Stress-activated cap’n’collar transcription factors in aging and human disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg

Alexa‐Stratulat, T., Pešić, M., Gašparović, A. Č., Trougakos, I. P., & Riganti, C. (2019) · Drug Resistance Updates · doi:10.1016/j.drup.2019.100643 · Cited by 77

Changing gears in Nrf1 research, from mechanisms of regulation to its role in disease and prevention

Bugno, M., Daniel, M., Chepelev, N. L., & Willmore, W. G. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.08.001 · Cited by 78

Function of NADPH Oxidase 1 in Pulmonary Arterial Smooth Muscle Cells After Monocrotaline-Induced Pulmonary Vascular Remodeling

Veit, F., Pak, O., Egemnazarov, B., Roth, M., Kosanovic, D., Seimetz, M., Sommer, N., Ghofrani, H. A., Seeger, W., Grimminger, F., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4904 · Cited by 76

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

Staab, T. A., Griffen, T. C., Corcoran, C., Evgrafov, O. V., Knowles, J. A., & Sieburth, D. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003354 · Cited by 79

An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

Leung, C. K., Wang, Y., Malany, S., Deonarine, A., Nguyen, K. H., Vasile, S., & Choe, K. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062166 · Cited by 75

Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors

Jiménez, M. T. B., Frenis, K., Hahad, O., Steven, S., Cohen, G., Cuadrado, A., Münzel, T. F., & Daiber, A. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.016 · Cited by 77

Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson’s Disease: Rationale for Clinical Trial, and Current Progress

Carroll, C., & Wyse, R. K. H. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-171203 · Cited by 73

Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration

Goodfellow, M. J., Borcar, A., Proctor, J. L., Greco, T., Rosenthal, R. E., & Fiskum, G. M. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113247 · Cited by 77

Caenorhabditis elegans: A Useful Model for Studying Metabolic Disorders in Which Oxidative Stress Is a Contributing Factor

Moreno-Arriola, E., Cárdenas‐Rodríguez, N., Coballase-Urrutía, E., Pedraza‐Chaverrí, J., Carmona‐Aparicio, L., & Ortega-Cuéllar, D. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/705253 · Cited by 79

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer′s Disease: Focus on Gene Therapy and Cell‐Based Therapy Applications

Malm, T., Koıstınaho, J., & Kanninen, K. M. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/517160 · Cited by 74

Defining the functional targets of cap'n'collar transcription factors NRF1, NRF2, and NRF3

Ibrahim, L., Mesgarzadeh, J., Xu, I., Powers, E. T., Wiseman, R. L., & Bollong, M. J. (2020) · Antioxidants · doi:10.3390/antiox9101025 · Cited by 67

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

Koppula, P., Olszewski, K. L., Zhang, Y., Kondiparthi, L., Liu, X., Lei, G., Das, M., Fang, B., Poyurovsky, M. V., & Gan, B. (2021) · iScience · doi:10.1016/j.isci.2021.102649 · Cited by 78

Nuclear Factor Erythroid 2 - Related Factor 2 Signaling in Parkinson Disease: A Promising Multi Therapeutic Target Against Oxidative Stress, Neuroinflammation and Cell Death

Kumar, H., Koppula, S., Kim, I., More, S. V., Kim, B.-W., & Choi, D. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311211080012 · Cited by 70

Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease

Kasai, S., Mimura, J., Ozaki, T., & Itoh, K. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00242 · Cited by 73

Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?

Hawk, M. A., McCallister, C. M., & Schafer, Z. T. (2016) · Cancers · doi:10.3390/cancers8100092 · Cited by 73

p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB

Jain, A., Rusten, T. E., Katheder, N. S., Elvenes, J., Bruun, J., Sjøttem, E., Lamark, T., & Johansen, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.656116 · Cited by 71

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

Tsakiri, E. N., Gumeni, S., Iliaki, K. K., Benaki, D. C., Vougas, K. N., Sykiotis, G. P., Gorgoulis, V. G., Mikros, E., Scorrano, L., & Trougakos, I. P. (2018) · Aging Cell · doi:10.1111/acel.12845 · Cited by 71

Regulation of Vascular Calcification by Reactive Oxygen Species

Tóth, A., Balogh, E., & Jeney, V. (2020) · Antioxidants · doi:10.3390/antiox9100963 · Cited by 75

Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress‐induced mitochondrial dysfunction

