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Fluconazole plus Cyclosporine: a Fungicidal Combination Effective against Experimental Endocarditis Due to Candida albicans
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Recent observations demonstrated that fluconazole plus cyclosporine (Cy) synergistically killed Candida albicans in vitro. This combination was tested in rats with C. albicans experimental endocarditis. The MICs of fluconazole and Cy for the test organism were 0.25 and >10 mg/liter, respectively. Rats were treated for 5 days with either Cy, amphotericin B, fluconazole, or fluconazole-Cy. Although used at high doses, the peak concentrations of fluconazole in the serum of rats (up to 4.5 mg/liter) were compatible with high-dose fluconazole therapy in humans. On the other hand, Cy concentrations in serum (up to 4.5 mg/liter) were greater than recommended therapeutic levels. Untreated rats demonstrated massive pseudohyphal growth in both the vegetations and the kidneys. However, only the kidneys displayed concomitant polymorphonuclear infiltration. The therapeutic results reflected this dissociation. In the vegetations, only the fungicidal fluconazole-Cy combination significantly decreased fungal densities compared to all groups, including amphotericin B ( P < 0.0001). In the kidneys, all regimens except the Cy regimen were effective, but fluconazole-Cy remained superior to amphotericin B and fluconazole alone in sterilizing the organs ( P < 0.0001). While the mechanism responsible for the fluconazole-Cy interaction is hypothetical, this observation opens new perspectives for fungicidal combinations between azoles and other drugs.
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“In a mouse model of invasive candidiasis by C. albicans, the efficacy of fluconazole was increased by co-administration of FK506 (56).”
From Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata (2026) · cites this paper as [56]
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Cites
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
ABC Transporters: From Microorganisms to Man
Higgins, C. F. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.000435 · Cited by 3,985
Antibiotics in Laboratory Medicine.
Lorian, V. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-4-653_4 · Cited by 2,809
The mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695
Secular Trends in the Epidemiology of Nosocomial Fungal Infections in the United States, 1980-1990
Beck‐Sagué, C. M., Jarvis, W. R., & System, N. N. I. S. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.5.1247 · Cited by 1,140
Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., van der Horst, C. M., Edwards, J. E., Washburn, R. G., Scheld, W. M., Karchmer, A. W., Dine, A. P., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411173312001 · Cited by 1,039
Amphotericin B: 30 Years of Clinical Experience
Gallis, H. A., Drew, R. H., & Pickard, W. W. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.2.308 · Cited by 1,013
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Fruman, D. A., Klee, C. B., Bierer, B. E., & Burakoff, S. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3686 · Cited by 823
Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M., & Bille, J. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.11.2378 · Cited by 815
Self-citation
Research works printed but not linked: 2
- Osato M. S. Roussel K. R. Wilhelmus K. R. Jones D. B. In vitro and in vivo antifungal activity of cyclosporine. Transplant. Proc. 15 1983 2927 2930
- Wood A. J. Maurer G. Niederberger W. Beveridge T. Cyclosporine: pharmacokinetics, metabolism, and drug interactions. Transplant. Proc. 15 1983 2409 2412
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Anderson, J. B., Sirjusingh, C., Parsons, A. B., Boone, C., Wickens, C., Cowen, L. E., & Kohn, L. M. (2003) · Genetics · doi:10.1093/genetics/163.4.1287 · Cited by 156
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Niimi, K., Harding, D. R. K., Parshot, R., King, A., Lun, D. J., Decottignies, A., Niimi, M., Lin, S., Cannon, R. D., Goffeau, A., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1256-1271.2004 · Cited by 115
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Treatment options of invasive fungal infections in adults
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Mehta, S., Li, H., Hogan, P. G., & Cunningham, K. W. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01197-08 · Cited by 83
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Tanabe, K., Lamping, E., Adachi, K., Takano, Y., Kawabata, K., Shizuri, Y., Niimi, M., & Uehara, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.110 · Cited by 74
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Guo, X.-L., Leng, P., Yang, Y., Yu, L., & Lou, H. (2008) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03617.x · Cited by 61
Li, Y., Sun, S., Guo, Q., Ma, L., Shi, C., Su, L., & Li, H. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm493 · Cited by 61
Marchetti, O., Moreillon, P., Entenza, J. M., Vouillamoz, J., Glauser, M. P., Billé, J., & Sanglard, D. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.5.1565-1570.2003 · Cited by 58
Self-citationAfeltra, J., Vitale, R. G., Mouton, J. W., & Verweij, P. E. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1335-1343.2004 · Cited by 56
Kim, J., Cho, Y.-J., Do, E., Choi, J., Hu, G., Cadieux, B., Chun, J., Lee, Y., Kronstad, J. W., & Jung, W. H. (2012) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2012.08.006 · Cited by 53
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Saini, P., Prasad, T., Gaur, N. A., Shukla, S., Jha, S., Komath, S. S., Khan, L. A., Haq, Q. M. R., & Prasad, R. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki183 · Cited by 47
Chen, S. C.-A., Lewis, R. E., & Kontoyiannis, D. P. (2011) · Virulence · doi:10.4161/viru.2.4.16764 · Cited by 41
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Tisi, R., Rigamonti, M. M., Groppi, S., & Belotti, F. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.4.505 · Cited by 41
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Signaling cascades as drug targets in model and pathogenic fungi.
