Origin of the U87MG glioma cell line: Good news and bad news
Abstract
The DNA profile of the publicly available and widely used glioma cell line U87MG is quite different from that of the original cell line.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies using the classic U87MG and U251MG glioma cell lines have shown that when grown in serum-containing medium these glioma cells exhibit transcriptomic deviation from the original tumour from which they were derived.
“studies using the classic U87MG and U251MG glioma cell lines have shown that when grown in serum-containing medium these glioma cells exhibit transcrip-tomic deviation from the original tumour from which they were derived63.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [63]
Cites
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950 · see citing works
Lee, J., Kotliarova, S. E., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., Pastorino, S., Purow, B. W., Christopher, N., Zhang, W., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.030 · Cited by 2,289 · see citing works
Pollard, S. M., Yoshikawa, K., Clarke, I. D., Danovi, D., Stricker, S., Russell, R., Bayani, J., Head, R., Lee, M., Bernstein, M., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.03.014 · Cited by 1,025 · see citing works
LONG TERM CULTURE OF NORMAL AND NEOPLASTIC HUMAN GLIA
Pontén, J., & Macintyre, E. H. (1968) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1968.tb03502.x · Cited by 721 · see citing works
Absence of HeLa Cell Contamination in 169 Cell Lines Derived From Human Tumors2
Fogh, J., Wright, W. C., & Loveless, J. D. (1977) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/58.2.209 · Cited by 663 · see citing works
Check your cultures! A list of cross‐contaminated or misidentified cell lines
Capes‐Davis, A., Theodosopoulos, G., Atkin, I., Drexler, H. G., Kohara, A., MacLeod, R. A. F., Masters, J. R., Nakamura, Y., Reid, Y. A., Reddel, R. R., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25242 · Cited by 520 · cited 1× · see citing works
“Theproblemof themisidentification of cell lines has beenhighlighted in several reports (11, 12), and a number of scientific journals now want the identity of the samples and cell lines used in their publication to be confirmed.”
BackgroundXie, Y., Bergström, T., Jiang, Y., Johansson, P., Marinescu, V. D., Lindberg, N., Segerman, A., Wicher, G., Niklasson, M., Baskaran, S., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.08.026 · Cited by 319 · see citing works
Self-citationCell line misidentification: the beginning of the end
American Type Culture Collection Standards Development Organization Workgroup ASN-0002 (2010) · Nature Reviews Cancer · doi:10.1038/nrc2852 · Cited by 266 · see citing works
DNA fingerprinting in forensics: past, present, future
Roewer, L. (2013) · Investigative Genetics · doi:10.1186/2041-2223-4-22 · Cited by 171 · see citing works
Schraer, L., Borum, I., & Sathyan, T. G. (1995) · Cited by 113 · see citing works
DNA fingerprinting of glioma cell lines and considerations on similarity measurements
Bady, P., Diserens, A.-C., Castella, V., Kalt, S., Heinimann, K., Hamou, M.-F., Delorenzi, M., & Hegi, M. E. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos072 · Cited by 57 · see citing works
Analysis of the Putative Remains of a European Patron Saint–St. Birgitta
Nilsson, M. E., Possnert, G., Edlund, H., Budowle, B., Kjellström, A., & Allen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008986 · Cited by 30 · see citing works
Self-citationSchmidt, L., Kling, T., Monsefi, N., Olsson, M. M., Hansson, C., Baskaran, S., Lundgren, B., Märtens, U., Häggblad, M., Westermark, B., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not111 · Cited by 23 · see citing works
Self-citationWestermark, B. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90126-2 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
1 of the 15 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Xue, J., Zhao, Z., Zhang, L., Xue, L., Shen, S., Wen, Y., Wei, Z., Wang, L., Kong, L., Sun, H., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.54 · Cited by 955 · see citing works
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancerPreprint
Gimple, R. C., Bhargava, S., Dixit, D., & Rich, J. N. (2019) · Genes & Development · doi:10.1101/gad.324301.119 · Cited by 539 · see citing works
Isolation and characterization of extracellular vesicle subpopulations from tissues
Crescitelli, R., Lässer, C., & Lötvall, J. O. (2021) · Nature Protocols · doi:10.1038/s41596-020-00466-1 · Cited by 512 · see citing works
Poynton, F. E., Bright, S. A., Blasco, S., Williams, D. C., Kelly, J. M., & Gunnlaugsson, T. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00680b · Cited by 425 · see citing works
Metabolic Reprogramming in Glioma
Strickland, M., & Stoll, E. A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00043 · Cited by 350 · see citing works
Glioma: experimental models and reality
Lenting, K., Verhaak, R. G. W., ter Laan, M., Wesseling, P., & Leenders, W. P. J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1671-4 · Cited by 286 · see citing works
Lewis, J. M., Vyas, A. D., Qiu, Y., Messer, K. S., White, R., & Heller, M. J. (2018) · ACS Nano · doi:10.1021/acsnano.7b08199 · Cited by 283 · see citing works
Vaubel, R. A., Tian, S., Remonde, D., Schroeder, M. A., Mladek, A. C., Kitange, G. J., Caron, A., Kollmeyer, T. M., Grove, R., Peng, S., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0909 · Cited by 227 · see citing works
Deciphering the complex role of thrombospondin-1 in glioblastoma development
Daubon, T., Léon, C., Clarke, K., Andrique, L., Salabert, L., Darbo, É., Pineau, R., Guérit, S., Maître, M., Dedieu, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08480-y · Cited by 219 · see citing works
Crescitelli, R., Lässer, C., Jang, S. C., Cvjetkovic, A., Malmhäll, C., Karimi, N., Höög, J. L., Johansson, I., Fuchs, J., Thorsell, A., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1722433 · Cited by 214 · see citing works
Zeng, W., Tang, Z., Li, Y., Yin, G., Liu, Z., Gao, J., Chen, Y., & Chen, F. (2020) · Cancer Cell International · doi:10.1186/s12935-019-1086-5 · Cited by 209 · see citing works
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies
Haddad, A. F., Young, J. S., Amara, D., Berger, M. S., Raleigh, D. R., Aghi, M. K., & Butowski, N. A. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab100 · Cited by 207 · see citing works
Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: Present and future
Li, S.-R., Man, Q., Gao, X., Lin, H., Wang, J., Su, F., Wang, H., Bu, L., Liu, B., & Chen, G. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12175 · Cited by 206 · see citing works
Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175 · see citing works
Guidance Document on Good In Vitro Method Practices (GIVIMP)
OECD (2018) · OECD Series on Testing and Assessment · doi:10.1787/9789264304796-en · Cited by 161 · see citing works
Patient-Derived Glioma Models: From Patients to Dish to Animals
da Hora, C. C., Schweiger, M. W., Würdinger, T., & Tannous, B. A. (2019) · Cells · doi:10.3390/cells8101177 · Cited by 150 · see citing works
Behaviors of Glioblastoma Cells in in Vitro Microenvironments
Diao, W., Tong, X., Cheng, Y., Zhang, F., Bao, C., Chen, H., Liu, L., Li, M., Ye, F., Fan, Q., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36347-7 · Cited by 139 · see citing works
Experimental models and tools to tackle glioblastoma
Robertson, F., Marqués‐Torrejón, M. Á., Morrison, G. M., & Pollard, S. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040386 · Cited by 121 · see citing works
Shen, Y., Wu, C., Uyeda, T. Q. P., Plaza, G. R., Liu, B., Han, Y., Lesniak, M. S., & Cheng, Y. (2017) · Theranostics · doi:10.7150/thno.18352 · Cited by 119 · see citing works
Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery
Hu, S., Kang, H., Baek, Y., Fakhri, G. E., Kuang, A., & Choi, H. S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800066 · Cited by 110 · see citing works
Evolution of Experimental Models in the Study of Glioblastoma: Toward Finding Efficient Treatments
Gómez‐Oliva, R., Domínguez‐García, S., Carrascal, L., Ábalos-Martínez, J., Pardillo-Díaz, R., Verástegui, C., Castro, C., Nunez‐Abades, P., & Geribaldi‐Doldán, N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.614295 · Cited by 107 · see citing works
Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?
