Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in Saccharomyces cerevisiae

Vik, Åshild; Rine, Jasper

doi:10.1128/mcb.21.19.6395-6405.2001

Cited by 277Fungal and yeast genetics researchCancer, Lipids, and MetabolismLipid metabolism and biosynthesis

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in Saccharomyces cerevisiae

Open access

Vik, Åshild, Rine, Jasper·2001·Molecular and Cellular Biology

DOI 10.1128/mcb.21.19.6395-6405.2001PMC PMC99787

Open this paper in CoChat — free account

Abstract

Sterol levels affect the expression of many genes in yeast and humans. We found that the paralogous transcription factors Upc2p and Ecm22p of yeast were sterol regulatory element (SRE) binding proteins (SREBPs) responsible for regulating transcription of the sterol biosynthetic genes ERG2 and ERG3. We defined a 7-bp SRE common to these and other genes, including many genes involved in sterol biosynthesis. Upc2p and Ecm22p activated ERG2 expression by binding directly to this element in the ERG2 promoter. Upc2p and Ecm22p may thereby coordinately regulate genes involved in sterol homeostasis in yeast. Ecm22p and Upc2p are members of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors and share no homology to the analogous proteins, SREBPs, that are responsible for transcriptional regulation by sterols in humans. These results suggest that Saccharomyces cerevisiae and human cells regulate sterol synthesis by different mechanisms.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mcb.21.19.6395-6405.2001

