The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
On the Origin of Leprosy
Open accessAbstract
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae . This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Self-citationSmith, J. M., Smith, N. H., O'Rourke, M., & Spratt, B. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4384 · Cited by 1,802
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Self-citationA new evolutionary scenario for the Mycobacterium tuberculosis complex
Brosch, R., Gordon, S. V., Marmiesse, M., Brodin, P., Buchrieser, C., Eiglmeier, K., Garnier, T., Gutierrez, C., Hewinson, G., Kremer, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052548299 · Cited by 1,603
Self-citationTraces of Human Migrations in Helicobacter pylori Populations
Falush, D., Wirth, T., Linz, B., Pritchard, J. K., Stephens, M., Kidd, M., Blaser, M. J., Graham, D. Y., Vacher, S., Perez-Perez, G. I., et al. (2003) · Science · doi:10.1126/science.1080857 · Cited by 1,022
The complete genome sequence of Mycobacterium bovis
Garnier, T., Eiglmeier, K., Camus, J.-C., Medina, N., Mansoor, H., Pryor, M., Duthoy, S., Grondin, S., Lacroix, C., Monsempe, C., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1130426100 · Cited by 955
Self-citationY chromosome sequence variation and the history of human populations
Underhill, P. A., Shen, P., Lin, A. A., Jin, L., Passarino, G., Yang, W. H., Kauffman, E., Bonné-Tamir, B., Bertranpetit, J., Francalacci, P., et al. (2000) · Nature Genetics · doi:10.1038/81685 · Cited by 715
Britton, W. J., & Lockwood, D. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15952-7 · Cited by 687
The application of molecular genetic approaches to the study of human evolution
Cavalli-Sforza, L. L., & Feldman, M. W. (2003) · Nature Genetics · doi:10.1038/ng1113 · Cited by 676
Whole-Genome Comparison of Mycobacterium tuberculosis Clinical and Laboratory Strains
Fleischmann, R. D., Alland, D., Eisen, J. A., Carpenter, L., White, O., Peterson, J., DeBoy, R., Dodson, R., Gwinn, M., Haft, D., et al. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.19.5479-5490.2002 · Cited by 672
Cited by
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak
Fraser, J. A., Giles, S. S., Wenink, E. C., Geunes-Boyer, S. G., Wright, J. R., Diezmann, S., Allen, A., Stajich, J. E., Dietrich, F. S., Perfect, J. R., et al. (2005) · Nature · doi:10.1038/nature04220 · Cited by 499
Origin, Spread and Demography of the Mycobacterium tuberculosis Complex
Wirth, T., Hildebrand, F., Allix-Béguec, C., Wölbeling, F., Kubica, T., Kremer, K., van Soolingen, D., Rüsch-Gerdes, S., Locht, C., Brisse, S., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000160 · Cited by 473
Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae
Schuenemann, V. J., Singh, P., Mendum, T. A., Krause-Kyora, B., Jäger, G., Bos, K. I., Herbig, A., Economou, C., Benjak, A., Busso, P., et al. (2013) · Science · doi:10.1126/science.1238286 · Cited by 358
Self-citationAncient pathogen genomics as an emerging tool for infectious disease research
Spyrou, M. A., Bos, K. I., Herbig, A., & Krause, J. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0119-1 · Cited by 285
Metadata
- Authors
- Monot, M., Honoré, N., Garnier, T., Araoz, R., Coppée, J.-Y., Lacroix, C., Sow, S., Spencer, J. S., Truman, R. W., Williams, D. L., Gelber, R., Virmond, M., Flageul, B., Cho, S.-N., Ji, B., Paniz-Mondolfi, A., Convit, J., Young, S., Fine, P. E., Rasolofo, V., Brennan, P. J., & Cole, S. T.
- Venue
- Science
- Published
- 2005-05-13
- Volume
- 308
- Issue
- 5724
- Pages
- 1040-1042
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2159367931
- Cited by
- 490
- References
- 23
- FWCI
- 22.01
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: On the Origin of Leprosy. https://app.cochat.ai/papers/10.1126/science/1109759
- The paper
- Monot, M., Honoré, N., Garnier, T., Araoz, R., Coppée, J.-Y., Lacroix, C., Sow, S., Spencer, J. S., Truman, R. W., Williams, D. L., Gelber, R., Virmond, M., Flageul, B., Cho, S.-N., Ji, B., Paniz-Mondolfi, A., Convit, J., Young, S., Fine, P. E., . . . Cole, S. T. (2005). On the Origin of Leprosy. Science. https://doi.org/10.1126/science/1109759
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
