Cited by 252Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersFunctional Brain Connectivity Studies

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Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2

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Scott-Van Zeeland, Ashley A., Abrahams, Brett S., Alvarez-Retuerto, Ana I., Sonnenblick, Lisa I., Rudie, Jeffrey D., Ghahremani, Dara, Mumford, Jeanette A., Poldrack, Russell A., Dapretto, Mirella, Geschwind, Daniel H., Bookheimer, Susan Y.·2010·Science Translational Medicine

DOI 10.1126/scitranslmed.3001344PMC PMC3065863

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Abstract

Children who carry one variant of a brain protein associated with autism exhibit fewer long-range connections between the prefrontal cortex and more posterior brain regions.

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Dosenbach, N. U. F., Nardos, B., Cohen, A. L., Fair, D. A., Power, J. D., Church, J. A., Nelson, S. M., Wig, G. S., Vogel, A. C., Lessov-Schlaggar, C. N., et al. (2010) · Science · doi:10.1126/science.1194144 · Cited by 2,183
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Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777
Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders
Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M. (2006) · Nature Neuroscience · doi:10.1038/nn1611 · Cited by 1,694
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Default-mode brain dysfunction in mental disorders: A systematic review
Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.002 · Cited by 1,675
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Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530

Show all 41 references

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Stein, M. B., Yang, B.-Z., Chavira, D. A., Hitchcock, C. A., Sung, S. C., Shipon-Blum, E., & Gelernter, J. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.008 · Cited by 89
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Dennis, E. L., & Thompson, P. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.05.007 · Cited by 79
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Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J. K., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.60 · Cited by 77
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Poelmans, G., Franke, B., Pauls, D. L., Glennon, J. C., & Buitelaar, J. K. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.48 · Cited by 76
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Thomas, M. S. C., Knowland, V. C. P., & Karmiloff‐Smith, A. (2011) · Psychological Review · doi:10.1037/a0025234 · Cited by 70
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Holt, R., & Monaco, A. P. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100157 · Cited by 52
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Thanseem, I., Anitha, A., Nakamura, K., Suda, S., Iwata, K., Matsuzaki, H., Ohtsubo, M., Ueki, T., Katayama, T., Iwata, Y., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.020 · Cited by 49
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Authors: Scott-Van Zeeland, A. A., Abrahams, B. S., Alvarez-Retuerto, A. I., Sonnenblick, L. I., Rudie, J. D., Ghahremani, D., Mumford, J. A., Poldrack, R. A., Dapretto, M., Geschwind, D. H., & Bookheimer, S. Y.
Affiliations: Center for Cognitive Neuroscience, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles (US)
Corresponding author: Abrahams, Brett S.
Geschwind, Daniel H.
Bookheimer, Susan Y.
ORCID: Rudie, Jeffrey D.
Ghahremani, Dara
Mumford, Jeanette A.
Poldrack, Russell A.
Dapretto, Mirella
Geschwind, Daniel H.
Bookheimer, Susan Y.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-11-03
Volume: 2
Issue: 56
Pages: 56ra80-56ra80
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3001344
PMC: PMC3065863
OpenAlex: W2127753140
Cited by: 252
References: 41
Citations by year: 2026: 4 · 2025: 2 · 2024: 4 · 2023: 12 · 2022: 16 · 2021: 11 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 23 · 2016: 24 · 2015: 19 · 2014: 10 · 2013: 29 · 2012: 31
FWCI: 16.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Autism Speaks (AS1626)
National Institute of Mental Health (F31MH079645, R01MH081754, T32MH073526)
National Center for Research Resources (P41RR013642, RR 13642, RR00865, M01RR000865, UL1RR025774, C06RR012169)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035470, P50-HD055784-03S1, P50HD055784, R01HD065280)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: CNTNAP2, autism spectrum disorder, functional connectivity, genotype-phenotype correlation, neurexin, common genetic variants, neurodevelopmental disorders, specific language impairment, human brain imaging
MeSH terms: Autistic Disorder, Frontal Lobe, Humans, Magnetic Resonance Imaging, Membrane Proteins, Nerve Tissue Proteins, Neural Pathways, Risk Factors, Genetic Predisposition to Disease

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Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2

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