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Detailed analyses demonstrated the crucial role of Upc2A-like factors in regulation of ERG gene biosynthesis.
“Detailed analyses demonstrated the crucial role of these Upc2A-like factors in regulation of ERG gene biosynthesis [30,37,38] but little was known about the full range of their target genes.”
From The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways (2021) · cites this paper as [30]
At the same time, the levels of Upc2, and their association to ERG promoters, strongly increase, which finally results in the transcriptional induction of ERG genes.
“At the same time, the levels of Upc2, and their association to ERG promoters, strongly increase, which finally results in the transcriptional induction of ERG genes [68,74].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [68]
Upon ergosterol depletion, the dissociation of the sterol ligand causes a conformational change that exposes Upc2 NLS, causing its translocation to the nucleus, where it activates the transcription of SRE/AR1c-containing genes including most ERG genes, sterol uptake genes (AUS1, PDR11), the DAN/TIR genes, and members of the PAU gene family.
“Upon ergosterol depletion, the dissociation of the sterol ligand causes a conformational change that exposes Upc2 NLS, causing its translocation to the nucleus, where it activates the transcription of SRE/AR1c-containing genes including most ERG genes, sterol uptake genes (AUS1, PDR11), the DAN/TIR genes, which encode nine cell wall mannoproteins, and members of the seripauperin (PAU) gene family”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [68]
During Saccharomycotina evolution, a member of the fungus specific Zn2-Cys6 binuclear cluster family of transcription factors called Upc2 displaced SREBP proteins as the major sterol regulator.
“During Saccharomycotina evolution, a member of the fungus specific Zn2-Cys6 binuclear cluster family of transcription factors called Upc2 displaced SREBP proteins as the major sterol regulator [68,69,70].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [68]
Under normal laboratory growth conditions, Ecm22 and, to a lesser extent, Upc2 bind to ERG gene promoters to maintain a basal expression level.
“Under normal laboratory growth conditions, Ecm22 and, to a lesser extent, Upc2 bind to ERG gene promoters to maintain a basal expression level (Figure 3A) [68].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [68]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,590
Transformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518
Methods in Yeast Genetics
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911
Current protocols in molecular biology
(1988) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(88)90131-4 · Cited by 4,234
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
Gietz, R. D., & Sugino, A. (1988) · Gene · doi:10.1016/0378-1119(88)90185-0 · Cited by 2,851
In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue
Bachmair, A., Finley, D. J., & Varshavsky, A. J. (1986) · Science · doi:10.1126/science.3018930 · Cited by 1,976
Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase
Carlson, M., & Botstein, D. (1982) · Cell · doi:10.1016/0092-8674(82)90384-1 · Cited by 1,541
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11041 · Cited by 1,134
Principles governing amino acid composition of integral membrane proteins: application to topology prediction 1 1Edited by J. Thornton
Tusnády, G., & Simon, I. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2107 · Cited by 1,073
Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing
Hoppe, T., Matuschewski, K., Rapé, M., Schlenker, S., Ulrich, H. D., & Jentsch, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00080-5 · Cited by 559
Prediction of Transmembrane Segments in Proteins Utilising Multiple Sequence Alignments
Persson, B. L., & Argos, P. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1220 · Cited by 460
Large Scale Identification of Genes Involved in Cell Surface Biosynthesis and Architecture in Saccharomyces cerevisiae
Lussier, M., White, A.-M., Sheraton, J., DiPaolo, T., Treadwell, J. A., Southard, S. B., Horenstein, C. I., Chen-Weiner, J., Ram, A. F. J., Kapteyn, J. C., et al. (1997) · Genetics · doi:10.1093/genetics/147.2.435 · Cited by 369
Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter
Magaña, M., & Osborne, T. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32689 · Cited by 336
Evolution of a Fungal Regulatory Gene Family: The Zn(II)2Cys6 Binuclear Cluster DNA Binding Motif
Todd, R. B., & Andrianopoulos, A. (1997) · Fungal Genetics and Biology · doi:10.1006/fgbi.1997.0993 · Cited by 295
The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes
Liu, Q., Li, M. Z., Leibham, D., Cortez, D., & Elledge, S. J. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00560-x · Cited by 282
T7 Vectors with a Modified T7lacPromoter for Expression of Proteins inEscherichia coli
Peränen, J., Rikkonen, M., Hyvönen, M., & Kääriäinen, L. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0187 · Cited by 270
Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene
Pfeifer, K. E., Arcangioli, B., & Guarente, L. (1987) · Cell · doi:10.1016/0092-8674(87)90750-1 · Cited by 246
Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins
Pai, J., Guryev, O. L., Brown, M. S., & Goldstein, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26138 · Cited by 221
Genome-Wide Expression Patterns in Saccharomyces cerevisiae : Comparison of Drug Treatments and Genetic Alterations Affecting Biosynthesis of Ergosterol
Bammert, G. F., & Fostel, J. M. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.5.1255-1265.2000 · Cited by 213
Induction of Meiosis in Saccharomyces cerevisiae Depends on Conversion of the Transcriptional Repressor Ume6 to a Positive Regulator by Its Regulated Association with the Transcriptional Activator Ime1
Rubin-Bejerano, I., Mandel, S. A., Robzyk, K., & Kassir, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2518 · Cited by 140
Capped mRNA Degradation Intermediates Accumulate in the Yeast spb8-2 Mutant
Boeck, R., Lapeyre, B., Brown, C. E., & Sachs, A. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5062 · Cited by 135
Topology prediction of membrane proteins
Argos, P., & Persson, B. L. (1996) · Protein Science · doi:10.1002/pro.5560050221 · Cited by 134
Regulatory Mechanisms Controlling Expression of the DAN/TIR Mannoprotein Genes During Anaerobic Remodeling of the Cell Wall in Saccharomyces cerevisiae
Abramova, N. E., Cohen, B. D., Sertil, O., Kapoor, R., Davies, K. J. A., & Lowry, C. V. (2001) · Genetics · doi:10.1093/genetics/157.3.1169 · Cited by 128
A Mutation in a Purported Regulatory Gene Affects Control of Sterol Uptake in Saccharomyces cerevisiae
Crowley, J. H., Leak, F. W., Shianna, K. V., Tove, S., & Parks, L. W. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.16.4177-4183.1998 · Cited by 123
Nuclear Dot Antigens may Specify Transcriptional Domains in the Nucleus
Xie, K., Lambie, E. J., & Snyder, M. P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6170-6179.1993 · Cited by 88
Induction and repression of DAN1 and the family of anaerobic mannoprotein genes in Saccharomyces cerevisiae occurs through a complex array of regulatory sites
Cohen, B. D. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.3.799 · Cited by 88
Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix™
Dimster-Denk, D., Rine, J., Phillips, J., Scherer, S., Cundiff, P., DeBord, K. L., Gilliland, D., Hickman, S., Jarvis, A., Tong, L., et al. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32120-9 · Cited by 84
Self-citation
Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post‐squalene portion of the yeast ergosterol pathway
Arthington, B. A., Crowell, D. N., Yang, H., Sturley, S. L., & Bard, M. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00807-1 · Cited by 80
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae.
Dimster-Denk, D., Thorsness, M. K., & Rine, J. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.6.655 · Cited by 78
Self-citation
Identification of a UPC2 Homolog in Saccharomyces cerevisiae and Its Involvement in Aerobic Sterol Uptake
Shianna, K. V., Dotson, W. D., Tove, S. R., & Parks, L. W. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.3.830-834.2001 · Cited by 63
A novel sequence element is involved in the transcriptional regulation of expression of the ERG1 (squalene epoxidase) gene in Saccharomyces cerevisiae
Leber, R., Zenz, R., Schröttner, K., Fuchsbichler, S., Pühringer, B., & Turnowsky, F. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.01940.x · Cited by 56
A New Class of Repression Modules Is Critical for Heme Regulation of the Yeast Transcriptional Activator Hap1
Hach, A., Hon, T., & Li, Z. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4324 · Cited by 46
Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae
Soustre, I., Dupuy, P.-H., Silve, S., Karst, F., & Loison, G. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01300-4 · Cited by 34

