High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

A simple technique for quantitation of low levels of DNA damage in individual cells

Singh, N. P., McCoy, M. T., Tice, R. R., & Schneider, E. L. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90265-0 · Cited by 10,828

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Chou, T.-C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.10 · Cited by 5,163

Rapid colorimetric assay for cell growth and survival

Denizot, F., & Lang, R. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90368-6 · Cited by 4,935

The metabolism of tumors in the body

Warburg, O., Wind, F., & Negelein, E. (1927) · Journal of General Physiology · doi:10.1085/jgp.8.6.519 · Cited by 4,416

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues

Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075

Vitamin C pharmacokinetics: Implications for oral and intravenous use

Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

Chen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717

The Role of Nutrition in Cancer: From Cellular and Molecular Perspective

Rasaei, N., Ildarabadi, A., Rahmani, F., Shiravi, F., Shoaibinobarian, N., & Tahvildari, A. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_354 · Cited by 1

Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway

Zhao, L., Wu, Y., Zhang, X., Li, Y., Li, Y., & Fu, Z. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01760-w · Cited by 1

Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer

Jameson, G., Legrand, S. D., Gordon, M. S., Roe, D. J., Wertheim, B. C., Olszewski, K. L., Rabinowitz, J. D., Evans, R. M., Downes, M., Truitt, M., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103895 · Cited by 1

Pharmacology of Vitamin C in the Treatment of Cancer: A Comprehensive Review

Jamwal, K., Komal, D., & Verma, K. K. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i1.7531 · Cited by 1

Characterizing clinical toxicity in cancer combination therapies

Wong, A. M., Meier-Scherling, C. P. G., & Crawford, L. A. (2026) · Bioinformatics · doi:10.1093/bioinformatics/btag007 · Cited by 1

High-dose ascorbic acid prolongs the suppression of cell proliferation by enhancing intracellular oxidative stress–induced damage and inhibits invasion and adhesion in human fibrosarcoma HT-1080 cells

Saitoh, Y., Tanimura, Y., Ueda, S., Furuhata, T., Takeda, M., Okawachi, K., & Fukukita, Y. (2026) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2026.130908 · Cited by 1

Unexplored potential of carrot ( Daucus carota L.) bioactive in combating cancer: an insight into intricate mechanisms

Kumar, S., Kesawat, M. S., Kherawat, B. S., Singh, A., Kumar, A., Kumari, S., Alamery, S. F., Singh, P., Masika, F. B., & Manohar, S. (2026) · All Life · doi:10.1080/26895293.2026.2619329 · Cited by 1

Low-Dose Vitamin C-Based Electroporation of Solid Tumors: A New Area in Non-Cytotoxic Electrochemotherapy

Yazdanparast, S. M., Manoochehri, N., & Abdolahad, M. (2026) · Biomedicines · doi:10.3390/biomedicines14040936 · Cited by 1

Could vitamin C be a useful adjunct to chemotherapy?

Killock, D. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.34 · Cited by 1

The role of antioxidant vitamins in gynecologic malignancies

Markowska, A., Jaszczyńska-Nowinka, K., Kaysiewicz, J., Roche Polska, W., Makówka, A., Roche Polska, W., & Markowska, J. (2016) · Ginekologia Onkologiczna/Current Gynecologic Oncology · doi:10.15557/cgo.2016.0005

Mit Bedacht kombinieren

Holzhauer, P. (2018) · Deutsche Zeitschrift für Onkologie · doi:10.1055/s-0044-101802 · Cited by 1

Vitamine und Spurenelemente in der Onkologie

Holch, J. W., Michl, M., Heinemann, V., & Erickson, N. T. (2018) · TumorDiagnostik & Therapie · doi:10.1055/a-0635-5628 · Cited by 1

EFFICIENCY OF FISH OIL IN PROTECTION OF PERIODONTAL LIGAMENT AND MANDIBULAR BONE OF RATS TREATED WITH CISPLATIN AND GAMMA RADIATION

Ahmed, S. F. (2017) · Egyptian Dental Journal /Egyptian Dental Journal · doi:10.21608/edj.2017.76182 · Cited by 1

Vitamin C: Current Concepts in Human Physiology

Carr, A. C., & Natarajan, R. (2018) · MDPI eBooks · doi:10.3390/books978-3-03897-295-2 · Cited by 1

Cancer

Noakes, T. D., Kalamian, M., Seyfried, T. N., Mukherjee, P., D’Agostino, D. P., Arismendi-Morillo, G., Chinopoulos, C., Tettenborn, M., & Winters, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821617-0.00012-7 · Cited by 1

