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Human airway mast cells proliferate and acquire distinct inflammation‐driven phenotypes during type 2 inflammation
Abstract
Mast cells in type 2 airway inflammation exhibit heterogeneous inflammation-associated phenotypes and proliferate in situ.
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“Similarly, Dwyer and colleagues identified a population of progenitor‐like immature mast cells in nasal polyps of patients with chronic rhinosinusitis. 102 These are distinct from circulating mast cell progenitors and appear highly proliferative.”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [102]
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“Cells with similar features were also found in fibrotic and asthmatic lung tissue. 102”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [102]
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Cited by
Sorted by citations
Mast cell ontogeny: From fetal development to life‐long health and disease
Chia, S. L., Kapoor, S., Carvalho, C., Bajénoff, M., & Gentek, R. (2023) · Immunological Reviews · doi:10.1111/imr.13191 · Cited by 60
Metadata
- Authors
- Dwyer, D. F., Ordovas-Montanes, J., Allon, S. J., Buchheit, K. M., Vukovic, M., Derakhshan, T., Feng, C., Lai, J., Hughes, T. K., Nyquist, S. K., Giannetti, M. P., Berger, B., Bhattacharyya, N., Roditi, R. E., Katz, H. R., Nawijn, M. C., Berg, M., van den Berge, M., Laidlaw, T. M., Shalek, A. K., Barrett, N. A., & Boyce, J. A.
- Affiliations
- Jeff and Penny Vinik Immunology Center, Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston, MA, USA.
- Division of Gastroenterology, Boston Children’s Hospital, Boston, MA, USA.
- Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- Computer Science and Artificial Intelligence Lab and Department of Mathematics, MIT, Cambridge, MA, USA.
- Department of Medicine, Harvard Medical School, Boston, MA, USA.
- Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
- ORCID
- Venue
- Science Immunology
- Published
- 2021-02-12
- Volume
- 6
- Issue
- 56
- ISSN
- 2470-9468
- PMC
- PMC8362933
- Cited by
- 175
- References
- 5
- Language
- en
- Funders
- National Institutes of Health (R37AI052353, R01AI136041, R01AI130109, R01HL136209, U19AI095219, R01HL120952, U24AI118672, T32AI007306, R01AI134989, U19AI070535, R01HL128241)
- Bill and Melinda Gates Foundation
- Alfred P. Sloan Foundation
- National Institute of Allergy and Infectious Diseases (K22AI146281)
- Damon Runyon Cancer Research Foundation (DRG-2274-16)
- Searle Scholars Program
- Beckman Young Investigator Program
- Pew-Stewart Scholars Program for Cancer Research
- Steven and Judy Kaye Young Innovators Award
- European Commission Directorate-General for Research and Innovation (grant agreement no. 874656 (discovAIR))
- Food Allergy Science Initiative
- AGA Research Foundation’s AGA-Takeda Pharmaceuticals Research Scholar Award in IBD (AGA2020-13-01)
- Richard and Susan Smith Family Foundation
- New York Stem Cell Foundation
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