Stress-activated cap’n’collar transcription factors in aging and human disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling

Sant, K. E., Hadley, M., Williams, L., Jacobs, H. M., Bowsher, A. M., Boisvert, J. D., Smolowitz, R. M., Pantazis, J. C., Annunziato, K. M., Nguyen, M., et al. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000057 · Cited by 19

Recent Advances in the Role of Nuclear Factor Erythroid-2-Related Factor 2 in Spinal Cord Injury: Regulatory Mechanisms and Therapeutic Options

Jiang, T., & He, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.851257 · Cited by 19

Nuclear Factor Erythroid 2-Related Factor 2 and Its Targets in Skeletal Muscle Repair and Regeneration

Łoboda, A., & Dulak, J. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0208 · Cited by 17

Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders

Jin, W., Qazi, T. J., Quan, Z., Li, N., & Qing, H. (2018) · The Neuroscientist · doi:10.1177/1073858418811787 · Cited by 17

Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress

Egge, N., Arneaud, S. L. B., Fonseca, R. S., Zuurbier, K. R., McClendon, J., & Douglas, P. M. (2021) · Nature Communications · doi:10.1038/s41467-021-21611-8 · Cited by 19

Açaí (Euterpe Oleraceae Mart.) Seeds Regulate NF-κB and Nrf2/ARE Pathways Protecting Lung against Acute and Chronic Inflammation.

Genovese, T., D’Amico, R., Fusco, R., Impellizzeri, D., Peritore, A. F., Crupi, R., Interdonato, L., Gugliandolo, E., Cuzzocrea, S., Paola, R. D., et al. (2022) · Cellular Physiology and Biochemistry · doi:10.33594/000000529 · Cited by 18

Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway

Deng, R., Zhu, Y., Liu, K., Zhang, Q., Hu, S., Wang, M., & Zhang, Y. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107212 · Cited by 18

The Mechanisms Underlying α-Amanitin Resistance in Drosophila melanogaster: A Microarray Analysis

Mitchell, C. L., Saul, M. C., Liang, L., Wei, H., & Werner, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093489 · Cited by 18

Immunohistochemical localization of Nrf2 in the human cochlea

Hosokawa, K., Hosokawa, S., Ishiyama, G. P., Ishiyama, A., & López, I. A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.07.004 · Cited by 18

Nach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to Humans

Zhu, Y., Wang, M., Xiang, Y., Qiu, L., Hu, S., Zhang, Z., Mattjus, P., Zhu, X., & Zhang, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102927 · Cited by 18

Nrf1 Is Endowed with a Dominant Tumor-Repressing Effect onto the Wnt/ β -Catenin-Dependent and Wnt/ β -Catenin-Independent Signaling Networks in the Human Liver Cancer

Chen, J., Wang, M., Ru, X., Xiang, Y., Ren, Y., Liu, X., Qiu, L., & Zhang, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5138539 · Cited by 18

WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes

Siswanto, F. M., Oguro, A., Arase, S., & Imaoka, S. (2020) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2020.06.007 · Cited by 18

TCF11 Has a Potent Tumor-Repressing Effect Than Its Prototypic Nrf1α by Definition of Both Similar Yet Different Regulatory Profiles, With a Striking Disparity From Nrf2

Wang, M., Ren, Y., Hu, S., Liu, K., Qiu, L., & Zhang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.707032 · Cited by 18

Nrf2 activation diminishes during adipocyte differentiation of ST2 cells.

Chartoumpekis, D., Ziros, P. G., Sykiotis, G., Zaravinos, A., Psyrogiannis, A., Kyriazopoulou, V., Spandidos, D., & Habeos, I. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.761 · Cited by 17

Nrf2 silencing to inhibit proteolytic defense induced by hyperthermia in HT22 cells

Bozaykut, P., Özer, N. K., & Karademir-Yilmaz, B. (2016) · Redox Biology · doi:10.1016/j.redox.2016.03.001 · Cited by 18

Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1

Leung, C. K., Empinado, H. M., & Choe, K. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.009 · Cited by 16

Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells

Sollinger, C. A., Lillis, J. A., Malik, J. T., Getman, M. R., Pröschel, C., & Steiner, L. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-14366-0 · Cited by 17

Transcriptional reprogramming by oxidative stress occurs within a predefined chromatin accessibility landscape

Levings, D. C., Lacher, S. E., Palacios‐Moreno, J. M., & Slattery, M. G. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.016 · Cited by 20

Age-Dependent Changes in Nrf2/Keap1 and Target Antioxidant Protein Expression Correlate to Lipoxidative Adducts, and Are Modulated by Dietary N-3 LCPUFA in the Hippocampus of Mice

Díaz, M. L., Valdés‐Baizabal, C., Pereda, D., & Marín, R. (2024) · Antioxidants · doi:10.3390/antiox13020206 · Cited by 17

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events

Tsakiri, E. N., Terpos, E., Papanagnou, E., Kastritis, E., Brieudes, V., Halabalaki, M., Bagratuni, T., Florea, B. I., Overkleeft, H. S., Scorrano, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17596-4 · Cited by 17

Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources—The MediHealth Project

Waltenberger, B., Halabalaki, M., Schwaiger, S., Adamopoulos, N., Allouche, N., Fiebich, B. L., Hermans, N., Jansen‐Dürr, P., Kesternich, V., Pieters, L. A. C., et al. (2018) · Molecules · doi:10.3390/molecules23051097 · Cited by 17

MicroRNAs in pemphigus and pemphigoid diseases

Papara, C., Zillikens, D., Sadik, C. D., & Baican, A. L. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102852 · Cited by 17

La voie Nrf2 en pathologie respiratoire

Boutten, A., Goven, D., Artaud-Macari, É., & Bonay, M. (2011) · médecine/sciences · doi:10.1051/medsci/20112711012 · Cited by 17

Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis

Hiebert, P., Martyts, A., Schwestermann, J., Janke, K., Hafner, J., Boukamp, P., Mazza, E., & Werner, S. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.09.002 · Cited by 18

A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons

Turner, C. D., Stuhr, N. L., Ramos, C. M., Camp, B. T. V., & Curran, S. P. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2308565120 · Cited by 13

Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis

Chang, L., Fan, C., Tseng, W., & Hua, C. (2019) · Cancer Biomarkers · doi:10.3233/cbm-190828 · Cited by 17

Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and Diseases

Carlson, J., Price, L., & Deng, H. (2020) · Progress in inflammation research · doi:10.1007/978-3-030-44599-7_3 · Cited by 17

Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis

Lee, E. C., Kim, H., Ditano, J. P., Manion, D., King, B. L., & Strange, K. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154156 · Cited by 16

Cardiac Aging – Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling

Narasimhan, M., & Rajasekaran, N. S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4307-9_13 · Cited by 17

Is the CncC/Keap1 complex a major factor in conferring pesticide resistance in arthropods? - A critical review

Amezian, D., & Leeuwen, T. V. (2025) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2025.104400 · Cited by 15

Itaconic acid facilitates inflammation abatement and alleviates liver ischemia-reperfusion injury by inhibiting NF-κB/NLRP3/caspase-1 inflammasome axis

Ma, E., Xing, H., Pei, J., Zhang, Q., Li, R., Shen, C., Tao, Y., Li, J., Ma, Z., Zhao, J., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3388 · Cited by 14

Targeting NRF2 to promote epithelial repair

Hiebert, P., & Werner, S. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220228 · Cited by 16

Oxidative status interactome map: towards novel approaches in experiment planning, data analysis, diagnostics and therapy

Zolotukhin, P. V., Kozlova, Y., Dovzhik, A. D., Коваленко, К. А., Kutsyn, K., Александрова, А. А., & Shkurat, T. P. (2013) · Molecular BioSystems · doi:10.1039/c3mb70096h · Cited by 15

Spotlite: Web Application and Augmented Algorithms for Predicting Co-Complexed Proteins from Affinity Purification – Mass Spectrometry Data

Goldfarb, D., Hast, B. E., Wang, W. W., & Major, M. B. (2014) · Journal of Proteome Research · doi:10.1021/pr5008416 · Cited by 15