Cano, M., Datta, S., Wang, L., Liu, T., Flores‐Bellver, M., Sachdeva, M. M., Sinha, D., & Handa, J. T. (2021) · Aging Cell · doi:10.1111/acel.13444 · Cited by 66

Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice

Thangthaeng, N., Rutledge, M. A., Wong, J. M., Vann, P. H., Forster, M. J., & Sumien, N. (2017) · Aging and Disease · doi:10.14336/ad.2016.1010 · Cited by 69

Effects of sulforaphane in the central nervous system

Huang, C., Wu, J., Chen, D., Jin, J., Wu, Y. H., & Chen, Z. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.03.010 · Cited by 71

Functional crosstalk among oxidative stress and O-GlcNAc signaling pathways

Chen, P., Chi, J., & Boyce, M. (2018) · Glycobiology · doi:10.1093/glycob/cwy027 · Cited by 68

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

Swamy, S., Rajasekaran, N. S., & Thannickal, V. J. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.02.022 · Cited by 67

Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease

Sun, Y., Huang, J., Chen, Y., Shang, H., Zhang, W., Yu, J., He, L., Xing, C., & Zhuang, C. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104172 · Cited by 73

Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells

Ryšavá, A., Vostálová, J., & Svobodová, A. R. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1962566 · Cited by 69

Redox signaling regulates skeletal muscle remodeling in response to exercise and prolonged inactivity

Powers, S. K., & Schrager, M. A. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102374 · Cited by 72

Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Tossetta, G., Fantone, S., Marzioni, D., & Roberta Mazzucchelli, A. (2023) · Cancers · doi:10.3390/cancers15113037 · Cited by 66

p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2

Cloer, E. W., Siesser, P. F., Cousins, E. M., Goldfarb, D., Mowrey, D. D., Harrison, J. S., Weir, S., Dokholyan, N. V., & Major, M. B. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00644-17 · Cited by 69

Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

Schultz, M., Hagan, S. S., Datta, A., Zhang, Y., Freeman, M. L., Sikka, S. C., Abdel‐Mageed, A. B., & Mondal, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087204 · Cited by 65

DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult

Zhang, X., Yuan, Y., Shao, Q.-H., Wang, Z., Zhu, C., Shi, J., Ma, K., Xu, Y., & Chen, N. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.02.022 · Cited by 65

Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.

Saleh, D. O., Mansour, D. F., Hashad, I. M., & Bakeer, R. M. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.04.043 · Cited by 65

Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster

Tsakiri, E. N., Iliaki, K. K., Höhn, A., Grimm, S., Papassideri, I. S., Grune, T., & Trougakos, I. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.186 · Cited by 64

Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights

Cheimonidi, C., Samara, P., Polychronopoulos, P., Tsakiri, E. N., Νίκου, Θ., Myrianthopoulos, V., Sakellaropoulos, T., Zoumpourlis, V. C., Mikros, E., Papassideri, I. S., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.015 · Cited by 64

The Role of Nrf2 in the Response to Normal Tissue Radiation Injury

Cameron, B. D., Sekhar, K. R., Ofori, M., & Freeman, M. L. (2018) · Radiation Research · doi:10.1667/rr15059.1 · Cited by 63

Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress

Chen, S., Wang, X., Nisar, M. F., Lin, M., & Zhong, J. L. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5416728 · Cited by 64

Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways

Tang, L., & Choe, K. P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.06.001 · Cited by 65

Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains

Zhang, Y., Ren, Y., Li, S., & Hayes, J. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093458 · Cited by 61

Keap1/Nrf2 Signaling: A New Player in Thyroid Pathophysiology and Thyroid Cancer

Renaud, C. O., Ziros, P. G., Chartoumpekis, D. V., Bongiovanni, M., & Sykiotis, G. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00510 · Cited by 62

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma

Zheng, A., Chevalier, N., Calderoni, M., Dubuis, G., Dormond, O., Ziros, P. G., Sykiotis, G., & Widmann, C. (2019) · OncoTarget · doi:10.18632/oncotarget.27361 · Cited by 55

Conventional and Nanotechnology Based Approaches to Combat Chronic Obstructive Pulmonary Disease: Implications for Chronic Airway Diseases

Passi, M., Shahid, S., Chockalingam, S., Sundar, I. K., & Packirisamy, G. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s242516 · Cited by 65

Molecular Targets of Brown Algae Phlorotannins for the Therapy of Inflammatory Processes of Various Origins

