High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

A simple technique for quantitation of low levels of DNA damage in individual cells

Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Chou, T.-C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.10 · Cited by 5,163

Rapid colorimetric assay for cell growth and survival

Denizot, F., & Lang, R. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90368-6 · Cited by 4,935

The metabolism of tumors in the body

Warburg, O., Wind, F., & Negelein, E. (1927) · Journal of General Physiology · doi:10.1085/jgp.8.6.519 · Cited by 4,416

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075

Vitamin C pharmacokinetics: Implications for oral and intravenous use

Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717

Clinical efficacy and safety of oral and intravenous vitamin C use in patients with malignant diseases

Hoppe, C., Freuding, M., Büntzel, J., Münstedt, K., & Hübner, J. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03759-4 · Cited by 29

Role of Vitamin C in Selected Malignant Neoplasms in Women

Markowska, A., Antoszczak, M., Markowska, J., & Huczyński, A. (2022) · Nutrients · doi:10.3390/nu14040882 · Cited by 30

Citric acid of ovarian cancer metabolite induces pyroptosis via the caspase‐4/TXNIP‐NLRP3‐GSDMD pathway in ovarian cancer

Wang, X., Yin, Y., Qian, W., Peng, C., Shen, S., Wang, T., & Zhao, S. (2022) · The FASEB Journal · doi:10.1096/fj.202101993rr · Cited by 27

Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back

González‐Montero, J., Chichiarelli, S., Eufemi, M., Fabio Altieri, F., Saso, L., & Rodrigo, R. (2022) · Molecules · doi:10.3390/molecules27123818 · Cited by 28

Safety of vitamin C in sepsis: a neglected topic

Rad, N. K., & Khalili, H. (2019) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000622 · Cited by 27

Role of Antioxidant Phytochemicals in Prevention, Formation and Treatment of Cancer

Koçyiğit, A., Güler, E. M., & Dikilitaş, M. (2018) · InTech eBooks · doi:10.5772/intechopen.72217 · Cited by 28

Why Vitamin C Could Be an Excellent Complementary Remedy to Conventional Therapies for Breast Cancer

Codini, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218397 · Cited by 27

Vitamin C and Cancer: The Role of Vitamin C in Disease Progression and Quality of Life in Cancer Patients

Abiri, B., & Vafa, M. (2020) · Nutrition and Cancer · doi:10.1080/01635581.2020.1795692 · Cited by 26

Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

Li, W.-N., Zhang, S.-J., Feng, J.-Q., & Jin, W. (2022) · Cancers · doi:10.3390/cancers14112608 · Cited by 30

Quantifying L-ascorbic acid-driven inhibitory effect on amyloid fibrillation

Lee, W., Kim, I., Lee, S. W., Lee, H., Lee, G., Kim, S., Lee, S. W., & Yoon, D. S. (2016) · Macromolecular Research · doi:10.1007/s13233-016-4126-1 · Cited by 24

Patients Undergoing Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation Exhibit Depleted Vitamin C Status in Association with Febrile Neutropenia

Carr, A. C., Spencer, E. S., Das, A. B., Meijer, N., Lauren, C., MacPherson, S. A., & Chambers, S. T. (2020) · Nutrients · doi:10.3390/nu12061879 · Cited by 25

The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response

Crake, R., Burgess, E. R., Royds, J. A., Phillips, E., Vissers, M. C. M., & Dachs, G. U. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.619300 · Cited by 25

The Result of Vitamin C Treatment of Patients with Cancer: Conditions Influencing the Effectiveness

Hunyady, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084380 · Cited by 29

Meaning and Significance of “Alkalization Therapy for Cancer”

Wada, H., Hamaguchi, R., Narui, R., & Morikawa, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.920843 · Cited by 25

Vitamin C Inhibits Metastasis of Peritoneal Tumors By Preventing Spheroid Formation in ID8 Murine Epithelial Peritoneal Cancer Model

Xu, Y., Guo, X., Wang, G., & Zhou, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00645 · Cited by 23

Improved Chemotherapy Outcomes of Patients With Small-cell Lung Cancer Treated With Combined Alkalization Therapy and Intravenous Vitamin C