Flagged first, then by citations

Sorted by citations

A Fungal Family of Transcriptional Regulators: the Zinc Cluster Proteins
MacPherson, S., Larochelle, M., & Turcotte, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00015-06 · Cited by 612
Exploration of Essential Gene Functions via Titratable Promoter Alleles
Mnaimneh, S., Davierwala, A. P., Haynes, J., Moffat, J., Peng, W.-T., Zhang, W., Yang, X., Pootoolal, J., Chua, G., Lopez, A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.06.013 · Cited by 604
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Jordá, T., & Puig, S. (2020) · Genes · doi:10.3390/genes11070795 · Cited by 489
A Library of Yeast Transcription Factor Motifs Reveals a Widespread Function for Rsc3 in Targeting Nucleosome Exclusion at Promoters
Badis, G., Chan, E. T., van Bakel, H., Peña‐Castillo, L., Tillo, D., Tsui, K., Carlson, C. D., Gossett, A. J., Hasinoff, M. J., Warren, C. L., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.020 · Cited by 472
Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
Engels, B., Dahm, P., & Jennewein, S. (2008) · Metabolic Engineering · doi:10.1016/j.ymben.2008.03.001 · Cited by 380
A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus
Willger, S. D., Puttikamonkul, S., Kim, K.-H., Burritt, J. B., Grahl, N., Metzler, L. J., Barbuch, R., Bard, M., Lawrence, C. B., & Cramer, R. A. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000200 · Cited by 345
Calcineurin is essential for survival during membrane stress in Candida albicans
Cruz, M. C., Goldstein, A. L., Blankenship, J. R., Del Poeta, M., Davis, D., Cardenas, M. E., Perfect, J. R., McCusker, J. H., & Heitman, J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.546 · Cited by 342
SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Hughes, A. L., Todd, B. L., & Espenshade, P. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.012 · Cited by 320
Genome-Wide Expression Profiling of the Response to Azole, Polyene, Echinocandin, and Pyrimidine Antifungal Agents in Candida albicans
Liu, T. T., Lee, R. E. B., Barker, K. S., Lee, R. E., Wei, L., Homayouni, R., & Rogers, P. D. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2226-2236.2005 · Cited by 313
Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates
Coste, A., Selmecki, A., Forche, A., Diogo, D., Bougnoux, M.-E., d'Enfert, C., Berman, J., & Sanglard, D. (2007) · Eukaryotic Cell · doi:10.1128/ec.00151-07 · Cited by 305
Membranes in Balance: Mechanisms of Sphingolipid Homeostasis
Breslow, D. K., & Weissman, J. S. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.005 · Cited by 306
Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation
Sanglard, D., Coste, A., & Ferrari, S. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00578.x · Cited by 285
Transcriptional profiling identifies two members of the ATP-Binding cassette transporter superfamily required for sterol uptake in yeast
Wilcox, L. J., Balderes, D. A., Wharton, B., Tinkelenberg, A. H., Rao, G., & Sturley, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204707200 · Cited by 250
Candida albicans Zinc Cluster Protein Upc2p Confers Resistance to Antifungal Drugs and Is an Activator of Ergosterol Biosynthetic Genes
MacPherson, S., Akache, B., Weber, S., De Deken, X., Raymond, M., & Turcotte, B. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1745-1752.2005 · Cited by 238
A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate
Dunkel, N., Liu, T. T., Barker, K. S., Homayouni, R., Morschhäuser, J., & Rogers, P. D. (2008) · Eukaryotic Cell · doi:10.1128/ec.00103-08 · Cited by 236
Yeast ABC transporters – A tale of sex, stress, drugs and aging
Jungwirth, H., & Kuchler, K. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.12.050 · Cited by 232
Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2
Yang, H., Tong, J., Lee, C. W., Ha, S., Eom, S. H., & Im, Y. J. (2015) · Nature Communications · doi:10.1038/ncomms7129 · Cited by 223
Role of Candida albicans Transcription Factor Upc2p in Drug Resistance and Sterol Metabolism
Silver, P. M., Oliver, B. G., & White, T. C. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.6.1391-1397.2004 · Cited by 216
Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae.
Agarwal, A. K., Rogers, P. D., Baerson, S. R., Jacob, M. R., Barker, K. S., Cleary, J. D., Walker, L. A., Nagle, D. G., & Clark, A. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306291200 · Cited by 204