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Combination antifungal therapy: a strategy for the management of invasive fungal infections.
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Shukla, S. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh308 · Cited by 25
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Tanabe, K., Lamping, E., Nagi, M., Okawada, A., Holmes, A. R., Miyazaki, Y., Cannon, R. D., Monk, B. C., & Niimi, M. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07820.x · Cited by 24
Onyewu, C., Eads, E., Schell, W. A., Perfect, J. R., Ullmann, Y., Kaufman, G., Horwitz, B. A., Berdicevsky, I., & Heitman, J. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00492-07 · Cited by 23
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Role of Ca2+/Calmodulin Signaling Pathway on Morphological Development of Candida albicans
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Jia, Y., Tang, R.-J., Wang, L., Zhang, X., Wang, Y., Jia, X.-M., & Jiang, Y.-Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048369 · Cited by 19
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Sanglard, D., & White, T. C. (2014) · ASM Press eBooks · doi:10.1128/9781555815776.ch14 · Cited by 19
Self-citationThomas, E., Sircaik, S., Román, E., Brunel, J. M., Johri, A. K., Plá, J., & Panwar, S. L. (2015) · FEMS Yeast Research · doi:10.1093/femsyr/fov095 · Cited by 18
Antifungal therapy - state of the art at the beginning of the 21st century
Polak, A. (2003) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7974-3_4 · Cited by 19
Reedy, J. L., Husain, S., Ison, M. G., Pruett, T. L., Singh, N., & Heitman, J. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1573-1577.2006 · Cited by 18
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Yuan, Y., Zhou, F., Su, H., & Zhang, Y. (2019) · Scientific Reports · doi:10.1038/s41598-019-48322-x · Cited by 16
Mo, D., Li, X., Wei, L., Sun, C., Liang, H., & Cao, C. (2014) · Mycopathologia · doi:10.1007/s11046-014-9787-8 · Cited by 16
Stefan, C. P., & Cunningham, K. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.508705 · Cited by 15
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Wibawa, T., Nurrokhman, Baly, I., Daeli, P. R., Kartasasmita, G., & Wijayanti, N. (2015) · PubMed · Cited by 11
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Pharmacotherapy of Candida bloodstream infections: new treatment options, new era
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MINIREVIEW Combination Antifungal Therapy
Johnson, J. R., Dougall, C. M., & Zeichner, L. O. (2004) · Cited by 7
Massuda, T. Y. C., Nagashima, L. A., Leonello, P. C., Kaminami, M. S., Mantovani, M. S., Sano, A., Uno, J., Venâncio, E. J., Camargo, Z. P. D., & Itano, E. N. (2010) · Mycopathologia · doi:10.1007/s11046-010-9359-5 · Cited by 6
Antifungal Drug Resistance: Pumps and Permutations
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Billé, J. (2000) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(00)00260-0 · Cited by 5
Harrington, A. A., Nickels, T. J., & Cunningham, K. W. (2026) · mBio · doi:10.1128/mbio.02546-25 · Cited by 4
“In a mouse model of invasive candidiasis by C. albicans , the efficacy of fluconazole was increased by co-administration of FK506 (56).”
Current and emerging therapies for fungal biofilms and systemic infections
Elgammal, Y., Martinez, R. I. G., Requejo, A., & Martinez, L. R. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2570185 · Cited by 4
Metadata
- Authors
- Marchetti, O., Entenza, J. M., Sanglard, D., Bille, J., Glauser, M. P., & Moreillon, P.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- <!--label omitted: 1-->Division of Infectious Diseases, Department of Internal Medicine,1 and
- <!--label omitted: 2-->Institute of Microbiology,2 Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-11
- Volume
- 44
- Issue
- 11
- Pages
- 2932-2938
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC101583
- OpenAlex
- W2080315399
- Cited by
- 113
- References
- 43
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- fluconazole, cyclosporine, Candida albicans, fungal endocarditis, combination antifungal therapy, amphotericin B, drug interactions, pseudohyphal growth, vegetation, serum drug concentration
- MeSH terms
- Animals, Antifungal Agents, Candida albicans, Candidiasis, Disease Models, Animal, Drug Resistance, Microbial, Drug Therapy, Combination, Endocarditis, Female, Kidney, Microbial Sensitivity Tests, Fluconazole, Cyclosporine, Treatment Outcome, Rats, Wistar, Rats
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