Molecular responses to therapeutic proteasome inhibitors in multiple myeloma patients are donor-, cell type- and drug-dependent

Papanagnou, E., Terpos, E., Kastritis, E., Papassideri, I. S., Tsitsilonis, O., Dimopoulos, M. A., & Trougakos, I. P. (2018) · Oncotarget · doi:10.18632/oncotarget.24882 · Cited by 15

The effects of aging on host resistance and disease tolerance to SARS‐CoV‐2 infection

Mok, D. Z. L., Chan, C. Y. Y., Ooi, E. E., & Chan, K. R. (2020) · FEBS Journal · doi:10.1111/febs.15613 · Cited by 15

Tracing the NGLY1 footprints: insights from Drosophila

Pandey, A., & Jafar‐Nejad, H. (2021) · The Journal of Biochemistry · doi:10.1093/jb/mvab084 · Cited by 15

A General Signal Pathway to Regulate Multiple Detoxification Genes Drives the Evolution of Helicoverpa armigera Adaptation to Xenobiotics

Zhang, L., Lv, S., Li, M., Gu, M., & Gao, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416126 · Cited by 14

α-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors

Conde, M. A., Alza, N. P., Funk, M. I., Maniscalchi, A., Juncos, O. N. B., Bergé, I., Uranga, R. M., & Salvador, G. A. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/5803323 · Cited by 14

Mapping stress-responsive signaling pathways induced by mitochondrial proteostasis perturbations

Madrazo, N., Khattar, Z., Powers, E. T., Rosarda, J. D., & Wiseman, R. L. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e24-01-0041 · Cited by 14

Emerging perspectives of copper-mediated transcriptional regulation in mammalian cell development

Fitisemanu, F. M., & Padilla‐Benavides, T. (2024) · Metallomics · doi:10.1093/mtomcs/mfae046 · Cited by 14

Oxidative Stress in the Aging Process: Fundamental Aspects and New Insights

del Valle, L. G., Hernández, R. G., Roche, L. D., & Fernández, O. (2015) · ACS symposium series · doi:10.1021/bk-2015-1200.ch006 · Cited by 15

Nuclear factor E2-related factor 2 knockdown enhances glucose uptake and alters glucose metabolism in AML12 hepatocytes

Yuan, X., Huang, H., Huang, Y., Wang, J., Yan, J., Ding, L., Zhang, C., & Zhang, L. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217694435 · Cited by 14

The regulation of animal behavior by cellular stress responses

Özbey, N. P., Thompson, M. A., & Taylor, R. C. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112720 · Cited by 19

The Putative bZIP Transcripton Factor BzpN Slows Proliferation and Functions in the Regulation of Cell Density by Autocrine Signals in Dictyostelium

Phillips, J. E., Huang, E., Shaulsky, G., & Gomer, R. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021765 · Cited by 14

Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum

Hu, S., Xiang, Y., Qiu, L., Wang, M., & Zhang, Y. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119299 · Cited by 14

Review of Nrf2-regulated genes induced in response to antioxidants

Atia, A., & Abdullah, A. (2014) · International Journal of Medical Research & Health Sciences · doi:10.5958/j.2319-5886.3.2.087 · Cited by 13

Prolonged exposure to the synthetic glucocorticoid dexamethasone induces brain damage via oxidative stress and apoptotic response in adult Danio rerio

Sánchez-Aceves, L. M., Pérez-Alvárez, I., Onofre-Camarena, D. B., Gutiérrez-Noya, V. M., Rosales-Pérez, K. E., Orozco-Hernández, J. M., Hernández‐Navarro, M. D., Islas‐Flores, H., & Gómez‐Oliván, L. M. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.143012 · Cited by 13

An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver

Kuklin, A., Slabber, C. F., Tortola, L., Kwan, C. L., Liebisch, G., Kondylis, V., Mair, F., Köpf, M., Weber, A., & Werner, S. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101480 · Cited by 13

Small‐Molecule Stimulators of NRF1 Transcriptional Activity

Iaconelli, J., Ibrahim, L. H., Chen, E., Hull, M. V., Schultz, P. G., & Bollong, M. J. (2019) · ChemBioChem · doi:10.1002/cbic.201900487 · Cited by 13

Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome

Muzumdar, S., Koch, M., Hiebert, H., Bapst, A. M., Gravina, A., Bloch, W., Beer, H., Werner, S., & Schäfer, M. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.042648 · Cited by 14

Oxidized forms of dietary antioxidants: Friends or foes?