Identifying transcription factor functions and targets by phenotypic activation
Chua, G., Morris, Q., Sopko, R., Robinson, M. D., Ryan, O. W., Chan, E. T., Frey, B. J., Andrews, B., Boone, C. M., & Hughes, T. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605140103 · Cited by 183
Coordination of Lipid Metabolism in Membrane Biogenesis
Nohturfft, A., & Zhang, S. C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175344 · Cited by 177
Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
Bien, C. M., & Espenshade, P. J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00358-09 · Cited by 173
Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae
Scalcinati, G., Partow, S., Siewers, V., Schalk, M., Daviet, L., & Nielsen, J. (2012) · Microbial Cell Factories · doi:10.1186/1475-2859-11-117 · Cited by 156
Redirection of flux through the FPP branch‐point in Saccharomyces cerevisiae by down‐regulating squalene synthase
Paradise, E. M., Kirby, J., Chan, R., & Keasling, J. D. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21766 · Cited by 148
Progress in terpene synthesis strategies through engineering of Saccharomyces cerevisiae
Paramasivan, K., & Mutturi, S. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1299679 · Cited by 145
Repression of ergosterol biosynthesis is essential for stress resistance and is mediated by the Hog1 MAP kinase and the Mot3 and Rox1 transcription factors
Montañés, F. M., Pascual‐Ahuir, A., & Proft, M. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07502.x · Cited by 137
Dual Activators of the Sterol Biosynthetic Pathway of Saccharomyces cerevisiae : Similar Activation/Regulatory Domains but Different Response Mechanisms
Davies, B. S. J., Wang, H. S., & Rine, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7375-7385.2005 · Cited by 138
Self-citation
Heme Levels Switch the Function of Hap1 of Saccharomyces cerevisiae between Transcriptional Activator and Transcriptional Repressor
Hickman, M. J., & Winston, F. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00887-07 · Cited by 137
A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum
Liu, Z., Jian, Y., Chen, Y., Kistler, H. C., He, P., Ma, Z., & Yin, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-09145-6 · Cited by 137
Metabolic engineering of Pichia pastoris X-33 for lycopene production
Bhataya, A., Schmidt‐Dannert, C., & Lee, P. C. (2009) · Process Biochemistry · doi:10.1016/j.procbio.2009.05.012 · Cited by 137
Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae
Peng, B., Nielsen, L. K., Kampranis, S. C., & Vickers, C. E. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.02.005 · Cited by 138
Regulation of the Hypoxic Response in Candida albicans
Synnott, J. M., Guida, A., Mulhern-Haughey, S., Higgins, D. G., & Butler, G. (2010) · Eukaryotic Cell · doi:10.1128/ec.00159-10 · Cited by 132
Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans
Holland, L., Schröder, M., Turner, S. A., Taff, H. T., Andes, D. R., Grózer, Z., Gácser, A., Ames, L., Haynes, K., Higgins, D. G., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004365 · Cited by 134
Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast
Hu, T., Zhou, J., Tong, Y., Su, P., Li, X., Liu, Y., Liu, N., Wu, X., Zhang, Y., Wang, J., et al. (2020) · Metabolic Engineering · doi:10.1016/j.ymben.2020.03.011 · Cited by 130
The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling
Lehto, M. J., & Olkkonen, V. M. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00364-5 · Cited by 127
A Role for Sterol Levels in Oxygen Sensing in Saccharomyces cerevisiae
Davies, B. S. J., & Rine, J. (2006) · Genetics · doi:10.1534/genetics.106.059964 · Cited by 123
Self-citation
Systems biology of lipid metabolism: From yeast to human
Nielsen, J. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.054 · Cited by 119
Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels
Zhang, Y., Nielsen, J., & Liu, Z. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox080 · Cited by 122
Genomewide Location Analysis of Candida albicans Upc2p, a Regulator of Sterol Metabolism and Azole Drug Resistance
Znaidi, S., Weber, S., Zin Al-Abdin, O., Bomme, P., Saidane, S., Drouin, S., Lemieux, S., De Deken, X., Robert, F., & Raymond, M. (2008) · Eukaryotic Cell · doi:10.1128/ec.00070-08 · Cited by 119
Dual Effects of Plant Steroidal Alkaloids on Saccharomycescerevisiae
