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From nature to industry: Harnessing enzymes for biocatalysis

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Buller, R., Lutz, S., Kazlauskas, R. J., Snajdrova, R., Moore, J. C., Bornscheuer, U. T.·2023·Science
DOI 10.1126/science.adh8615
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Abstract

Biocatalysis harnesses enzymes to make valuable products. This green technology is used in countless applications from bench scale to industrial production and allows practitioners to access complex organic molecules, often with fewer synthetic steps and reduced waste. The last decade has seen an explosion in the development of experimental and computational tools to tailor enzymatic properties, equipping enzyme engineers with the ability to create biocatalysts that perform reactions not present in nature. By using (chemo)-enzymatic synthesis routes or orchestrating intricate enzyme cascades, scientists can synthesize elaborate targets ranging from DNA and complex pharmaceuticals to starch made in vitro from CO 2 -derived methanol. In addition, new chemistries have emerged through the combination of biocatalysis with transition metal catalysis, photocatalysis, and electrocatalysis. This review highlights recent key developments, identifies current limitations, and provides a future prospect for this rapidly developing technology.

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Cited by

Metadata

Authors
Buller, R., Lutz, S., Kazlauskas, R. J., Snajdrova, R., Moore, J. C., & Bornscheuer, U. T.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2023-11-24
Volume
382
Issue
6673
Pages
eadh8615-eadh8615
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.adh8615
OpenAlex
W4388936967
Cited by
706
References
20
FWCI
52.75
Type
journal article
Language
en
Open access
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