Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363

Metabolic Regulation of T Lymphocytes

MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,141

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 747

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

Blagih, J., Coulombe, F., Vincent, E. E., Dupuy, F., Galicia-Vázquez, G., Yurchenko, E., Raissi, T. C., van der Windt, G. J. W., Viollet, B., Pearce, E. L., et al. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.030 · Cited by 679

Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells

Terraza‐Aguirre, C., Campos‐Mora, M., Elizondo-Vega, R. J., Contreras-López, R. A., Luz‐Crawford, P., Jørgensen, C., & Djouad, F. (2020) · Cells · doi:10.3390/cells9071660 · Cited by 50

Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity

Seki, S. M., & Gaultier, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01549 · Cited by 49

Immunometabolism, pregnancy, and nutrition

Thiele, K., Diao, L., & Arck, P. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0660-y · Cited by 48

Origins of rheumatoid arthritis

Boissier, M., Biton, J., Semerano, L., Decker, P., & Bessis, N. (2019) · Joint Bone Spine · doi:10.1016/j.jbspin.2019.11.009 · Cited by 51

The Untapped Opportunity and Challenge of Immunometabolism: A New Paradigm for Drug Discovery

Mazumdar, C., Driggers, E. M., & Turka, L. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.014 · Cited by 47

Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections

Chi, X., Huang, M., Tu, H., Zhang, B., Lin, X., Xu, H., Dong, C., & Hu, X. (2023) · Science China Life Sciences · doi:10.1007/s11427-021-2187-3 · Cited by 47

Metabolic dysregulation of lymphocytes in autoimmune diseases

Wang, S., Yang, N., & Zhang, H. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.01.005 · Cited by 49

Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity

Liebmann, M., Korn, L., Janoschka, C., Albrecht, S., Lauks, S., Herrmann, A. M., Schulte‐Mecklenbeck, A., Schwab, N., Schneider‐Hohendorf, T., Eveslage, M., et al. (2021) · Brain · doi:10.1093/brain/awab307 · Cited by 44

T cell aging as a risk factor for autoimmunity

Liu, Q., Zheng, Y., Goronzy, J. J., & Weyand, C. M. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102947 · Cited by 48

Targeting age‐specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival

Nian, Y., Iske, J., Maenosono, R., Minami, K., Heinbokel, T., Quante, M., Yang, L., Azuma, H., Yang, J., Abdi, R., et al. (2021) · Aging Cell · doi:10.1111/acel.13299 · Cited by 42

ALOX5 drives the pyroptosis of CD4 + T cells and tissue inflammation in rheumatoid arthritis

Cai, H., Zhang, J., Xu, H., Sun, W., Wu, W., Dong, C., Zhou, P., Xue, C., Nan, Y., Ni, Y., et al. (2024) · Science Signaling · doi:10.1126/scisignal.adh1178 · Cited by 42

Immunometabolic shifts in autoimmune disease: Mechanisms and pathophysiological implications

Chen, Y., Lin, Q., Cheng, H., Xiang, Q., Zhou, W., Wu, J., & Wang, X. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103738 · Cited by 41

Metabolic Fitness of T Cells in Autoimmune Disease

Wu, B., Goronzy, J. J., & Weyand, C. M. (2020) · Immunometabolism · doi:10.20900/immunometab20200017 · Cited by 37

CD4+ T cell metabolism, gut microbiota, and autoimmune diseases: implication in precision medicine of autoimmune diseases

Yang, W., Yu, T., & Cong, Y. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac018 · Cited by 42

Redox mechanisms in autoimmune thyroid eye disease

Buonfiglio, F., Ponto, K. A., Pfeiffer, N., Kahaly, G. J., & Gericke, A. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103534 · Cited by 40

Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils

Hua, P., Liang, R., Tu, Y., Yin, Y., Law, M. K., & Chen, M. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.021 · Cited by 38

The role of metabolism in the pathogenesis of systemic sclerosis

Zhu, H., Chen, W., Liu, D., & Luo, H. (2018) · Metabolism · doi:10.1016/j.metabol.2018.12.004 · Cited by 38

Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions

Masoumi, M., Alesaeidi, ‬., Khorramdelazad, H., Behzadi, M., Baharlou, R., Alizadeh‐Fanalou, S., & Karami, J. (2022) · Inflammation · doi:10.1007/s10753-022-01751-9 · Cited by 41

T-cell senescence: A crucial player in autoimmune diseases

Lu, Y., Ruan, Y., Pan, H., Rui, K., Liu, Q., Wang, S., & Cui, D. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109202 · Cited by 41

Macrophage Membrane‐Reversibly Cloaked Nanotherapeutics for the Anti‐Inflammatory and Antioxidant Treatment of Rheumatoid Arthritis

Shan, B., Zhou, Y., Yin, M., Deng, Y., Ge, C., Liu, Z., Zhou, R., Dong, Q., Zhou, X., & Yin, L. (2023) · Small Methods · doi:10.1002/smtd.202300667 · Cited by 38

The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis

Wang, Z., Zhang, J., An, F., Zhang, J., Meng, X., Liu, S., Xia, R., Wang, G., & Yan, C. (2023) · Arthritis Research & Therapy · doi:10.1186/s13075-023-03159-8 · Cited by 39

G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity

Yang, C., Huang, H., Lin, C., & Chang, J. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2911-8 · Cited by 37

Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

Walls, J. F., Subleski, J. J., Palmieri, E. M., Gonzalez-Cotto, M., Gardiner, C. M., McVicar, D. W., & Finlay, D. K. (2020) · eLife · doi:10.7554/elife.59166 · Cited by 35

Influence of the microenvironment on modulation of the host response by typhoid toxin

Martin, O. C. B., Bergonzini, A., Chiloeches, M. L., Paparouna, E., Butter, D., Theodorou, S. D. P., Haykal, M. M., Boutet-Robinet, E. A., Tebaldi, T., Wakeham, A. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108931 · Cited by 34

Metabolic Factors that Contribute to Lupus Pathogenesis

Li, W., Sivakumar, R., Titov, A. A., Choi, S., & Morel, L. M. (2016) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2016017164 · Cited by 35

Metabolic checkpoints in rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2024) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2024.152586 · Cited by 38

Immunometabolic Regulation of Interleukin-17-Producing T Helper Cells: Uncoupling New Targets for Autoimmunity

Binger, K. J., Côrte‐Real, B. F., & Kleinewietfeld, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00311 · Cited by 36

Immunometabolism changes in fibrosis: from mechanisms to therapeutic strategies

Feng, L., Chen, X., Huang, Y., Zhang, X., Zheng, S., & Xie, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1243675 · Cited by 35

Roles of Reactive Oxygen Species in Rheumatoid Arthritis Pathogenesis

Yoo, S., Go, E., Kim, Y.-E., Lee, S., & Kwon, J. (2016) · Journal of Rheumatic Diseases · doi:10.4078/jrd.2016.23.6.340 · Cited by 33

Immune cell metabolism in autoimmunity

Teng, X., Li, W., Cornaby, C., & Morel, L. M. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13277 · Cited by 33

Immune Cell Metabolism in Systemic Lupus Erythematosus

Choi, S., Titov, A. A., Sivakumar, R., Li, W., & Morel, L. M. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0615-7 · Cited by 32

Sex hormone influence on female-biased autoimmune diseases hints at puberty as an important factor in pathogenesis

Yang, Q., Kennicott, K., Zhu, R., Kim, J., Wakefield, H., Studener, K., & Liang, Y. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1051624 · Cited by 36

The paradox of aging: Aging-related shifts in T cell function and metabolism

Quinn, K. M., Moreno-Vicencio, D., & Gruta, N. L. L. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101834 · Cited by 28

Novel therapeutic strategy for cancer and autoimmune conditions: Modulating cell metabolism and redox capacity

Fan, X., Pan, H., Li, Y., Guo, R., Leung, E. L., & Liu, L. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.06.010 · Cited by 28

DNA Damage Response Signals Transduce Stress From Rheumatoid Arthritis Risk Factors Into T Cell Dysfunction

Shao, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03055 · Cited by 29

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis

Mensah, K. A., Chen, J. W., Schickel, J., Isnardi, I., Yamakawa, N., Vega-Loza, A., Anolik, J. H., Gatti, R. A., Gelfand, E. W., Montgomery, R. R., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw4626 · Cited by 30