Ledur, P. F., Onzi, G. R., Zong, H., & Lenz, G. (2017) · Oncotarget · doi:10.18632/oncotarget.20193 · Cited by 106 · see citing works
Branched‐chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype
Silva, L. S., Poschet, G., Nonnenmacher, Y., Becker, H. M., Sapcariu, S. C., Gaupel, A., Schlotter, M., Wu, Y., Kneisel, N., Seiffert, M., et al. (2017) · EMBO Reports · doi:10.15252/embr.201744154 · Cited by 106 · see citing works
Patrizii, M., Bartucci, M., Pine, S. R., & Sabaawy, H. E. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00023 · Cited by 104 · see citing works
Lane, R., Simon, T., Vintu, M., Solkin, B., Koch, B., Stewart, N. A., Benstead-Hume, G., Pearl, F. M. G., Critchley, G. R., Stebbing, J., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0560-x · Cited by 98 · see citing works
Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy
Klein, E., Hau, A., Oudin, A., Golebiewska, A., & Niclou, S. P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.604121 · Cited by 98 · see citing works
Integrating the Glioblastoma Microenvironment Into Engineered Experimental Models
Xiao, W., Sohrabi, A., & Seidlits, S. K. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0094 · Cited by 95 · see citing works
Riccardi, C., Napolitano, E., Platella, C., Musumeci, D., & Montesarchio, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107649 · Cited by 94 · see citing works
A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy
Teh, D. B. L., Bansal, A., Chai, C., Toh, T. B., Tucker, R. A. J., Gammad, G. G. L., Yeo, Y., Lei, Z., Zheng, X., Yang, F., et al. (2020) · Advanced Materials · doi:10.1002/adma.202001459 · Cited by 93 · see citing works
Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment
Cai, Q., Li, X., Xiong, H., Fan, H., Gao, X., Vemireddy, V., Margolis, R., Li, J., Ge, X., Giannotta, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40579-1 · Cited by 92 · see citing works
Cullinane, C. M., Waldeck, K., Kirby, L., Rogers, B. E., Eu, P., Tothill, R. W., & Hicks, R. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-67199-9 · Cited by 89 · see citing works
Sperry, J., Condro, M. C., Guo, L., Braas, D., VanderVeer-Harris, N., Kim, K. K. O., Pope, W. B., Divakaruni, A. S., Lai, A., Christofk, H. R., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101453 · Cited by 88 · see citing works
Advances in Research of Adult Gliomas
Finch, A., Solomou, G., Wykes, V., Pohl, U., Bardella, C., & Watts, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020924 · Cited by 87 · see citing works
Bian, X., Yang, Z., Feng, H., Sun, H., & Liu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09660-w · Cited by 86 · see citing works
Organoid Models of Glioblastoma and Their Role in Drug Discovery
Rybin, M. J., Ivan, M. E., Ayad, N. G., & Zeier, Z. R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.605255 · Cited by 81 · see citing works
Poon, M. T. C., Bruce, M., Simpson, J. E., Hannan, C. J., & Brennan, P. M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08972-5 · Cited by 78 · see citing works
Glioblastoma’s Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy Research
Caragher, S. P., Chalmers, A. J., & Gomez-Roman, N. (2019) · Cancers · doi:10.3390/cancers11010044 · Cited by 76 · see citing works
Gao, L., Chen, B., Li, J., Yang, F., Cen, X., Liao, Z., & Long, X.-A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181346 · Cited by 76 · see citing works
Neurotrophin receptor tyrosine kinases regulated with near-infrared light
Leopold, A. V., Chernov, K. G., Shemetov, A. A., & Verkhusha, V. V. (2019) · Nature Communications · doi:10.1038/s41467-019-08988-3 · Cited by 71 · see citing works
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma
Johansson, P., Krona, C. C., Kundu, S., Doroszko, M., Baskaran, S., Schmidt, L., Vinel, C., Almstedt, E., Elgendy, R., Elfineh, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107897 · Cited by 69 · see citing works
Self-citationFatal correlation between YAP1 expression and glioma aggressiveness: clinical and molecular evidence
Guichet, P., Masliantsev, K., Tachon, G., Petropoulos, C., Godet, J., Ciron, D. L., Milin, S., Wager, M., & Karayan, L. (2018) · The Journal of Pathology · doi:10.1002/path.5133 · Cited by 68 · see citing works
Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches
Yeini, E., Ofek, P., Albeck, N., Ajamil, D. R., Neufeld, L., Eldar‐Boock, A., Kleiner, R., Vaskovich‐Koubi, D., Koshrovski‐Michael, S., Dangoor, S. I., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000124 · Cited by 68 · see citing works
Kuang, R., Jahangiri, A., Mascharak, S., Nguyen, A. T., Chandra, A., Flanigan, P. M., Yagnik, G., Wagner, J. R., Lay, M. D. D., Carrera, D. A., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.88815 · Cited by 67 · see citing works
EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma
An, Z., Knobbe-Thomsen, C. B., Wan, X., Fan, Q. W., Reifenberger, G., & Weiss, W. A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3551 · Cited by 66 · see citing works
Huang, H., Song, J., Liu, Z., Li, P., & Xu, G. (2017) · Oncology Letters · doi:10.3892/ol.2017.7446 · Cited by 65 · see citing works
Organoid models of glioblastoma: advances, applications and challenges.
