Cited by 341Connective Tissue Growth Factor ResearchFibroblast Growth Factor ResearchBone and Dental Protein Studies

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Cyr61, a Product of a Growth Factor-Inducible Immediate-Early Gene, Promotes Cell Proliferation, Migration, and Adhesion

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Kireeva, Maria L., Mo, Fan-E, Yang, George P., Lau, Lester F.·1996·Molecular and Cellular Biology

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Abstract

cyr61 was first identified as a growth factor-inducible immediate-early gene in mouse fibroblasts. The encoded Cyr61 protein is a secreted, cystein-rich heparin-binding protein that associates with the cell surface and the extracellular matrix, and in these aspects it resembles the Wnt-1 protein and a number of known growth factors. During embryogenesis, cyr61 is expressed most notably in mesenchymal cells that are differentiating into chondrocytes and in the vessel walls of the developing circulatory system. cyr61 is a member of an emerging gene family that encodes growth regulators, including the connective tissue growth factor and an avian proto-oncoprotein, Nov cyr61 also shares sequence similarities with two Drosophila genes, twisted gastrulation and short gastrulation, which interact with decapentaplegic to regulate dorsal-ventral patterning. In this report we describe the purification of the Cyr61 protein in a biologically active form, and we show that purified Cyr61 has the following activities: (i) it promotes the attachment and spreading of endothelial cells in a manner similar to that of fibronectin; (ii) it enhances the effects of basic fibroblast growth factor and platelet-derived growth factor on the rate of DNA synthesis of fibroblasts and vascular endothelial cells, although it has no detectable mitogenic activity by itself; and (iii) it acts as a chemotactic factor for fibroblasts. Taken together, these activities indicate that Cyr61 is likely to function as an extracellular matrix signaling molecule rather than as a classical growth factor and may regulate processes of cell proliferation, migration, adhesion, and differentiation during development.

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10.1128/mcb.12.1.10-21.1992 · DOI
10.1128/mcb.10.7.3569-3577.1990 · DOI · Paper page
Yang, G. P. 1993. Ph.D. thesis. The University of Illinois at Chicago, Chicago.

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Authors: Kireeva, M. L., Mo, F.-E., Yang, G. P., & Lau, L. F.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Kireeva, Maria L.
Mo, Fan-E
Yang, George P.
Lau, Lester F.
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 1996-04
Volume: 16
Issue: 4
Pages: 1326-1334
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.16.4.1326
PMC: PMC231116
OpenAlex: W1925481732
Cited by: 341
References: 50
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 15 · 2015: 12 · 2014: 12 · 2013: 11 · 2012: 10
FWCI: 4.29
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
National Cancer Institute (R01 CA46565-08, R01CA046565)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: CYR61, connective tissue growth factor, immediate early genes, heparin-binding protein, extracellular matrix signaling, cell adhesion, cell migration, cell proliferation, endothelial cell adhesion, basic fibroblast growth factor, platelet-derived growth factor, chemotaxis, fibroblast differentiation, chondrogenic differentiation, twisted gastrulation, short gastrulation, decapentaplegic, dorsoventral patterning, embryonic development
MeSH terms: Animals, Cell Adhesion, Cell Division, Cell Movement, Chemotaxis, DNA, Growth Substances, Heparin, Recombinant Proteins, 3T3 Cells, Genes, Immediate-Early, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Mice, Cysteine-Rich Protein 61

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Cyr61, a Product of a Growth Factor-Inducible Immediate-Early Gene, Promotes Cell Proliferation, Migration, and Adhesion

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