Biopolymer Bacterial Cellulose Produced by Bacteria and Its Use in Health

Bayraktar, A. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1286 · Cited by 1

Balance and Physical Activity in Children with Neurodevelopmental Disorders

Candiri, B., Arıkan, A. N., & Çolak, S. C. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1255 · Cited by 1

The Future of Ovarian Cancer Treatment: The Promise of Epigenetic Markers

Alghazawi, F., Azami, N., Dehghani, A., Aslan, E. S., & Eslamkhah, S. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1253 · Cited by 1

Pharmacologic ascorbate induces transient hypoxia sensitizing pancreatic ductal adenocarcinoma to a hypoxia activated prodrug

Kishimoto, S., Crooks, D. R., Otowa, Y., Kota, Y., Yamamoto, K., Linehan, W. M., Levine, M. N., Krishna, M. C., & Brender, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.008 · Cited by 1

Ascorbic acid regulates in vitro and in vivo toxicogenetic effects of hydroxyurea on eukaryotic cells

de Aguiar, R. P. S., Souza, J. M. T., de Menezes, A. P. M., do Nascimento, M. L. L. B., Sousa, J. M. D. C. E., Cavalcante, A. A. D. C. M., Ferreira, P. M. P., Araújo, A. J., & Filho, J. D. B. M. (2024) · Drug and Chemical Toxicology · doi:10.1080/01480545.2024.2425990 · Cited by 1

Phytochemical Inhibitors of SARS‐CoV‐2 Entry: Targeting the ACE2‐RBD Interaction with l ‐Tartaric Acid, l ‐Ascorbic Acid, and Curcuma longa Extract

Najimi, N., Amssayef, A., Bouadid, I., Hakmi, M., Festali, R., Kadi, C., Seghrouchni, F., Hassani, R. A. E., Eddouks, M., & Bakri, Y. (2025) · ChemistrySelect · doi:10.1002/slct.202406035 · Cited by 1

Suppression of Paclitaxel‐Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE‐2‐PyP 5+ (BMX‐001)

Spasojević, I., Huang, Z., da Silva, W. T. A., Duan, W., Du, L., Chen, C., Cao, J., Zhang, S., Lee, H., Lo, G., et al. (2025) · Oxidative Medicine and Cellular Longevity · doi:10.1155/omcl/6333148 · Cited by 1

Cell‐Type‐Dependent Differential Cytotoxic and Genotoxic Effects: Comprehensive Mechanistic Insights of L ‐Ascorbic Acid on Healthy Lymphocytes and HL‐60 Cancer Cells

Hüsunet, M. T., Yılmaz, M. B., & İla, H. B. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.70093 · Cited by 1

Znaczenie witaminy C dla organizmu człowieka

Zawada, K. D. (2016) · HERBALISM · doi:10.12775/herb.2016.002 · Cited by 1

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Holzhauer, P. (2017) · Deutsche Heilpraktiker-Zeitschrift · doi:10.1055/s-0043-113060 · Cited by 1

Chloroquine Inhibits Self-Renewal of Blast Progenitors Synergistically With Phytochemicals or Nonsteroidal Anti-inflammatory Drugs in Hematological Malignant Cell Lines

Kawaguchi-Ihara, N., Zhao, Y., NAKAMURA, S., Suzuki, K., Zhang, Y., Tohda, S., & MUROHASHI, I. (2018) · Anticancer Research · doi:10.21873/anticanres.13083 · Cited by 1

Alternative medicine: therapeutic effects on gastric original signet ring carcinoma via ascorbate and combination with sodium alpha lipoate

Chen, W., Xu, L., Chang, E., Gowrishankar, G., Ferrara, K. W., & Gambhir, S. S. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03541-0 · Cited by 1

Cytotoxicity of ascorbate to cancer cells: mathematical modelling, mechanisms and clinical implications

Chen, C. (2015) · The University of Queensland · doi:10.14264/uql.2015.292 · Cited by 1

Vitamin C administration by intravenous infusion increases tumour ascorbate content in patients with colon cancer: a clinical intervention studyPreprint

Dachs, G. U., Gandhi, J., Wohlrab, C., Carr, A. C., Morrin, H. R., Pullar, J. M., Bayer, S. B., Eglinton, T., Robinson, B. A., & Vissers, M. C. M. (2020) · doi:10.21203/rs.3.rs-65137/v1 · Cited by 1

Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint

Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2024) · eLife · doi:10.7554/elife.94988.1 · Cited by 1

