear-conditioning paradigm (Martin-Fernandez et al., 2017); and (c) potentiation of the amplitude of evoked EPSC and, when chemogenetic activation is carried out at specific…”
BackgroundVentral tegmental area astrocytes orchestrate avoidance and approach behavior
Gomez, J. A., Perkins, J., Beaudoin, G. M. J., Cook, N. B., Quraishi, S., Szoeke, E. A., Kannan, T., Tschumi, C. W., Wanat, M. J., Maroof, A. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09131-y · Cited by 80 · see citing works
Endocannabinoid signaling in astrocytes
Eraso‐Pichot, A., Pouvreau, S., Oliveira-Pinto, A., Gómez-Sotres, P., Skupio, U., & Marsicano, G. (2022) · Glia · doi:10.1002/glia.24246 · Cited by 82 · see citing works
“…brain regions, such as the hippocampus, amygdala, striatum or spinal cord (Carlsen et al., 2021; Covelo & Araque, 2018; Martín et al., 2015; Martin-Fernandez et al., 2017; Navarrete & Araque, 2008; Robin et al., 2018) were shown to modulate a number of short- and long-term effects on…”
BackgroundSelf-citationAstrocyte Signaling Gates Long-Term Depression at Corticostriatal Synapses of the Direct Pathway
Cavaccini, A., Durkee, C. A., Kofuji, P., Tonini, R., & Araque, A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2369-19.2020 · Cited by 83 · see citing works
“This approach has previously been shown to reliably elevate astrocyte Ca21 in a phospholipase C (PLC)-dependent and IP3R2-dependent manner on application of the DREADD ligand CNO (Chai et al., 2017; Martin-Fernandez et al., 2017; Durkee et al., 2019).”
BackgroundSelf-citationZhang, K., Förster, R., He, W., Liao, X., Li, J., Yang, C., Qin, H., Wang, M., Ding, R., Li, R., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00949-8 · Cited by 325 · see citing works
Cortical astrocytes regulate ethanol consumption and intoxication in mice
Erickson, E. K., DaCosta, A., Mason, S., Blednov, Y. A., Mayfield, R. D., & Harris, R. A. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0721-0 · Cited by 80 · see citing works
Regulation of food intake by astrocytes in the brainstem dorsal vagal complex
MacDonald, A. J., Holmes, F. E., Beall, C., Pickering, A. E., & Ellacott, K. L. J. (2019) · Glia · doi:10.1002/glia.23774 · Cited by 77 · see citing works
Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression
Liu, J., Mo, J., Wang, X., An, Z., Zhang, S., Zhang, C.-Y., Yi, P., Leong, A. T. L., Ren, J., Chen, L.-Y., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo2098 · Cited by 75 · see citing works
Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation
Sardar, D., Cheng, Y.-T., Woo, J., Choi, D., Lee, Z.-F., Kwon, W., Chen, H., Lozzi, B., Cervantes, A., Rajendran, K., et al. (2023) · Science · doi:10.1126/science.ade0027 · Cited by 77 · see citing works
Astrocytes and major depression: The purinergic avenue
Zhao, Y. F., Verkhratsky, A., Tang, Y. C., & Illés, P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109252 · Cited by 73 · see citing works
Beyond the neuron: Role of non-neuronal cells in stress disorders
Cathomas, F., Holt, L. M., Parise, E. M., Liu, J., Murrough, J. W., Casaccia, P., Nestler, E. J., & Russo, S. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.033 · Cited by 70 · see citing works
Wang, M., Li, P., Li, Z., da Silva, B. S., Zheng, W., Xiang, Z., He, Y., Xu, T., Cordeiro, C., Deng, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37601-x · Cited by 73 · see citing works
A Central Amygdala Input to the Parafascicular Nucleus Controls Comorbid Pain in Depression
Zhu, X., Zhou, W., Jin, Y., Tang, H.-D., Cao, P., Mao, Y., Xie, W., Zhang, X., Zhao, F., Luo, M.-H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.003 · Cited by 72 · see citing works
Kang, S., Hong, S., Lee, J., Peyton, L., Baker, M. R., Choi, S. H., Kim, H. J., Chang, S.-Y., & Choi, D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.04.023 · Cited by 68 · see citing works
“Previous studies have demonstrated that endogenous Gq-GPCRs induce calcium influx in astrocytes (33-36), thereby promoting astrocyte-neuron interaction and results in behavioral changes (18, 21, 37-40).”
BackgroundRetraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory
Badia‐Soteras, A., Heistek, T. S., Kater, M. S. J., Mak, A., Negrean, A., van den Oever, M. C., Mansvelder, H. D., Khakh, B. S., Min, R., Smit, A. B., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.10.013 · Cited by 70 · see citing works
CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
Covelo, A., Eraso‐Pichot, A., Fernández‐Moncada, I., Serrat, R., & Marsicano, G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108678 · Cited by 64 · see citing works
Self-citationAstroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration
Serrat, R., Covelo, A., Kouskoff, V., Delcasso, S., Ruiz-Calvo, A., Chenouard, N., Stella, C., Blancard, C., Salin, B., Julio‐Kalajzić, F., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110133 · Cited by 65 · see citing works
Self-citationCircuit-specific enteric glia regulate intestinal motor neurocircuits
Ahmadzai, M. M., Seguella, L., & Gulbransen, B. D. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025938118 · Cited by 67 · see citing works
Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors
Pittolo, S., Yokoyama, S., Willoughby, D. D., Taylor, C. R., Reitman, M. E., Tse, V., Wu, Z., Etchenique, R., Li, Y., & Poskanzer, K. E. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111426 · Cited by 67 · see citing works
“, 2014) and can lead to synaptic depression (Corkrum et al., 2020; Martin-Fernandez et al., 2017; Pascual et al., 2005; Zhang et al., 2003).”
BackgroundOpioid-Mediated Astrocyte–Neuron Signaling in the Nucleus Accumbens
Corkrum, M., Rothwell, P. E., Thomas, M. J., Kofuji, P., & Araque, A. (2019) · Cells · doi:10.3390/cells8060586 · Cited by 65 · see citing works
Self-citationRole of astrocytes in synapse formation and maturation
Tan, C. X., Burrus, C. J., & Eroğlu, Ç. (2021) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.12.010 · Cited by 63 · see citing works
Astrocytic IP3Rs: Beyond IP3R2
Sherwood, M. W., Arizono, M., Panatier, A., Mikoshiba, K., & Oliet, S. H. R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.695817 · Cited by 65 · see citing works
Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
Iwai, Y., Ozawa, K., Yahagi, K., Mishima, T., Akther, S., Vo, C. T., Lee, A. B., Tanaka, M., Itohara, S., & Hirase, H. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.658343 · Cited by 56 · see citing works
Ou, L., Przybilla, M. J., Ahlat, O., Kim, S., Overn, P., Jarnes, J., O’Sullivan, M. G., & Whitley, C. B. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.03.018 · Cited by 56 · see citing works
“Fear conditioning was performed according to an established protocol.(64) Briefly, on the first day, the mice were put in an enclosed container and given stimuli, followed by electric shock.”
MethodThe Astrocytic cAMP Pathway in Health and Disease
Zhou, Z., Ikegaya, Y., & Koyama, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030779 · Cited by 59 · see citing works
Endocannabinoid signaling in the central nervous system
Ramirez, C. E. M., Ruiz‐Pérez, G., Stollenwerk, T. M., Behlke, C., Doherty, A., & Hillard, C. J. (2022) · Glia · doi:10.1002/glia.24280 · Cited by 54 · see citing works
A novel gene editing system to treat both Tay–Sachs and sandhoff diseases
Ou, L., Przybilla, M. J., Tăbăran, A.-F., Overn, P., O’Sullivan, M. G., Jiang, X., Sidhu, R., Kell, P. J., Ory, D. S., & Whitley, C. B. (2020) · Gene Therapy · doi:10.1038/s41434-019-0120-5 · Cited by 52 · see citing works
Herrewegen, Y. V. D., Sanderson, T. M., Sahu, S., Bundel, D. D., Bortolotto, Z. A., & Smolders, I. J. (2021) · Molecular Brain · doi:10.1186/s13041-021-00856-w · Cited by 49 · see citing works
Chipman, P. H., Fung, C. C. A., Fernández, A. P., Sawant, A., Tedoldi, A., Kawai, A., Gautam, S. G., Kurosawa, M., Abe, M., Sakimura, K., et al. (2021) · eLife · doi:10.7554/elife.70818 · Cited by 50 · see citing works
Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons
Requie, L. M., Gómez‐Gonzalo, M., Speggiorin, M., Managò, F., Melone, M., Congiu, M., Chiavegato, A., Lia, A., Zonta, M., Losi, G., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01193-4 · Cited by 48 · see citing works
Self-citationEmerging technologies to study glial cells
Hirbec, H., Déglon, N., Foo, L. C., Goshen, I., Grutzendler, J., Hangen, E., Kreisel, T., Linck, N., Muffat, J., Regio, S., et al. (2020) · Glia · doi:10.1002/glia.23780 · Cited by 47 · see citing works
“Expression of this DREADD in centromedial amygdala astrocytes selectively increased inhibitory synaptic transmission, depressed excitatory transmission, and reduced fear perception (Martin-Fernandez et al., 2017).”
