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Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3
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“E6 has also been shown to abrogate the transactivation of p53-responsive genes via interactions with CBP/p300, [181,182,183], with hADA3 [184,185,186], and by destabilizing TIP60 [185]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [186]
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Citations
Cites
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017 · cited 1×
“For example, E7 protein binds to and inactivates the function of the retinoblastoma tumor suppressor protein ( 14 , 51) by targeting it for degradation via the ubiquitin-proteasome pathway (8, 25).”
BackgroundHuibregtse, J. M., Scheffner, M., & Howley, P. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04990.x · Cited by 879
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P. M., & Livingston, D. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80140-9 · Cited by 414
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Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Kumar, A., Zhao, Y., Meng, G., Zeng, M., Srinivasan, S., Delmolino, L. M., Gao, Q., Dimri, G., Weber, G. F., Wazer, D. E., Band, H., & Band, V.
- Affiliations
- Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center
- Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02111
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2002-08-01
- Volume
- 22
- Issue
- 16
- Pages
- 5801-5812
- ISSN
- 1098-5549
- Cited by
- 131
- References
- 3
- Language
- en
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- CoChat. (2026). Citation check: Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3. https://app.cochat.ai/papers/10.1128/mcb.22.16.5801-5812.2002
- The paper
- Kumar, A., Zhao, Y., Meng, G., Zeng, M., Srinivasan, S., Delmolino, L. M., Gao, Q., Dimri, G., Weber, G. F., Wazer, D. E., Band, H., & Band, V. (2002). Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.22.16.5801-5812.2002