Roles of Altered Macrophages and Cytokines: Implications for Pathological Mechanisms of Postmenopausal Osteoporosis, Rheumatoid Arthritis, and Alzheimer’s Disease

Xu, Y., Yan, H., Zhang, X., Zhuo, J., Han, Y., Zhang, H., Xie, D., Lan, X., Cai, W., Wang, X., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.876269 · Cited by 29

Metabolism of T Lymphocytes in Health and Disease

Gaber, T., Chen, Y., Krauß, P.-L., & Buttgereit, F. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.06.002 · Cited by 32

Redox Pathogenesis in Rheumatic Diseases

Laniak, O. T., Winans, T., Patel, A., Park, J. S., & Perl, A. (2024) · ACR Open Rheumatology · doi:10.1002/acr2.11668 · Cited by 28

tRNA derived fragment (tRF)-3009 participates in modulation of IFN-α-induced CD4+ T cell oxidative phosphorylation in lupus patients

Geng, G., Wang, H., Xin, W., Liu, Z., Chen, J., Zhang, D., Han, F., & Ye, S. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02967-3 · Cited by 28

An overview of multi-omics technologies in rheumatoid arthritis: applications in biomarker and pathway discovery

Gong, X., Su, L., Huang, J., Liu, J., Wang, Q., Luo, X., Yang, G., & Chi, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1381272 · Cited by 30

Cell type-specific regulation of the pentose phosphate pathway during development and metabolic stress-driven autoimmune diseases: Relevance for inflammatory liver, renal, endocrine, cardiovascular and neurobehavioral comorbidities, carcinogenesis, and aging

Bánki, K., & Perl, A. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103781 · Cited by 27

Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished TH17 but Enhanced Treg Differentiation

Liang, J., Ziegler, J. D., Jahraus, B., Orlik, C., Blatnik, R., Blank, N., Niesler, B., Wabnitz, G. H., Ruppert, T., Hübner, K., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01172 · Cited by 29

ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer

Wang, Z., Zhang, X., Li, W., Su, Q., Huang, Z., Zhang, X., Chen, H., Mo, C., Huang, B., Ou, W., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001758 · Cited by 27

Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Cachat, J., Deffert, C., Alessandrini, M., Roux‐Lombard, P., Gouëllec, A. L., Stasia, M. J., Hugues, S., & Krause, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01555 · Cited by 27

Mitochondria as disease-relevant organelles in rheumatoid arthritis

Weyand, C. M., Wu, B., Huang, T., Hu, Z., & Goronzy, J. J. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac107 · Cited by 29

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Hu, Y., Zhao, Q., Dai, H., Wu, Y., Tang, X., Zhang, N., Jiang, H., Rui, H., & Liu, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1687755 · Cited by 26

A robust intracellular metabolite extraction protocol for human neutrophil metabolic profiling

Chokesuwattanaskul, S., Phelan, M. M., Edwards, S. W., & Wright, H. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209270 · Cited by 24

Decreased Peripheral Naïve T Cell Number and Its Role in Predicting Cardiovascular and Infection Events in Hemodialysis Patients

Xiang, F., Cao, X., Chen, X., Zhang, Z., Ding, X., Zou, J., & Shen, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.644627 · Cited by 24

Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a randomized double-blind placebo-controlled trial

Esalatmanesh, K., Jamali, A., Esalatmanesh, R., Soleimani, Z., Khabbazi, A., & Mahdavi, A. M. (2022) · Amino Acids · doi:10.1007/s00726-022-03134-8 · Cited by 24

BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer

Lv, Y., Lv, X., Zhang, J., Cao, G., Xu, C., Zhang, B., & Lin, W. (2022) · Antioxidants · doi:10.3390/antiox11040661 · Cited by 25

The Involvement of Glucose and Lipid Metabolism Alteration in Rheumatoid Arthritis and Its Clinical Implication

Luo, T.-T., Wu, Y., Yin, Q., Chen, W.-G., & Zuo, J. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s398291 · Cited by 25

Cellular metabolism dictates T cell effector function in health and disease

Kolan, S. S., Li, G., Wik, J. A., Malachin, G., Guo, S., Kolan, P., & Skålhegg, B. S. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12956 · Cited by 24

