Stress-activated cap’n’collar transcription factors in aging and human disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma

Köhler, U. A., Böhm, F., Rolfs, F., Egger, M., Hornemann, T., Pasparakis, M., Weber, A., & Werner, S. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.033 · Cited by 50

The redox-sensing gene Nrf2 affects intestinal homeostasis, insecticide resistance, and Zika virus susceptibility in the mosquito Aedes aegypti

Bottino-Rojas, V., Talyuli, O. A. C., Carrara, L., Martins, A. J., James, A. A., de Oliveira, P. L., & Paiva‐Silva, G. O. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001589 · Cited by 46

Irisin lowers blood pressure by activating the Nrf2 signaling pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Huo, C.-J., Yu, X., Sun, Y., Li, H., Su, Q., Bai, J., Li, Y., Liu, K., Qi, J., Zhou, S., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114953 · Cited by 52

Inflammation and oxidative stress induced by lipid peroxidation metabolite 4-hydroxynonenal in human corneal epithelial cells

Liu, H., Gambino, F., Algenio, C. S., Wu, C. G., Gao, Y., Bouchard, C. S., Qiao, L., Bu, P., & Zhao, S. (2020) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-020-04647-2 · Cited by 49

NGLY1 Deficiency, a Congenital Disorder of Deglycosylation: From Disease Gene Function to Pathophysiology

Pandey, A., Adams, J., Han, S. Y., & Jafar‐Nejad, H. (2022) · Cells · doi:10.3390/cells11071155 · Cited by 46

The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity

Zhang, Y., & Hayes, J. D. (2013) · Scientific Reports · doi:10.1038/srep02006 · Cited by 45

Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption

Bayele, H. K., Balesaria, S., & Srai, S. K. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.11.001 · Cited by 47

TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells

Ren, Y., Qiu, L., Lu, F.-L., Ru, X., Li, S., Xiang, Y., Yu, S., & Zhang, Y. (2016) · Scientific Reports · doi:10.1038/srep23775 · Cited by 45

The Role of Cyclo(His-Pro) in Neurodegeneration

Grottelli, S., Ferrari, I., Pietrini, G., Peirce, M. J., Minelli, A., & Bellezza, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081332 · Cited by 47

Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice

Liu, Z., Han, K., Huo, X., Yan, B., Gao, M., Lv, X., Yu, P., Gao, G., & Chang, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117838 · Cited by 45

Transcriptional regulation and overexpression of GST cluster enhances pesticide resistance in the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae)

Jin, M., Peng, Y., Peng, J., Zhang, H., Shan, Y., Liu, K., & Xiao, Y. (2023) · Communications Biology · doi:10.1038/s42003-023-05447-0 · Cited by 46

The Nrf2‐inducible antioxidant defense in astrocytes can be both up‐ and down‐regulated by activated microglia:Involvement of p38 MAPK

Correa, F., Ljunggren, E., Mallard, C. E., Nilsson, M., Weber, S. G., & Sandberg, M. (2011) · Glia · doi:10.1002/glia.21151 · Cited by 46

Bisphenol A Increases BeWo Trophoblast Survival in Stress-Induced Paradigms through Regulation of Oxidative Stress and Apoptosis

Ponniah, M., Billett, E. E., & Girolamo, L. A. D. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00093 · Cited by 49

Nrf2 in aging – Focus on the cardiovascular system

Klóska, D., Kopacz, A., Piechota-Polańczyk, A., Nowak, W. N., Dulak, J., Józkowicz, A., & Grochot‐Przeczek, A. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.08.009 · Cited by 47

Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2

McMahon, M. J., Swift, S., & Hayes, J. D. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.033 · Cited by 46

Natural Allies for Heart Health: Nrf2 Activation and Cardiovascular Disease Management

Khan, S. U., Khan, S. U., Suleman, M., Khan, S. U., Suleman, M., Arbi, F. M., Hussain, T., Alsuhaibani, A. M., & Refat, M. S. E.-D. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102084 · Cited by 47

