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Antifungal 3-Hydroxy Fatty Acids from Lactobacillus plantarum MiLAB14
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We report the identification and chemical characterization of four antifungal substances, 3-(R)-hydroxydecanoic acid, 3-hydroxy-5-cis-dodecenoic acid, 3-(R)-hydroxydodecanoic acid and 3-(R)-hydroxytetradecanoic acid, from Lactobacillus plantarum MiLAB 14. The concentrations of the 3-hydroxy fatty acids in the supernatant followed the bacterial growth. Racemic mixtures of the saturated 3-hydroxy fatty acids showed antifungal activity against different molds and yeasts with MICs between 10 and 100 micrograms ml-1.
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“Sjogren et al. [174] found that hydroxylated fatty acids possess strong antifungal activity against a broad spectrum of yeasts and molds.”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [174]
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Metadata
- Authors
- Sjögren, J., Magnusson, J., Broberg, A., Schnürer, J., & Kenne, L.
- Affiliations
- Department of Chemistry
- Swedish University of Agricultural Sciences (SE)
- Department of Microbiology, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2003-12
- Volume
- 69
- Issue
- 12
- Pages
- 7554-7557
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC309954
- OpenAlex
- W1986816587
- Cited by
- 328
- References
- 27
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 15 · 2023: 17 · 2022: 25 · 2021: 15 · 2020: 20 · 2019: 14 · 2018: 14 · 2017: 13 · 2016: 21 · 2015: 15 · 2014: 20 · 2013: 20 · 2012: 17
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stiftelsen för Miljöstrategisk Forskning
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Keywords
- antifungal agents, 3-hydroxy fatty acids, Lactobacillus plantarum, 3-hydroxydecanoic acid, 3-hydroxytetradecanoic acid, fungal growth inhibition, molds, yeast, minimum inhibitory concentration
- MeSH terms
- Antifungal Agents, Decanoic Acids, Fungi, Lactobacillus, Microbial Sensitivity Tests, Molecular Sequence Data, Culture Media, Conditioned, Sequence Analysis, DNA, Oleaceae
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