The DOI matches its Crossref record; 72 of the 73 references it cites were found in a registry or an index.
PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene
Open accessAbstract
Growth factor receptors play an important role in hematopoiesis. In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis, we initiated a study investigating the transcription factors activating the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha gene. Here, we demonstrate that the human GM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in myelomonocytic cells, which correlates with its expression pattern as analyzed by reverse transcription PCR. The GM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of reporter constructs. We show that the myeloid and B cell transcription factor PU.1 binds specifically to this site. Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity. C/EBP alpha is the major CCAAT/enhancer-binding protein (C/EBP) form binding to this site in nuclear extracts of U937 cells. Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only. Furthermore, we demonstrate that in myeloid and B cell extracts, PU.1 forms a novel, specific, more slowly migrating complex (PU-SF) when binding the GM-CSF receptor alpha promoter PU.1 site. This is the first demonstration of a specific interaction with PU.1 on a myeloid PU.1 binding site. The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1, including T cells and epithelial cells, but not from erythroid cells. Furthermore, we demonstrate that the PU-SF complex binds to PU.1 sites found on a number of myeloid promoters, and its formation requires an intact PU.1 site adjacent to a single-stranded region. Expression of PU.1 in nonmyeloid cells can activate the GM-CSF receptor alpha promoter. Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter. Finally, we demonstrate that C/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells. These results suggest that PU.1 and C/EBP alpha direct the cell-type-specific expression of GM-CSF receptor alpha, further establish the role of PU.1 as a key regulator of hematopoiesis, and point to C/EBP alpha as an additional important factor in this process.
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In the citing paper
“PU.1 imparts its key functions by regulating vast number of myeloid gene promoters that include GM-CSF receptor a, M-CSF receptor (M-CSFR), scavenger receptor CD163, and CD11b, etc (6,7).”
From FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1 (2021) · cites this paper as [6]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In cotransfection experiments, RUNX1, PU.1, and CEBPA play essential roles in activation of the hematopoietic differentiation genes MCSFR and GMCSFR.7,8,31”
From RUNX1 regulates corepressor interactions of PU.1 (2011) · cites this paper as [31]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The block in the development of these lineages occurs at very early stages, because the mutant animals completely lack lymphoid and myeloid progenitor cells, rendering it difficult to determine the precise role of PU.1 during stage- and lineage-specific gene expression.”
From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [67]
Experimental — accuracy not yet measuredIn the citing paper
“In myeloid lineages, the putative PU.1 target genes include G-SCF receptor [23], GM-CSF receptor [24] and M-CSF receptor [25].”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [24]
In the citing paper
“C/EBP-α expression is prominent in immature myeloid cells [24, 101].”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [24]
In the citing paper
“Each factor has been shown to synergize on various promoters, including M-CSF receptor promoter and neutrophil elastase (NE) promoter [24, 63].”
From PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis (2009) · cites this paper as [24]
In the citing paper
“C/EBP-␣ minimally activates several myeloid cell-specific promoters, including those for cytokine receptors (e.g., GM-CSF, G-CSF, and M-CSF receptors) (26,65,78,79) and granule proteins (e.g., NE) (50).”
From The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation (1998) · cites this paper as [26]
In the citing paper
“Moreover, C/EBP-␣ cooperates with other myeloid transcription factors, including AML-1B and PU.1, to synergistically upregulate the expression of several myeloid cellspecific promoters (26,50,78).”
From The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation (1998) · cites this paper as [26]
In the citing paper
“Each factor has been shown to synergize on various promoters, including M-CSF receptor promoter and neutrophil elastase promoter.15,35”
From Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions (2002) · cites this paper as [15]
In the citing paper
“Targeted disruption of PU.1 in mice severely impairs the development of lymphoid (B cells) and myeloid (macrophages and neutrophils) lineages.”
From AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain (2001) · cites this paper as [67]
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Citations
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262
A new method for sequencing DNA.
Maxam, A. M., & Gilbert, W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.2.560 · Cited by 7,929
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science · doi:10.1126/science.8079170 · Cited by 1,532
EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS
Johnson, P. F., & McKnight, S. L. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.004055 · Cited by 1,210
Luciferase reporter gene vectors for analysis of promoters and enhancers.
Nordeen, S. K. (1988) · PubMed · Cited by 994
The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
Klemsz, M. J., McKercher, S. R., Celada, A., Van Beveren, C., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90219-5 · Cited by 954
Expression cloning of a receptor for human granulocyte‐macrophage colony‐stimulating factor.