Poljšak, B., & Milisav, I. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.07.011 · Cited by 13

Hyperoside extends lifespan in Caenorhabditis elegans through SEK-1/PMK-1/SKN-1 pathway

Yu, X., Shi, L., Huang, Q., Li, B., Li, Y., Ou, L., Luo, H., & Wu, G.-S. (2025) · Biogerontology · doi:10.1007/s10522-025-10322-y · Cited by 13

Transcription factors, cap ‘n’ collar isoform C regulates the expression of CYP450 genes involving in insecticides susceptibility in Locusta migratoria

Liu, J., Wu, H., Zhang, Y., Zhang, J., Ma, E., & Zhang, X. (2023) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2023.105627 · Cited by 12

Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation

Ramos, C. M., & Curran, S. P. (2023) · GeroScience · doi:10.1007/s11357-023-00937-9 · Cited by 12

Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

Han, L., Wang, Z., Wang, D., Gao, Z., Hu, S., Shi, D., & Shu, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1305433 · Cited by 14

Deciphering Acetaminophen-Induced Hepatotoxicity: The Crucial Role of Transcription Factors like Nuclear Factor Erythroid 2–Related Factor 2 as Genetic Determinants of Susceptibility to Drug-Induced Liver Injury

Laddha, A. P., Wu, H., & Manautou, J. E. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.124.001282 · Cited by 12

The role of SLC7A11 in diabetic wound healing: novel insights and new therapeutic strategies

Zhang, W., Feng, J., Ni, Y., Li, G., Wang, Y., Cao, Y., Zhou, M., & Zhao, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1467531 · Cited by 16

Importance of genetic background of oxysterol signaling in cancer

Holý, P., Kloudova, A., & Souček, P. (2018) · Biochimie · doi:10.1016/j.biochi.2018.04.023 · Cited by 12

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in autophagy-induced hepatocellular carcinoma

Zhou, J., Zhang, X., Tang, H., Yu, J., Zu, X., Xie, Z., Yang, X., Hu, J., Tan, F., Li, Q., et al. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.02.028 · Cited by 12

Kunling Wan improves oocyte quality by regulating the PKC/Keap1/Nrf2 pathway to inhibit oxidative damage caused by repeated controlled ovarian hyperstimulation

Guan, F., Zhang, S., Fan, L., Sun, Y., Ma, Y., Cao, C., Zhang, Y., He, M., & Du, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115777 · Cited by 12

Para-hormesis: An innovative mechanism for the health protection brought by antioxidants in wine

Forman, H. J., & Ursini, F. (2014) · Nutrition and Aging · doi:10.3233/nua-130033 · Cited by 12

Exposure of keratinocytes to non-thermal dielectric barrier discharge plasma increases the level of 8-oxoguanine via inhibition of its repair enzyme

Kim, K. C., Kumara, M. H. S. R., Kang, K. A., Piao, M. J., Oh, M. C., Ryu, Y. S., Jo, J. O., Mok, Y. S., Shin, J. H., Park, Y., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7454 · Cited by 12

CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish

Mills, M. G., Ramsden, R., Ma, E. Y., Corrales, J., Kristofco, L. A., Steele, W. B., Saari, G. N., Melnikov, F., Kostal, J., Kavanagh, T. J., et al. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00346 · Cited by 12

Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain

Vasconcelos, A. R., Paixão, A. G., Kinoshita, P. F., Orellana, A. M., Scavone, C., & Kawamoto, E. M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.022 · Cited by 13

