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Garbage Truck of the Brain
Open accessAbstract
An intercellular “glymphatic” pathway clears cell waste from the brain and may reveal new targets for treating neurodegenerative diseases.
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The glymphatic system depends on astrocytic aquaporin-4 water channels and adopts functions homologous to peripheral lymphatic removal of interstitial metabolic byproducts.
“These pathways were named the glymphatic system on the basis of their dependence on astrocytic aquaporin-4 (AQP4) water channels and the adoption of functions homologous to peripheral lymphatic removal of interstitial metabolic byproducts (14).”
From Sleep Drives Metabolite Clearance from the Adult Brain (2013) · cites this paper as [14]
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Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
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Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803
Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X.-L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003716 · Cited by 958
Yang, L., Kress, B. T., Weber, H. J., Thiyagarajan, M., Wang, B., Deane, R., Benveniste, H., Iliff, J. J., & Nedergaard, M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-107 · Cited by 317
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Research works printed but not linked: 11
- 10.1101/cshperspect.a006338 · DOI · Paper page
- 10.1038/nrn2786 · DOI · Paper page
- Walker L. C., Diamond M. I., Duff K. E., Hyman B. T., J. Am. Med. Assoc. Neurol. 70, 304 (2013).
- 10.1002/ca.21194 · DOI
- 10.1152/physrev.1971.51.2.273 · DOI · Paper page
- 10.1016/j.neuroscience.2004.08.053 · DOI
- 10.1161/STROKEAHA.112.678698 · DOI
- 10.1038/jcbfm.2013.30 · DOI
- 10.1016/S0006-8993(02)02920-7 · DOI
- 10.1186/alzrt6 · DOI
- 10.1172/JCI67677 · DOI · Paper page
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Metadata
- Authors
- Nedergaard, M.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Nedergaard, Maiken
- ORCID
- Nedergaard, Maiken
- Venue
- Science
- Published
- 2013-06-28
- Volume
- 340
- Issue
- 6140
- Pages
- 1529-1530
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3749839
- OpenAlex
- W2042683896
- Cited by
- 718
- References
- 4
- Citations by year
- 2026: 75 · 2025: 78 · 2024: 74 · 2023: 63 · 2022: 59 · 2021: 65 · 2020: 62 · 2019: 63 · 2018: 40 · 2017: 54 · 2016: 35 · 2015: 23 · 2014: 21 · 2013: 5
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH099578)
- National Institute of Neurological Disorders and Stroke (R01NS078304, R01NS078167, R01NS075177)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- glymphatic system, neurodegenerative diseases
- MeSH terms
- Animals, Brain, Cerebrospinal Fluid, Humans, Neuroglia, Neurons, Neurodegenerative Diseases, Lymphatic Vessels, Extracellular Fluid, Mice, Rats, Aquaporin 4
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