Stress-activated cap’n’collar transcription factors in aging and human disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

A cytoprotective perspective on longevity regulation

Shore, D. E., & Ruvkun, G. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.04.007 · Cited by 137

Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy

Digaleh, H., Kiaei, M., & Khodagholi, F. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1409-y · Cited by 140

Keap1-Nrf2 signaling pathway: Mechanisms of regulation and role in protection of cells against toxicity caused by xenobiotics and electrophiles

Turpaev, K. T. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913020016 · Cited by 135

The Molecular Chaperone Apolipoprotein J/Clusterin as a Sensor of Oxidative Stress: Implications in Therapeutic Approaches - A Mini-Review

Trougakos, I. P. (2013) · Gerontology · doi:10.1159/000351207 · Cited by 134

Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease

Sharma, C., & Kim, S. R. (2021) · Antioxidants · doi:10.3390/antiox10081231 · Cited by 145

Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1

Zhang, Y., Koppula, P., & Gan, B. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1597506 · Cited by 138

Transcription factor cap n collar C regulates multiple cytochrome P450 genes conferring adaptation to potato plant allelochemicals and resistance to imidacloprid in Leptinotarsa decemlineata (Say)

Kalsi, M., & Palli, S. R. (2017) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2017.02.002 · Cited by 134

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

Zhang, Y., & Xiang, Y. (2016) · Biochemical Journal · doi:10.1042/bj20151182 · Cited by 125

Natural compounds with anti-ageing activity

Argyropoulou, A., Aligiannis, N., Trougakos, I. P., & Skaltsounis, A. (2013) · Natural Product Reports · doi:10.1039/c3np70031c · Cited by 132

Genetic evidence of a redox‐dependent systemic wound response via Hayan Protease‐Phenoloxidase system in Drosophila

Nam, H.-J., Jang, I.-H., You, H., Lee, K., & Lee, W. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.476 · Cited by 129

Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk

Vekić, J., Stromsnes, K., Mazzalai, S., Zeljković, A., Rizzo, M., & Gambini, J. (2023) · Biomedicines · doi:10.3390/biomedicines11112897 · Cited by 145

The Nrf2 Pathway in Ischemic Stroke: A Review

Farina, M., Vieira, L. E., Buttari, B., Profumo, E., & Saso, L. (2021) · Molecules · doi:10.3390/molecules26165001 · Cited by 129

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

Uruno, A., Yagishita, Y., Katsuoka, F., Kitajima, Y., Nunomiya, A., Nagatomi, R., Pi, J., Biswal, S. S., & Yamamoto, M. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01095-15 · Cited by 126

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

Shore, D. E., Carr, C. E., & Ruvkun, G. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002792 · Cited by 124

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in aDrosophilamodel of Parkinson’s disease

Barone, M. C., Sykiotis, G. P., & Bohmann, D. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007575 · Cited by 124

Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy

Li, B., Liu, S., Miao, L., & Cai, L. (2012) · Experimental Diabetes Research · doi:10.1155/2012/216512 · Cited by 126

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0070-3 · Cited by 122

Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity

Mendonca, P., & Soliman, K. F. A. (2020) · Antioxidants · doi:10.3390/antiox9080659 · Cited by 126

Mechanisms and functions of Nrf2 signaling in Drosophila

Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 129

Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart Disease

Brewer, A. C., Mustafi, S. B., Murray, T. V., Rajasekaran, N. S., & Benjamin, I. J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4914 · Cited by 121

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

Telorack, M., Meyer, M., Ingold, I., Conrad, M., Bloch, W., & Werner, S. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005800 · Cited by 116

Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2

Bahn, G., & Jo, D. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-018-08523-5 · Cited by 118

Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

Baldelli, S., Aquilano, K., & Ciriolo, M. R. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.04.006 · Cited by 120

4-hydroxynonenal-mediated signaling and aging

Zhang, H., & Forman, H. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.032 · Cited by 114

Proteasome dysfunction inDrosophilasignals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging

Tsakiri, E. N., Sykiotis, G. P., Papassideri, I. S., Terpos, E., Dimopoulos, M. A., Gorgoulis, V. G., Bohmann, D., & Trougakos, I. P. (2013) · Aging Cell · doi:10.1111/acel.12111 · Cited by 113

Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells

Moorefield, E., Andres, S. F., Blue, R. E., Landeghem, L. V., Mah, A. T., Santoro, M. A., & Ding, S. (2017) · Aging · doi:10.18632/aging.101279 · Cited by 112

Genetic Mechanisms of Coffee Extract Protection in aCaenorhabditis elegansModel of β-Amyloid Peptide Toxicity

Dostal, V., Roberts, C. M., & Link, C. D. (2010) · Genetics · doi:10.1534/genetics.110.120436 · Cited by 115

WDR23 regulates NRF2 independently of KEAP1

Lo, J. Y., Spatola, B. N., & Curran, S. P. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006762 · Cited by 116

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes

Keum, Y. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.144 · Cited by 114

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Bruns, D. R., Drake, J. C., Biela, L. M., Peelor, F. F., Miller, B. F., & Hamilton, K. L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/732596 · Cited by 113

MicroRNA Networks Modulate Oxidative Stress in Cancer

Lin, Y.-H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184497 · Cited by 117

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

Rotblat, B., Southwell, A. L., Ehrnhoefer, D. E., Skotte, N. H., Metzler, M., Franciosi, S., Leprivier, G., Somasekharan, S. P., Barokas, A., Deng, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314421111 · Cited by 111

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J.-H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J. B., Matsui, W. H., MacVittie, T. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70812 · Cited by 114

Nrf2 promotes survival following exposure to ionizing radiation

Sekhar, K. R., & Freeman, M. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.035 · Cited by 109

Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress

Alonso-Piñero, J. A., González-Rovira, A., Sánchez-Gomar, I., Moreno, J. A., & Durán-Ruiz, M. C. (2021) · Antioxidants · doi:10.3390/antiox10091463 · Cited by 120

The KEAP1-NRF2 System and Neurodegenerative Diseases

Uruno, A., & Yamamoto, M. P. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0234 · Cited by 113

Integrating the DNA damage and protein stress responses during cancer development and treatment

Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108

Astroglia as a cellular target for neuroprotection and treatment of neuro‐psychiatric disorders

Liu, B., Teschemacher, A. G., & Kasparov, S. (2017) · Glia · doi:10.1002/glia.23136 · Cited by 111

Lactate and lactylation in cardiovascular diseases: current progress and future perspectives

Zhu, W., Guo, S., Sun, J., Zhao, Y., & Liu, C. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155957 · Cited by 111

Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)

Hahn, M. E., Timme‐Laragy, A. R., Karchner, S. I., & Stegeman, J. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.022 · Cited by 106

Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Kobayashi, A., Tsukide, T., Miyasaka, T., Morita, T., Mizoroki, T., Saito, Y., Ihara, Y., Takashima, A., Noguchi, N., Fukamizu, A., et al. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2011.01522.x · Cited by 106

Insecticides induce the co-expression of glutathione S-transferases through ROS/CncC pathway in Spodoptera exigua

Hu, B. H., Hu, S., Huang, H., Wei, Q., Ren, M., Huang, S., Tian, X., & Su, J. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.01.008 · Cited by 107

Ferroptosis regulation by the NGLY1/NFE2L1 pathway

Forcina, G. C., Pope, L. E., Murray, M. B., Dong, W., Abu-Remaileh, M., Bertozzi, C. R., & Dixon, S. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118646119 · Cited by 103

New Player on An Old Field; the Keap1/Nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome

Chartoumpekis, D. V., & Kensler, T. W. (2013) · Current Diabetes Reviews · doi:10.2174/1573399811309020005 · Cited by 105