Persistent organic pollutants (POPs) in marine crustaceans: Bioaccumulation, physiological and cellular responses

Camacho‐Jiménez, L., González-Ruiz, R., & Yepiz-Plascencia, G. M. (2023) · Marine Environmental Research · doi:10.1016/j.marenvres.2023.106184 · Cited by 45

Mechanisms of Toxicity of Hydroxylated Polybrominated Diphenyl Ethers (HO-PBDEs) Determined by Toxicogenomic Analysis with a Live Cell Array Coupled with Mutagenesis in Escherichia coli

Su, G., Yu, H., Lam, M. H., Giesy, J. P., & Zhang, X. (2014) · Environmental Science & Technology · doi:10.1021/es5003023 · Cited by 45

Nrf2 as a master regulator of tissue damage control and disease tolerance to infection

Soares, M. P., & Ribeiro, A. M. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150054 · Cited by 46

TCF11/Nrf1-Mediated Induction of Proteasome Expression Prevents Cytotoxicity by Rotenone

Sotzny, F., Schormann, E., Kühlewindt, I., Koch, A., Brehm, A., Goldbach‐Mansky, R. T., Gilling, K. E., & Krüger, E. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6539 · Cited by 46

NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury

Khodo, S. N., Dissard, R., Hasler, U., Schäfer, M., Pircher, H., Jansen‐Dürr, P., Krause, K., Martin, P., & de Seigneux, S. (2016) · Scientific Reports · doi:10.1038/srep38598 · Cited by 45

Systems Approach Reveals Nuclear Factor Erythroid 2-Related Factor 2/Protein Kinase R Crosstalk in Human Cutaneous Leishmaniasis

Vivarini, Á. D. C., Calegari-Silva, T., Saliba, A. M., Boaventura, V. S., França‐Costa, J., Khouri, R., Dierckx, T., Teixeira, K. L. D., Fasel, N. J., Barral, A. M. P., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01127 · Cited by 44

The molecular biology and therapeutic potential of Nrf2 in leukemia

Khodakarami, A., Adibfar, S., Karpisheh, V., Abolhasani, S., Jalali, P., Mohammadi, H., Navashenaq, J. G., Hojjat‐Farsangi, M., & Jadidi‐Niaragh, F. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02660-5 · Cited by 46

Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells

Zhang, T., Hu, Q., Shi, L., Li, Q., Zhang, Q., & Mi, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167020 · Cited by 44

ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond

Hamazaki, J., & Murata, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103683 · Cited by 44

Mechanisms of sensing and response to proteotoxic stress

Santiago, A., Gonçalves, D. L., & Morano, K. A. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112240 · Cited by 43

Neuronal responses to stress and injury in C. elegans

Kim, K. W., & Jin, Y. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.005 · Cited by 43

Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation

Martemucci, G., Portincasa, P., Centonze, V., Mariano, M., Khalil, M., & D‘Alessandro, A. G. (2022) · Medicinal Chemistry · doi:10.2174/1573406419666221130162512 · Cited by 48

Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes

Li, X., Chatterjee, N., Spirohn, K., Boutros, M., & Bohmann, D. (2016) · Scientific Reports · doi:10.1038/srep21455 · Cited by 44

Rapamycin and the inhibition of the secretory phenotype

Wang, R., Sunchu, B., & Pérez, V. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.026 · Cited by 42

miR‐128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells

Caggiano, R., Cattaneo, F., Moltedo, O., Esposito, G., Perrino, C., Trimarco, B., Ammendola, R., & Faraonio, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9308310 · Cited by 43

Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention

Eggler, A. L., & Savinov, S. N. (2013) · Springer eBooks · doi:10.1007/978-3-319-00581-2_7 · Cited by 42

Proteome Stability as a Key Factor of Genome Integrity

Gumeni, S., Evangelakou, Z., Gorgoulis, V. G., & Trougakos, I. P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102036 · Cited by 44

Phytochemical Combination PB125 Activates the Nrf2 Pathway and Induces Cellular Protection against Oxidative Injury

Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2019) · Antioxidants · doi:10.3390/antiox8050119 · Cited by 42

The dietary triterpenoid 18α–Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway

Lefaki, M., Papaevgeniou, N., Tur, J. A., Vorgias, C. E., Sykiotis, G. P., & Chondrogianni, N. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101317 · Cited by 41

Quantitative Proteomics Identifies Reduced NRF2 Activity and Mitochondrial Dysfunction in Atopic Dermatitis

Koch, M., Kockmann, T., Rodríguez, E., Wehkamp, U., Hiebert, P., Greenwald, M. B., Stölzl, D., Beer, H., Tschachler, E., Weidinger, S., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.08.048 · Cited by 45

Regulation of Synaptic nlg-1/Neuroligin Abundance by the skn-1/Nrf Stress Response Pathway Protects against Oxidative Stress

Staab, T. A., Egrafov, O., Knowles, J. A., & Sieburth, D. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004100 · Cited by 44

Pinewood nematode-associated bacteria contribute to oxidative stress resistance of Bursaphelenchus xylophilus

Vicente, C. S. L., Ikuyo, Y., Mota, M. M., & Hasegawa, K. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-299 · Cited by 41

Keap1 inhibition attenuates glomerulosclerosis

Miyazaki, Y., Shimizu, A., Pastan, I. H., Taguchi, K., Naganuma, E., Suzuki, T., Hosoya, T., Yokoo, T., Saito, A., Miyata, T., et al. (2014) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfu002 · Cited by 41

The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice

Higashi, C., Kawaji, A., Tsuda, N., Hayashi, M., Saito, R., Yagishita, Y., Suzuki, T., Uruno, A., Nakamura, M., Nakao, K., et al. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.044 · Cited by 44

Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc

Brock, A. R., Seto, M., & Smith-Bolton, R. K. (2017) · Genetics · doi:10.1534/genetics.116.196832 · Cited by 41

Nuclear Factor Erythroid-2-Related Factor 2 Signaling in the Neuropathophysiology of Inherited Metabolic Disorders

Seminotti, B., Grings, M., Tucci, P., Leipnitz, G., & Saso, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.785057 · Cited by 45

Role of NRF2 in Pathogenesis of Alzheimer’s Disease

Chu, C., Uruno, A., Katsuoka, F., & Yamamoto, M. (2024) · Antioxidants · doi:10.3390/antiox13121529 · Cited by 43

Transcriptional regulation of the 26S proteasome by Nrf1

Koizumi, S., Hamazaki, J., & Murata, S. (2018) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.94.021 · Cited by 43

Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach

Evangelakou, Z., Manola, M. S., Gumeni, S., & Trougakos, I. P. (2019) · Genes & Nutrition · doi:10.1186/s12263-019-0638-6 · Cited by 40

Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors

Kobayashi, A. (2020) · Cancers · doi:10.3390/cancers12092681 · Cited by 41

Honey bee sHSP are responsive to diverse proteostatic stresses and potentially promising biomarkers of honey bee stress

Shih, S. R., Bach, D. M., Rondeau, N. C., Sam, J., Lovinger, N. L., Lopatkin, A. J., & Snow, J. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-01547-1 · Cited by 39

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Gounder, S. S., Kannan, S., Devadoss, D., Miller, C. J., Whitehead, K. J., Odelberg, S. J., Firpo, M. A., Paine, R., Hoidal, J. R., Abel, E. D., et al. (2012) · PLoS ONE · doi:10.1371/annotation/8690bb36-3c5d-48a6-b3be-39a2b50896e1 · Cited by 40

The Nrf1 CNC-bZIP Protein Is Regulated by the Proteasome and Activated by Hypoxia

Chepelev, N. L., Bennitz, J. D., Huang, T., McBride, S., & Willmore, W. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029167 · Cited by 40

A novel role of topical iodine in skin: Activation of the Nrf2 pathway

Greenwald, M. B., Frušić‐Zlotkin, M., Soroka, Y., Ben‐Sasson, S. A., Bianco‐Peled, H., & Kohen, R. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.011 · Cited by 38

Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits

Xiang, Y., Wang, M., Hu, S., Qiu, L., Yang, F., Zhang, Z., Yu, S., Pi, J., & Zhang, Y. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.036 · Cited by 39

Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells

Katsuoka, F., Otsuki, A., Takahashi, M., Ito, S., & Yamamoto, M. P. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00273-19 · Cited by 39

Differential Yet Integral Contributions of Nrf1 and Nrf2 in the Human HepG2 Cells on Antioxidant Cytoprotective Response against Tert-Butylhydroquinone as a Pro-Oxidative Stressor

Wufuer, R., Fan, Z., Liu, K., & Zhang, Y. (2021) · Antioxidants · doi:10.3390/antiox10101610 · Cited by 39

Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2

Deng, H., Wan, M., Li, H., Chen, Q., Li, R., Liang, B., & Zhu, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.1994720 · Cited by 40

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L. M., Fazeli, A., Casal, L. L., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx394 · Cited by 38

Differential effects of chronic stress in young-adult and old female mice: cognitive-behavioral manifestations and neurobiological correlates

Lotan, A., Lifschytz, T., Wolf, G., Keller, S., Ben-Ari, H., Tatarskyy, P., Pillar, N., Oved, K., Sharabany, J., Merzel, T. K., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.237 · Cited by 39

Targeting Protein Quality Control Mechanisms by Natural Products to Promote Healthy Ageing

Wedel, S., Manola, M. S., Cavinato, M. S., Trougakos, I. P., & Jansen‐Dürr, P. (2018) · Molecules · doi:10.3390/molecules23051219 · Cited by 39

Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model

Han, F., Xu, L., Huang, Y., Chen, T., Zhou, T., & Yang, L. (2018) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-4850-1 · Cited by 38

ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancerPreprint

Purohit, V., Wang, L., Yang, H., Li, J., Ney, G. M., Gumkowski, E. R., Vaidya, A. J., Wang, A., Bhardwaj, A., Zhao, E., et al. (2021) · Genes & Development · doi:10.1101/gad.344184.120 · Cited by 39

Oral supplementation with cocoa extract reduces UVB-Induced wrinkles in hairless mouse skin

Kim, J.-E., Song, D., Kim, J., Choi, J., Kim, J. R., Yoon, H.-S., Bae, J.-S., Han, M., Lee, S., Hong, J. S., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.11.032 · Cited by 37

Hemostasis and Anti-Inflammatory Abilities of AuNPs-Coated Chitosan Dressing for Burn Wounds

Cherng, J., Lin, C. J., Liu, C., Yeh, J.-Z., Fan, G.-Y., Tsai, H., Chung, C.-F., & Hsu, S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12071089 · Cited by 37

Dynamic and Coordinated Regulation of KEAP1-NRF2-ARE and p53/p21 Signaling Pathways Is Associated with Acetaminophen Injury Responsive Liver Regeneration

Fan, X., Chen, P., Tan, H., Zeng, H., Jiang, Y., Wang, Y., Wang, Y., Hou, X., Bi, H., & Huang, M. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.059394 · Cited by 37

Early life exposure to di(2-ethylhexyl)phthalate causes age-related declines associated with insulin/IGF-1-like signaling pathway and SKN-1 in Caenorhabditis elegans

How, C. M., Yen, P.-L., Wei, C., Li, S.-W., & Liao, V. H. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.04.141 · Cited by 37

Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

Komatsu, T., Park, S., Hayashi, H., Mori, R., Yamaza, H., & Shimokawa, I. (2019) · Nutrients · doi:10.3390/nu11123068 · Cited by 41

Non-coding RNAs rewire cancer metabolism networks

Lin, X., Wu, Z., Hu, H., Luo, M., & Song, E. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.019 · Cited by 37

Nrf2 Is Commonly Activated in Papillary Thyroid Carcinoma, and It Controls Antioxidant Transcriptional Responses and Viability of Cancer Cells