Besednova, N. N., Andryukov, B. G., Zaporozhets, T. S., Kuznetsova, T. A., Kryzhanovsky, S. P., Ermakova, S. P., Galkina, I. V., & Shchelkanov, M. Y. (2022) · Marine Drugs · doi:10.3390/md20040243 · Cited by 67

Neuroprotection during Thrombectomy for Acute Ischemic Stroke: A Review of Future Therapies

Dammavalam, V. M., Lin, S. Y., Nessa, S., Daksla, N., Stefanowski, K., Costa, A., & Bergese, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020891 · Cited by 61

Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis

Trougakos, I. P., Sesti, F., Tsakiri, E. N., & Gorgoulis, V. G. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.02.024 · Cited by 63

6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts

Sklirou, A. D., Gaboriaud‐Kolar, N., Papassideri, I. S., Skaltsounis, A., & Trougakos, I. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-11662-7 · Cited by 62

AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegans

Peng, Y., Sun, Q., Gao, R., & Park, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00705 · Cited by 63

Bromodomain and Extraterminal Proteins Suppress NF-E2–Related Factor 2–Mediated Antioxidant Gene Expression

Michaeloudes, C., Mercado, N., Clarke, C., Bhavsar, P. K., Adcock, I. M., Barnes, P. J., & Chung, K. F. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301984 · Cited by 60

Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway

Xu, W., Wang, M., Cui, G., Li, L., Jiao, D., Yao, B., Xu, K., Chen, Y., Long, M., Yang, S., et al. (2019) · Toxins · doi:10.3390/toxins11090540 · Cited by 59

Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery

Madden, S. K., & Itzhaki, L. S. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140405 · Cited by 62

PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma

Jiang, T., Pan, Y., Wan, Z., Lin, Y., Zhu, B., Yuan, Z.-G., Ma, Y., Shi, Y., Zeng, T., Dong, L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0152 · Cited by 60

Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and Alleviate Diabetic Complications

Feng, C., Yu, B., Song, C., Wang, J., Zhang, L., Ji, X., Wang, Y., Fang, Y., Liao, Z., Wei, M., et al. (2022) · Cells · doi:10.3390/cells11030443 · Cited by 62

Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities

Pérez, R., Burgos, V., Marín, V., Camins, A., Olloquequi, J., González‐Chavarría, I., Ulrich, H., Wyneken, Ú., Luarte, A., Ortíz, L., et al. (2023) · Antioxidants · doi:10.3390/antiox12081500 · Cited by 58

The Casein Kinase 2-Nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression

Tsuchiya, Y., Taniguchi, H., Ito, Y., Morita, T., Karim, M. R., Ohtake, N., Fukagai, K., Ito, T., Okamuro, S., Iemura, S., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01271-12 · Cited by 59

The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster

Pomatto, L. C. D., Wong, S., Carney, C., Shen, B., Tower, J., & Davies, K. J. A. (2017) · Aging · doi:10.18632/aging.101218 · Cited by 59

Unravelling the role of NFE2L1 in stress responses and related diseases

Liu, X., Xu, C., Xiao, W., & Yan, N. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102819 · Cited by 55

Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise

West, J. D., Wang, Y., & Morano, K. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300264x · Cited by 59

Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis

Pomatto, L. C. D., Tower, J., & Davies, K. J. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx083 · Cited by 56

Regulation and Functions of the ER-Associated Nrf1 Transcription FactorPreprint

Ruvkun, G., & Lehrbach, N. J. (2022) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041266 · Cited by 58

Redox Homeostasis Plays Important Roles in the Maintenance of the Drosophila Testis Germline Stem Cells

Tan, S. W. S., Lee, Q. Y., Wong, B. S. E., Cai, Y., & Baeg, G. H. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.034 · Cited by 61

Structural basis of transcription regulation by CNC family transcription factor, Nrf2

Sengoku, T., Shiina, M., Suzuki, K., Hamada, K., Sato, K., Uchiyama, A., Kobayashi, S., Oguni, A., Itaya, H., Kasahara, K., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1102 · Cited by 56

Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11

Wang, C., Liu, H., Xu, S., Deng, Y. L., Xu, B., Yang, T., & Liu, W. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01343-7 · Cited by 57

Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity

Attucks, O. C., Jasmer, K. J., Hannink, M., Kassis, J. N., Zhong, Z., Gupta, S., Victory, S. F., Güzel, M., Rao, P. D., Andrews, R., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101044 · Cited by 55

