Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO
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Bacterial infection induces macrophages to produce mitochondrial reactive oxygen species that covalently link NEMO molecules.
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- Authors
- Herb, M., Gluschko, A., Wiegmann, K., Farid, A., Wolf, A., Utermöhlen, O., Krut, O., Krönke, M., & Schramm, M.
- Affiliations
- University of Cologne (DE)
- Paul Ehrlich Institut (DE)
- Corresponding author
- Schramm, Michael
- ORCID
- Venue
- Science Signaling
- Published
- 2019-02-12
- Volume
- 12
- Issue
- 568
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2911702205
- Cited by
- 119
- References
- 52
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 19 · 2023: 13 · 2022: 13 · 2021: 23 · 2020: 11 · 2019: 3
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 670)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- mitochondrial reactive oxygen species, NEMO, disulfide bonds, NF-κB signaling, ERK signaling, inflammatory cytokines, macrophages, bacterial infection, innate immunity
- MeSH terms
- NADPH Oxidase 2, Animals, Cysteine, Disulfides, Listeria monocytogenes, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Mitochondria, Signal Transduction, Cytokines, NF-kappa B, Reactive Oxygen Species, Mice, Knockout, Inflammation Mediators, Intracellular Signaling Peptides and Proteins, Extracellular Signal-Regulated MAP Kinases, Host-Pathogen Interactions
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