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2

Kainoh, K., Takano, R., Sekiya, M., Saito, K., Sugasawa, T., Ma, Y., Murayama, Y., Sugano, Y., Osaki, Y., IWASAKI, H. O., et al. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.05.069 · Cited by 12

Host cell factor 1 inhibits SKN‐1 to modulate oxidative stress responses in Caenorhabditis elegans

Rizki, G., Picard, C. L., Pereyra, C., & Lee, S. S. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00831.x · Cited by 12

Sexual dimorphism in Caenorhabditis elegans stress resistance

Piloto, J., Rodriguez, M. J., & Choe, K. P. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272452 · Cited by 9

Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin

Carlson, J., Price, L., Cook, I., & Deng, H. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.10.003 · Cited by 11

An antioxidant response element regulates the HIF1α axis in breast cancer cells

Lacher, S. E., Skon-Hegg, C., Ruis, B. L., Krznarich, J., & Slattery, M. G. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.05.003 · Cited by 12

Nrf2 protein in melanoma progression, as a new means of treatment

Feng, Q., Xu, X., & Zhang, S. (2023) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13137 · Cited by 12

Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion

Shi, C., Chen, L., Pi, H., Cui, H., Fan, C., Tan, F., Qu, X., Sun, R., Zhao, F., Song, Y., et al. (2023) · Oncogenesis · doi:10.1038/s41389-023-00500-3 · Cited by 14

Oxidative Stress in Diabetes

Wang, Y., Miao, X., Sun, J., & Cai, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00006-3 · Cited by 11

Establishment of Nrf2-deficient HaCaT and immortalized primary human foreskin keratinocytes and characterization of their responses to ROS-induced cytotoxicity

Choi, M., Park, M., Lee, S., Lee, J. W., Choi, W. J., & Lee, C.-H. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104602 · Cited by 11

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1

Kim, K., Lee, I., Kang, K. A., Piao, M. J., Ryu, M., Kim, J. H., Lee, N. H., & Hyun, J. W. (2014) · Marine Drugs · doi:10.3390/md12115357 · Cited by 11

Review of Insecticide Resistance and Its Underlying Mechanisms inTribolium castaneum

Shamjana, U., & Grace, T. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100050 · Cited by 10

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova, N., Khamdiyeva, O., Garshin, A., Baratzhanova, G., Amirgaliyeva, A., Seisenbayeva, A., Abylkassymova, G., Yergali, К., Tolebaeva, A., Skvortsova, L., et al. (2023) · Toxics · doi:10.3390/toxics11120948 · Cited by 14

The cytosolic sulfotransferase gene TcSULT1 is involved in deltamethrin tolerance and regulated by CncC in Tribolium castaneum

Xu, X., Meng, X., Zhang, N., Jiang, H., Ge, H., Qian, K., & Wang, J. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.104905 · Cited by 10

Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila

Saeedi, B. J., Hunter-Chang, S., Luo, L., Li, K., Liu, K., & Robinson, B. S. (2022) · Scientific Reports · doi:10.1038/s41598-022-21156-w · Cited by 10

Unveiling the role of bZIP transcription factors CREB and CEBP in detoxification metabolism of Nilaparvata lugens (Stål)

Jin, R., He, B., Qin, Y., Du, Z., Cao, C., & Li, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126576 · Cited by 10

Nfe2l3 promotes neuroprotection and long-distance axon regeneration after injury in vivo

Łukomska, A., Frost, M. P., Theune, W. C., Xing, J., Gupta, M., & Trakhtenberg, E. F. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114741 · Cited by 10

Analysis of mtDNA, miR-155 and BACH1 expression in hearts from donors with and without Down syndrome

Hefti, E., Quiñones‐Lombraña, A., Redzematovic, A., Hui, J., & Blanco, J. G. (2014) · Mitochondrial DNA Part A · doi:10.3109/19401736.2014.926477 · Cited by 10

Enhanced expression of SLC4A11 by tert-Butylhydroquinone is mediated by direct binding of Nrf2 to the promoter of SLC4A11

Guha, S., & Roy, S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.006 · Cited by 10