Upregulation of Nrf2 expression by human cytomegalovirus infection protects host cells from oxidative stress

Lee, J., Koh, K., Kim, Y.-E., Ahn, J., & Kim, S. (2013) · Journal of General Virology · doi:10.1099/vir.0.052142-0 · Cited by 56

Nrf2-mediated protection against UVA radiation in human skin keratinocytes

Tian, F., Zhang, F., Lai, X., Wang, L., Yang, L. C., Wang, X., Singh, G. K., & Zhong, J. L. (2011) · BioScience Trends · doi:10.5582/bst.2011.v5.1.23 · Cited by 56

Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2

van der Kammen, R., Song, J., de Rink, I., Janssen, H., Madonna, S., Scarponi, C., Albanesi, C., Brugman, W., & Innocenti, M. (2017) · Development · doi:10.1242/dev.156323 · Cited by 54

Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches

Owings, K. G., Lowry, J., Bi, Y., Might, M., & Chow, C. Y. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy026 · Cited by 56

Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding

Maruyama, A., Mimura, J., & Itoh, K. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1169 · Cited by 57

Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency

Marcus, N. Y., Blomenkamp, K., Ahmad, M., & Teckman, J. H. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012106 · Cited by 55

Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome

Grimberg, K. B., Beskow, A., Lundin, D., Davis, M. M., & Young, P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00799-10 · Cited by 55

Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease

Zhang, J., Li, X., Wei, J., Chen, H., Lu, Y., Li, L., Han, L., & Lu, C. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.048 · Cited by 55

Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease

Wang, W., Yu-Hai, Wang, H., Chasuna, & Bagenna (2019) · Biological Research · doi:10.1186/s40659-019-0255-2 · Cited by 54

Role of the Nrf2 signaling system in health and disease

Hybertson, B. M., & Gao, B. (2014) · Clinical Genetics · doi:10.1111/cge.12474 · Cited by 55

Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate Restores Nrf2 Activity and Ameliorates Crescentic Glomerulonephritis

Ye, T., Zhen, J., Du, Y., Zhou, J. K., Peng, A., Vaziri, N. D., Mohan, C., Xu, Y. H., & Zhou, X. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119543 · Cited by 54

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

Levings, D. C., Wang, X., Kohlhase, D., Bell, D. A., & Slattery, M. G. (2018) · Redox Biology · doi:10.1016/j.redox.2018.07.026 · Cited by 53

NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland

Ziros, P. G., Habeos, I. G., Chartoumpekis, D. V., Ntalampyra, E., Somm, E., Renaud, C. O., Bongiovanni, M., Trougakos, I. P., Yamamoto, M. P., Kensler, T. W., et al. (2018) · Thyroid · doi:10.1089/thy.2018.0018 · Cited by 53

Dynamic Regulation of Proteasome Expression

Motosugi, R., & Murata, S. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00030 · Cited by 56

The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling

Chew, L. Y., Zhang, H., He, J., & Yu, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109466 · Cited by 53

Developmental Expression of the Nfe2-Related Factor (Nrf) Transcription Factor Family in the Zebrafish, Danio rerio

Williams, L., Timme‐Laragy, A. R., Goldstone, J. V., McArthur, A. G., Stegeman, J. J., Smolowitz, R. M., & Hahn, M. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079574 · Cited by 52

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

Zhang, Y., Li, S., Xiang, Y., Qiu, L., Zhao, H., & Hayes, J. D. (2015) · Scientific Reports · doi:10.1038/srep12983 · Cited by 51

SLC4A11 depletion impairs NRF2 mediated antioxidant signaling and increases reactive oxygen species in human corneal endothelial cells during oxidative stress

Guha, S., Chaurasia, S., Ramachandran, C., & Roy, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-03654-4 · Cited by 52

Structural characterization and antioxidant effect of green alga Enteromorpha prolifera polysaccharide in Caenorhabditis elegans via modulation of microRNAs

Lin, G., Wu, D., Xiao, X.-W., Huang, Q.-Y., Chen, H., Liu, D., Fu, H.-Q., Chen, X., & Zhao, C. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.114 · Cited by 53

Rule-Based Cell Systems Model of Aging using Feedback Loop Motifs Mediated by Stress Responses

Kriete, A., Bosl, W. J., & Booker, G. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000820 · Cited by 56

The Nrf2 transcription factor: A multifaceted regulator of the extracellular matrix

Hiebert, P. (2021) · Matrix Biology Plus · doi:10.1016/j.mbplus.2021.100057 · Cited by 54

Bisphenol A Activates the Nrf1/2-Antioxidant Response Element Pathway in HEK 293 Cells

Chepelev, N. L., Enikanolaiye, M. I., Chepelev, L. L., Almohaisen, A., Chen, Q., Scoggan, K. A., Coughlan, M. C., Cao, X., Jin, X., & Willmore, W. G. (2013) · Chemical Research in Toxicology · doi:10.1021/tx400036v · Cited by 52

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

Greenwald, M. B., Frušić‐Zlotkin, M., Soroka, Y., Sasson, S. B., Bitton, R., Bianco‐Peled, H., & Kohen, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5205471 · Cited by 54

Nrf2-mediated neuroprotection by MANF against 6-OHDA-induced cell damage via PI3K/AKT/GSK3β pathway

Zhang, J., Tong, W., Sun, H., Jiang, M., Shen, Y., Liu, Y., Gu, H., Guo, J., Fang, J., & Jin, L. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.021 · Cited by 52

Flies, worms and the Free Radical Theory of ageing

Clancy, D. J., & Birdsall, J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.03.011 · Cited by 51

The expression of P450 genes mediating fenpropathrin resistance is regulated by CncC and Maf in Tetranychus cinnabarinus (Boisduval)

Shi, L., Wang, M., Yichao, Z., Shen, G., Di, H., Wang, Y., & He, L. (2017) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2017.05.002 · Cited by 51

Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases

Yuan, J., Zhang, S., & Zhang, Y. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.09.037 · Cited by 47

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

Tsakiri, E. N., Gumeni, S., Vougas, K. N., Pendin, D., Papassideri, I. S., Daga, A., Gorgoulis, V. G., Juhász, G., Scorrano, L., & Trougakos, I. P. (2019) · Autophagy · doi:10.1080/15548627.2019.1596477 · Cited by 54

Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and Pathogenesis

Bender, D., & Hildt, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184659 · Cited by 56

Transcription factor CncC potentially regulates the expression of multiple detoxification genes that mediate indoxacarb resistance in Spodoptera litura

Shi, L., Shi, Y., Liu, M., Ya, Z., & Liao, X. (2020) · Insect Science · doi:10.1111/1744-7917.12860 · Cited by 51

TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways

Meng, X., Zhang, C., Guo, Y., Han, Y., Wang, C., Chu, H., Kong, L., & Ma, H. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8787156 · Cited by 49

NADPH Oxidase 4 (NOX4) in Cancer: Linking Redox Signals to Oncogenic Metabolic Adaptation

Szántó, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052702 · Cited by 52

NRF2 and microRNAs: new but awaited relations

Kurinna, S. M., & Werner, S. (2015) · Biochemical Society Transactions · doi:10.1042/bst20140317 · Cited by 50

Piceatannol attenuates behavioral disorder and neurological deficits in aging mice via activating the Nrf2 pathway

Zhang, Y., Zhang, L.-H., Chen, X., Zhang, N., & Li, G. (2017) · Food & Function · doi:10.1039/c7fo01511a · Cited by 50

Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2‐related factor 2 signalling in ischaemic stroke

Wu, C., Chen, J., Yang, R., Duan, F., Li, S., & Chen, X. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14537 · Cited by 50

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49

Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice

Zhu, G., Yin, F., Wang, L., Wei, W., Jiang, L., & Qin, J. (2015) · Integrative Biology · doi:10.1039/c5ib00243e · Cited by 52

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro

Ning, C., Gao, X., Wang, C., Kong, Y., Liu, Z., Sun, H., Sun, P., Huo, X., Ma, X., Meng, Q., et al. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.07.012 · Cited by 49

S-lactoyl modification of KEAP1 by a reactive glycolytic metabolite activates NRF2 signaling

Ko, Y., Hong, M., Lee, S., Kumar, M., Ibrahim, L. H., Nutsch, K., Stanton, C. R., Sondermann, P., Sandoval, B. A., Bulos, M. L., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300763120 · Cited by 49

Preserving transcriptional stress responses as an anti‐aging strategy

Cheng, Y., Pitoniak, A., Wang, J., & Bohmann, D. (2021) · Aging Cell · doi:10.1111/acel.13297 · Cited by 16

Mechanisms and functions of Nrf2 signaling in Drosophila

Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 129

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622

Declining signal dependence of Nrf2‐ Maf S ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 40