Metabolic control of T cells in autoimmunity

Kono, M., Yoshida, N., & Tsokos, G. C. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000685 · Cited by 23

Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis

He, Y., Mai, C.-T., Pan, H., Liu, L., Zhou, H., & Xie, Y. (2021) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2021.09.005 · Cited by 23

Mitochondrial Control of Proteasomal Psmb5 Drives the Differentiation of Tissue‐Resident Memory T Cells in Patients with Rheumatoid Arthritis

Wu, T., Su, D., Zhang, L., Liu, T., Wang, Q., Yan, C., Liu, M., Ji, H., Lei, J., Zheng, M., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42954 · Cited by 21

Important Role of Mitochondrial Dysfunction in Immune Triggering and Inflammatory Response in Rheumatoid Arthritis

Li, P., Zhou, M., Wang, J., Tian, J., Zhang, L., Wei, Y., Yang, F., Xu, Y., & Wang, G. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s499473 · Cited by 28

Changes of T-cell Immunity Over a Lifetime

Nian, Y., Minami, K., Maenesono, R., Iske, J., Yang, J., Azuma, H., Elkhal, A., & Tullius, S. G. (2019) · Transplantation · doi:10.1097/tp.0000000000002786 · Cited by 22

Lactate and lactylation: emerging roles in autoimmune diseases and metabolic reprogramming

Liu, W., Yang, R., Zhan, Y., Yang, X., Zeng, H., Chen, B., Zeng, J., Hu, T., Hu, J., Xiao, Q., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1589853 · Cited by 21

Metabolic control of arthritis: Switch pathways to treat

Tsokos, G. C. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf4953 · Cited by 20

Immunometabolism in rheumatoid arthritis

Okano, T., Saegusa, J., Takahashi, S., Ueda, Y., & Morinobu, A. (2018) · Immunological Medicine · doi:10.1080/25785826.2018.1531186 · Cited by 20

Editorial: Mitochondrial dysfunction in inflammation and autoimmunity

Staal, J., Blanco, L. P., & Perl, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1304315 · Cited by 20

T Cell Dysregulation in Rheumatoid Arthritis: from Genetic Susceptibility to Established Disease

Chin, A., Small, A., Wong, S. W., & Wechalekar, M. D. (2025) · Current Rheumatology Reports · doi:10.1007/s11926-025-01180-1 · Cited by 19

Rebalancing redox homeostasis: A pivotal regulator of the cGAS-STING pathway in autoimmune diseases

Zhao, Y., Xu, T., Wu, Z., Li, N., & Liang, Q. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103823 · Cited by 21

Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis

Huang, T., Takashima, Y., Kumar, J., Morales, J., Le, K., Hu, Z., Rubino, S., Trousdale, R. T., Berry, G. J., Goronzy, J. J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.019 · Cited by 24

Mitochondrial Control for Healthy and Autoimmune T Cells

Li, J., Zhang, L., Liu, M., Ji, H., Wen, Z., & Wang, C. (2023) · Cells · doi:10.3390/cells12131800 · Cited by 19

Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets

Lai, L., Ran, S., Li, Y., Cui, J., Zhang, X., Yu, J., Zou, Y., Cheng, Z., Xia, J., & Wu, J. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02533-z · Cited by 24

Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis

Urbonaviciute, V., Romero‐Castillo, L., Xu, B., Luo, H., Schneider, N., Weisse, S., Do, N., Coelho, A., Lahore, G. F., Li, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2218668120 · Cited by 18

Glucose metabolism pattern of peripheral blood immune cells in myasthenia gravis patients

Li, Z., Peng, Y., Li, Y., Zhou, R., Chen, D., Jin, W., Xu, Q., Xu, L., Luo, Z., & Yang, H. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-918 · Cited by 17

DNA Damage Response in the Adaptive Arm of the Immune System: Implications for Autoimmunity

Manolakou, T., Verginis, P., & Boumpas, D. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115842 · Cited by 17

Towards Personalized Antioxidant Use in Female Infertility: Need for More Molecular and Clinical Studies

Tesařík, J. (2021) · Biomedicines · doi:10.3390/biomedicines9121933 · Cited by 18

Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage

Fang, M. M., Barman, P. K., Thiruppathi, M., Mirza, R. E., McKinney, R. D., Deng, J., Christman, J. W., Du, X., Fukai, T., Ennis, W. J., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800252 · Cited by 18

Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes

Li, Z., Zhao, M., Li, J., Luo, W., Huang, J., Huang, G., Xie, Z., Xiao, Y., Huang, J., Li, X., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109729 · Cited by 17

MAZ-mediated up-regulation of BCKDK reprograms glucose metabolism and promotes growth by regulating glucose-6-phosphate dehydrogenase stability in triple-negative breast cancer

Li, Y., Lin, Y., Tang, Y., Jiang, M., Chen, X., Chen, H., Nie, Q., Wu, J., Tong, X., Li, J., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06835-y · Cited by 18

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?

Fotopoulou, F., Rodriguez-Correa, E., Dussiau, C., & Milsom, M. D. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104698 · Cited by 17

NRF2/Itaconate Axis Regulates Metabolism and Inflammatory Properties of T Cells in Children with JIA

Rajendiran, A., Subramanyam, S. H., Klemm, P., Jankowski, V., van Loosdregt, J., Vastert, S. J., Vollbach, K., Wagner, N., Tenbrock, K., & Ohl, K. (2022) · Antioxidants · doi:10.3390/antiox11122426 · Cited by 19

Reduction of peripheral regulatory T cells in active rheumatoid arthritis patients with coronary artery disease

Wang, Y., Su, R. J., Li, B., Guo, Q., Hu, F., Yu, X., Ma, M., Wang, L., Gao, C., Li, X., et al. (2021) · BMC Immunology · doi:10.1186/s12865-021-00466-0 · Cited by 16

Effects of Metabolic Disorders in Immune Cells and Synoviocytes on the Development of Rheumatoid Arthritis

Blagov, A. V., Grechko, A. V., Nikiforov, N. G., Zhuravlev, A. D., Sadykhov, N. K., & Orekhov, A. N. (2022) · Metabolites · doi:10.3390/metabo12070634 · Cited by 15

Analyzation of the Peripheral Blood Mononuclear Cells Atlas and Cell Communication of Rheumatoid Arthritis Patients Based on Single-Cell RNA-Seq

Song, X., Zhang, Y., Zhao, L., Fan, J., Peng, T., Ma, Y., Guo, N., Wang, X., Liu, X., Liu, Z., et al. (2023) · Journal of Immunology Research · doi:10.1155/2023/6300633 · Cited by 15

Crosstalk of Microorganisms and Immune Responses in Autoimmune Neuroinflammation: A Focus on Regulatory T Cells

Schroeter, C. B., Huntemann, N., Böck, S., Nelke, C., Kremer, D., Pfeffer, K., Meuth, S. G., & Ruck, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.747143 · Cited by 16

Mitochondria Transfer to CD4+ T Cells May Alleviate Rheumatoid Arthritis by Suppressing Pro-Inflammatory Cytokine Production

Giwa, R., & Brestoff, J. R. (2022) · Immunometabolism · doi:10.20900/immunometab20220009 · Cited by 15

Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate

MacIver, N. J., & Rathmell, J. C. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.06.002 · Cited by 16

Interleukin-34-regulated T-cell responses in rheumatoid arthritis

Park, H. E., Oh, H., & Baek, J.-H. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1078350 · Cited by 12

Role of Bioactive Compounds, Novel Drug Delivery Systems, and Polyherbal Formulations in the Management of Rheumatoid Arthritis

Rana, N., Gupta, P., Singh, H., & Nagarajan, K. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207326666230914103714 · Cited by 13

Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis

Zhang, J., Cai, H., Sun, W., Wu, W., Nan, Y., Ni, Y., Wu, X., Chen, M., Xu, H., & Wang, Y. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03271-3 · Cited by 13

T-cell metabolism in rheumatoid arthritis: focus on mitochondrial and lysosomal dysfunction

Parab, A., & Bhatt, L. K. (2024) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2024.2330645 · Cited by 13

T cell dysregulation in rheumatoid arthritis: Recent advances and natural product interventions

Hu, M., Zhou, Y., Yao, Z., Tang, Y., Zhang, Y., Liao, J., Cai, X., & Liu, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114499 · Cited by 14