Gearing, D. P., King, J. A., Gough, N. M., & Nicola, N. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08541.x · Cited by 683
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
Staudt, L. M., Singh, H., Sen, R., Wirth, T. C., Sharp, P. A., & Baltimore, D. (1986) · Nature · doi:10.1038/323640a0 · Cited by 658
Lin, F., & Lane, M. (1994) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.91.19.8757 · Cited by 459
Friedman, A. D., Landschulz, W. H., & McKnight, S. L. (1989) · Genes & Development · doi:10.1101/gad.3.9.1314 · Cited by 451
Spi-1 is a putative oncogene in virally induced murine erythroleukaemias
Moreau-Gachelin, F., Tavitian, A., & Tambourin, P. (1988) · Nature · doi:10.1038/331277a0 · Cited by 447
Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5
Miyajima, A., Mui, A. L.-F., Ogorochi, T., & Sakamaki, K. (1993) · Blood · doi:10.1182/blood.v82.7.1960.bloodjournal8271960 · Cited by 414
Zhang, D.-E., Hetherington, C. J., Chen, H.-M., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.373-381.1994 · Cited by 411
Self-citationScott, L., Civin, C., Rorth, P., & Friedman, A. (1992) · Blood · doi:10.1182/blood.v80.7.1725.1725 · Cited by 409
Arcari, P., Martinelli, R., & Salvatore, F. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.23.9179 · Cited by 409
Zhang, D.-E., Hetherington, C. J., Meyers, S., Rhoades, K. L., Larson, C. J., Chen, H.-M., Hiebert, S. W., & Tenen, D. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1231 · Cited by 396
Self-citationPongubala, J. M., Nagulapalli, S., Klemsz, M. J., McKercher, S. R., Maki, R. A., & Atchison, M. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.368 · Cited by 354
DUNCAN, R. C., Bazar, L. S., Michelotti, G. A., Tomonaga, T., Krutzsch, H. C., Avigan, M., & Levens, D. (1994) · Genes & Development · doi:10.1101/gad.8.4.465 · Cited by 326
Hagemeier, C., Bannister, A. J., Cook, A., & Kouzarides, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1580 · Cited by 303
The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., & Tenen, D. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53496-7 · Cited by 301
Self-citationNuchprayoon, I., Meyers, S., Scott, L. M., Suzow, J., Hiebert, S., & Friedman, A. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5558 · Cited by 296
Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6
Natsuka, S., Akira, S., Nishio, Y., Hashimoto, S., Sugita, T., Isshiki, H., & Kishimoto, T. (1992) · Blood · doi:10.1182/blood.v79.2.460.460 · Cited by 289
Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation
Pongubala, J., Van Beveren, C., Nagulapalli, S., Klemsz, M., McKercher, Maki, R., & Atchison, M. (1993) · Science · doi:10.1126/science.8456286 · Cited by 271 · cited 10×
“NF-EM5 (47), did not abolish the ability of PU.1 to form PU-SF (Fig.”
BackgroundResultInfluentialMyb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.Preprint
Ness, S. A., Kowenz‐Leutz, E., Casini, T., Graf, T., & Leutz, A. (1993) · Genes & Development · doi:10.1101/gad.7.5.749 · Cited by 262
CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter.
Skalnik, D. G., Strauss, E. C., & Orkin, S. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55363-1 · Cited by 259
Cellular Nucleic Acid Binding Protein Regulates the CT Element of the Human c- myc Protooncogene
Michelotti, E. F., Tomonaga, T., Krutzsch, H. C., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9494 · Cited by 233
Park, L., Waldron, P. E., Friend, D., et al. (1989) · Blood · doi:10.1182/blood.v74.1.56.56 · Cited by 232
Overlapping positive and negative regulatory domains of the human beta-interferon gene.
Goodbourn, S., & Maniatis, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1447 · Cited by 232
An HMG-like protein that can switch a transcriptional activator to a repressor
Lehming, N., Thanos, D., Brickman, J. M., Ma, J., Maniatis, T., & Ptashne, M. (1994) · Nature · doi:10.1038/371175a0 · Cited by 225
Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
Chen, H., Zhang, P., Voso, M., Hohaus, S., Gonzalez, D., Glass, C., Zhang, D., & Tenen, D. (1995) · Blood · doi:10.1182/blood.v85.10.2918.bloodjournal85102918 · Cited by 216
Self-citationZhang, D., Fujioka, K., Hetherington, C. J., Shapiro, L., Chen, H. M., Look, A. T., & Tenen, D. G. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8085 · Cited by 202
Synergistic activation of the chicken mim‐1 gene by v‐myb and C/EBP transcription factors.
Burk, O., Mink, S., Ringwald, M., & Klempnauer, K.-H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05852.x · Cited by 190
Characterization of the human granulocyte-macrophage colony-stimulating factor receptor.
