The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation
Open accessAbstract
Bacterial biofilms cause numerous problems in health care and industry; notably, biofilms are associated with a large number of infections. Biofilm-dwelling bacteria are particularly resistant to antibiotics, making it hard to eradicate biofilm-associated infections. Bacteria rely on efflux pumps to get rid of toxic substances. We discovered that efflux pumps are highly active in bacterial biofilms, thus making efflux pumps attractive targets for antibiofilm measures. A number of efflux pump inhibitors (EPIs) are known. EPIs were shown to reduce biofilm formation, and in combination they could abolish biofilm formation completely. Also, EPIs were able to block the antibiotic tolerance of biofilms. The results of this feasibility study might pave the way for new treatments for biofilm-related infections and may be exploited for prevention of biofilms in general.
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Citations
Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Fexby, S., Bjarnsholt, T., Jensen, P. Ø., Roos, V., Høiby, N., Givskov, M., & Klemm, P. (2007) · Infection and Immunity · doi:10.1128/iai.01117-06 · Cited by 58
Self-citation
Cited by
Bacterial multidrug efflux pumps: Mechanisms, physiology and pharmacological exploitations
Sun, J., Deng, Z., & Yan, A. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.05.090 · Cited by 746
Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance.
Blair, J. M., Richmond, G. E., & Piddock, L. J. (2014) · Future Microbiology · doi:10.2217/fmb.14.66 · Cited by 481
Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016) · Molecules · doi:10.3390/molecules21070877 · Cited by 308
Strategies for combating antibiotic resistance in bacterial biofilms
Grooters, K. E., Ku, J. C., Richter, D. M., Krinock, M. J., Minor, A., Li, P., Kim, A., Sawyer, R., & Li, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1352273 · Cited by 156
Metadata
- Authors
- Kvist, M., Hancock, V., & Klemm, P.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2008-12
- Volume
- 74
- Issue
- 23
- Pages
- 7376-7382
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2153763474
- Cited by
- 353
- References
- 4
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Kvist, M., Hancock, V., & Klemm, P. (2008). Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.01310-08
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