Zhang, C., Jin, M.-Z., Zhao, J., Chen, J., & Jin, W. (2020) · PubMed Central · Cited by 64 · see citing works
You, Y., Wang, R., Shao, N., Zhi, F., & Yang, Y. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s191158 · Cited by 63 · see citing works
Rat and Mouse Brain Tumor Models for Experimental Neuro-Oncology Research
Sahu, U., Barth, R. F., Otani, Y., McCormack, R., & Kaur, B. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac021 · Cited by 61 · see citing works
Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2
Iwasawa, T., Zhang, P., Ohkawa, Y., Momota, H., Wakabayashi, T., Ohmi, Y., Bhuiyan, R. H., Furukawa, K., & Furukawa, K. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4266 · Cited by 61 · see citing works
Ma, B., Gao, Z., Lou, J., Zhang, H., Yuan, Z., Wu, Q., Li, X., & Zhang, B. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6897 · Cited by 60 · see citing works
TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3
Sang, Y., Li, Y., Song, L., Alvarez, A. A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2774 · Cited by 60 · see citing works
Characterization and comparison of human glioblastoma models
Schulz, J., Rodgers, L. T., Kryscio, R. J., Hartz, A. M. S., & Bauer, B. (2022) · BMC Cancer · doi:10.1186/s12885-022-09910-9 · Cited by 59 · see citing works
Single cell polarity in liquid phase facilitates tumour metastasis
Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03139-6 · Cited by 59 · see citing works
Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma
Lei, K., Gu, X., Alvarado, A. G., Du, Y., Luo, S., Ahn, E. H., Kang, S. S., Ji, B., Liu, X., Mao, H. Z., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00979-y · Cited by 58 · see citing works
Almeida, A., Godfroid, C., Leavitt, R., Montay‐Gruel, P., Petit, B., Romero, J. F., Ollivier, J., Meziani, L., Sprengers, K., Paisley, R., et al. (2023) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2023.10.031 · Cited by 58 · see citing works
Ivanov, V. N., Wu, J., & Hei, T. K. (2017) · Oncotarget · doi:10.18632/oncotarget.18240 · Cited by 57 · see citing works
Gedeon, P. C., Schaller, T. H., Chitneni, S. K., Choi, B. D., Kuan, C., Suryadevara, C. M., Snyder, D. J., Schmittling, R. J., Szafranski, S. E., Cui, X., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0126 · Cited by 57 · see citing works
Crosslink between Temozolomide and PD-L1 immune-checkpoint inhibition in glioblastoma multiforme
Heynckes, S., Daka, K., Franco, P., Gaebelein, A., Frenking, J. H., Doria-Medina, R., Mader, I., Delev, D., Schnell, O., & Heiland, D. H. (2019) · BMC Cancer · doi:10.1186/s12885-019-5308-y · Cited by 57 · see citing works
Anywar, G., Kakudidi, E. K., Oryem‐Origa, H., Schubert, A., & Jassoy, C. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.832780 · Cited by 56 · see citing works
Glioblastoma, from disease understanding towards optimal cell-based in vitro models
Boccellato, C., & Rehm, M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00684-7 · Cited by 56 · see citing works
Godoy, P. R. D. V., Khavari, A. P., Rizzo, M., Sakamoto‐Hojo, E. T., & Haghdoost, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2534643 · Cited by 56 · see citing works
Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S. K., Looper, J., Podell, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19085 · Cited by 55 · see citing works
OECD (2018) · OECD series on testing and assessment · doi:10.1787/9789264304796-1-en · Cited by 54 · see citing works
Oraiopoulou, M., Tzamali, E., Tzedakis, G., Vakis, A. F., Papamatheakis, J. D., & Sakkalis, V. (2017) · BioMed Research International · doi:10.1155/2017/8569328 · Cited by 53 · see citing works
Schulz, J. B., Cookson, M. R., & Hausmann, L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13844 · Cited by 52 · see citing works
Zhang, Z., Wang, Y., Chen, J., Tan, Q., Xie, C., Li, C., Zhan, W., & Wang, M. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3188-2 · Cited by 52 · see citing works
Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas
Azzalin, A., Nato, G., Parmigiani, E., Garello, F., Buffo, A., & Magrassi, L. (2017) · Neoplasia · doi:10.1016/j.neo.2017.02.009 · Cited by 52 · see citing works
The promise of DNA damage response inhibitors for the treatment of glioblastoma
Majd, N., Yap, T. A., Koul, D., Balasubramaniyan, V., Li, X., Khan, S., Gandy, K. S., Yung, W. K. A., & de Groot, J. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab015 · Cited by 51 · see citing works
Fròsina, G., Profumo, A., Marubbi, D., Marcello, D., Ravetti, J. L., & Daga, A. (2018) · Radiation Oncology · doi:10.1186/s13014-018-1020-3 · Cited by 50 · see citing works
Jia, W., Jiang, X., Liu, W., Wang, L., Zhu, B., Zhu, H., Liu, X., Zhong, M., Xie, D., Huang, W. J., et al. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4330 · Cited by 50 · see citing works
Lee, Y., Seo, H. W., Baek, J.-H., Lim, S. H., Hwang, S., & Kim, E. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-68473-6 · Cited by 50 · see citing works
Zhang, X., Zhang, T., Davis, J. N., Marzi, A., Marchese, A. M., Robek, M. D., & van den Pol, A. N. (2020) · Journal of Virology · doi:10.1128/jvi.01967-19 · Cited by 49 · see citing works
Soubéran, A., & Tchoghandjian, A. (2020) · Cancers · doi:10.3390/cancers12092347 · Cited by 49 · see citing works
A Xenotransplant Model of Human Brain Tumors in Wild-Type Mice
Hoffmann, N., Fernández, V., Pereira, R. C., Rancati, S., Pelizzoli, R., & Tonelli, D. D. P. (2019) · iScience · doi:10.1016/j.isci.2019.100813 · Cited by 48 · see citing works
Gerigk, M., Bulstrode, H. J. C. J., Shi, H., Tönisen, F., Cerutti, C., Morrison, G. M., Rowitch, D. H., & Huang, Y. Y. S. (2021) · Lab on a Chip · doi:10.1039/d1lc00271f · Cited by 48 · see citing works
Using Light for Therapy of Glioblastoma Multiforme (GBM)
Vasilev, A., Sofi, R., Rahman, R., Smith, S. J., Teschemacher, A. G., & Kasparov, S. (2020) · Brain Sciences · doi:10.3390/brainsci10020075 · Cited by 48 · see citing works
Tarpley, M., Oladapo, H. O., Strepay, D., Caligan, T. B., Chdid, L., Shehata, H., Roques, J., Thomas, R., Laudeman, C. P., Onyenwoke, R. U., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105821 · Cited by 48 · see citing works
Considering the Experimental Use of Temozolomide in Glioblastoma Research
Herbener, V. J., Burster, T., Goreth, A., Pruss, M., von Bandemer, H., Baisch, T., Fitzel, R., Siegelin, M. D., Karpel‐Massler, G., Debatin, K., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8060151 · Cited by 47 · see citing works
T lymphocyte-targeted immune checkpoint modulation in glioma
Kelly, W., Giles, A. J., & Gilbert, M. R. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000379 · Cited by 46 · see citing works
Moisan, F., Ouchérif, S., Kaulanjan‐Checkmodine, P., Prey, S., Rousseau, B., Bonneu, M., Claverol, S., Gontier, É., Lacomme, S., Dousset, L., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018690118 · Cited by 46 · see citing works
Park, Y., Heider, D., & Hauschild, A.-C. (2021) · Cancers · doi:10.3390/cancers13133148 · Cited by 45 · see citing works
Liu, P., Griffiths, S., Veljanoski, D., Vaughn-Beaucaire, P. C., Speirs, V., & Brüning‐Richardson, A. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.20 · Cited by 45 · see citing works
Agosti, E., Antonietti, S., Ius, T., Fontanella, M. M., Zeppieri, M., & Panciani, P. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147979 · Cited by 44 · see citing works
Palumbo, P., Lombardi, F., Siragusa, G., Dehcordi, S. R., Luzzi, S., Cimini, A., Cifone, M. G., & Cinque, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092801 · Cited by 44 · see citing works
Sun, A., Meng, F., & Wang, M.-G. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7642 · Cited by 42 · see citing works
Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors
Xu, C., Liu, X., Geng, Y., Bai, Q., Pan, C., Sun, Y., Chen, X., Yu, H., Wu, Y., Zhang, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19656 · Cited by 41 · see citing works
Wan, J., Guo, A. A., Chowdhury, I., Guo, S., Hibbert, J. M., Wang, G., & Liu, M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01413 · Cited by 41 · see citing works