DiPersio, J. F., Billing, P. A., Kaufman, S., Eghtesady, P., Williams, R. E., & Gasson, J. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77952-6 · Cited by 187
Katz, S., Kowenz‐Leutz, E., Müller, C., Meese, K., Ness, S. A., & Leutz, A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05777.x · Cited by 183
Eisenbeis, C. F., Singh, H., & Storb, U. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6452 · Cited by 182
C/EBP beta regulation of the tumor necrosis factor alpha gene.
Pope, R. M., Leutz, A., & Ness, S. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117482 · Cited by 173
Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.
Ray, D., Bosselut, R., Ghysdael, J., Mattei, M. G., Tavitian, A., & Moreau-Gachelin, F. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4297 · Cited by 157
Kominato, Y., Galson, D. L., Waterman, W. R., Webb, A. C., & Auron, P. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.59 · Cited by 146
Inhibition of hematopoiesis by competitive binding of transcription factor PU.1
Voso, M. T., Burn, T. C., Wulf, G., Lim, B., Leone, G., & Tenen, D. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.7932 · Cited by 141
Rapoport, A. P., Abboud, C. N., & DiPersio, J. F. (1992) · Blood Reviews · doi:10.1016/0268-960x(92)90007-d · Cited by 135
Park, L. S., Friend, D. J., Gillis, S. A., & Urdal, D. L. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.1.251 · Cited by 132
Shin, M. K., & Koshland, M. E. (1993) · Genes & Development · doi:10.1101/gad.7.10.2006 · Cited by 126
Evidence of Changes in Protease Sensitivity and Subunit Exchange Rate on DNA Binding by C/EBP
Shuman, J. D., Vinson, C., & McKnight, S. L. (1990) · Science · doi:10.1126/science.2202050 · Cited by 125
The PU.1 transcription factor is the product of the putative oncogene Spi-1
Goebl, M. G. (1990) · Cell · doi:10.1016/0092-8674(90)90676-6 · Cited by 120
Improved site-directed mutagenesis method using PCR
Kuipers, O. P., Boot, H. J., & de Vos, W. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.16.4558 · Cited by 116
Paul, R., Schuetze, S., Kozak, S. L., Kozak, C. A., & Kabat, D. (1991) · Journal of Virology · doi:10.1128/jvi.65.1.464-467.1991 · Cited by 113
Raines, M. A., Liu, L., Quan, S. G., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.18.8203 · Cited by 104
CD18 (beta 2 leukocyte integrin) promoter requires PU.1 transcription factor for myeloid activity.
Rosmarin, A. G., Caprio, D. G., Levy, R., & Simkevich, C. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.801 · Cited by 94
Pahl, H. L., Burn, T. C., & Tenen, D. G. (1991) · PubMed · Cited by 93
Sterneck, E., Müller, C., Katz, S., & Leutz, A. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05034.x · Cited by 89
The Ets-Related Transcription Factor PU.1 Immortalizes Erythroblasts
Schuetze, S. M., Stenberg, P. E., & Kabat, D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5670 · Cited by 88
Feinman, R., Qiu, W. Q., Pearse, R. N., Nikolajczyk, B. S., Sen, R., Sheffery, M., & Ravetch, J. V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06696.x · Cited by 88
Role of the PU.1 Transcription Factor in Controlling Differentiation of Friend Erythroleukemia Cells
Schuetze, S. M., Paul, R. W., Gliniak, B., & Kabat, D. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.7.2967 · Cited by 86
Eichbaum, Q. G., Iyer, R., Raveh, D. P., Mathieu, C., & Ezekowitz, R. A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.6.1985 · Cited by 86
Moulton, K. S., Semple, K., Wu, H., & Glass, C. K. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4408 · Cited by 86
Perez, C., Coeffier, E., Moreau-Gachelin, F., Wietzerbin, J., & Benech, P. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5023 · Cited by 84
Characterization of the ets oncogene family member, fli-1.