Simons, V., Morrissey, J. P., Latijnhouwers, M., Csukai, M., Cleaver, A., Yarrow, C., & Osbourn, A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00289-06 · Cited by 122
Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights
Gordân, R., Murphy, K. F., McCord, R. P., Zhu, C., Vedenko, A., & Bulyk, M. L. (2011) · Genome biology · doi:10.1186/gb-2011-12-12-r125 · Cited by 121
Mechanisms of sterol uptake and transport in yeast
Jacquier, N., & Schneiter, R. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.11.014 · Cited by 116
Development of a novel multiplex DNA microarray for Fusarium graminearum and analysis of azole fungicide responses
Becher, R., Weihmann, F., Deising, H. B., & Wirsel, S. G. R. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-52 · Cited by 117
An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates of Candida albicans
Hoot, S. J., Smith, A. R., Brown, R. P., & White, T. C. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00995-10 · Cited by 107
Proteolysis and Sterol Regulation
Hampton, R. Y. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.032002.131219 · Cited by 104
Metabolic-State-Dependent Remodeling of the Transcriptome in Response to Anoxia and Subsequent Reoxygenation in Saccharomyces cerevisiae
Lai, L.-C., Kosorukoff, A. L., Burke, P. V., & Kwast, K. E. (2006) · Eukaryotic Cell · doi:10.1128/ec.00107-06 · Cited by 97
Construction of new Pichia pastoris X-33 strains for production of lycopene and β-carotene
Araya-Garay, J. M., Feijoo-Siota, L., dos Santos, F. R., Veiga‐Crespo, P., & Villa, T. G. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3764-7 · Cited by 97
Synergistic repression of anaerobic genes by Mot3 and Rox1 in Saccharomyces cerevisiae
Sertil, O. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg792 · Cited by 88
Storage lipids of yeasts: a survey of nonpolar lipid metabolism inSaccharomyces cerevisiae, Pichia pastoris, andYarrowia lipolytica
Koch, B., Schmidt, C. C., & Daum, G. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12069 · Cited by 89
Comparison of Sterol Import under Aerobic and Anaerobic Conditions in Three Fungal Species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae
Zavrel, M., Hoot, S. J., & White, T. C. (2013) · Eukaryotic Cell · doi:10.1128/ec.00345-12 · Cited by 86
Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris
Bing, J., Hu, T., Zheng, Q., Muñoz, J. F., Cuomo, C. A., & Huang, G. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01466-20 · Cited by 86
SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process
ALIMARDANI, P., RÉGNACQ, M., MOREAU-VAUZELLE, C., FERREIRA, T., ROSSIGNOL, T., BLONDIN, B., & BERGÈS, T. (2004) · Biochemical Journal · doi:10.1042/bj20040297 · Cited by 84
Dynamical Remodeling of the Transcriptome during Short-Term Anaerobiosis in Saccharomyces cerevisiae : Differential Response and Role of Msn2 and/or Msn4 and Other Factors in Galactose and Glucose Media
Lai, L.-C., Kosorukoff, A. L., Burke, P. V., & Kwast, K. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.4075-4091.2005 · Cited by 84
Allylamines, Benzylamines, and Fungal Cell Permeability: A Review of Mechanistic Effects and Usefulness against Fungal Pathogens
Halat, D. H., Younes, S., Mourad, N., & Rahal, M. K. (2022) · Membranes · doi:10.3390/membranes12121171 · Cited by 81
Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis
Guida, A., Lindstädt, C., Maguire, S. L., Ding, C., Higgins, D. G., Corton, N., Berriman, M., & Butler, G. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-628 · Cited by 78
Gene transcription profiling of Fusarium graminearum treated with an azole fungicide tebuconazole
Liu, X., Jiang, J., Shao, J., Yin, Y., & Ma, Z. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2273-4 · Cited by 76
The emergence of yeast lipidomics
Gaspar, M. L., Aregullin, M. A., Jesch, S. A., Nunez, L. R., Villa‐Garcia, M., & Henry, S. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.06.011 · Cited by 75
Multilocus resistance evolution to azole fungicides in fungal plant pathogen populations
Mohd‐Assaad, N., McDonald, B. A., & Croll, D. (2016) · Molecular Ecology · doi:10.1111/mec.13916 · Cited by 75
Transcription factors and ABC transporters: from pleiotropic drug resistance to cellular signaling in yeast
Buechel, E. R., & Pinkett, H. W. (2020) · FEBS Letters · doi:10.1002/1873-3468.13964 · Cited by 72
Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae
Hongay, C., Jia, N., Bard, M., & Winston, F. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf415 · Cited by 72
Yeast Cells Lacking the ARV1 Gene Harbor Defects in Sphingolipid Metabolism
Swain, E., Stukey, J., McDonough, V. M., Germann, M., Liu, Y., Sturley, S. L., & Nickels, J. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206624200 · Cited by 72
Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution
Maguire, S. L., Wang, C., Holland, L. M., Brunel, F., Neuvéglise, C., Nicaud, J.-M., Zavrel, M., White, T. C., Wolfe, K. H., & Butler, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004076 · Cited by 69
Refactoring β‐amyrin synthesis in S accharomyces cerevisiae
Zhang, G., Cao, Q., Liu, J., Liu, B., Li, J., & Li, C. (2015) · AIChE Journal · doi:10.1002/aic.14950 · Cited by 69
Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata: Gene expression in sterol-depleted Candida
Nagi, M., Nakayama, H., Tanabe, K., Bard, M., Aoyama, T., Okano, M., Higashi, S., Ueno, K., Chibana, H., Niimi, M., et al. (2011) · Genes to Cells · doi:10.1111/j.1365-2443.2010.01470.x · Cited by 68
The Hog1 Mitogen-Activated Protein Kinase Mediates a Hypoxic Response in Saccharomyces cerevisiae
Hickman, M. J., Spatt, D., & Winston, F. (2011) · Genetics · doi:10.1534/genetics.111.128322 · Cited by 68
Fungal cytochrome P450 protein Cyp51: What we can learn from its evolution, regulons and Cyp51-based azole resistance
Song, J., Zhang, S., & Lü, L. (2018) · Fungal Biology Reviews · doi:10.1016/j.fbr.2018.05.001 · Cited by 70
Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism
Petranović, D., Tyo, K. E. J., Vemuri, G. N., & Nielsen, J. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00689.x · Cited by 67
Exceptional Solvent Tolerance in Yarrowia lipolytica Is Enhanced by Sterols
Walker, C., Ryu, S., & Trinh, C. T. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2019.03.003 · Cited by 65
Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae
Rintala, E., Toivari, M. H., Pitkänen, J., Wiebe, M. G., Ruohonen, L., & Penttilä, M. E. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-461 · Cited by 65
Ergosterol Biosynthesis and Regulation Impact the Antifungal Resistance and Virulence of Candida spp
Eliaš, D., Tóth Hervay, N., & Gbelská, Y. (2024) · Stresses · doi:10.3390/stresses4040041 · Cited by 63
Genome-Wide Analysis of Sterol-Lipid Storage and Trafficking in Saccharomyces cerevisiae
Fei, W., Alfaro, G., Muthusamy, B.-P., Klaassen, Z. W. A., Graham, T. R., Yang, H., & Beh, C. T. (2007) · Eukaryotic Cell · doi:10.1128/ec.00386-07 · Cited by 63
Heterologous production of polyunsaturated fatty acids in Saccharomyces cerevisiae causes a global transcriptional response resulting in reduced proteasomal activity and increased oxidative stress
Ruenwai, R., Neiss, A., Laoteng, K., Vongsangnak, W., Badoei-Dalfard, A., Cheevadhanarak, S., Petranović, D., & Nielsen, J. (2010) · Biotechnology Journal · doi:10.1002/biot.201000316 · Cited by 61
Nuclear receptor-like transcription factors in fungiPreprint
Näär, A. M., & Thakur, J. K. (2009) · Genes & Development · doi:10.1101/gad.1743009 · Cited by 59
Recent advances in the microbial production of squalene
Paramasivan, K., & Mutturi, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03273-w · Cited by 60
A latent variable model for chemogenomic profiling
Flaherty, P., Giaever, G. N., Kumm, J., Jordan, M. I., & Arkin, A. P. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti515 · Cited by 60
Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi?
Grahl, N., & Cramer, R. A. (2009) · Medical Mycology · doi:10.3109/13693780902947342 · Cited by 59
Yeast sphingolipid metabolism: clues and connections
Sims, K. J., Spassieva, S. D., Voit, E. O., & Obeid, L. M. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-086 · Cited by 59
Sterol-dependent Regulation of Sphingolipid Metabolism in Saccharomyces cerevisiae
Swain, E., Baudry, K., Stukey, J., McDonough, V., Germann, M., & Nickels, J. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204115200 · Cited by 57
Pulsed addition of HMF and furfural to batch-grown xylose-utilizing Saccharomyces cerevisiaeresults in different physiological responses in glucose and xylose consumption phase
Ask, M., Bettiga, M., Duraiswamy, V. R., & Lisbeth Olsson, A. (2013) · Biotechnology for Biofuels · doi:10.1186/1754-6834-6-181 · Cited by 56