Factors Related to Serum Vitamin C Level in Terminally Ill Cancer Patients

Kim, H. J., Hwang, I. C., Yeom, C. H., Ahn, H. Y., Choi, Y. S., Lee, J. J., & Lim, S. H. (2014) · The Korean Journal of Hospice and Palliative Care · doi:10.14475/kjhpc.2014.17.4.241

Tumor-Specific Induction of Oxidative Stress with Dichloroacetate and Auranofin May Complement the Efficacy of PARP Inhibition in Cancer Control

Carty, M. F. M. (2014) · Chemotherapy Open access · doi:10.4172/2167-7700.1000143

The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation

Carson, G. (2016) · doi:10.26686/wgtn.17014772

The use of high‐dose intravenous vitamin C in the management of cancer: a case for vitamin C in the management of cancer

Ewer, T. (2016) · Focus on Alternative and Complementary Therapies · doi:10.1111/fct.12275

Vitamine und Spurenelemente in der Onkologie

Holch, J. W., Michl, M., Heinemann, V., & Erickson, N. T. (2018) · Aktuelle Ernährungsmedizin · doi:10.1055/a-0600-0535

Unterstützende Infusionen in der integrativen Onkologie bei Brustkrebs und gynäkologischen Krebserkrankungen – Bericht über die Zufriedenheit der Patientinnen sowie über selbstberichtete Wirkungen und Nebenwirkungen

Hack, C. C., Antoniadis, S., Beckmann, M. W., Brandl, A. L., Fasching, P. A., Hackl, J., Langemann, H., Katja, S., Weber, N., & Theuser, A. (2019) · Senologie - Zeitschrift für Mammadiagnostik und -therapie · doi:10.1055/a-0894-7181

Examining the markers of vitamin C cytotoxicity in pancreatic ductal adenocarcinoma

Warren, C. (2019) · cIRcle (University of British Columbia) · doi:10.14288/1.0377751

Oncothermia in Combination with Vitamin C Infusion for Non-small Cell Lung Cancer: a Case Report

Ou, J. W., Lu, Y., Zhu, X. Y., & Pang, C. L. K. (2019) · journal of nutritional oncology · doi:10.34175/jno201903007

Anticancer activity of vitamin C

Woźniak, M., Bieńkowska, A., Stachowiak, N., & Małecki, M. (2018) · Farmacja Polska · doi:10.32383/farmpol/118779

Vitamine und Spurenelemente

Hack, C. C., & Wasner, S. (2020) · Der Gynäkologe · doi:10.1007/s00129-020-04727-8

Pharmacological ascorbate and use in pancreatic cancer

Carroll, R. S., Buettner, G. R., & Cullen, J. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819547-5.00046-8

Witaminy i mikroelementy w chemoprewencji raka błony śluzowej trzonu macicy oraz raka jajnika

Plagens-Rotman, K. (2021) · Pielęgniarstwo Polskie · doi:10.20883/pielpol.2021.3

In Situ Silver-based Electrochemical Bioreactor In VivoPreprint

Huang, Y. D., Zhong, L., Deng, Z., Wu, P., He, J., Bai, Z., Zhong, Y. P., Peng, H., Zhang, K., Liang, X., et al. (2020) · doi:10.21203/rs.3.rs-103588/v1

Pharmacological Ascorbate Induces Osteosarcoma Cells Death via H2O2 Mediated-Oxidative Stress and Enhances the Efficacy of Cisplatin in OsteosarcomaPreprint

Zhou, L., Zhao, X., Wang, S., Lv, H., Shaikh, A. B., & Shang, P. (2020) · Research Square · doi:10.21203/rs.3.rs-69358/v1

Vitamin C in Cancer Management: Clinical Evidence and Involvement of Redox Role

Bhattacharya, S. (2021) · Springer eBooks · doi:10.1007/978-981-15-4501-6_161-1

Developments of Profluorescent Nitroxide Probes for Highly Sensitive and Selective Detection of Biological Redox Molecules

Matsuoka, Y. (2021) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.21-00149

High Dose Intravenous Vitamin C as Adjunctive Therapy for COVID-19 Patients with Cancer: Two Cases

Guo, G., Chen, Q., Luo, G., Meng, Z., Pan, L., Chen, P., & Drisko, J. (2022) · Life · doi:10.3390/life12030335 · Cited by 1

SERPINB7, TMEM158, and SERPINE1 signature as predictors of non-small-cell lung cancer prognosis after intravenous vitamin C treatmentPreprint

Ou, J., Liao, Q., Du, Y., Xi, W., Meng, Q., Li, K., Cai, Q., & Pang, C. L. K. (2022) · Research Square · doi:10.21203/rs.3.rs-1472206/v1