Klemsz, M. J., Maki, R. A., Papayannopoulou, T., Moore, J., & Hromas, R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53385-8 · Cited by 82
Bretz, J. D., Williams, S. C., Baer, M., Johnson, P. F., & Schwartz, R. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7306 · Cited by 81
Monocyte maturation controls expression of equine infectious anemia virus
Maury, W. J. (1994) · Journal of Virology · doi:10.1128/jvi.68.10.6270-6279.1994 · Cited by 71
Sun, S., Stoflet, E. S., Cogan, J. G., et al. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2429 · Cited by 70
Wognum, A., Westerman, Y., Visser, T., & Wagemaker, G. (1994) · Blood · doi:10.1182/blood.v84.3.764.764 · Cited by 70
Shibuya, T., & Mak, T. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.12.3721 · Cited by 63
Emanuel, P. D., Bates, L. J., Sw, Z., Rp, C., Gualtieri, R., & Zuckerman, K. (1991) · PubMed · Cited by 52
Ahne, B., & Strätling, W. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32378-5 · Cited by 49
The PU.1 transcription factor is the product of the putative oncogene Spi-1
Moreau-Gachelin, F., Ray-Gallet, D., Tambourin, P. E., Tavitian, A., Klemsz, M. J., McKercher, S. R., Celada, A., Beveren, C. V., & Maki, R. A. (1990) · Cell · doi:10.1016/0092-8674(90)90677-7 · Cited by 45
Nakagawa, Y., Kosugi, H., Miyajima, A., Arai, K., & Yokota, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34144-3 · Cited by 38
Smith, F. O., Broudy, V., Zsebo, K. M., Lampkin, B., Buckley, C., Buckley, J., Opie, T., Woods, W. G., Hammond, G. D., & Bernstein, I. D. (1994) · Blood · doi:10.1182/blood.v84.3.847.847 · Cited by 35
Constitutive monocyte-restricted activity of NF-M, a nuclear factor that binds to a C/EBP motif
Haas, J., Ströbel, M., Leutz, A., Wendelgaß, P., Müller, C., Sterneck, E., Riethmüller, G., & Ziegler-Heitbrock, H. W. L. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.1.237 · Cited by 27
Jubinsky, P., Laurie, A., Nathan, D., et al. (1994) · Blood · doi:10.1182/blood.v84.12.4174.bloodjournal84124174 · Cited by 26
Wang, Z. Y., Lin, X.-H., Nobyuoshi, M., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42265-x · Cited by 25
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
Research works printed but not linked: 13
- Eisenbeis C. F., 1993, Mol. Cell. Biol., 13, 6452
- Emanuel P. D., 1991, Exp. Hematol., 19, 1017
- 10.1182/blood.V82.7.1960.1960 · DOI
- Moulton K. S., 1994, Mol. Cell. Biol., 14, 4408
- Nordeen S. K., 1988, BioTechniques, 6, 454
- 10.1128/mcb.14.8.5558-5568.1994 · DOI · Paper page
- Pahl H. L., 1991, Exp. Hematol., 19, 1038
- Perez C., 1994, Mol. Cell. Biol., 14, 5023
- Pongubala J. M., 1992, Mol. Cell. Biol., 12, 368
- Ray D., 1992, Mol. Cell. Biol., 12, 4297
- Schuetze S., 1992, Mol. Cell. Biol., 12, 2967
- Schuetze S., 1993, Mol. Cell. Biol., 13, 5670
- Zhang D. E., 1994, Mol. Cell. Biol., 14, 8085
Cited by
Sorted by citations
Granules of the Human Neutrophilic Polymorphonuclear Leukocyte
Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,554
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
McKercher, S. R., Torbett, B. E., Anderson, K. L., Henkel, G. W., Vestal, D. J., Baribault, H., Klemsz, M., Feeney, A. J., Wu, G. E., Paige, C. J., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00949.x · Cited by 1,130
Zhang, D.-E., Zhang, P., Wang, N.-D., Hetherington, C. J., Darlington, G. J., & Tenen, D. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.569 · Cited by 910
Self-citationGenetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease
Segal, B. H., Leto, T. L., Gallin, J. I., Malech, H. L., & Holland, S. M. (2000) · Medicine · doi:10.1097/00005792-200005000-00004 · Cited by 887
Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors
Lekstrom-Himes, J., & Xanthopoulos, K. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28545 · Cited by 801
Metadata
- Authors
- Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z., Zhang, D.-E., & Tenen, D. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Tenen, Daniel G.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1995-10-01
- Volume
- 15
- Issue
- 10
- Pages
- 5830-5845
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC230835
- OpenAlex
- W2161743101
- Cited by
- 284
- References
- 73
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Funders
- American Lung Association
- National Cancer Institute (CA 41456, R01CA041456)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK048660, DK48660)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- PU.1, SPI-1, C/EBPα, GM-CSF receptor alpha, transcription factor binding sites, myelomonocytic cells, B cells, promoter regulation, transcriptional activation, hematopoiesis, single-stranded DNA binding, U937 cells
- MeSH terms
- Amino Acid Sequence, B-Lymphocytes, Base Sequence, Cell Line, DNA, DNA-Binding Proteins, DNA, Single-Stranded, Hematopoiesis, Humans, Methylation, Molecular Sequence Data, Monocytes, Mutation, Nuclear Proteins, Promoter Regions, Genetic, T-Lymphocytes, Transcription Factors, Transcriptional Activation, Retroviridae Proteins, Oncogenic, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Genes, Reporter, CCAAT-Enhancer-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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