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Human Gut Metagenomes Encode Diverse GH156 Sialidases
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Abstract
Sialic acids occupy terminal positions of human glycans where they act as receptors for microbes, toxins, and immune signaling molecules. Microbial enzymes that remove sialic acids, sialidases, are abundant in the human microbiome where they may contribute to shaping the microbiota community structure or contribute to pathology.
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Metadata
- Authors
- Mann, E., Shekarriz, S., & Surette, M. G.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Surette, Michael G.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2022-12-13
- Volume
- 88
- Issue
- 23
- Pages
- e0175522-e0175522
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC9746317
- OpenAlex
- W4309245555
- Cited by
- 12
- References
- 15
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gouvernement du Canada | Canadian Institutes of Health Research
- W. Garfield Weston Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
- Keywords
- neuraminidase, human gut microbiome, sialic acid, microbial enzymes, diet variation, gut microbiota diversity, cancer therapy
- MeSH terms
- Gastrointestinal Microbiome, Glycoside Hydrolases, Humans, Neuraminidase, Polysaccharides, Sialic Acids, Metagenome
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