Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363

Metabolic Regulation of T Lymphocytes

MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,141

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 747

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

Blagih, J., Coulombe, F., Vincent, E. E., Dupuy, F., Galicia-Vázquez, G., Yurchenko, E., Raissi, T. C., van der Windt, G. J. W., Viollet, B., Pearce, E. L., et al. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.030 · Cited by 679

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Guo, Q., Wang, Y., Xu, D., Nossent, J. C., Pavlos, N. J., & Xu, J. (2018) · Bone Research · doi:10.1038/s41413-018-0016-9 · Cited by 1,829

Immunopathogenesis of Rheumatoid Arthritis

Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Certo, M., Tsai, C.-H., Pucino, V., Ho, P.-C., & Mauro, C. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-0406-2 · Cited by 924

Metabolism of immune cells in cancer

Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877

The immunology of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Nature Immunology · doi:10.1038/s41590-020-00816-x · Cited by 835

The pentose phosphate pathway in health and disease

TeSlaa, T. A., Ralser, M., Fan, J., & Rabinowitz, J. D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00863-2 · Cited by 714

The pathogenicity of Th17 cells in autoimmune diseases

Yasuda, K., Takeuchi, Y., & Hirota, K. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00733-8 · Cited by 586

Aging of the Immune System. Mechanisms and Therapeutic Targets

Weyand, C. M., & Goronzy, J. J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-095aw · Cited by 586

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

Pucino, V., Certo, M., Bulusu, V., Cucchi, D., Goldmann, K., Pontarini, E., Haas, R., Smith, J., Headland, S. E., Blighe, K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.004 · Cited by 555

Redox regulation of immunometabolism

Muri, J., & Köpf, M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00478-8 · Cited by 519

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting

Malmström, V., Catrina, A. I., & Klareskog, L. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.124 · Cited by 469

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

Holers, V. M., Demoruelle, M. K., Kuhn, K. A., Buckner, J. H., Robinson, W. H., Okamoto, Y., Norris, J. M., & Deane, K. D. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0070-0 · Cited by 428

The spectrum of T cell metabolism in health and disease

Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 436

Energy metabolism in health and diseases

Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 484

Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis

Bustamante, M. F., Garcia‐Carbonell, R., Whisenant, K. D., & Gumá, M. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1303-3 · Cited by 429

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Fugger, L. H., Jensen, L. T., & Rossjohn, J. (2020) · Cell · doi:10.1016/j.cell.2020.03.007 · Cited by 415

Aging, obesity, and inflammatory age-related diseases

Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01745 · Cited by 371

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362

Metabolism as a guiding force for immunity

Jung, J., Zeng, H., & Horng, T. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0217-x · Cited by 354

Metabolic regulation of inflammation

Gaber, T., Strehl, C., & Buttgereit, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.37 · Cited by 320

Mitochondria, Oxidative Stress and Innate Immunity

Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315

Targeting metabolism to regulate immune responses in autoimmunity and cancer

Patel, C. H., Leone, R. D., Horton, M. R., & Powell, J. D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0032-5 · Cited by 311

Metabolic adaptation of lymphocytes in immunity and disease

Chapman, N. M., & Chi, H. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.012 · Cited by 317

Immunometabolism in early and late stages of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.49 · Cited by 296

Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O.

Alarcon, M. F., McLaren, Z., & Wright, H. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649693 · Cited by 288

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

Pérez-Torres, I., Guarner‐Lans, V., & Rubio-Ruiz, M. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102098 · Cited by 263

Lactate at the crossroads of metabolism, inflammation, and autoimmunity

Pucino, V., Bombardieri, M., Pitzalis, C., & Mauro, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201646477 · Cited by 253

Immunometabolism in systemic lupus erythematosus

Morel, L. M. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.43 · Cited by 219

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis

Zhang, H., Watanabe, R., Berry, G. J., Tian, L., Goronzy, J. J., & Weyand, C. M. (2017) · Circulation · doi:10.1161/circulationaha.117.030423 · Cited by 218

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis

Fang, Q., Zhou, C., & Nandakumar, K. S. (2020) · Mediators of Inflammation · doi:10.1155/2020/3830212 · Cited by 227

Immunometabolism in the development of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193

Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress

Bellanti, F., Coda, A. R. D., Trecca, M. I., Buglio, A. L., Serviddio, G., & Vendemiale, G. (2025) · Antioxidants · doi:10.3390/antiox14060656 · Cited by 222

