Cited by 119NF-κB Signaling PathwaysRedox biology and oxidative stressImmune Response and Inflammation

Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO

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Herb, Marc, Gluschko, Alexander, Wiegmann, Katja, Farid, Alina, Wolf, Anne, Utermöhlen, Olaf, Krut, Oleg, Krönke, Martin +1 more·2019·Science Signaling

Abstract

Bacterial infection induces macrophages to produce mitochondrial reactive oxygen species that covalently link NEMO molecules.

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Crossref · 10.1126/scisignal.aar5926

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Research works printed but not linked: 8

  1. Insight into functional additives: Revealing individual and combined effects on post-transport recovery and muscle quality of Litopenaeus vannamei, Aquaculture, 623, (744136), (2026).https://doi.org/10.1016/j.aquaculture.2026.744136 · DOI
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Authors
Herb, M., Gluschko, A., Wiegmann, K., Farid, A., Wolf, A., Utermöhlen, O., Krut, O., Krönke, M., & Schramm, M.
Affiliations
  • University of Cologne (DE)
  • Paul Ehrlich Institut (DE)
Corresponding author
Schramm, Michael
Venue
Science Signaling
Published
2019-02-12
Volume
12
Issue
568
ISSN
  • 1937-9145 (ISSN-L)
  • 1945-0877
OpenAlex
W2911702205
Cited by
119
References
52
Citations by year
2026: 19 · 2025: 18 · 2024: 19 · 2023: 13 · 2022: 13 · 2021: 23 · 2020: 11 · 2019: 3
FWCI
3.98
Type
journal article
Language
en
Open access
Locations
  • Science Signaling (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft (SFB 670)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
mitochondrial reactive oxygen species, NEMO, disulfide bonds, NF-κB signaling, ERK signaling, inflammatory cytokines, macrophages, bacterial infection, innate immunity
MeSH terms
NADPH Oxidase 2, Animals, Cysteine, Disulfides, Listeria monocytogenes, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Signal Transduction, Cytokines, NF-kappa B, Reactive Oxygen Species, Mice, Knockout, Inflammation Mediators, Intracellular Signaling Peptides and Proteins, Extracellular Signal-Regulated MAP Kinases, Host-Pathogen Interactions

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