Cited by 466Glioma Diagnosis and TreatmentCancer Genomics and DiagnosticsGene expression and cancer classification

Origin of the U87MG glioma cell line: Good news and bad news

Allen, Marie, Bjerke, Mia, Edlund, Hanna, Nelander, Sven, Westermark, Bengt·2016·Science Translational Medicine

Abstract

The DNA profile of the publicly available and widely used glioma cell line U87MG is quite different from that of the original cell line.

Integrity signals

Registry

Crossref · 10.1126/scitranslmed.aaf6853

Cites

14 of 14 references verified0 citation errors · 0 not checkable

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  • Studies using the classic U87MG and U251MG glioma cell lines have shown that when grown in serum-containing medium these glioma cells exhibit transcriptomic deviation from the original tumour from which they were derived.

    “studies using the classic U87MG and U251MG glioma cell lines have shown that when grown in serum-containing medium these glioma cells exhibit transcrip-tomic deviation from the original tumour from which they were derived63.”

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Authors
Allen, M., Bjerke, M., Edlund, H., Nelander, S., & Westermark, B.
Affiliations
Uppsala University (SE)
Corresponding author
Westermark, Bengt
Venue
Science Translational Medicine
Published
2016-08-31
Volume
8
Issue
354
Pages
354re3-354re3
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2509121458
Cited by
466
References
15
Citations by year
2026: 28 · 2025: 33 · 2024: 43 · 2023: 36 · 2022: 49 · 2021: 41 · 2020: 59 · 2019: 51 · 2018: 84 · 2017: 37 · 2016: 5
FWCI
42.81
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Swedish Cancer Society
  • Swedish Crime Victim Compensation and Support Authority
Topics
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Keywords
glioma cell lines, glioblastoma, tumor origin, genetic profiling, gene expression profiling, cell line misidentification, translational oncology
MeSH terms
Brain Neoplasms, DNA, Mitochondrial, DNA, Neoplasm, Glioblastoma, Glioma, Humans, DNA Fingerprinting, Microsatellite Repeats, Cell Culture Techniques, Gene Expression Profiling, Cell Line, Tumor, Translational Research, Biomedical

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