Glycosylation of KEAP1 links nutrient sensing to redox stress signaling

Chen, P., Smith, T. J., Wu, J., Siesser, P. F., Bisnett, B. J., Khan, F., Hogue, M., Soderblom, E. J., Tang, F., Marks, J. R., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201696113 · Cited by 105

NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors

Chevillard, G., & Blank, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0747-x · Cited by 105

NF-E2-Related Factor 1 (Nrf1) Serves as a Novel Regulator of Hepatic Lipid Metabolism through Regulation of the Lipin1 and PGC-1 β Genes

Hirotsu, Y., Hataya, N., Katsuoka, F., & Yamamoto, M. P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06706-11 · Cited by 102

Dual Regulation of the Transcriptional Activity of Nrf1 by β-TrCP- and Hrd1-Dependent Degradation Mechanisms

Tsuchiya, Y., Morita, T., Kim, M., Iemura, S.-I., Natsume, T., Yamamoto, M. P., & Kobayashi, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05663-11 · Cited by 102

Proteostasis and longevity: when does aging really begin?

Labbadia, J., & Morimoto, R. I. (2014) · F1000Prime Reports · doi:10.12703/p6-07 · Cited by 100

The transcription factor Maf-S regulates metabolic resistance to insecticides in the malaria vector Anopheles gambiae

Ingham, V. A., Pignatelli, P. M., Moore, J. D., Wagstaff, S. C., & Ranson, H. (2017) · BMC Genomics · doi:10.1186/s12864-017-4086-7 · Cited by 101

CncC/Maf‐mediated xenobiotic response pathway in insects

Palli, S. R. (2020) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21674 · Cited by 101

Declining signal dependence of Nrf2‐ Maf S ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

SKN-1/Nrf2 Inhibits Dopamine Neuron Degeneration in a Caenorhabditis elegans Model of Methylmercury Toxicity

VanDuyn, N., Settivari, R. S., Wong, G., & Nass, R. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq285 · Cited by 100

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

Kuwahara, M., Ise, W., Ochi, M., Suzuki, J., Kometani, K., Maruyama, S., Izumoto, M., Matsumoto, A., Takemori, N., Takemori, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms12596 · Cited by 100

Metformin Protects against LPS-Induced Intestinal Barrier Dysfunction by Activating AMPK Pathway

Wu, W.-C., Wang, S., Liu, Q., Shan, T., & Wang, Y. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00332 · Cited by 104

The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., et al. (2014) · Nature Communications · doi:10.1038/ncomms4555 · Cited by 98

Cap n collar transcription factor regulates multiple genes coding for proteins involved in insecticide detoxification in the red flour beetle, Tribolium castaneum

Kalsi, M., & Palli, S. R. (2017) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2017.09.009 · Cited by 97

A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses inCaenorhabditis elegans

Dodd, W., Tang, L., Lone, J., Wimberly, K., Wu, C., Consalvo, C. D., Wright, J. E., Pujol, N., & Choe, K. P. (2018) · Genetics · doi:10.1534/genetics.118.300827 · Cited by 97

Gut microbiota and mTOR signaling: Insight on a new pathophysiological interaction

Noureldein, M. H., & Eid, A. A. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.03.021 · Cited by 99

Targeting Signalling Pathways in Chronic Wound Healing

Bonnici, L., Suleiman, S., Schembri-Wismayer, P., & Cassar, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010050 · Cited by 97

A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative-stress adaptation in mammals, C. elegans and D. melanogaster

Pickering, A. M., Staab, T. A., Tower, J., Sieburth, D., & Davies, K. J. A. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.074757 · Cited by 96

Hyperandrogenism and insulin resistance‐induced fetal loss: evidence for placental mitochondrial abnormalities and elevated reactive oxygen species production in pregnant rats that mimic the clinical features of polycystic ovary syndrome

Zhang, Y., Zhao, W., Xu, H., Hu, M., Guo, X., Jia, W., Liu, G., Li, J., Cui, P., Lager, S., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277879 · Cited by 96

A Bibliometric Review of the Keap1/Nrf2 Pathway and its Related Antioxidant Compounds

