The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence
Open accessAbstract
Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration.
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“Similarly, transforming growth factor-β improves liver regeneration on injury by blocking paracrine senescence in neighbouring uninjured hepatocytes188.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [188]
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In the citing paper
“While the role of paracrine senescence in cancer is yet undefined, it has been found to contribute to liver dysfunction upon acetaminophen overdose (Bird et al. 2018).”
From Senescence and the SASP: many therapeutic avenues (2020) · cites this paper as Bird et al. 2018
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“Other times, individual SASP components, such as TGF-β, might be pinpointed as disease drivers and targeting them specifically might be appropriate (Bird et al. 2018).”
From Senescence and the SASP: many therapeutic avenues (2020) · cites this paper as Bird et al. 2018
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Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
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InfluentialFast gapped-read alignment with Bowtie 2
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Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“Macrophages are a known source of TGF ligands, particularly in the context of tissue injury (32).”
BackgroundCellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · cited 1×
“These findings contrast with previous reports in which senescence after injury in other organs may facilitate regeneration (37) and limit fibrosis after liver injury (11).”
Self-citationSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · cited 1×
“Macrophage recruitment in liver injury shares similarities to the p21-dependent recruitment observed during hepatic oncogene-induced senescence (40) and the clearance of early hepatocellular carcinoma (13).”
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 17×
“An OIS signature was defined by the top 100 up-regulated genes in the IMR90 ER:RAS model (15).”
InfluentialSelf-citationEarly indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085 · cited 1×
“However, once acute liver failure of a defined clinical severity is established, no specific medical therapies exist, recovery is unlikely, and, unless liver transplantation occurs, death usually ensues (5).”
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027 · cited 3×
“SASP may also modulate fibrosis and regeneration in response to acute tissue injury (11, 16, 17).”
Research works printed but not linked: 1
- 10.1016/j.cell.2008.06.049 · DOI · Paper page
Cited by
Sorted by citations
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277
Senescence and the SASP: many therapeutic avenues
Birch, J., & Gil, J. (2020) · Genes & Development · doi:10.1101/gad.343129.120 · Cited by 1,177
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Dewidar, B., Meyer, C., Dooley, S., & Meindl-Beinker, A. N. (2019) · Cells · doi:10.3390/cells8111419 · Cited by 837
“A number of hepatocytes undergo senescence upon acute acetaminophen (APAP) induced liver damage [253].”
BackgroundEvasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
Hinz, B., & Lagares, D. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0324-5 · Cited by 642
Metadata
- Authors
- Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., Ferreira-Gonzalez, S., Cole, A. M., Hay, T., Simpson, K. J., Clark, W., Hedley, A., Clarke, M., Gentaz, P., Nixon, C., Bryce, S., Kiourtis, C., Sprangers, J., Nibbs, R. J. B., Van Rooijen, N., Bartholin, L., McGreal, S. R., Apte, U., Barry, S. T., Iredale, J. P., Clarke, A. R., Serrano, M., Roskams, T. A., Sansom, O. J., & Forbes, S. J.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Cancer Research UK Scotland Institute (GB)
- Spanish National Cancer Research Centre (ES)
- Universitair Ziekenhuis Leuven (BE)
- Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
- Cardiff University (GB)
- University of Glasgow (GB)
- Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.
- Lyon 1 Université (FR)
- University of Kansas Medical Center (US)
- AstraZeneca (United Kingdom) (GB)
- University of Bristol (GB)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Bird, Thomas G.
- Clarke, Alan R.
- ORCID
- Bird, Thomas G.
- Müller, Miryam
- Boulter, Luke
- Vincent, David F.
- Ridgway, Rachel A.
- Lopez-Guadamillas, Elena
- Lu, Wei-Yu
- Jamieson, Thomas
- Govaere, Olivier
- Campbell, Andrew D.
- Ferreira-Gonzalez, Sofía
- Cole, Alicia M.
- Hay, Trevor
- Clark, William
- Hedley, Ann
- Clarke, Mairi
- Gentaz, Pauline
- Nixon, Colin
- Bryce, Steven
- Kiourtis, Christos
- Nibbs, Robert J. B.
- Van Rooijen, Nico
- Bartholin, Laurent
- McGreal, Steven R.
- Apte, Udayan
- Barry, Simon T.
- Iredale, John P.
- Clarke, Alan R.
- Serrano, Manuel
- Roskams, Tania A.
- Sansom, Owen J.
- Forbes, Stuart J.
- Venue
- Science Translational Medicine
- Published
- 2018-08-15
- Volume
- 10
- Issue
- 454
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6420144
- OpenAlex
- W2887276938
- Cited by
- 261
- References
- 61
- Citations by year
- 2026: 16 · 2025: 34 · 2024: 47 · 2023: 42 · 2022: 31 · 2021: 28 · 2020: 37 · 2019: 24 · 2018: 2
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
- Bristol Research (University of Bristol) (publishedVersion, other-oa)
- Explore Bristol Research (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01 DK98414)
- Wellcome Trust (107492Z, 081604AIA)
- Medical Research Council (G1000868, G0900992)
- Cancer Research UK (2016-CRUK core running, A12481)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- acute liver injury, liver regeneration, hepatocyte senescence, paracrine senescence, TGF-β1, acetaminophen toxicity, p21, macrophages, hepatocyte proliferation, acute liver failure
- MeSH terms
- Animals, Disease Models, Animal, Humans, Liver, Liver Regeneration, Macrophages, Male, Mice, Inbred C57BL, Necrosis, Signal Transduction, Transforming Growth Factor beta, Cellular Senescence, Paracrine Communication, Hepatocytes, Cyclin-Dependent Kinase Inhibitor p21
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