NGLY1: insights from Caenorhabditis elegans

Lehrbach, N. J. (2021) · The Journal of Biochemistry · doi:10.1093/jb/mvab112 · Cited by 11

Global gene profiling of aging lungs in Atp8b1 mutant mice

Soundararajan, R., Stearns, T. M., Czachor, A., Fukumoto, J., Turn, C. S., Westermann-Clark, E., Breitzig, M., Tan, L. C., Lockey, R. F., King, B. L., et al. (2016) · Aging · doi:10.18632/aging.101056 · Cited by 10

Potential Targets of Natural Products for Improving Cardiac Ischemic Injury: The Role of Nrf2 Signaling Transduction

Wang, H., Han, J., Gorbachev, D. O., & Zhang, X. (2024) · Molecules · doi:10.3390/molecules29092005 · Cited by 9

Anti-Osteoporotic Effect of Viscozyme-Assisted Polysaccharide Extracts from Portulaca oleracea L. on H2O2-Treated MC3T3-E1 Cells and Zebrafish

Fu, Y., Hu, X., Zhou, D., Li, X., Tao, X., Yang, D., Zheng, F. Y., Dai, Y., & Yue, H. (2022) · Separations · doi:10.3390/separations9050128 · Cited by 9

Induction of Cardiac Pathology: Endogenous versus Exogenous Nrf2 Upregulation

Mathis, B. J., Kato, H., & Hiramatsu, Y. (2022) · Cells · doi:10.3390/cells11233855 · Cited by 9

The Ratio of Thioredoxin/Keap1 Protein Level is a Predictor of Distant Metastasis in Colorectal Cancer

Chang, L., Fan, C., Tseng, W., Chein, H., Hsieh, T.-Y., Chen, J., Hwang, C., & Hua, C. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0107 · Cited by 9

The Effect of Carnosine on UVA-Induced Changes in Intracellular Signaling of Human Skin Fibroblast Spheroids

Aiello, G., Rescigno, F., Méloni, M., Zoanni, B., Aldini, G., Carini, M., & D’Amato, A. (2023) · Antioxidants · doi:10.3390/antiox12020300 · Cited by 9

Keratin function and regulation in tissue homeostasis and pathogenesis

Roth, W., Hatzfeld, M., Friedrich, M., Thiering, S., & Magin, T. M. (2012) · BioMolecular Concepts · doi:10.1515/bmc.2011.060 · Cited by 9

Interplay between autophagy and CncC regulates dendrite pruning in Drosophila

Tan, J. Y. K., Chew, L. Y., Juhász, G., & Yu, F.-W. (2024) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2310740121 · Cited by 5

Quantifying redox transcription factor dynamics as a tool to investigate redox signalling

Lind, D. J., Naidoo, K. C., Tomalin, L. E., Rohwer, J. M., Veal, E. A., & Pillay, C. S. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.004 · Cited by 8

Subcellular Redox Signaling

Zhu, L., Lu, Y., Zhang, J., & Hu, Q. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_25 · Cited by 9

Raspberry extract prevents NLRP3 inflammasome activation in gut epithelial cells induced by pathogenic Escherichia coli

Xue, Y., Du, ‬., & Zhu, M. J. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.03.005 · Cited by 8

Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases

Li, L., Ni, Z., Si, X., Jiang, L., Sang, H., Xia, W., Chen, Z., Huang, J., Jin, J., Shao, A., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6659908 · Cited by 8

The level of S-glutathionylated protein is a predictor for metastasis in colorectal cancer and correlated with those of Nrf2/Keap1 pathway

Chang, L.-C., Fan, C.-W., Tseng, W.-K., & Hua, C. (2021) · Biomarkers · doi:10.1080/1354750x.2021.1999503 · Cited by 8

Preserving transcriptional stress responses as an anti‐aging strategy

Cheng, Y., Pitoniak, A., Wang, J., & Bohmann, D. (2021) · Aging Cell · doi:10.1111/acel.13297 · Cited by 16

Mechanisms and functions of Nrf2 signaling in Drosophila

Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 129

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622

Declining signal dependence of Nrf2‐ Maf S ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 40