High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

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Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

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Vitamin C and Cell Death

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Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage

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Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin‐Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway

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Diet and supplements in cancer prevention and treatment: Clinical evidences and future perspectives

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Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer

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PEGylated Chitosan Nanoparticles Encapsulating Ascorbic Acid and Oxaliplatin Exhibit Dramatic Apoptotic Effects against Breast Cancer Cells

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A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study)

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Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models

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Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations

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Cross‐Talk between Oxidative Stress and m6A RNA Methylation in Cancer

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Hypoxia-Induced Reactive Oxygen Species: Their Role in Cancer Resistance and Emerging Therapies to Overcome It

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Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

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Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update

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Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile

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DNA damage response and repair in ovarian cancer: Potential targets for therapeutic strategies

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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response

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High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro

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A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer

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Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

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Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer

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Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy

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Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence

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Vitamin C: From nutrition to oxygen sensing and epigenetics

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Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner

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Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer

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Vitamin C Effect on Mitoxantrone-Induced Cytotoxicity in Human Breast Cancer Cell Lines

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Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells

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Fasting and fasting-mimicking diets for chemotherapy augmentation

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Navigating the redox landscape: reactive oxygen species in regulation of cell cycle

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Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth

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Vitamin C in the critically ill - indications and controversies

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Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy

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Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy

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Redox modifications of cysteine-containing proteins, cell cycle arrest and translation inhibition: Involvement in vitamin C-induced breast cancer cell death

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Roles of vitamins in stem cells

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Epigenetic Impacts of Ascorbate on Human Metastatic Melanoma Cells

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SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts

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Concentration Does Matter: The Beneficial and Potentially Harmful Effects of Ascorbate in Humans and Plants

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Inhibition of thioredoxin-dependent H2O2 removal sensitizes malignant B-cells to pharmacological ascorbate

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The pharmacology of vitamin C

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Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

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Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives

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A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer

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High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition

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Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy

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Dietary Supplements Commonly Used by Cancer Survivors: Are There Any Benefits?

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Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma

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Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study

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The unpaved journey of vitamin C in cancer treatment

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Co-delivery of docetaxel and palmitoyl ascorbate by liposome for enhanced synergistic antitumor efficacy

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Pharmacologic ascorbate (P-AscH−) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma

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Integrative oncology: really the best of both worlds?

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Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

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Combined treatment with vitamin C and methotrexate inhibits triple-negative breast cancer cell growth by increasing H2O2 accumulation and activating caspase-3 and p38 pathways

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Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma

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Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage

Buranasudja, V., Doskey, C. M., Gibson, A. R., Wagner, B. A., Du, J., Gordon, D. J., Koppenhafer, S. L., Cullen, J. J., & Buettner, G. R. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0381 · Cited by 40

Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy

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Potassium increases the antitumor effects of ascorbic acid in breast cancer cell lines in vitro

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Paradoxical Effects of Antioxidants on Cancer

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Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications

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Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells

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Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity

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Food-Derived Pharmacological Modulators of the Nrf2/ARE Pathway: Their Role in the Treatment of Diseases

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High-Dose Vitamin C Injection to Cancer Patients May Promote Thrombosis Through Procoagulant Activation of Erythrocytes

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Fluorescence probe for the convenient and sensitive detection of ascorbic acid

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Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines

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Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate

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High-dose vitamin C and cancer

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Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer

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Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer

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The Xc− inhibitor sulfasalazine improves the anti-cancer effect of pharmacological vitamin C in prostate cancer cells via a glutathione-dependent mechanism

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Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism

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