Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

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Modulation of TRPV4 protects against degeneration induced by sustained loading and promotes matrix synthesis in the intervertebral disc

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Sclerostin: From Molecule to Clinical Biomarker

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The role of calcium channels in osteoporosis and their therapeutic potential

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Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca 2+ signals that are inhibited by oncogenic KRas

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TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations

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Osteocyte-mediated mechanical response controls osteoblast differentiation and function

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OCY454 Osteocytes as an in Vitro Cell Model for Bone Remodeling Under Mechanical Loading

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Aging, Osteo-Sarcopenia, and Musculoskeletal Mechano-Transduction

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Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes

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Research progress on the regulatory mechanism of integrin‐mediated mechanical stress in cells involved in bone metabolism

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Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts

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Dexamethasone Induced Osteocyte Apoptosis in Steroid‐Induced Femoral Head Osteonecrosis through ROS ‐Mediated Oxidative Stress

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Perception and response of skeleton to mechanical stress

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TRPV4 differentially controls inflammatory cytokine networks during static and dynamic compression of the intervertebral disc

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The Impact of Plasma Membrane Ion Channels on Bone Remodeling in Response to Mechanical Stress, Oxidative Imbalance, and Acidosis

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Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality

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Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing

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Primary cilia in skeletal development and disease

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High-fat and high-carbohydrate diets increase bone fragility through TGF-β–dependent control of osteocyte function

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Adenylyl cyclases and TRPV4 mediate Ca2+/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes.

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Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts

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Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues

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Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine‐induced status epilepticus

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The Skeletal Cellular and Molecular Underpinning of the Murine Hindlimb Unloading Model

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The regulation and functions of the matricellular CCN proteins induced by shear stress

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New and Old Osteocytic Cell Lines and 3D Models

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The Diminishing Returns of Mechanical Loading and Potential Mechanisms that Desensitize Osteocytes

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Mechanical effects in aging of the musculoskeletal system: Molecular signaling and spatial scale alterations

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NAD+/Nrf2 signaling promotes osteogenesis by regulating oxidative level of BMSCs under mechanical stress

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Connexin43 regulates osteoprotegerin expression via ERK1/2 -dependent recruitment of Sp1

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Osteocyte Dendrites: How Do They Grow, Mature, and Degenerate in Mineralized Bone?

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Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications

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Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes

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Small molecule compound M12 reduces vascular permeability in obese mice via blocking endothelial TRPV4–Nox2 interaction

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The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila

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Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading

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Current status and future direction of mechanotransduction mechanisms: Perspectives from cell membrane to nucleus

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Mechanobiology and Primary Cilium in the Pathophysiology of Bone Marrow Myeloproliferative Diseases

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The roles of focal adhesion and cytoskeleton systems in fluid shear stress-induced endothelial cell response

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Nitric oxide contributes to rapid sclerostin protein loss following mechanical load

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Cells Involved in Mechanotransduction Including Mesenchymal Stem Cells

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Inhibition of transient receptor potential vanilloid 4: A promising novel strategy for myocardial ischemia/reperfusion injury treatment

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High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation system

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P2Y2 Inhibition Modifies the Anabolic Response to Exercise in Adult Mice

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Differential distribution of microtubules in immature osteocytes in vivo

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Mechanical Stimulation Drives Multicellular Synergy and Signaling Pathways in Developing Skeletal Tissues

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Mechanobiological crosstalk among bone cells and between bone and other organs

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Mechanobiology of osteocytes

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Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanicsPreprint

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Investigation of mechanosensing and mechanoresponse mechanisms in osteoblasts and osteocytes: in vitro experiments targeting subcellular components

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Breaking the redox–calcium loop: Pharmacology, physiology and therapeutic promise of disrupting the endothelial TRPV4–NOX2 complex

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Genome-wide CRISPR interference screen identifies Clip2 as a novel regulator of osteocyte maturation and morphology

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Making sense of subcellular H2O2 in mammals

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Tension force causes cell cycle arrest at G2/M phase in osteocyte-like cell line MLO-Y4

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Mechanically-Evoked TRPV4-Mediated Currents Are Modulated by Activated Integrin β1

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Osteocyte Mechanobiology in Aging and Disease

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Epidermal TRPV4 ion channels regulate UVB induced sunburn by triggering inflammmasome activation and ERK signalingPreprint

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OSTEOCYTE SIGNALING AND ITS EFFECTS ON THE ACTIVITES OF OSTEOBLASTS AND BREAST CANCER CELLS

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Effect of transient receptor potential vanilloid 4 activation on the delayed rectifier potassium current in the hippocampal pyramidal neurons and Kv subunit expression in the hippocampi of micePreprint

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Microtubule Mechanotransduction through Nox2-ROS Initiates TRPV4 Calcium Influx and Purinergic Calcium Oscillations that Regulate Osteocyte Mechano-Sensing

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TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations

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Nitric oxide contributes to rapid sclerostin protein loss following mechanical load

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Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

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