Membrane-active Compounds Activate the Transcription Factors Pdr1 and Pdr3 Connecting Pleiotropic Drug Resistance and Membrane Lipid Homeostasis inSaccharomyces cerevisiae
Schüller, C., Mamnun, Y. M., Wolfger, H., Rockwell, N. C., Thorner, J. W., & Kuchler, K. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0610 · Cited by 55
Functional analyses of PAU genes in Saccharomyces cerevisiae
Luo, Z., & van Vuuren, H. J. J. (2009) · Microbiology · doi:10.1099/mic.0.030726-0 · Cited by 54
Phylogenetically and spatially conserved word pairs associated with gene-expression changes in yeasts
Chiang, D. Y., Moses, A. M., Kellis, M., Lander, E. S., & Eisen, M. B. (2003) · Genome biology · doi:10.1186/gb-2003-4-7-r43 · Cited by 53
UPC2A Is Required for High-Level Azole Antifungal Resistance in Candida glabrata
Whaley, S. G., Caudle, K. E., Vermitsky, J.-P., Chadwick, S. G., Toner, G., Barker, K. S., Gygax, S. E., & Rogers, P. D. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02217-13 · Cited by 52
Transcriptome analysis of Botrytis cinerea in response to tea tree oil and its two characteristic components
Li, Z., Shao, X., Wei, Y., Dai, K., Xu, J., Xu, F., & Wang, H. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10382-9 · Cited by 52
Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae
Henneberry, A. L., & Sturley, S. L. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.01.006 · Cited by 50
Yeast ABC transporters in lipid trafficking
Prasad, R., Khandelwal, N., & Banerjee, A. (2016) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2016.05.008 · Cited by 49
Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae
Cirigliano, A., Macone, A., Bianchi, M. M., Oliaro‐Bosso, S., Balliano, G., Negri, R., & Rinaldi, T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.12.002 · Cited by 47
Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures
Boender, L. G. M., van Maris, A. J. A., de Hulster, E. A. F., Almering, M. J. H., van der Klei, I. J., Marten Veenhuis, A., de Winde, J. H., Pronk, J. T., & Daran-Lapujade, P. A. S. (2011) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00750.x · Cited by 50
Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae
Marie, C., Leyde, S., & White, T. C. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.07.004 · Cited by 47
Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast
Gu, Y., Xue, J., Ye, L., & Yu, H. (2021) · Bioresources and Bioprocessing · doi:10.1186/s40643-021-00460-9 · Cited by 46
Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation
Revie, N. M., Iyer, K. R., Maxson, M. E., Zhang, J., Yan, S., Fernandes, C. M., Meyer, K. J., Chen, X., Skulska, I., Fogal, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31308-1 · Cited by 48
Metabolic engineering for the production of clinically important molecules: Omega‐3 fatty acids, artemisinin, and taxol
Ye, V. M., & Bhatia, S. K. (2011) · Biotechnology Journal · doi:10.1002/biot.201100289 · Cited by 47
RNA-sequencing of Cercospora beticola DMI-sensitive and -resistant isolates after treatment with tetraconazole identifies common and contrasting pathway induction
Bolton, M. D., Ebert, M. K., Faino, L., Rivera-Varas, V. V., de Jonge, R., de Peer, Y. V., Thomma, B. P. H. J., & Secor, G. A. (2016) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2016.04.003 · Cited by 47
Direct Role for the Rpd3 Complex in Transcriptional Induction of the Anaerobic DAN/TIR Genes in Yeast
Sertil, O., Vemula, A., Salmon, S. L., Morse, R. H., & Lowry, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02297-06 · Cited by 47
Hypoxia and Gene Expression in Eukaryotic Microbes
Butler, G. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155658 · Cited by 48
The Smell of Synthetic Biology: Engineering Strategies for Aroma Compound Production in Yeast
van Wyk, N., Kroukamp, H., & Pretorius, I. S. (2018) · Fermentation · doi:10.3390/fermentation4030054 · Cited by 44
Phytosterol biosynthesis and production by diatoms (Bacillariophyceae)
Jaramillo-Madrid, A. C., Ashworth, J. R., Fabris, M., & Ralph, P. J. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.03.018 · Cited by 44
Role of MCC/Eisosome in Fungal Lipid Homeostasis
Zahumenský, J., & Malinsky, J. (2019) · Biomolecules · doi:10.3390/biom9080305 · Cited by 43
H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A
South, P. F., Harmeyer, K. M., Serratore, N. D., & Briggs, S. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215768110 · Cited by 42