Mannucci, S., Tambalo, S., Conti, G., Ghin, L., Milanese, A., Carboncino, A., Nicolato, E., Marinozzi, M. R., Benati, D., Bassi, R., et al. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/2198703 · Cited by 39 · see citing works
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Li, J., Garavaglia, S., Ye, Z., Moretti, A., Belyaeva, O. V., Beiser, A., Ibrahim, M., Wilk, A. M., McClellan, S., Klyuyeva, A. V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02949-7 · Cited by 39 · see citing works
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
Lee, S. B., Ko, A., Oh, Y. T., Shi, P., D’Angelo, F., Frangaj, B., Koller, A. A., Chen, E. I., Cardozo, T. J., Iavarone, A., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.021 · Cited by 38 · see citing works
miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1
Yin, C., Kong, W., Jiang, J., Xu, H., & Zhao, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.9777 · Cited by 37 · see citing works
Sui, A., Yongbing, X., Yang, J., Pan, B., Wu, J., Guo, T., Shen, Y., & Guo, X. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.006 · Cited by 37 · see citing works
Kwon, Y., Je, J., Cha, S., Oh, Y., & Cho, W. (2019) · Oncology Reports · doi:10.3892/or.2019.7289 · Cited by 37 · see citing works
Expression and function of chondroitin 4‐sulfate and chondroitin 6‐sulfate in human glioma
Pan, H., Xue, W., Zhao, W., & Schachner, M. (2019) · The FASEB Journal · doi:10.1096/fj.201901621rrr · Cited by 37 · see citing works
G-protein-coupled receptors as therapeutic targets for glioblastoma
Byrne, K., Pal, A., Curtin, J. F., Stephens, J. C., & Kinsella, G. K. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.008 · Cited by 37 · see citing works
Leth, J. M., & Ploug, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.732015 · Cited by 37 · see citing works
MV1035 Overcomes Temozolomide Resistance in Patient-Derived Glioblastoma Stem Cell Lines
Malacrida, A., Domizio, A. D., Bentivegna, A., Cislaghi, G., Messuti, E., Tabano, S. M., Giussani, C. G., Zuliani, V., Rivara, M., & Nicolini, G. (2022) · Biology · doi:10.3390/biology11010070 · Cited by 37 · see citing works
The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling
Beiriger, J., Habib, A., Jovanovich, N., Kodavali, C. V., Edwards, L., Amankulor, N., & Zinn, P. O. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.790976 · Cited by 37 · see citing works
Panzarini, E., Tacconi, S., Carata, E., Mariano, S., Tata, A. M., & Dini, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218353 · Cited by 36 · see citing works
MFSD6 is an entry receptor for enterovirus D68
Varanese, L., Xu, L., Peters, C. E., Pintilie, G. D., Roberts, D. S., Raj, S. V. A., Liu, M., Ooi, Y. S., Diep, J., Qiao, W., et al. (2025) · Nature · doi:10.1038/s41586-025-08908-0 · Cited by 36 · see citing works
- Authors
- Allen, M., Bjerke, M., Edlund, H., Nelander, S., & Westermark, B.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Westermark, Bengt
- Venue
- Science Translational Medicine
- Published
- 2016-08-31
- Volume
- 8
- Issue
- 354
- Pages
- 354re3-354re3
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2509121458
- Cited by
- 466
- References
- 15
- Citations by year
- 2026: 28 · 2025: 33 · 2024: 43 · 2023: 36 · 2022: 49 · 2021: 41 · 2020: 59 · 2019: 51 · 2018: 84 · 2017: 37 · 2016: 5
- FWCI
- 42.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Cancer Society
- Swedish Crime Victim Compensation and Support Authority
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Keywords
- glioma cell lines, glioblastoma, tumor origin, genetic profiling, gene expression profiling, cell line misidentification, translational oncology
- MeSH terms
- Brain Neoplasms, DNA, Mitochondrial, DNA, Neoplasm, Glioblastoma, Glioma, Humans, DNA Fingerprinting, Microsatellite Repeats, Cell Culture Techniques, Gene Expression Profiling, Cell Line, Tumor, Translational Research, Biomedical
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review