Hamaguchi, R., Narui, R., Morikawa, H., & Wada, H. (2021) · Cancer Diagnosis & Prognosis · doi:10.21873/cdp.10021 · Cited by 23

Sequential Therapy of Breast Cancer Cell Lines with Vitamin C and Quercetin Improves the Efficacy of Chemotherapeutic Drugs

Ramezani, F., Samadi, N., & Mostafavi‐Pour, Z. (2017) · Nutrition and Cancer · doi:10.1080/01635581.2017.1339813 · Cited by 23

Pharmacological ascorbate induces ‘BRCAness’ and enhances the effects of Poly(ADP‑Ribose) polymerase inhibitors against BRCA1/2 wild‑type ovarian cancer

Ma, Y., Chen, P., Drisko, J., Khabele, D., Godwin, A. K., & Chen, Q. (2020) · Oncology Letters · doi:10.3892/ol.2020.11364 · Cited by 22

Molecular mechanisms of pharmacological doses of ascorbate on cancer cells

Venturelli, S., Sinnberg, T. W., Niessner, H., & Busch, C. (2015) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-015-0356-7 · Cited by 24

Mitochondrial Redox Vulnerabilities in Triple-Negative Breast Cancer: Integrative Perspectives and Emerging Therapeutic Strategies

Cruz‐Gregorio, A. (2026) · Metabolites · doi:10.3390/metabo16010060 · Cited by 24

Insight into the roles of vitamins C and D against cancer: Myth or truth?

Zhao, C., Li, Y., Meng, X., Li, S., Liu, Q., Tang, G., Gan, R., & Li, H. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.039 · Cited by 23

Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy

Zaher, A., Stephens, L. M., Miller, A. M., Hartwig, S. M., Stolwijk, J. M., Petronek, M. S., Zacharias, Z. R., Wadas, T. J., Monga, V., Cullen, J. J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.989000 · Cited by 25

In Situ Silver‐Based Electrochemical Oncolytic Bioreactor

Huang, Y., Zhong, L., Li, X., Wu, P., He, J., Tang, C. W., Tang, Z., Su, J., Feng, Z., Wang, B., et al. (2022) · Advanced Materials · doi:10.1002/adma.202109973 · Cited by 22

Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy

Jung, I., An, J., & Ko, M. (2023) · Biomedicines · doi:10.3390/biomedicines11030654 · Cited by 22

Ascorbic acid modulates cell migration in differentiated HL‐60 cells and peripheral blood leukocytes

Schwager, J., Bompard, A., Weber, P., & Raederstorff, D. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400893 · Cited by 22

High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial

Paller, C. J., ZAHURAK, M. L., Mandl, A., Metri, N. A., Lalji, A., Heath, E. I., Kelly, W. K., Hoimes, C. J., Barata, P. C., Taksey, J. D., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0225 · Cited by 21

Parenteral high‑dose ascorbate - A possible approach for the treatment of glioblastoma (Review)

Renner, O., Burkard, M., Michels, H., Vollbracht, C., Sinnberg, T. W., & Venturelli, S. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5215 · Cited by 24

The Mechanisms of the Growth Inhibitory Effects of Paclitaxel on Gefitinib-resistant Non-small Cell Lung Cancer Cells

Mohiuddin, M., & Kasahara, K. (2021) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20288 · Cited by 21

The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review

Krejbich, P., & Birringer, M. (2022) · Antioxidants · doi:10.3390/antiox11112149 · Cited by 22

Balanced Duality: H2O2-Based Therapy in Cancer and Its Protective Effects on Non-Malignant Tissues

Zaher, A., Petronek, M. S., Allen, B. G., & Mapuskar, K. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168885 · Cited by 23

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

Mehdi, Z., Petronek, M. S., Stolwijk, J. M., Mapuskar, K. A., Kalen, A. L., Buettner, G. R., Cullen, J. J., Spitz, D. R., Buatti, J. M., & Allen, B. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910880 · Cited by 23

In vitro and in vivo assessment of high-dose vitamin C against murine tumors

Wang, G., Yin, T., & Wang, Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3707 · Cited by 20

Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression

Qin, S., Wang, G., Chen, L., Geng, H., Zheng, Y., Xia, C., Wu, S., Yao, J., & Deng, L. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010629 · Cited by 21

Ascorbate mediates the non-enzymatic reduction of nitrite to nitric oxide

Du, J., Filipović, M. R., Wagner, B. A., & Buettner, G. R. (2023) · Advances in Redox Research · doi:10.1016/j.arres.2023.100079 · Cited by 22

Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin

Rubiś, B., Łuczak, M. W., Krawic, C., & Zhitkovich, A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.03.026 · Cited by 21

Daily Lifestyle Modifications to Improve Quality of Life and Survival in Glioblastoma: A Review

Travers, S. S., & Litofsky, N. S. (2021) · Brain Sciences · doi:10.3390/brainsci11050533 · Cited by 19

Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy

Cushing, C. M., Petronek, M. S., Bodeker, K. L., Vollstedt, S., Brown, H. A., Opat, E., Hollenbeck, N. J., Shanks, T., Berg, D., Smith, B. J., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101804 · Cited by 20

Natural Health Products for Anti-Cancer Treatment: Evidence and Controversy

Conti, V., Polcaro, G., Bellis, E. D., Donnarumma, D., Rosa, F. D., Stefanelli, B., Corbi, G., Sabbatino, F., & Filippelli, A. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14070685 · Cited by 22

Combined effects of vitamin C and cold atmospheric plasma-conditioned media against glioblastoma via hydrogen peroxide

Yu, H., Song, X., Yang, F., Wang, J., Sun, M., Liu, G., Ahmad, N., Zhou, Y., Zhang, Y., Shi, G., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.028 · Cited by 18

Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

Brabson, J. P., Leesang, T. E., Yap, Y. S., Wang, J., Lam, M. Q., Fang, B., Dolgalev, I., Barbieri, D. A., Strippoli, V., Bañuelos, C. P., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112027 · Cited by 18

Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate

Petronek, M. S., Teferi, N., Caster, J. M., Stolwijk, J. M., Zaher, A., Buatti, J. M., Hasan, D. M., Wafa, E. I., Salem, A. K., Gillan, E. G., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102651 · Cited by 18

Current status and prospects of MOFs loaded with H 2 O 2 -related substances for ferroptosis therapy

Deng, Y., Huang, S., Jiang, G., Zhou, L., Nezamzadeh‐Ejhieh, A., Liu, J., & Zhou, Z. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00261j · Cited by 19

Data Triumph at C

Levine, M., & Violet, P.-C. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.03.008 · Cited by 17

High Dose Ascorbate Causes Both Genotoxic and Metabolic Stress in Glioma Cells

Castro, M., Carson, G. M., McConnell, M. J., & Herst, P. M. (2017) · Antioxidants · doi:10.3390/antiox6030058 · Cited by 18

Hepatomas are exquisitely sensitive to pharmacologic ascorbate (P-AscH-)

Zhang, X., Liu, T., Li, Z., Yanling, F., Corpe, C. P., Liu, S., Zhang, J., He, X., Liu, F., Li, X., et al. (2019) · Theranostics · doi:10.7150/thno.35378 · Cited by 18

Vitamin C protects carboplatin-exposed oocytes from meiotic failure

Zhou, C., Zhang, X., Zhang, Y., ShiYang, X., Yu, L., Shi, X., & Xiong, B. (2019) · Molecular Human Reproduction · doi:10.1093/molehr/gaz046 · Cited by 17

Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin

Oka, N., Komuro, A., Amano, H., Dash, S., Honda, M., Ota, K., Nishimura, S., Ueda, T., Akagi, M., & Okada, H. (2020) · Pharmacology Research & Perspectives · doi:10.1002/prp2.632 · Cited by 16

Preserved Ovarian Function Following Toxicity With Doxorubicin in Rats: Protective Effect of Nasturtium Officinale Extract

Rad, P., Safari, F., Mohammadi, J., & Delaviz, H. (2021) · Iranian Journal of Toxicology · doi:10.32598/ijt.15.1.747.1 · Cited by 17