Pharmacological possibilities of vitamin C in oncology

Lapka, M. (2022) · Vnitřní lékařství · doi:10.36290/vnl.2022.025

Prevention of Fertility Due to Chemotherapy-Induced Ovarian Failure: Role of Therapeutic Antioxidants

Melekoğlu, R., Doğan, Ü. K., Çelik, N. Z., & Yılmaz, E. (2022) · Handbook of Oxidative Stress in Cancer: Therapeutic Aspects · doi:10.1007/978-981-16-1247-3_10-1

The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation

Carson, G. (2016) · doi:10.26686/wgtn.17014772.v1

Faculty Opinions recommendation of Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.

Western, P. S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726696342.793554069

In This Issue

Block, K. I. (2014) · Integrative Cancer Therapies · doi:10.1177/1534735414540997

Anti-Cancer and Stress Response Pathway Effects of Nanosilver and Sodium Ascorbate

Cameron, S. J. (2022) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2022-15048

Improving outcome of haematopoietic stem cell transplantation

van Gorkom, G. N. Y. (2022) · Research Publications (Maastricht University) · doi:10.26481/dis.20220616gg

Vitamin C: is there a place in anticancer treatment?

Gerk, I., & Moiseenko, V. M. (2022) · Practical oncology · doi:10.31917/2303133

Supplementary Figure from A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study)

Wang, F., He, M.-M., Xiao, J., Zhang, Y., Yuan, X., Fang, W. J., Zhang, Y., Wang, W., Hu, X.-H., Ma, Z., et al. (2023) · doi:10.1158/1078-0432.22488381

Effect of Triple IV therapy (Artesunate, Ascorbate, and Doxycycline) on Circulating Tumor Cells and DNA: Two Consecutive Cases

Standish, L. J. (2022) · Cancer therapy & Oncology International Journal · doi:10.19080/ctoij.2022.22.556092

Vitamina C en el manejo de la sepsis

Rodríguez-Vélez, J., Rivera-Diaz, A., Báez-Gutiérrez, P., Fonseca-Ferrer, V., & Rodríguez-Cintrón, W. (2023) · Revista de Educación en Cuidados Críticos (REduCrític) · doi:10.24875/recc.23000006

Studienevidenz zu Vitamin-C-Infusionen in der Onkologie

Vollbracht, C. (2023) · Erfahrungsheilkunde · doi:10.1055/a-2107-7184

ANTIMICROBIAL EFFECT OF HIGH DOSE ASCORBATE IN MOUSE MODEL WITH BACTERIAL INFECTION

Wirapakorn, C. (2017) · doi:10.58837/chula.the.2017.353

Current Researches in Health Sciences-III

BİLGİLİ, A., Baygutalp, F., Duysak, L., Urhan, E., Can, H. Y., Alkan, S., Şevik, A. E., Keskindağ, B., Tosun, V., Depboylu, B., et al. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305

The Importance of Non-vitamin K Antagonists (NOAC) in Their Current Use

Tosun, V. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1250

The Impact of Genetic Mutational Typing of Endometrial Carcinoma for Adjuvant Oncologic Treatment and Treatment Outcome

Depboylu, B. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1251

Evaluation of Eating Disorder Within the Scope of Addiction Concept

Gördağ, M., & Uysal, İ. İ. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1258

Bacillus cereus Isolates Obtained from Food Used in Infant and Child Nutrition

Urhan, E., & Can, H. Y. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1247

Understanding Smoking Behaviour: Interpretative Phenomenological Analysis Highlighting Cognitive Dissonance

Keskindağ, B. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1249

Robotics in Healthcare: A Brief Introduction

Büyükşirin, B. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1254

Cartilage Oligomeric Matrix Protein (COMP) As a Candidate Biomarker in Osteoarthritis

Baygutalp, F., & Duysak, L. (2023) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub305.c1246

Current Status of Antioxidants in clinical practices - A Review

Bhure, A. S., Joshi, A., Khanavkar, R., & Agashe, A. (2023) · International Journal of Allied Medical Sciences and Clinical Research · doi:10.61096/ijamscr.v11.iss4.2023.487-495

Successful Treatment, with Chemotherapy and Intravenous Administration of Ascorbic Acid, of a Patient with Peripheral T-Cell Lymphoma, Not Otherwise Specified

Tokoro, C., Tashiro, A., Ina, K., Tanaka, Y., Kobayakawa, H., Yoshida, T., & Kayukawa, S. (2024) · Journal of cancer research updates · doi:10.30683/1929-2279.2024.13.01

Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint

Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2024) · eLife · doi:10.7554/elife.94988

Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated ProdrugPreprint

Kishimoto, S., Crooks, D. R., Otowa, Y., Kota, Y., Yamamoto, K., Linehan, W. M., Levine, M. N., Krishna, M. C., & Brender, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.13.593896

Supplementary: Trial Protocol from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial

Paller, C. J., ZAHURAK, M. L., Mandl, A., Metri, N. A., Lalji, A., Heath, E. I., Kelly, W. K., Hoimes, C. J., Barata, P. C., Taksey, J. D., et al. (2024) · doi:10.1158/2767-9764.26788888.v1

Supplementary: Trial Protocol from High-Dose Intravenous Vitamin C Combined with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase II Trial

Paller, C. J., ZAHURAK, M. L., Mandl, A., Metri, N. A., Lalji, A., Heath, E. I., Kelly, W. K., Hoimes, C. J., Barata, P. C., Taksey, J. D., et al. (2024) · doi:10.1158/2767-9764.26788888

To Elucidate the Effective Role of Small Molecule Regulated lncRNAs in the Tumour Microenvironment in Immunotherapy

Al-Qaysi, A. S. A., Alkan, A. H., Gadashli, İ., & Cansaran‐Duman, D. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673318929240829065611

Case report: The efficacy of adding high doses of intravenous vitamin C to the combination therapy of atezolizumab and bevacizumab in unresectable HCC

Kian, W., Remilah, A. A., Shatat, C., Spector, M., Roisman, L. C., & Ryvo, L. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1461127

Alkalinising of the Acidic Tumour Microenvironment Makes Cancer Treatment Easier and Milder

Wada, H., Hamaguchi, R., Isowa, M., Narui, R., Morikawa, H., & Okamoto, T. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_456

Critical evaluation of intravenous vitamin C in practice

Lapka, M. (2024) · Medicína pro praxi · doi:10.36290/med.2024.033

Substanzen

Hübner, J. (2024) · Elsevier eBooks · doi:10.1016/b978-3-437-15076-0.00002-8

Functional food for cancer management: integrating complementary approaches

Karabacak, A. Ö., Demir, B. S., Tamer, C. E., Saygıdeğer, Y., & Süfer, Ö. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-28862-3.00014-5

Combination Therapy with Pharmacological Ascorbate and Rucosopasem Selectively Radiosensitizes Colorectal Tumors to Clinically Relevant Radiation Doses

George, B. N., Pulliam, C. F., Petronek, M. S., King, S. A., Awasthi, K., Fath, M. A., O’Leary, B. R., Loeffler, B. T., Spitz, D. R., Howard, M. E., et al. (2026) · Radiation Research · doi:10.1667/rade-26-00056.1

Ascorbate induces G2/M arrest and necrosis without generation of direct DNA double-strand breaks

Hariri, M., Papalanis, E., Spiegelberg, D., Plotnikov, E. V., Viktorsson, K., & Stenerlöw, B. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e43964

Exploiting vitamin C as a prooxidant to activate ROS-responsive prodrugs for potent and selective tumor killing

Ali, T., Ponnamperumage, T. N. F., Miller, C. J., Li, D., Awoyera, W. O., Peterson, A. K., Gao, H., Pandey, J., Jakusz, J. A. R., Fan, H., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104229

Additional file 1 of Alternative medicine: therapeutic effects on gastric original signet ring carcinoma via ascorbate and combination with sodium alpha lipoate

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Modélisation des interactions entre trois médicaments actifs sur une lignée cellulaire de cancer du pancréas

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Vitamin C as an Adjunctive Therapy in Cancer

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Beyond redox: vitamin C in signaling, epigenetic regulation and protein modification—relevance to cancer therapy

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Nutrition as Modulator of Oxidative Stress in Cancer Prevention and Treatment

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Interactions of Salicyluric Acid with Metal Ions and Ascorbic Acid: Possible Biological and Toxicity Implications in Aspirin Use

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IV Vitamin C with Chemotherapy for Cisplatin-Ineligible Bladder Cancer Patients: A Forgotten Group

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Ascorbate is a physiological tumor suppressor metabolite in leukemiaPreprint

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Misleading and erroneous papers on vitamin C: A list of critiques by Harri Hemilä

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Parenteral Ascorbate Is Beneficial in Ovarian Cancer Therapy

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The role of redox-active iron metabolism in the selective toxicity of pharmacological ascorbate in cancer therapy

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