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

Li, Y., Shen, Y., Jin, K., Wen, Z., Cao, W., Wu, B., Wen, R. M., Tian, L., Berry, G. J., Goronzy, J. J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.016 · Cited by 190

Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis

van Hamburg, J. P., & Tas, S. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.006 · Cited by 192

T cells, aging and senescence

Pangrazzi, L., & Weinberger, B. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110887 · Cited by 188

A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis

Pan, H., Guo, R., Ju, Y., Wang, Q., Zhu, J., Xie, Y., Zheng, Y., Li, T., Liu, Z., Lu, L., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0719-1 · Cited by 179

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis

Yang, X., Chang, Y., & Wei, W. (2020) · Cell Proliferation · doi:10.1111/cpr.12854 · Cited by 176

Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma

Chen, D., Ning, W.-R., Jiang, Z.-Z., Peng, Z.-P., Zhu, L., Zhuang, S., Kuang, D., Zheng, L., & Wu, Y. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.007 · Cited by 170

Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis

Qiu, J., Wu, B., Goodman, S. B., Berry, G. J., Goronzy, J. J., & Weyand, C. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652771 · Cited by 170

The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment

Wang, X., Fan, D., Cao, X., Ye, Q., Wang, Q., Zhang, M., & Xiao, C. (2022) · Antioxidants · doi:10.3390/antiox11061153 · Cited by 176

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

Wen, Z., Jin, K., Shen, Y., Yang, Z., Li, Y., Wu, B., Tian, L., Shoor, S., Roche, N. E., Goronzy, J. J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0296-7 · Cited by 162

Mitochondrial Metabolism Regulation of T Cell–Mediated Immunity

Steinert, E. M., Vasan, K., & Chandel, N. S. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-082015 · Cited by 161

Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

Zuo, J., Tang, J., Lü, M., Zhou, Z., Li, Y., Tian, H., Liu, E., Gao, B., Liu, T., & Shao, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.779787 · Cited by 156

Metabolic signatures of T-cells and macrophages in rheumatoid arthritis

Weyand, C. M., Zeisbrich, M., & Goronzy, J. J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.04.010 · Cited by 153

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

Abboud, G., Choi, S., Kanda, N., Zeumer-Spataro, L., Roopenian, D. C., & Morel, L. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01973 · Cited by 145

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021) · Nature Immunology · doi:10.1038/s41590-021-01065-2 · Cited by 141

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

Li, Y., Shen, Y., Hohensinner, P. J., Ju, J., Wen, Z., Goodman, S. B., Zhang, H., Goronzy, J. J., & Weyand, C. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.013 · Cited by 138

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway

Wen, Z., Shen, Y., Berry, G. J., Shahram, F., Li, Y., Watanabe, R., Liao, Y. J., Goronzy, J. J., & Weyand, C. M. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3322 · Cited by 138

Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells

Shen, Y., Wen, Z., Li, Y., Matteson, E. L., Hong, J., Goronzy, J. J., & Weyand, C. M. (2017) · Nature Immunology · doi:10.1038/ni.3808 · Cited by 132

B-cell-specific diversion of glucose carbon utilization reveals a unique vulnerability in B cell malignancies

Xiao, G., Chan, L. N., Klemm, L., Braas, D., Chen, Z., Geng, H., Zhang, Q. C., Aghajanirefah, A., Cosgun, K. N., Sadras, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.048 · Cited by 129

Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response

Luque‐Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J., & Luz‐Crawford, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00798 · Cited by 132

Review: Metabolic Control of Immune System Activation in Rheumatic Diseases

Perl, A. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40223 · Cited by 113

Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells

Wu, B., Qiu, J., Zhao, T. V., Wang, Y., Maeda, T., Goronzy, I. N., Akiyama, M., Ohtsuki, S., Jin, K., Tian, L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.025 · Cited by 114

Metabolomics in rheumatoid arthritis: Advances and review

Xu, L., Chang, C., Jiang, P., Wei, K., Zhang, R., Jin, Y., Zhao, J., Xu, L., Shi, Y., Guo, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.961708 · Cited by 110

Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

Fearon, U., Hanlon, M. M., Floudas, A., & Veale, D. J. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00771-x · Cited by 109

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

López-Armada, M. J., Fernández-Rodríguez, J. A., & Blanco, F. J. (2022) · Antioxidants · doi:10.3390/antiox11061151 · Cited by 118

Immune aging – A mechanism in autoimmune disease

Zheng, Y., Liu, Q., Goronzy, J. J., & Weyand, C. M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101814 · Cited by 109

Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis

Souto‐Carneiro, M., Klika, K. D., Abreu, M., Meyer, A. P., Saffrich, R., Sandhoff, R., Jennemann, R., Kraus, F. V., Tykocinski, L., Eckstein, V., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41420 · Cited by 107

Mitochondrial Reactive Oxygen Species and Type 1 Diabetes

Chen, J., Stimpson, S. E., Fernandez‐Bueno, G. A., & Mathews, C. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7346 · Cited by 100

Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism

Lin, W., Shen, P., Song, Y., Huang, Y., & Tu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635021 · Cited by 105

Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis

Clayton, S. A., MacDonald, L., Kurowska‐Stolarska, M., & Clark, A. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673916 · Cited by 100

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Schett, G. A., Tanaka, Y., & Isaacs, J. D. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00543-5 · Cited by 93

Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses

Zhang, H., Jadhav, R. R., Cao, W., Goronzy, I. N., Zhao, T. V., Jin, J., Ohtsuki, S., Hu, Z., Morales, J., Greenleaf, W. J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01369-x · Cited by 86

Immunometabolism: An Overview and Therapeutic Prospects in Autoimmune Diseases

Stathopoulou, C., Nikoleri, D., & Bertsias, G. K. (2019) · Immunotherapy · doi:10.2217/imt-2019-0002 · Cited by 90

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Milanese, C., Bombardieri, C. R., Sepe, S., Barnhoorn, S., Payán‐Gómez, C., Caruso, D., Audano, M., Pedretti, S., Vermeij, W. P., Brandt, R. M. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12640-5 · Cited by 82

Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

McGarry, T., Hanlon, M. M., Marzaioli, V., Cunningham, C. C., Krishna, V., Murray, K., Hurson, C. J., Gallagher, P., Nagpal, S., Veale, D. J., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1237 · Cited by 89

Metabolic Checkpoints in Rheumatoid Arthritis

Pucino, V., Certo, M., Varricchi, G., Marone, G., Ursini, F., Rossi, F. W., de Paulis, A., Mauro, C., Raza, K., & Buckley, C. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00347 · Cited by 81

Fine tuning of immunometabolism for the treatment of rheumatic diseases

Rhoads, J. P., Major, A. S., & Rathmell, J. C. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.54 · Cited by 81

Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

Ye, Z., Shen, Y., Jin, K., Qiu, J., Hu, B., Jadhav, R. R., Sheth, K., Weyand, C. M., & Goronzy, J. J. (2021) · Nature Communications · doi:10.1038/s41467-021-21242-z · Cited by 82

Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis

Kachler, K., Andreev, D., Thapa, S., Royzman, D., Gießl, A., Karuppusamy, S., Perez, M. L., Liu, M., Hofmann, J., Gessner, A., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224774 · Cited by 77

DNA damage, metabolism and aging in pro-inflammatory T cells

Li, Y., Goronzy, J. J., & Weyand, C. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.027 · Cited by 80

Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione

Liang, J., Jahraus, B., Balta, E., Ziegler, J. D., Hübner, K., Blank, N., Niesler, B., Wabnitz, G. H., & Samstag, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02584 · Cited by 80

Sulforaphane as anticancer agent: a double-edged sword? Tricky balance between effects on tumor cells and immune cells

Liang, J., Hänsch, G. M., Hübner, K., & Samstag, Y. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.11.006 · Cited by 72

Mitochondrial Dysfunction in Rheumatoid Arthritis

Ma, C., Wang, J., Hong, F., & Yang, S. (2022) · Biomolecules · doi:10.3390/biom12091216 · Cited by 71

Metabolic regulation of TH17 cells

Shen, H., & Shi, L. Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.03.005 · Cited by 72

The interplay between obesity, immunosenescence, and insulin resistance

Shimi, G., Sohouli, M. H., Ghorbani, A., Shakery, A., & Zand, H. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00414-7 · Cited by 79

Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment

Martin, O. C. B., & Frisan, T. (2020) · Toxins · doi:10.3390/toxins12020063 · Cited by 70

Redox-sensitive signaling in inflammatory T cells and in autoimmune disease

Weyand, C. M., Shen, Y., & Goronzy, J. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.004 · Cited by 68

How the redox state regulates immunity

Mullen, L., Mengozzi, M., Hanschmann, E.-M., Alberts, B. M., & Ghezzi, P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.022 · Cited by 66