Dual Activators of the Sterol Biosynthetic Pathway of Saccharomyces cerevisiae : Similar Activation/Regulatory Domains but Different Response Mechanisms
Davies, B. S. J., Wang, H. S., & Rine, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7375-7385.2005 · Cited by 138
Self-citation
Transcriptional regulation of sterol metabolism in Saccharomyces cerevisiae
Gallo, C. M., & Nickels, J. T. (2008) · doi:10.17918/00000735
Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae
Marie, C., Leyde, S., & White, T. C. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.07.004 · Cited by 47
Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution
Maguire, S. L., Wang, C., Holland, L. M., Brunel, F., Neuvéglise, C., Nicaud, J.-M., Zavrel, M., White, T. C., Wolfe, K. H., & Butler, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004076 · Cited by 69
Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Jordá, T., & Puig, S. (2020) · Genes · doi:10.3390/genes11070795 · Cited by 489

Authors: Vik, Å., & Rine, J.
Affiliations: University of California, Berkeley (US)
Corresponding author: Rine, Jasper
ORCID: Rine, Jasper
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2001-10
Volume: 21
Issue: 19
Pages: 6395-6405
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.21.19.6395-6405.2001
PMC: PMC99787
OpenAlex: W2160849328
Cited by: 277
References: 33
Citations by year: 2026: 7 · 2025: 11 · 2024: 18 · 2023: 9 · 2022: 17 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 8
FWCI: 3.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Norges Forskningsråd
National Institutes of Health
National Institute of General Medical Sciences (R01GM035827, GM 35827)
National Institute of Environmental Health Sciences (ESO1896, P30ES001896)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: sterol biosynthesis, sterol regulatory element, SREBP, transcriptional regulation, ERG2, ERG3, sterol homeostasis, Saccharomyces cerevisiae
MeSH terms: Cell Division, DNA-Binding Proteins, Fungal Proteins, Genes, Fungal, Oxidoreductases, Promoter Regions, Genetic, RNA, Fungal, Saccharomyces cerevisiae, Steroid Isomerases, Sterols, Transformation, Genetic, Transcriptional Activation, Trans-Activators, Gene Expression Regulation, Fungal, Response Elements, Saccharomyces cerevisiae Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in Saccharomyces cerevisiae

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks