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Cited by 99

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RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosa

Cruz, Renae L., Asfahl, Kyle L., Van den Bossche, Sara, Coenye, Tom, Crabbé, Aurélie, Dandekar, Ajai A.·2020·mBio
DOI 10.1128/mbio.00532-20

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Abstract

Pseudomonas aeruginosa is a prominent cystic fibrosis (CF) pathogen that uses quorum sensing (QS) to regulate virulence. In laboratory strains, the key QS regulator is LasR. Many isolates from patients with chronic CF infections appear to use an alternate QS circuitry in which another transcriptional regulator, RhlR, mediates QS. We show that a LasR-null CF clinical isolate engages in QS through RhlR and remains capable of inducing cell death in an in vivo- like lung epithelium cell model. Our findings support the notion that LasR-null clinical isolates can engage in RhlR QS and highlight the centrality of RhlR in chronic P. aeruginosa infections.

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Metadata

Authors
Cruz, R. L., Asfahl, K. L., Van den Bossche, S., Coenye, T., Crabbé, A., & Dandekar, A. A.
Venue
mBio
Publisher
American Society for Microbiology
Published
2020-04-28
Volume
11
Issue
2
ISSN
  • 2161-2129
  • 2150-7511
DOI
10.1128/mbio.00532-20
Cited by
99
References
1
Language
en
Licence
Funders
  • HHS | NIH | National Institute of General Medical Sciences (R01 GM125714)
  • Burroughs Wellcome Fund (1012253)
  • Doris Duke Charitable Foundation (2017072)
  • Fonds Wetenschappelijk Onderzoek (G.0.E53.14N, 3S55719)
  • HHS | NIH | National Heart, Lung, and Blood Institute (T32 HL007287)

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CoChat. (2026). Citation check: RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosa. https://app.cochat.ai/papers/10.1128/mbio.00532-20
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Cruz, R. L., Asfahl, K. L., Van den Bossche, S., Coenye, T., Crabbé, A., & Dandekar, A. A. (2020). RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosa. mBio. https://doi.org/10.1128/mbio.00532-20

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.