BackgroundEngram stability and maturation during systems consolidation
Refaeli, R., Kreisel, T., Groysman, M., Adamsky, A., & Goshen, I. (2023) · Current Biology · doi:10.1016/j.cub.2023.07.042 · Cited by 42 · see citing works
Prefrontal cortex astroglia modulate anhedonia-like behavior
Codeluppi-Arrowsmith, S. A., Xu, M., Bansal, Y., Lepack, A. E., Duric, V., Chow, M., Muir, J., Bagot, R. C., Licznerski, P., Wilber, S. L., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02246-1 · Cited by 43 · see citing works
“We also conducted a control study assessing the behavioral effects of CNO in control, non-surgerized mice subjected to or not to CRS (C57Bl/6 mice, n = 10/group, 4 groups, 50% female) (Supplementary Method).”
MethodBossuyt, J., Herrewegen, Y. V. D., Nestor, L., Buckinx, A., Bundel, D. D., & Smolders, I. J. (2023) · Glia · doi:10.1002/glia.24390 · Cited by 42 · see citing works
“, 2016) Central amygdala: " Ca events (Martin-Fernandez et al., 2017) Hippocampus: " Ca events (Durkee et al.”
BackgroundMiguel‐Quesada, C., Zaforas, M., Herrera-Pérez, S., Lines, J., Fernández‐López, E., Alonso‐Calviño, E., Ardaya, M., Soria, F. N., Araque, A., Aguilar, J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112950 · Cited by 40 · see citing works
Self-citationChen, Y., Lin, S., Jin, S., & Gao, T. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.04.013 · Cited by 42 · see citing works
Assessment of astrocytes as a mediator of memory and learning in rodents
Akther, S., & Hirase, H. (2021) · Glia · doi:10.1002/glia.24099 · Cited by 38 · see citing works
“Astrocytic A1 and A3 receptors are coupled to the Gi family of GPCRs, A2A receptors are coupled to the Gs family of proteins, and A2B couples to both Gs and Gq (Boison et al., 2010).”
BackgroundInfluentialPatton, A. P., Smyllie, N. J., Chesham, J. E., & Hastings, M. H. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2337-21.2022 · Cited by 40 · see citing works
Suthard, R. L., Senne, R. A., Buzharsky, M. D., Pyo, A. Y., Dorst, K. E., Diep, A. H., Cole, R. H., & Ramirez, S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1775-22.2023 · Cited by 39 · see citing works
Essential Role of Astrocytes in Learning and Memory
Escalada, P., Ezkurdia, A., Ramírez, M. J., & Solas, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031899 · Cited by 42 · see citing works
Astrocytic microRNAs and transcription factors in Alzheimer’s disease and therapeutic interventions
Nassar, A., Kodi, T., Satarker, S., Chowdari Gurram, P., Upadhya, D., SM, F., Mudgal, J., & Nampoothiri, M. (2022) · Cells · doi:10.3390/cells11244111 · Cited by 36 · see citing works
The endocannabinoid system in the amygdala and modulation of fear
Gunduz‐Cinar, O. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110116 · Cited by 38 · see citing works
Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse
Noriega‐Prieto, J. A., & Araque, A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03317-x · Cited by 38 · see citing works
Self-citationRapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury
Mandwie, M., Piper, J., Gorrie, C. A., Keay, K. A., Musumeci, G., Al‐Badri, G., & Castorina, A. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.317982 · Cited by 38 · see citing works
“…the amygdala and PAG, two regions pivotal in mediating emotional coping behaviours and that play important roles in the development of the behavioural dysfunction comorbid with injury and trauma (Keay and Bandler, 2001; Phelps and LeDoux, 2005; Mor et al., 2015; Motta et al., 2017), were evaluated.”