Genetically Engineered Exosomes as a Potential Regulator of Th1 Cells Response in Rheumatoid Arthritis

Ren, Z., Liu, X., Abdollahi, E., & Tavasolian, F. (2023) · Biopreservation and Biobanking · doi:10.1089/bio.2022.0003 · Cited by 13

A Mitochondrial Checkpoint in Autoimmune Disease

Weyand, C. M., & Goronzy, J. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.014 · Cited by 12

ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus

Li, W., Ling, Z., Wang, J., Su, Z., Lu, J., Yang, X., Cheng, B., & Tao, X. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115767 · Cited by 13

Peripheral blood mononuclear cells show markers of mitochondrial dysfunction in rheumatoid arthritis

Abbasifard, A., Solgi, G., Khodadadi, I., Doosti‐Irani, A., Tayebinia, H., & Fazaeli, A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4025 · Cited by 13

Metabolic T-cell phenotypes: from bioenergetics to function

Jantz-Naeem, N., Guvencli, N., Loschinski, R., Böttcher, M., Mougiakakos, D., & Kahlfuß, S. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00478.2024 · Cited by 13

Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis

Chang, H., Ho, C., Tomita, B., Silva, A. A., Sparks, J. A., Karlson, E. W., Rao, D. A., Lee, Y., & Ho, I. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.04.012 · Cited by 12

Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis

Kumar, P., Yao, L. J., Saidin, S., Paleja, B. S., van Loosdregt, J., Chua, C. J. H., Arkachaisri, T., Consolaro, A., Gattorno, M., Martini, A., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.07.014 · Cited by 12

Polyamide microplastics can mitigate the effects of pathogenic bacterium on the health of marine mussels

Pan, Y., Zhao, W., Fang, J. K., Shi, J., Abo‐Raya, M. H., Li, D., Hu, M., & Wang, Y. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135646 · Cited by 11

The small molecule inhibitor 3PO is a modulator of neutrophil metabolism, ROS production, and NET release

Alarcon, M. F., Abdullah, G. A., Nolan, A., Linford, C., Meschis, M. M., Cross, A. L., Sellin, A., Phelan, M. M., & Wright, H. L. (2025) · Clinical & Experimental Immunology · doi:10.1093/cei/uxaf012 · Cited by 11

NIR-photocatalytic LDHB-mimetic CuS@ZnS nanoenzyme regulates arthritis microenvironment through lactate oxidation and hydrogen evolution

Lu, D., Wu, F., Chen, K., Li, W., Zhang, P., Hou, Y., Su, Y., Liu, W., Wang, T., Liu, Y., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.151772 · Cited by 11

Redox-Mediated Carbamylation As a Hapten Model Applied to the Origin of Antibodies to Modified Proteins in Rheumatoid Arthritis

Trejo‐Zambrano, M. I., Gómez-Bañuelos, E., & Andrade, F. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0064 · Cited by 11

mTOR activation in CD8+ cells contributes to disease activity of rheumatoid arthritis and increases therapeutic response to TNF inhibitors

Zhang, M., Iwata, S., Sonomoto, K., Ueno, M., Fujita, Y., Anan, J., Miyazaki, Y., Ohkubo, N., Hajime, M., Todoroki, Y., et al. (2021) · Rheumatology · doi:10.1093/rheumatology/keab834 · Cited by 11

Immunometabolism Dysfunction in the Pathophysiology and Treatment of Rheumatoid Arthritis

Masoumi, M., Hashemi, N., Moadab, F., Didehdar, M., Farahani, R., Khorramdelazad, H., Sahebkar, A., Johnston, T. P., & Karami, J. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220907151213 · Cited by 11

Metabolic interventions repair CD4+ T cells in RA

Shipman, L. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.54

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis

Maurice, M. M., Nakamura, H., van der Voort, E. A., Vliet, A. I. V., Staal, F. J. T., Tak, P. P., Breedveld, F. C., & Verweij, C. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.3.1458 · Cited by 165

Metabolic control of arthritis: Switch pathways to treat

Tsokos, G. C. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf4953 · Cited by 20

Immunometabolism in the development of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193

Metabolic reprogramming of T cells in RA

Leah, E. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.158 · Cited by 5