Ziros, P. G., Manolakou, S. D., Habeos, I. G., Lilis, I., Chartoumpekis, D. V., Koika, V., Soares, P., Kyriazopoulou, V. E., Scopa, C. D., Papachristou, D. J., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1510 · Cited by 37

Sporadic activation of an oxidative stress–dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies

Pereira, E. J., Burns, J. S., Lee, C. Y., Marohl, T., Calderon, D., Wang, L., Atkins, K. A., Wang, C., & Janes, K. A. (2020) · Science Signaling · doi:10.1126/scisignal.aba4200 · Cited by 36

Silencing of Nrf2 in Litopenaeus vannamei, decreased the antioxidant capacity, and increased apoptosis and autophagy

Huang, Y., Li, Q., Yuan, Y., Zhang, Z., Jiang, B., Yang, S., & Jian, J. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.02.010 · Cited by 36

Succinylation of a KEAP1 sensor lysine promotes NRF2 activation

Ibrahim, L. H., Stanton, C. R., Nutsch, K., Nguyen, T. T. A., Li-Ma, C., Ko, Y., Lander, G. C., Wiseman, R. L., & Bollong, M. J. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.07.014 · Cited by 36

A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants

Aboulkassim, T., Tian, X., Liu, Q., Qiu, D., Hancock, M. A., Wu, J. H., & Batist, G. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113104 · Cited by 35

Action of trichostatin A on Alzheimer’s disease-like pathological changes in SH-SY5Y neuroblastoma cells

Li, L., Tian, X., Peng, W., Deng, Y., & Li, J. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.265564 · Cited by 34

The role of Nrf2 in acute and chronic muscle injury

Bronisz-Budzyńska, I., Kozakowska, M., Podkalicka, P., Kachamakova‐Trojanowska, N., Łoboda, A., & Dulak, J. (2020) · Skeletal Muscle · doi:10.1186/s13395-020-00255-0 · Cited by 33

Acute hypoxia effects on Keap1/Nrf2 (Mafs)-GST pathway related oxidative metabolism in muscle of Japanese flounder (Paralichthys olivaceus)

Liu, B., Wen, H., Li, X., Yang, J., Li, G., Zhang, M., Li, J., & He, F. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148646 · Cited by 35

RS 9, a novel Nrf2 activator, attenuates light‐induced death of cells of photoreceptor cells and Müller glia cells

Inoue, Y., Shimazawa, M., Noda, Y., Nagano, R., Otsuka, T., Kuse, Y., Nakano, Y., Tsuruma, K., Nakagami, Y., & Hara, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14029 · Cited by 35

Transcript Profiling Identifies Dynamic Gene Expression Patterns and an Important Role for Nrf2/Keap1 Pathway in the Developing Mouse Esophagus

Chen, H., Li, J., Li, H., Hu, Y., Tevebaugh, W., Yamamoto, M. P., Que, J., & Chen, X. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036504 · Cited by 34

Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans

Li, H., Su, L., Su, X., Liu, X., Wang, D., Li, H., Ba, X., Zhang, Y., Lu, J., Huang, B., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101111 · Cited by 34

An NRF2 Perspective on Stem Cells and Ageing

Dodson, M. B., Anandhan, A., Zhang, D. D., & Madhavan, L. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.690686 · Cited by 35

Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives

Łoboda, A., Rojczyk, E., Bednarczyk–Cwynar, B., Zaprutko, L., Józkowicz, A., & Dulak, J. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.6.499 · Cited by 34

Modulation of energy balance by fibroblast growth factor 21

Ramos, D. C., & Aguilar-Salinas, C. A. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0023 · Cited by 36

Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts

Jodar, L., Mercken, E. M., Ariza, J., Younts, C., Gonzalez-Reyes, J. A., Alcain, F. J., Buron, I., de Cabo, R., & Villalba, J. M. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glq181 · Cited by 33

Novel molecular mechanisms of doxorubicin cardiotoxicity: latest leading-edge advances and clinical implications

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