Friend or Foe: The Relativity of (Anti)oxidative Agents and Pathways

Szarka, A., Lőrincz, T., & Hajdinák, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095188 · Cited by 18

Molecular mechanism of the unusual biphasic effects of the natural compound hinokitiol on iron-induced cellular DNA damage

Qin, M., Shao, B., Li, L., Zhang, Z., Sheng, Z.-G., Qin, L., Shao, J., & Zhu, B. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.042 · Cited by 17

Cobalt Single-Atom Nanozyme Co-Administration with Ascorbic Acid Enables Redox Imbalance for Tumor Catalytic Ablation

Ren, G., Lu, M., Zhao, Z., Qin, F., Li, K., Chen, W., & Lin, Y. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01301 · Cited by 18

Blue light promotes vitamin C-mediated ferroptosis of melanoma through specifically upregulating transporter SVCT2 and generating Fe2+

Yang, R., Deng, F., Yang, Y., Tian, Q. C., Huangfu, S., Yang, L., Hou, J., Yang, G., Pang, W., Lu, J., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122186 · Cited by 17

SERPINE1 and SERPINB7 as potential biomarkers for intravenous vitamin C treatment in non-small-cell lung cancer

Ou, J., Liao, Q., Du, Y., Xi, W., Meng, Q., Li, K., Cai, Q., & Pang, C. L. K. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.10.391 · Cited by 17

Antioxidant Roles/Functions of Ascorbic Acid (Vitamin C)

Agwu, E., Ezihe, C. O., & Kaigama, G. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110589 · Cited by 23

Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy

Erudaitius, D. T., Mantooth, J., Huang, A., Soliman, J., Doskey, C. M., Buettner, G. R., & Rodgers, V. G. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.044 · Cited by 17

A Retrospective Study of Gemcitabine and Carboplatin With or Without Intravenous Vitamin C on Patients With Advanced Triple-Negative Breast Cancer

Ou, J., Zhu, X., Zhang, H., Du, Y., Chen, P., Wang, J., Peng, X., Bao, S., Zhang, X., Zhang, T., et al. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735419895591 · Cited by 17

Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells

Shao, C., Wu, J., Han, S., Liu, Y., Su, Z., Zhu, H., Liu, H., & Qian, Y. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.114029 · Cited by 17

Pharmacological Vitamin C-induced high H2O2 generation mediates apoptotic cell death by caspase 3/7 activation in breast cancer tumor spheroids

Mussa, A., Hamid, M., Hajissa, K., Murtadha, A. H., Al-Hatamleh, M. A. I., Mokhtar, N. F., Uskoković, V., Plebanski, M., Mohamud, R., & Hassan, R. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06016-7 · Cited by 16

High-Dose Ascorbate in Combination with Anti-PD1 Checkpoint Inhibition as Treatment Option for Malignant Melanoma

Burkard, M., Niessner, H., Leischner, C., Piotrowsky, A., Renner, O., Marongiu, L., Lauer, U. M., Busch, C., Sinnberg, T. W., & Venturelli, S. (2023) · Cells · doi:10.3390/cells12020254 · Cited by 17

Vitamin C, a Multi-Tasking Molecule, Finds a Molecular Target in Killing Cancer Cells

Li, Y. R. (2016) · Reactive Oxygen Species · doi:10.20455/ros.2016.829 · Cited by 17

Identification of a DnaJC3 gene in Apis cerana cerana and its involvement in various stress responses

Zhang, X., Li, G., Yang, X., Wang, L., Wang, Y., Guo, X., Li, H., & Xu, B. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.08.007 · Cited by 16

Dietary Antioxidants and Human Cancer

Borek, C. G. (2017) · Journal of Restorative Medicine · doi:10.14200/jrm.2017.6.0105 · Cited by 16

L-Dehydroascorbate efficiently degrades non-thermal plasma-induced hydrogen peroxide

Okazaki, Y., Ishidzu, Y., Ito, F., Tanaka, H., Hori, M., & Toyokuni, S. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108762 · Cited by 15

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

Krishnamoorthy, J., Tenkerian, C., Gupta, J., Ghaddar, N., Wang, S., Darini, C., Staschke, K. A., Ghosh, A., Gandin, V., Topisirović, I., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0326-2 · Cited by 15

Drug Repurposing of Pantoprazole and Vitamin C Targeting Tumor Microenvironment Conditions Improves Anticancer Effect in Metastatic Castration-Resistant Prostate Cancer

Li, Z., He, P., Long, Y., Yuan, G., Shen, W., Chen, Z., Zhang, B., Wang, Y., Yue, D., Seidl, C., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.660320 · Cited by 15

Hydroxyl radical-involved cancer therapy via Fenton reactions

Liu, M., Xu, Y., Zhao, Y., Wang, Z., & Shi, D. (2021) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-021-2077-3 · Cited by 15

Protective Effects of omega-3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

Fahmy, H. A., El-Azime, A. S. A., & Gharib, O. A. (2016) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.50.4.17 · Cited by 15

High-dose vitamin C: A promising anti-tumor agent, insight from mechanisms, clinical research, and challenges

Zhao, H., Fu, W., Yang, X., Zhang, W., Wu, S., Ma, J., Zhang, T., Yao, H., & Zhang, Z. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101742 · Cited by 15

Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis

Jiang, X., Liu, J., Mao, J., Han, W., Fan, Y., Luo, T., Xia, J., Lee, M. J., & Lin, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122037 · Cited by 14

Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage

Sanookpan, K., Chantaravisoot, N., Kalpongnukul, N., Chuenjit, C., Wattanathamsan, O., Shoaib, S., Pithi Chanvorachote, B., & Buranasudja, V. (2023) · Antioxidants · doi:10.3390/antiox12091775 · Cited by 16

Effect of oocyte vitrification on glucose transport in mouse metaphase II oocytes

Wang, Y., Chang, H., He, Q., Xue, Y., Zhang, K., Kang, J., Wang, Y., Xu, Z., Zhang, Y., & Quan, F. (2021) · Reproduction · doi:10.1530/rep-21-0007 · Cited by 14

Emerging roles of lamins and DNA damage repair mechanisms in ovarian cancer

Sengupta, D., Mukhopadhyay, A., & Sengupta, K. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200713 · Cited by 13

New Emerging Therapeutic Strategies Based on Manipulation of the Redox Regulation Against Therapy Resistance in Cancer

Nazari, A., Osati, P., Fakhr, S. S., Faghihkhorasani, F., Ghanaatian, M., Faghihkhorasani, F., Rezaei‐Tazangi, F., Far, N. P., Shourideh, A., Ebrahimi, N., et al. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0491 · Cited by 13

The dual role of vitamin C in cancer: from antioxidant prevention to prooxidant therapeutic applications

Cao, X., Yi, Y., Ji, M., Liu, Y., Wang, D., & Zhu, H. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1633447 · Cited by 13

Effect of vitamins C and E on cancer survival; a systematic review

Mohseni, S., Tabatabaei‐Malazy, O., Ejtahed, H., Qorbani, M., Azadbakht, L., Khashayar, P., & Larijani, B. A. (2022) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-022-00451-x · Cited by 17

The Emerging Role of Cyclin-Dependent Kinase Inhibitors in Treating Diet-Induced Obesity: New Opportunities for Breast and Ovarian Cancers?

Dominguez-Benot, R., Cimini, A., Barone, D., Giordano, A., & Pentimalli, F. (2022) · Cancers · doi:10.3390/cancers14112709 · Cited by 13

The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: a triple-blind clinical trial

Gholami, M., Najafizadeh, H., Teimouri, H., Ardalan, A., Pooria, A., & Tarrahi, M. J. (2019) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2018-0113 · Cited by 13

Oxidized forms of dietary antioxidants: Friends or foes?

Poljšak, B., & Milisav, I. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.07.011 · Cited by 13

Distinct functions between ferrous and ferric iron in lung cancer cell growth

Hinokuma, H., Kanamori, Y., Ikeda, K., Li, H., Maruno, M., Yamane, T., Maeda, A., Nita, A., Shimoda, M., Niimura, M., et al. (2023) · Cancer Science · doi:10.1111/cas.15949 · Cited by 12

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Lin, C., Dong, J., Wei, Z., Cheng, K., Li, J., Song, Y., Liu, Y., Wang, X., & Chen, Z. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00635 · Cited by 11

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Rajendran, G., Taylor, J. A., & Woolbrigh, B. L. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.69 · Cited by 12

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Mukherjee, S., Dutta, A., & Chakraborty, A. (2021) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2021.108368 · Cited by 12

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Bharadwaj, R., & Medhi, S. (2021) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2021.1934858 · Cited by 12

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Scott, A. J., Lyssiotis, C. A., & Wahl, D. R. (2021) · The Cancer Journal · doi:10.1097/ppo.0000000000000550 · Cited by 11

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Hemilä, H., & Chalker, E. (2022) · Life · doi:10.3390/life12010062 · Cited by 13

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McConnell, M. J., & Herst, P. M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008488 · Cited by 12

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Kong, H., & Chandel, N. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00030-4 · Cited by 12

Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells

Gregoraszczuk, E. Ł., Zajda, K., Tekla, J., Respekta, N., Zdybał, P., & Such, A. (2020) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000634 · Cited by 12

Combination treatment of cordycepin and radiation induces MA-10 mouse Leydig tumor cell death via ROS accumulation and DNA damage.

Lee, Y.-P., Lin, C.-R., Chen, S.-S., Chen, R.-J., Wu, Y.-H., Chen, Y., & Huang, B. (2023) · PubMed Central · Cited by 11

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Gaur, T., Ali, A., Sharma, D., Gupta, S. K., Gota, V., Bagal, B. P., Platzbeckar, U., Mishra, R., Dutt, A., Khattry, N., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.111004 · Cited by 11

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Mastrangelo, D., Massai, L., Fioritoni, G., & Lo‐Coco, F. (2017) · InTech eBooks · doi:10.5772/intechopen.68746 · Cited by 13

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Miura, K., Haraguchi, M., Ito, H., & Tai, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020535 · Cited by 11

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Chen, B., Dong, X., Dong, X., Wang, Q., Wu, M., Wu, J., Lou, X., Xia, F., Wang, W., Dai, J., et al. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s291285 · Cited by 11

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Locasale, J. W., Goncalves, M. D., Tano, M. D., & Burgos-Barragan, G. (2024) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041549 · Cited by 12

Iron oxide nanozymes enhanced by ascorbic acid for macrophage-based cancer therapy

Yi, Z., Yang, X., Liang, Y., & Tong, S. (2024) · Nanoscale · doi:10.1039/d4nr01208a · Cited by 11

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Zhuang, F., Bai, X., Shi, Y., Chang, L., Ai, W., Du, J., Liu, W., Liu, H., Zhou, X., Wang, Z., et al. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.913967 · Cited by 10

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Zhao, Y., Yu, X., Kong, W., Kong, R., Zhang, E., Xia, L., Zhang, J., Qu, F., & Tan, W. (2023) · Chemical Science · doi:10.1039/d3sc02945j · Cited by 10

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Yin, X., Guo, Z., & Song, C. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09050-8 · Cited by 10

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Rodriguez, D., Guerrero, M. E., Maldonado, B. M., Vollbracht, C., & Herrera, S. A. (2017) · Translational Medicine Communications · doi:10.1186/s41231-017-0012-x · Cited by 10

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Cioloboc, D., & Kurtz, D. M. J. (2020) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-020-01774-3 · Cited by 10

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(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-043 · Cited by 1

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Parrow, N. L., Leshin, J. A., & Levine, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5372 · Cited by 101

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Zhou, L., Zhao, X., Wang, S., Lv, H., Shaikh, A. B., & Shang, P. (2020) · Research Square · doi:10.21203/rs.3.rs-69358/v1

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Boretti, A. A. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110290 · Cited by 1

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Schoenfeld, J. D., Spitz, D. R., Allen, B. G., Buettner, G. R., Cullen, J. J., Domann, F. E., & Weiner, G. J. (2018) · doi:10.17077/etd.yahmbqfe