A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22

Chang, H., Liu, G., Dwivedi, N., Sun, B., Okamoto, Y., Kinslow, J. D., Deane, K. D., Demoruelle, M. K., Norris, J. M., Thompson, P. R., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90045 · Cited by 61

Immunometabolism and autoimmunity

Freitag, J., Berod, L., Kamradt, T., & Sparwasser, T. D. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.77 · Cited by 61

Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases

Qin, Y., Gao, C., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828191 · Cited by 68

The metabolic signature of T cells in rheumatoid arthritis

Weyand, C. M., Wu, B., & Goronzy, J. J. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000683 · Cited by 58

Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis

Cai, W., Yu, Y., Zong, S.-Y., & Wei, F. (2020) · Inflammation Research · doi:10.1007/s00011-020-01391-5 · Cited by 63

Cancer and Autoimmune Diseases: A Tale of Two Immunological Opposites?

Elkoshi, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.821598 · Cited by 61

ROS fine-tunes the function and fate of immune cells

Liu, S., Huang, B., Cao, J., Wang, Y., Xiao, H., Zhu, Y., & Zhang, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110069 · Cited by 62

Immunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases

Wang, T., Jiao, Y., & Zhang, X. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08821-6 · Cited by 61

The Lipid Paradox as a Metabolic Checkpoint and Its Therapeutic Significance in Ameliorating the Associated Cardiovascular Risks in Rheumatoid Arthritis Patients

Behl, T., Kaur, I., Sehgal, A., Zengin, G., Brisc, C., Brisc, M. C., Munteanu, M. A., Nistor-Cseppento, C. D., & BUNGAU, S. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249505 · Cited by 61

A20: a master regulator of arthritis

Wu, Y., He, X., Huang, N., Yu, J., & Shao, B. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02281-1 · Cited by 56

Glycolysis, a driving force of rheumatoid arthritis

Gan, P., Wu, H., Zhu, Y., Shu, Y., & Wei, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111913 · Cited by 57

Mucosa–Environment Interactions in the Pathogenesis of Rheumatoid Arthritis

Lucchino, B., Spinelli, F. R., Iannuccelli, C., Guzzo, M. P., Conti, F., & Franco, M. D. (2019) · Cells · doi:10.3390/cells8070700 · Cited by 56

Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation

Certo, M., Elkafrawy, H., Pucino, V., Cucchi, D., Cheung, K. C.-P., & Mauro, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15002 · Cited by 54

Glucose transporter 1 in rheumatoid arthritis and autoimmunity

Zezina, E. A., Sercan-Alp, Ö., Herrmann, M., & Biesemann, N. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1483 · Cited by 57

Immunosenescence of T cells: a key player in rheumatoid arthritis

Gao, Y. Q., Cai, W., Zhou, Y., Li, Y., Cheng, J., & Wei, F. (2022) · Inflammation Research · doi:10.1007/s00011-022-01649-0 · Cited by 53

Immune Aging in Rheumatoid Arthritis

Weyand, C. M., & Goronzy, J. J. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43105 · Cited by 61

Metabolic Targets for Treatment of Autoimmune Diseases

Piranavan, P., Bhamra, M. S., & Perl, A. (2020) · Immunometabolism · doi:10.20900/immunometab20200012 · Cited by 55

Interleukin‐34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony‐Stimulating Factor Receptor

Raemdonck, K. V., Umar, S., Palasiewicz, K., Volin, M. V., Elshabrawy, H. A., Romay, B., Tetali, C., Ahmed, A., Amin, M. A., Zomorrodi, R. K., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.41792 · Cited by 50

T-Cell Aging-Associated Phenotypes in Autoimmune Disease

Zhao, T. V., Sato, Y., Goronzy, J. J., & Weyand, C. M. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.867950 · Cited by 50

Immunometabolism: A new target for improving cancer immunotherapy

Guo, C., Chen, S., Liu, W., Ma, Y., Li, J., Fisher, P. B., Fang, X., & Wang, X. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.004 · Cited by 56

Metabolic interventions repair CD4+ T cells in RA

Shipman, L. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.54

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis

Maurice, M. M., Nakamura, H., van der Voort, E. A., Vliet, A. I. V., Staal, F. J. T., Tak, P. P., Breedveld, F. C., & Verweij, C. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.3.1458 · Cited by 165

Metabolic control of arthritis: Switch pathways to treat

Tsokos, G. C. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf4953 · Cited by 20

Immunometabolism in the development of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193

Metabolic reprogramming of T cells in RA

Leah, E. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.158 · Cited by 5