Stress-activated cap’n’collar transcription factors in aging and human disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Trash Talk: Mammalian Proteasome Regulation at the Transcriptional Level

Kaya, H. E. K., & Radhakrishnan, S. K. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.09.005 · Cited by 32

Regulation of APC development, immune response, and autoimmunity by Bach1/HO-1 pathway in mice

So, A. Y., Garcia-Flores, Y., Minisandram, A., Martin, A., Taganov, K. D., Boldin, M., & Baltimore, D. (2012) · Blood · doi:10.1182/blood-2012-04-426247 · Cited by 31

F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans

Wu, C., Wang, Y., & Choe, K. P. (2017) · Genetics · doi:10.1534/genetics.117.200592 · Cited by 30

Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity

Chhunchha, B., Kubo, E., & Singh, D. P. (2022) · Cells · doi:10.3390/cells11193021 · Cited by 31

Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Kombairaju, P., Kerr, J. P., Roche, J. A., Pratt, S. J. P., Lovering, R. M., Sussan, T. E., Kim, J., Shi, G., Biswal, S. S., & Ward, C. W. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00057 · Cited by 30

Aging affects sex- and organ-specific trace element profiles in mice

Lossow, K., Kopp, J. F., Schwarz, M., Finke, H., Winkelbeiner, N., Renko, K., Meçi, X., Ott, C., Alker, W., Hackler, J., et al. (2020) · Aging · doi:10.18632/aging.103572 · Cited by 32

Bach2 regulates autophagy to modulate UVA-induced photoaging in skin fibroblasts

Wang, M., Lei, M., Chang, L., Yang, X., Guo, Y., Pourzand, C., Bartsch, J. W., Chen, J., Luo, J., Karisma, V. W., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.003 · Cited by 32

An enriched polyphenolic extract obtained from the by-product of Rosa damascena hydrodistillation activates antioxidant and proteostatic modules

Dina, E., Sklirou, A. D., Chatzigeorgiou, S., Manola, M. S., Cheilari, A., Louka, X. P., Argyropoulou, A., Xynos, N., Skaltsounis, A., Aligiannis, N., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153757 · Cited by 32

The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2

Plafker, K. S., & Plafker, S. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1057 · Cited by 30

Promoter DNA demethylation of Keap1 gene in diabetic cardiomyopathy.

Liu, Z.-Z., Zhao, X.-Z., Zhang, X., & Zhang, M. (2014) · Europe PMC (PubMed Central) · Cited by 30

Structure and Function of the Ubiquitin–Proteasome System

Chondrogianni, N., & Gonos, E. S. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00002-x · Cited by 31

Activation of the Nrf-2/HO-1 signalling axis can alleviate metabolic syndrome in cardiovascular disease

Liu, C., Xu, X., HE, X. J., Ren, J., Chi, M., Deng, G., Li, G., & Nasser, M. I. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2284890 · Cited by 29

Comparative Study on the Larvicidal Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Drosophila melanogaster til-til

Montenegro, I., Pino, L., Werner, E., Madrid, A., Espinoza, L., Moreno, L., Villena, J., & Cuéllar, M. (2013) · Molecules · doi:10.3390/molecules18044192 · Cited by 29

Transcription factor Nrf1 is negatively regulated by its O‐GlcNAcylation status

Chen, J., Liu, X., Lu, F.-L., Liu, X., Ru, Y., Ren, Y., Yao, L., & Zhang, Y. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.07.030 · Cited by 29

Antioxidant activities of novel resveratrol analogs in breast cancer

Chatterjee, A., Ronghe, A. M., Padhyé, S., Spade, D. A., Bhat, N. K., & Bhat, H. K. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21925 · Cited by 29

NRF3 suppresses breast cancer cell metastasis and cell proliferation and is a favorable predictor of survival in breast cancer

Sun, J., Zheng, Z., Chen, Q., Pan, Y., Lu, H., Zhang, H., Yu, Y., & Dai, Y. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s197409 · Cited by 29

The Dangerous Liaisons in the Oxidative Stress Response to Leishmania Infection

Reverte, M., Snäkä, T., & Fasel, N. J. (2022) · Pathogens · doi:10.3390/pathogens11040409 · Cited by 30

Cap'n'collar differentiates the mandible from the maxilla in the beetle Tribolium castaneum

Coulcher, J. F., & Telford, M. J. (2012) · EvoDevo · doi:10.1186/2041-9139-3-25 · Cited by 29

A Comprehensive Enumeration of the Human Proteostasis Network. 1. Components of Translation, Protein Folding, and Organelle-Specific SystemsPreprint

coordination, O., Elsasser, S., Elia, L. P., Morimoto, R. I., Powers, E. T., Finley, D. J., Mockler, E., Lima, L. D. A., Finkbeiner, S. M., Gestwicki, J. E., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.30.505920 · Cited by 32

Identification of UV-protective Activators of Nuclear Factor Erythroid-derived 2-Related Factor 2 (Nrf2) by Combining a Chemical Library Screen with Computer-based Virtual Screening

Lieder, F., Reisen, F., Geppert, T., Sollberger, G., Beer, H.-D., auf dem Keller, U., Schäfer, M., Detmar, M., Schneider, G., & Werner, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.383430 · Cited by 27

Beyond Antioxidation: Keap1–Nrf2 in the Development and Effector Functions of Adaptive Immune Cells

Pant, A., Dasgupta, D., Tripathi, A., & Pyaram, K. (2023) · ImmunoHorizons · doi:10.4049/immunohorizons.2200061 · Cited by 28

Disrupting the SKN-1 homeostat: mechanistic insights and phenotypic outcomes

Turner, C. D., Ramos, C. M., & Curran, S. P. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1369740 · Cited by 29

Gene regulatory effects of disease-associated variation in the NRF2 network

Lacher, S. E., & Slattery, M. G. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.09.001 · Cited by 27

Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion

Siegenthaler, B., Defila, C., Muzumdar, S., Beer, H., Meyer, M., Tanner, S. L., Bloch, W., Blank, V., Schäfer, M., & Werner, S. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0074-y · Cited by 28

Nrf2 exerts mixed inflammation and glucose metabolism regulatory effects on murine RAW264.7 macrophages

Ding, L., Yuan, X., Yan, J., Huang, Y., Xu, M., Yang, Z. L., Yang, N., Wang, M., Zhang, C., & Zhang, L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.03.023 · Cited by 29

Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications

Peyrat, L., Tsafantakis, N., Georgousaki, K., Ouazzani, J., Genilloud, O., Trougakos, I. P., & Fokialakis, N. (2019) · Molecules · doi:10.3390/molecules24091836 · Cited by 31

Keap1 governs ageing-induced protein aggregation in endothelial cells

Kopacz, A., Klóska, D., Targosz‐Korecka, M., Zapotoczny, B., Cysewski, D., Personnic, N., Werner, E., Hajduk, K., Józkowicz, A., & Grochot‐Przeczek, A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101572 · Cited by 28

Premature Senescence and Increased Oxidative Stress in the Thymus of Down Syndrome Patients

Marcovecchio, G. E., Ferrua, F., Fontana, E., Beretta, S., Genua, M., Bortolomai, I., Conti, A., Montin, D., Cascarano, M. T., Bergante, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669893 · Cited by 30

Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

Mercado, N., Kizawa, Y., Ueda, K., Xiong, Y., Kimura, G., Moses, A. S., Curtis, J. M., Ito, K., & Barnes, P. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088168 · Cited by 28

Organelle aging: Lessons from model organisms

Bouska, M. J., Huang, K., Kang, P., & Bai, H. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.03.011 · Cited by 27

Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates

Spatola, B. N., Lo, J. Y., Wang, B., & Curran, S. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-48286-y · Cited by 25

MicroRNA-1246 Mediates Drug Resistance and Metastasis in Breast Cancer by Targeting NFE2L3

Dai, Y., Pan, Y., Quan, M., Chen, Q., Pan, Y., Ruan, Y.-Y., & Sun, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.677168 · Cited by 27

Dexamethasone Administration in Mice Leads to Less Body Weight Gain over Time, Lower Serum Glucose, and Higher Insulin Levels Independently of NRF2

Filippopoulou, F., Habeos, G. I., Rinotas, V. E., Sophocleous, A., Sykiotis, G. P., Douni, E. K., & Chartoumpekis, D. V. (2021) · Antioxidants · doi:10.3390/antiox11010004 · Cited by 29

Inhibition of the oxidative stress response by heat stress inCaenorhabditis elegans

Crombie, T. A., Tang, L., Choe, K. P., & Julian, D. A. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.135327 · Cited by 25

A hypermorphic antioxidant response element is associated with increased MS4A6A expression and Alzheimer's disease

Lacher, S. E., Alazizi, A., Wang, X., Bell, D. A., Piqué-Regi, R., Luca, F., & Slattery, M. G. (2017) · Redox Biology · doi:10.1016/j.redox.2017.10.018 · Cited by 26

Distinct isoforms of Nrf1 diversely regulate different subsets of its cognate target genes

Wang, M., Qiu, L., Ru, X., Song, Y., & Zhang, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-39536-0 · Cited by 27

Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration

Pastar, I., Stojadinović, O., Sawaya, A. P., Stone, R. C., Lindley, L. E., Ojeh, N. O., Vukelic, S., Samuels, H. H., & Tomic‐Canic, M. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25357 · Cited by 26

Zinc is essential for the transcription function of the PGC-1α/Nrf2 signaling pathway in human primary endometrial stromal cells

Lü, X., Zhang, Q., Xu, L., Xiuying, L., Fu, J., Wang, X., Liu, Y., Lin, Y., Li, B., Wang, R., et al. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00152.2019 · Cited by 26

Novel NRF2 ‐activated cancer treatments utilizing synthetic lethality

Baird, L., Kensler, T. W., & Yamamoto, M. P. (2022) · IUBMB Life · doi:10.1002/iub.2680 · Cited by 26

Loss of NRF2 impairs gastric nitrergic stimulation and function

Mukhopadhyay, S., Sekhar, K. R., Hale, A., Channon, K. M., Farrugia, G., Freeman, M. L., & Gangula, P. R. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.044 · Cited by 26

Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3)

Kannan, M. B., Dodard-Friedman, I., & Blank, V. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666446 · Cited by 26

Nrf2 is highly expressed in neutrophils, but myeloid cell-derived Nrf2 is dispensable for wound healing in mice

Joshi, N., & Werner, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187162 · Cited by 27

Dietary restriction and aging in rodents: a current view on its molecular mechanisms.

Shimokawa, I., & Trindade, L. S. (2010) · Europe PMC (PubMed Central) · Cited by 26

Molecular Mechanisms of Ferroptosis and Its Role in Viral Pathogenesis

Huang, R.-W., Wu, J., Ma, Y., & Kang, K. (2023) · Viruses · doi:10.3390/v15122373 · Cited by 26

The C-Terminal Domain of Nrf1 Negatively Regulates the Full-Length CNC-bZIP Factor and Its Shorter Isoform LCR-F1/Nrf1β; Both Are Also Inhibited by the Small Dominant-Negative Nrf1γ/δ Isoforms that Down-Regulate ARE-Battery Gene Expression

Zhang, Y., Qiu, L., Li, S., Xiang, Y., Chen, J., & Ren, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109159 · Cited by 25

The Indirubin Derivative 6-Bromoindirubin-3′-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects

Tsakiri, E. N., Gaboriaud‐Kolar, N., Iliaki, K. K., Tchoumtchoua, J., Papanagnou, E., Chatzigeorgiou, S., Tallas, K. D., Mikros, E., Halabalaki, M., Skaltsounis, A., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6910 · Cited by 25

Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

Offenburger, S.-L., Jongsma, E., & Gartner, A. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007106 · Cited by 26

Interaction of Genetic Variations in NFE2L2 and SELENOS Modulates the Risk of Hashimoto's Thyroiditis

Santos, L. R., Durães, C., Ziros, P. G., Pestana, A., Esteves, C., Neves, C., Carvalho, D. M., Bongiovanni, M., Renaud, C. O., Chartoumpekis, D. V., et al. (2019) · Thyroid · doi:10.1089/thy.2018.0480 · Cited by 25

Lability of the Nrf2/Keap/ARE Cell Defense System in Different Models of Cell Aging and Age-Related Pathologies

Shilovsky, G. A. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922010060 · Cited by 24

Constitutive activation of Drosophila CncC transcription factor reduces lipid formation in the fat body

Karim, M. R., Taniguchi, H., & Kobayashi, A. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.05.126 · Cited by 25

Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory Networks

Xiao, H., Lu, F.-L., Stewart, D., & Zhang, Y. (2013) · Current Chemical Biology · doi:10.2174/2212796811307020008 · Cited by 25

Melatonin ameliorates ANIT‑induced cholestasis by activating Nrf2 through a PI3K/Akt‑dependent pathway in rats

Li, Y., Yu, H., Xu, Z., Shi, S., Wang, D., Shi, X., Wang, Y., Zeng, B., Deng, H., Deng, X., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9746 · Cited by 25

CBP-1/p300 acetyltransferase regulates SKN-1/Nrf cellular levels, nuclear localization, and activity in C. elegans

Ganner, A., Gerber, J. P., Ziegler, A.-K., Li, Y., Kandzia, J., Matulenski, T., Kreis, S., Breves, G., Klein, M., Walz, G., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110690 · Cited by 25

Excessive reactive oxygen species induce apoptosis via the APPL1-Nrf2/HO-1 antioxidant signalling pathway in trophoblasts with missed abortion

Luan, X., Yan, Y., Zheng, Q., Wang, M., Chen, W., Yu, J. J., & Fang, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117781 · Cited by 25

Ferroptosis regulation by Cap’n’collar family transcription factors

Murray, M. B., & Dixon, S. J. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107583 · Cited by 26

A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant

Hensen, S. M. M., Heldens, L., van Genesen, S. T., Pruijn, G. J. M., & Lubsen, N. H. (2013) · Cell Stress and Chaperones · doi:10.1007/s12192-012-0400-0 · Cited by 24

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development

Ruf, V., Holzem, C., Peyman, T., Walz, G., Blackwell, T. K., & Neumann‐Haefelin, E. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.08.011 · Cited by 25

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Uruno, A., Saigusa, D., Suzuki, T., Yumoto, A., Nakamura, T., Matsukawa, N., Yamazaki, T., Saito, R., Taguchi, K., Suzuki, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02904-6 · Cited by 25

Autocrine and Paracrine Regulation of Keratinocyte Proliferation through a Novel Nrf2–IL-36γ Pathway

Kurinna, S. M., Muzumdar, S., Köhler, U. A., Kockmann, T., Keller, U. A. D., Schäfer, M., & Werner, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501447 · Cited by 24

Toward Understanding Induction of Oxidative Stress and Apoptosis by Proteasome Inhibitors

Paniagua, G., de Bruin, G., Overkleeft, H. S., & Florea, B. I. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5794 · Cited by 24

Limited expression of Nrf2 in neurons across the central nervous system

Levings, D. C., Pathak, S. S., Yang, Y., & Slattery, M. G. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102830 · Cited by 23

Iron accumulation and lipid peroxidation: implication of ferroptosis in hepatocellular carcinoma

Li, X., Meng, F., Wang, H., Sun, L., Chang, S., Li, G., & Chen, F. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1319969 · Cited by 25

HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi’s Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity

Kumar, B., Roy, A., Asha, K., Sharma-Walia, N., Ansari, M. A., & Chandran, B. (2019) · Journal of Virology · doi:10.1128/jvi.01812-18 · Cited by 23

Salvianolic Acid B Improves Postresuscitation Myocardial and Cerebral Outcomes in a Murine Model of Cardiac Arrest: Involvement of Nrf2 Signaling Pathway

Ji, Q., Li, Y.-J., Wang, Y., Wang, Z., Fang, L., Shen, L., Lu, Y., Shen, L., & He, B. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1605456 · Cited by 23

N-γ-(L-glutamyl)-L-selenomethionine shows neuroprotective effects against Parkinson's disease associated with SKN-1/Nrf2 and TRXR-1 in Caenorhabditis elegans

Chang, C., Wei, C., Ho, C., & Liao, V. H. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153733 · Cited by 23

Role of Nrf2 and HO-1 in intervertebral disc degeneration

Zhang, C., Hu, X., Zhang, G., Liu, M.-Q., Chen, H., & Kang, X. (2022) · Connective Tissue Research · doi:10.1080/03008207.2022.2089565 · Cited by 23

Distinct Roles of Nrf1 and Nrf2 in Monitoring the Reductive Stress Response to Dithiothreitol (DTT)

Wufuer, R., Fan, Z., Yuan, J., Zheng, Z., Hu, S., Sun, G., & Zhang, Y. (2022) · Antioxidants · doi:10.3390/antiox11081535 · Cited by 23

Natural Antioxidants Exhibit Chemopreventive Characteristics through the Regulation of CNC b‐Zip Transcription Factors in Estrogen‐Induced Breast Carcinogenesis

Chatterjee, A., Ronghe, A. M., Singh, B., Bhat, N. K., Chen, J., & Bhat, H. K. (2014) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21594 · Cited by 23

Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System

Yukitake, H., Takizawa, M., & Kimura, H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8584930 · Cited by 23

A Genetic Analysis of the Caenorhabditis elegans Detoxification Response

Fukushige, T., Smith, H. E., Miwa, J., Krause, M., & Hanover, J. A. (2017) · Genetics · doi:10.1534/genetics.117.202515 · Cited by 23

Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level

Wright, J. A., McHugh, P., Pan, S., Cunningham, A., & Brown, D. R. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.09.002 · Cited by 22

The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer

Chang, L., Fan, C., Tseng, W., Chein, H., Hsieh, T.-Y., Chen, J., Hwang, C., & Hua, C. (2016) · Disease Markers · doi:10.1155/2016/8143465 · Cited by 22

Integrated mRNA and miRNA profiling revealed deregulation of cellular stress response in bone marrow mesenchymal stem cells derived from patients with immune thrombocytopenia

Zhang, J., Zhu, X., Xue, J., Liu, X., Zheng, X. L., Chang, Y., Liu, K., Huang, X., & Zhang, X. (2018) · Functional & Integrative Genomics · doi:10.1007/s10142-018-0591-2 · Cited by 22

Subdivision of arthropod cap-n-collar expression domains is restricted to Mandibulata

Sharma, P. P., Gupta, T., Schwager, E. E., Wheeler, W. C., & Extavour, C. G. M. (2014) · EvoDevo · doi:10.1186/2041-9139-5-3 · Cited by 22

Ampelopsin attenuates 6-OHDA-induced neurotoxicity by regulating GSK-3β/NRF2/ARE signalling

Kou, X., Li, J., Bian, J., Yang, Y., Yang, X., Fan, J., Jia, S., & Chen, N. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.10.010 · Cited by 22

Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model

Boerma, M., Singh, P., Sridharan, V., Tripathi, P., Sharma, S., & Singh, S. P. (2015) · Radiation Research · doi:10.1667/rr13979.1 · Cited by 22

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression

Fukagai, K., Waku, T., Chowdhury, A. M. M. A., Kubo, K., Matsumoto, M., Kato, H., Natsume, T., Tsuruta, F., Chiba, T., Taniguchi, H., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.045 · Cited by 22

7,8-Dihydroxyflavone Suppresses Oxidative Stress-Induced Base Modification in DNA via Induction of the Repair Enzyme 8-Oxoguanine DNA Glycosylase-1

Kim, K. C., Lee, I. K., Kang, K. A., Cha, J. W., Cho, S. J., Na, S. Y., Chae, S., Kim, H. S., Kim, S., & Hyun, J. W. (2013) · BioMed Research International · doi:10.1155/2013/863720 · Cited by 22

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex #

Naha, N., Gandhi, D., Ak, G., & Prakash, J. R. (2017) · Human & Experimental Toxicology · doi:10.1177/0960327117698543 · Cited by 22

New roles for old actors, ROS and PRMT1

Palli, S. R. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715062114 · Cited by 21

Single‐cell RNA sequencing reveals that NRF2 regulates vascular smooth muscle cell phenotypic switching in abdominal aortic aneurysm

Xiao, X., Li, C., Huang, X., Chen, G., Huang, X., Song, F., Zhou, Y., Liu, X., Xueke, Z., Meng, J., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400001rr · Cited by 21

African-American esophageal squamous cell carcinoma expression profile reveals dysregulation of stress response and detox networks

Erkizan, H. V., Johnson, K. R., Ghimbovschi, S. D., Karkera, D., Trachiotis, G. D., Adib, H., Hoffman, E. P., & Wadleigh, R. G. (2017) · BMC Cancer · doi:10.1186/s12885-017-3423-1 · Cited by 21

Uterine Insulin Sensitivity Defects Induced Embryo Implantation Loss Associated with Mitochondrial Dysfunction‐Triggered Oxidative Stress

Chen, M., Li, J., Zhang, B., Zeng, X., Zeng, X., Cai, S., Ye, C., Yang, G., Ye, C., Shang, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6655685 · Cited by 21

Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells

Musrati, M. A., Stijlemans, B., Azouz, A., Kancheva, D., Mesbahi, S., Hadadi, E., Lebegge, E., Ali, L., De Vlaminck, K., Scheyltjens, I., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.07.007 · Cited by 21

Bidirectional Association Between Psoriasis and Obesity: Benefits and Risks

El-Boghdady, N. A., Ismail, M. F., Abd-Alhameed, M. F., Ahmed, A. S., & Ahmed, H. H. (2017) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2017.0105 · Cited by 21

BET‐ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors

Chatterjee, N., & Bohmann, D. (2018) · BioEssays · doi:10.1002/bies.201800007 · Cited by 21

Genome-wide identification and analysis of Nrf2 binding sites – Antioxidant response elements in zebrafish

Raghunath, A., Raju, N., Sundarraj, K., Panneerselvam, L., & Perumal, E. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.013 · Cited by 24

The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice

Yang, J., Zhang, R., Lin, J., Cao, M.-C., Wang, Q., Cui, H., Sun, S.-G., & Wang, L. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000494478 · Cited by 21

Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway

Luan, J., Yu, M., Gu, Q., Zhou, X., Shao, Y., Chen, T., Zhang, J., Zhu, Z., Song, N., & Yang, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1532021 · Cited by 20

Melatonin activates ABCA1 via the BiP/NRF1 pathway to suppress high-cholesterol-induced apoptosis of mesenchymal stem cells

Kim, J. S., Jung, Y. H., Lee, H. J., Chae, C. W., Choi, G. E., Lim, J. R., Kim, S. Y., Lee, J., & Han, H. J. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02181-4 · Cited by 20

Leishmania Parasites Differently Regulate Antioxidant Genes in Macrophages Derived From Resistant and Susceptible Mice

Bichiou, H., Rabhi, S., Hamda, C. B., Bouabid, C., Belghith, M., Piquemal, D., Trentin, B., Rabhi, I., & Guizani-Tabbane, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.748738 · Cited by 20

Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia

Han, G., Cao, C., Yang, X., Zhao, G., Hu, X.-J., Yu, D., Yang, R., Yang, K. G., Zhang, Y., Wang, W., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102239 · Cited by 20

CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis

Bhat, K. P., Vijay, J., Vilas, C. K., Asundi, J., Zou, J., Lau, T., Cai, X. T., Ahmed, M., Kabza, M., Weng, J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114345 · Cited by 23

Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics

Gumeni, S., Evangelakou, Z., Tsakiri, E. N., Scorrano, L., & Trougakos, I. P. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101219 · Cited by 21

Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers

Hirotsu, Y., Katsuoka, F., Itoh, K., & Yamamoto, M. P. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01496.x · Cited by 20

The critical role of Bach2 in regulating type 2 chronic airway inflammation

Yamashita, M., & Kuwahara, M. (2018) · International Immunology · doi:10.1093/intimm/dxy020 · Cited by 19

FOXO acts as a positive regulator of CncC and deltamethrin tolerance in the red flour beetle, Tribolium castaneum

Xu, X., Zhang, N., Meng, X., Jiang, H., Ge, H., Yang, Z., Qian, K., & Wang, J. (2022) · Pest Management Science · doi:10.1002/ps.6811 · Cited by 19

Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs

Li, D., Zhao, H., Xu, P., Lin, Q., Zhao, T., Li, C., Cui, Z., & Tian, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.887833 · Cited by 19

Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2‐mediated antioxidant signalling

Sun, J., Wang, X., Song, F., Li, D., Gao, S., Zhang, L., Wu, J., Liu, D.-Q., Wang, L., Zhou, Y., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16195 · Cited by 19

Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response

Dresen, A., Finkbeiner, S., Dottermusch, M., Beume, J., Li, Y., Walz, G., & Neumann‐Haefelin, E. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.01.021 · Cited by 21

Preserving transcriptional stress responses as an anti‐aging strategy

Cheng, Y., Pitoniak, A., Wang, J., & Bohmann, D. (2021) · Aging Cell · doi:10.1111/acel.13297 · Cited by 16

Mechanisms and functions of Nrf2 signaling in Drosophila

Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 129

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622

Declining signal dependence of Nrf2‐ Maf S ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 40