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Cited by 73Infant Nutrition and HealthGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated Akkermansia Is Strain Dependent

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Luna, Estefani, Parkar, Shanthi G., Kirmiz, Nina, Hartel, Stephanie, Hearn, Erik, Hossine, Marziiah, Kurdian, Arinnae, Mendoza, Claudia +11 more·2022·Applied and Environmental Microbiology
DOI 10.1128/aem.01487-21PMC PMC8752153

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Abstract

Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk and provide several benefits to developing infants, including the recruitment of beneficial bacteria to the human gut. Akkermansia strains are largely considered beneficial bacteria and have been detected in colostrum, breast milk, and young infants. A. muciniphila Muc T belonging to the AmI phylogroup contributes to the HMO deconstruction capacity of the infant. Here, using phylogenomics, we examined the genomic capacities of four Akkermansia phylogroups to deconstruct HMOs.

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Authors
Luna, E., Parkar, S. G., Kirmiz, N., Hartel, S., Hearn, E., Hossine, M., Kurdian, A., Mendoza, C., Orr, K., Padilla, L., Ramirez, K., Salcedo, P., Serrano, E., Choudhury, B., Paulchakrabarti, M., Parker, C. T., Huynh, S., Cooper, K., & Flores, G. E.
Affiliations
  • California State University, Northridge (US)
  • UC San Diego Health System (US)
  • Agricultural Research Service (US)
  • University of Arizona (US)
Corresponding author
Flores, Gilberto E.
ORCID
Venue
Applied and Environmental Microbiology
Publisher
American Society for Microbiology
Published
2022-01-11
Volume
88
Issue
1
ISSN
  • 0099-2240 (ISSN-L)
  • 1098-5336
DOI
10.1128/aem.01487-21
PMC
PMC8752153
OpenAlex
W4288059046
Cited by
73
References
84
Citations by year
2026: 13 · 2025: 18 · 2024: 20 · 2023: 17 · 2022: 5
FWCI
6.69
Type
journal article
Language
en
Open access
Licence
Locations
  • Applied and Environmental Microbiology (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
Funders
HHS | NIH | National Institute of General Medical Sciences (SC2GM122620 and SC1GM136546, TL4GM118977 RL5GM118975 and UL1GM118976)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
human milk oligosaccharides, Akkermansia, Akkermansia muciniphila, infant gut microbiota, phylogenomics, colostrum, breast milk

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