BackgroundJi, S., Han, S., Yu, L., Du, L., You, Y., Chen, J., Wang, M., Wu, S., Li, S., Sun, X., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153940 · Cited by 38 · see citing works
Glial cells in Parkinson´s disease: protective or deleterious?
Domingues, A. V., Pereira, I. M., Vilaça-Faria, H., Salgado, A. J., Rodrigues, A. J., & Teixeira, F. G. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03584-x · Cited by 37 · see citing works
Lei, Z., Xie, L., Li, C. H., Lam, Y. Y., Ramkrishnan, A. S., Fu, Z., Zeng, X., Liu, S., Iqbal, Z., & Li, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116092 · Cited by 35 · see citing works
“Recent studies have shown that Gq pathway activation in the HPC enhances neuronal activity through NMDA receptors [13,32], while Gq pathway activation in the CeM decreased neuron firing [15].”
BackgroundInfluentialScheyer, A. F., Yasmin, F., Naskar, S., & Patel, S. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01438-7 · Cited by 36 · see citing works
Endocannabinoid signaling in synaptic function
Noriega‐Prieto, J. A., Kofuji, P., & Araque, A. (2022) · Glia · doi:10.1002/glia.24256 · Cited by 35 · see citing works
“that the selective and differential regulation of excitatory and inhibitory synapses exerted by eCB-stimulated astrocytes determines animal fear responses (Martin-Fernandez et al., 2017).”
BackgroundSelf-citationIqbal, Z., Lei, Z., Ramkrishnan, A. S., Liu, S., Hasan, M., Akter, M., Lam, Y. Y., & Li, Y. (2023) · Communications Biology · doi:10.1038/s42003-022-04405-6 · Cited by 33 · see citing works
Delepine, C., Li, K., Shih, J., Gaudeaux, P., & Sur, M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1982-22.2023 · Cited by 34 · see citing works
“…processing from synaptic (Araque et al., 1999; Haydon, 2001) to network levels (Sasaki et al., 2014 ; Perea et al., 2014a; Mederos et al., 2019; Lines et al., 2020) to drive myriad behavioral outputs (Oliveira et al., 2015; Martin-Fernandez et al., 2017; Yu et al., 2018; Nagai et al., 2019).”
BackgroundEngram reactivation mimics cellular signatures of fear
Suthard, R. L., Senne, R. A., Buzharsky, M. D., Diep, A. H., Pyo, A. Y., & Ramirez, S. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113850 · Cited by 34 · see citing works
- Authors
- Martin-Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G., & Araque, A.
- Affiliations
- University of Minnesota (US)
- Université de Bordeaux (FR)
- Servicio de Salud de Castilla La Mancha (ES)
- Corresponding author
- Araque, Alfonso
- Venue
- Nature Neuroscience
- Published
- 2017-09-25
- Volume
- 20
- Issue
- 11
- Pages
- 1540-1548
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5903286
- OpenAlex
- W2759821008
- Cited by
- 345
- References
- 64
- Citations by year
- 2026: 28 · 2025: 51 · 2024: 45 · 2023: 48 · 2022: 44 · 2021: 41 · 2020: 37 · 2019: 29 · 2018: 20 · 2017: 1
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS097312)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocytes, central amygdala, fear expression, fear conditioning, adenosine A1 receptor, adenosine A2A receptor, synaptic transmission, excitatory synapses, inhibitory synapses, basolateral amygdala, astrocyte-neuron interaction, neuronal firing rate
- MeSH terms
- Amygdala, Animals, Astrocytes, Fear, Male, Mice, Inbred C57BL, Nerve Net, Organ Culture Techniques, Synapses, Mice, Knockout, 6-Cyano-7-nitroquinoxaline-2,3-dione, Maze Learning, Receptor, Adenosine A2A, Mice, Adenosine A2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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