Insula response and connectivity during social and non-social attention in children with autism
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Autism spectrum disorder (ASD) is characterized by reduced attention to salient social stimuli. Here, we use two visual oddball tasks to investigate brain systems engaged during attention to social (face) and non-social (scene) stimuli. We focused on the dorsal and ventral subdivisions of the anterior insula (dAI and vAI, respectively), anatomically distinct regions contributing to a 'salience network' that is known to regulate attention to behaviorally meaningful stimuli. Children with ASD performed comparably to their typically developing (TD) peers, but they engaged the right dAI and vAI differently in response to deviant faces compared with deviant scenes. Multivariate activation patterns in the dAI reliably discriminated between children with ASD and TD children with 85% classification accuracy, and children with ASD activated the vAI more than their TD peers. Children with ASD and their TD peers also differed in dAI connectivity patterns to deviant faces, with stronger within-salience network interactions in the ASD group and stronger cross-network interactions in the TD group. Our findings point to atypical patterns of right anterior insula activation and connectivity in ASD and suggest that multiple functions subserved by the insula, including attention and affective processing of salient social stimuli, are aberrant in children with the disorder.
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Empathic deficits in autism spectrum disorder (ASD) are related to insular cortex activity and connectivity.
“empathic deficits in autism spectrum disorder (ASD) are related to insular cortex activity and connectivity6–9.”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [9]
Abnormalities in emotion recognition are central to several psychiatric conditions including ASD, in which OTR polymorphisms and insular cortex hypofunction are correlates of symptom severity.
“Abnormalities in emotion recognition are central to several psychiatric conditions including ASD47,48, in which OTR polymorphisms49,50 and insular cortex hypofunction8,9 are correlates of symptom severity.”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [9]
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- Authors
- Odriozola, P., Uddin, L. Q., Lynch, C. J., Kochalka, J., Chen, T., & Menon, V.
- Affiliations
- Stanford Medicine (US)
- University of Miami (US)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-10-09
- Volume
- 11
- Issue
- 3
- Pages
- 433-444
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC4769628
- OpenAlex
- W2242884585
- Cited by
- 95
- References
- 59
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 12 · 2023: 4 · 2022: 14 · 2021: 10 · 2020: 11 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 3 · 2013: 1
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Simons Foundation
- National Alliance for Research on Schizophrenia and Depression (R01MH107549)
- International Society for Autism Research
- National Institute of Mental Health (K01MH092288, K01MH092288 and R01MH107549, R01MH084164, R01MH107549)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Keywords
- autism spectrum disorder, anterior insula, dorsal anterior insula, ventral anterior insula, salience network, social attention, visual oddball, face processing, deviant stimuli, functional connectivity, children, emotional processing
- MeSH terms
- Attention, Autistic Disorder, Cerebral Cortex, Child, Child Development Disorders, Pervasive, Discrimination, Psychological, Face, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Photic Stimulation, Social Behavior, Social Environment, Visual Perception, Asperger Syndrome
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