Paunkov, A., Chartoumpekis, D. V., Ziros, P. G., & Sykiotis, G. P. (2019) · Antioxidants · doi:10.3390/antiox8090353 · Cited by 94

Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress

Tsakiri, E. N., Sykiotis, G. P., Papassideri, I. S., Gorgoulis, V. G., Bohmann, D., & Trougakos, I. P. (2013) · The FASEB Journal · doi:10.1096/fj.12-221408 · Cited by 94

Nuclear factor‐erythroid 2‐related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice

Lee, C. S., Ho, D. V., & Chan, J. Y. (2013) · FEBS Journal · doi:10.1111/febs.12350 · Cited by 94

Developmental Toxicity Assays Using the Drosophila Model

Rand, M. D., Montgomery, S. L., Prince, L. M., & Vorojeikina, D. P. (2014) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx0112s59 · Cited by 93

Cap 'n' collar C regulates genes responsible for imidacloprid resistance in the Colorado potato beetle, Leptinotarsa decemlineata

Chandra, G. S., Kalsi, M., Roy, A., & Palli, S. R. (2018) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2018.05.006 · Cited by 93

m TORC 2‐ SGK ‐1 acts in two environmentally responsive pathways with opposing effects on longevity

Mizunuma, M., Neumann‐Haefelin, E., Moroz, N., Li, Y., & Blackwell, T. K. (2014) · Aging Cell · doi:10.1111/acel.12248 · Cited by 92

JNK signaling in Drosophila immunity and homeostasis

Tafesh‐Edwards, G., & Eleftherianos, I. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.06.017 · Cited by 92

Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans

Lynn, D. A., Dalton, H. M., Sowa, J. N., Wang, M. C., Soukas, A. A., & Curran, S. P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514012112 · Cited by 96

Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs

Paladino, S., Conte, A., Caggiano, R., Pierantoni, G. M., & Faraonio, R. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491465 · Cited by 92

Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer

Khurana, N., & Sikka, S. C. (2018) · Cancers · doi:10.3390/cancers10100352 · Cited by 93

A transgenic mouse model for monitoring oxidative stress

Oikawa, D., Akai, R., Tokuda, M., & Iwawaki, T. (2012) · Scientific Reports · doi:10.1038/srep00229 · Cited by 88

Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells

Wang, L., Kondo, N., Cano, M., Ebrahimi, K. B., Yoshida, T., Barnett, B. P., Biswal, S. S., & Handa, J. T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.015 · Cited by 92

Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection

Nhan, J. D., Turner, C. D., Anderson, S. M., Yen, C., Dalton, H. M., Cheesman, H. K., Ruter, D. L., Naresh, N. U., Haynes, C. M., Soukas, A. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909666116 · Cited by 89

The pleiotropic AMPK–CncC signaling pathway regulates the trade-off between detoxification and reproduction

Jiang, H., Meng, X., Zhang, N., Ge, H., Wei, J., Qian, K., Yang, Z., Park, Y., Palli, S. R., & Wang, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214038120 · Cited by 89

Injury-induced immune responses in Hydra

Wenger, Y., Buzgariu, W., Reiter, S., & Galliot, B. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.06.004 · Cited by 95

The transposable elementBari‐Jhehmediates oxidative stress response in Drosophila

Guio, L., Barrón, M. G., & González, J. (2014) · Molecular Ecology · doi:10.1111/mec.12711 · Cited by 88

Active form of vitamin D analogue mitigates neurodegenerative changes in Alzheimer’s disease in rats by targeting Keap1/Nrf2 and MAPK-38p/ERK signaling pathways

El‐Din, S. S., Rashed, L. A., Medhat, E., Aboulhoda, B. E., Badawy, A. D., ShamsEldeen, A. M., & Abdelgwad, M. (2020) · Steroids · doi:10.1016/j.steroids.2020.108586 · Cited by 87

