Cited by 776Genomics, phytochemicals, and oxidative stressGenetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stress

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Stress-activated cap’n’collar transcription factors in aging and human disease

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Sykiotis, Gerasimos P., Bohmann, Dirk·2010·Science Signaling

DOI 10.1126/scisignal.3112re3PMC PMC2991085

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The oxidative stress response is an attractive target for treating human diseases and extending the healthy life span.

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Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1
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Nuclear Import and Export Signals in Control of Nrf2
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Phosphorylation of Tyrosine 568 Controls Nuclear Export of Nrf2
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Prothymosin-α Mediates Nuclear Import of the INrf2/Cul3·Rbx1 Complex to Degrade Nuclear Nrf2
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Phosphorylation and Dephosphorylation of Tyrosine 141 Regulate Stability and Degradation of INrf2
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Authors: Sykiotis, G. P., & Bohmann, D.
Affiliations: Harvard University (US)
University of Rochester Medicine (US)
Corresponding author: Sykiotis, Gerasimos P.
ORCID: Sykiotis, Gerasimos P.
Bohmann, Dirk
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-03-09
Volume: 3
Issue: 112
Pages: re3-re3
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.3112re3
PMC: PMC2991085
OpenAlex: W2163292409
Cited by: 776
References: 324
Citations by year: 2026: 26 · 2025: 20 · 2024: 37 · 2023: 45 · 2022: 58 · 2021: 58 · 2020: 45 · 2019: 61 · 2018: 65 · 2017: 68 · 2016: 49 · 2015: 47 · 2014: 53 · 2013: 57 · 2012: 39
FWCI: 4.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R03CA123591)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: Nrf2, NRF1, Nrf3, SKN-1, CncC, oxidative stress response, aging, age-related diseases, neurodegeneration, respiratory diseases, cancer, longevity
MeSH terms: Aging, Animals, Humans, Polymorphism, Genetic, Repressor Proteins, Transcription Factors, Oxidative Stress, Drosophila Proteins

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Stress-activated cap’n’collar transcription factors in aging and human disease

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