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf

Ogawa, T., Kodera, Y., Hirata, D., Blackwell, T. K., & Mizunuma, M. (2016) · Scientific Reports · doi:10.1038/srep21611 · Cited by 88

Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

Pant, T., Uche, N., Juric, M., Zielonka, J., & Bai, X. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103077 · Cited by 91

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis

Köhler, U. A., Kurinna, S. M., Schwitter, D., Marti, A. T., Schäfer, M., Hellerbrand, C., Speicher, T., & Werner, S. (2013) · Hepatology · doi:10.1002/hep.26964 · Cited by 85

Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation

Chowdhury, A. M. M. A., Katoh, H., Hatanaka, A., Iwanari, H., Nakamura, N., Hamakubo, T., Natsume, T., Waku, T., & Kobayashi, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12675-y · Cited by 84

The “Goldilocks Zone” from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle

Alleman, R. J., Katunga, L. A., Nelson, M. A. M., Brown, D. A., & Anderson, E. J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00358 · Cited by 89

Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate

Mulvaney, K. M., Matson, J. P., Siesser, P. F., Tamir, T. Y., Goldfarb, D., Jacobs, T. M., Cloer, E. W., Harrison, J. S., Vaziri, C., Cook, J. G., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.729418 · Cited by 82

Molecular Insights into Parkinson's Disease

Rochet, J., Hay, B. A., & Guo, M. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00011-4 · Cited by 87

Extending healthy ageing: nutrient sensitive pathway and centenarian population

Davinelli, S., Willcox, D. C., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-9 · Cited by 85

High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Müller retinal cells in vitro

Albert-Garay, J. S., Riesgo‐Escovar, J. R., & Salceda, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-05284-x · Cited by 82

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes

Kurinna, S. M., Schäfer, M., Ostano, P., Karouzakis, E., Chiorino, G., Bloch, W., Bachmann, A., Gay, S., Garrod, D. R., Lefort, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms6099 · Cited by 82

Hyperandrogenism and insulin resistance induce gravid uterine defects in association with mitochondrial dysfunction and aberrant reactive oxygen species production

Hu, M., Zhang, Y., Guo, X., Jia, W., Liu, G., Zhang, J., Li, J., Cui, P., Sferruzzi-Perri, A. N., Han, Y., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00359.2018 · Cited by 81

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Зенков, Н. К., Брониславовна, М. Е., & Tkachev, V. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913010033 · Cited by 82

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Ross, A. E., Marchionni, L., Vuica‐Ross, M., Cheadle, C., Fan, J., Berman, D. M., & Schaeffer, E. M. (2011) · The Prostate · doi:10.1002/pros.21373 · Cited by 83

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Richer, M. J., Lang, M. L., & Butler, N. S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600847 · Cited by 77

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Kim, M., & Jeon, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052846 · Cited by 81

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Fetoni, A. R., Zorzi, V., Paciello, F., Ziraldo, G., Peres, C., Raspa, M., Scavizzi, F., Salvatore, A. M., Crispino, G., Tognola, G., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.08.002 · Cited by 82

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Nászai, M., Carroll, L. R., & Cordero, J. B. (2015) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2015.05.016 · Cited by 78

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Lacher, S. E., Lee, J. S., Wang, X., Campbell, M. R., Bell, D. A., & Slattery, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.044 · Cited by 77

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Hiebert, P., & Werner, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163856 · Cited by 84

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Lashmanova, E., Proshkina, E., Zhikrivetskaya, S. O., Шевченко, О. Г., Marusich, E., Leonov, S. V., Melerzanov, A., Zhavoronkov, A. A., & Moskalev, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.08.009 · Cited by 79

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Tsakiri, E. N., & Trougakos, I. P. (2014) · International review of cytology · doi:10.1016/bs.ircmb.2014.09.002 · Cited by 81

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Cheng, Y., Pitoniak, A., Wang, J., & Bohmann, D. (2021) · Aging Cell · doi:10.1111/acel.13297 · Cited by 16

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Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 129

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622

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Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

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Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 40