The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The LRP5 G171V mutation allows for autocrine Wnt signaling within intracellular compartments.
“In this regard, it is interesting to note that the LRP5 mutation that causes high bone mass (G171V) disrupts LRP5 interaction with Mesd (Zhang et al., 2004) but allows for autocrine Wnt signaling within the intracellular compartments.”
From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Zhang et al., 2004
The LRP5 mutation that causes high bone mass (G171V) disrupts LRP5 interaction with Mesd.
“In this regard, it is interesting to note that the LRP5 mutation that causes high bone mass (G171V) disrupts LRP5 interaction with Mesd (Zhang et al., 2004) but allows for autocrine Wnt signaling within the intracellular compartments.”
From Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding (2005) · cites this paper as Zhang et al., 2004
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoporosis Prevention, Diagnosis, and Therapy
NIH Consensus Development Panel on Osteoporosis Prevention, D. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.6.785 · Cited by 5,529
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591
Self-citationKato, M., Patel, M. S., Levasseur, R., Lobov, I., Chang, B. H.-J., Glass, D. A., Hartmann, C., Li, L., Hwang, T.-H., Brayton, C. F., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201089 · Cited by 1,086
Self-citationMao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 1×
“Furthermore, LRP5 and Arrow were found to be involved in transducing the canonical Wnt signals by binding Axin and leading to Axin degradation and -catenin stabilization ( 24 , 35).”
BackgroundSelf-citationNovel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772
Dishevelled Proteins Lead to Two Signaling Pathways
Li, L., Yuan, H., Xie, W., Mao, J., Caruso, A. M., McMahon, A., Sussman, D. J., & Wu, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.129 · Cited by 290
Self-citationWg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
Tolwinski, N. S., Wehrli, M., Rives, A., Erdeniz, N., DiNardo, S., & Wieschaus, E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00063-7 · Cited by 286 · cited 1×
“Furthermore, LRP5 and Arrow were found to be involved in transducing the canonical Wnt signals by binding Axin and leading to Axin degradation and -catenin stabilization (24, 35 ).”
BackgroundMesd Encodes an LRP5/6 Chaperone Essential for Specification of Mouse Embryonic Polarity
Hsieh, J.-C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M. E., Rosenquist, T., & Holdener, B. C. (2003) · Cell · doi:10.1016/s0092-8674(03)00045-x · Cited by 237
Flagged first, then by citations
Research works printed but not linked: 32
- 10.1359/jbmr.2003.18.6.960 · DOI
- 10.1016/S0006-291X(02)02951-0 · DOI
- 10.1016/S0092-8674(02)01279-5 · DOI · Paper page
- 10.1042/bj3290209 · DOI
- 10.1038/34848 · DOI · Paper page
- 10.1016/S0092-8674(01)00571-2 · DOI · Paper page
- 10.1016/S0959-437X(98)80114-7 · DOI
- 10.1128/MCB.18.8.4807 · DOI
- 10.1038/88556 · DOI
- 10.1359/jbmr.2002.17.1.15 · DOI
- 10.1007/s001980070112 · DOI
- 10.1016/S0378-1119(99)00365-0 · DOI
- 10.1074/jbc.M111131200 · DOI
- 10.1093/emboj/18.15.4233 · DOI
- 10.1016/S0002-9343(97)90021-8 · DOI
- 10.1086/338450 · DOI · Paper page
- 10.1038/nature756 · DOI · Paper page
- 10.1038/35077108 · DOI
- 10.1016/S0925-4773(99)00138-0 · DOI
- 10.1038/35077199 · DOI
- Pandur P., 2001, Bioessays, 23, 207, 10.1002/1521-1878(200103)23:3<207::AID-BIES1029>3.0.CO;2-0 · DOI
- 10.1093/nar/29.9.e45 · DOI · Paper page
- 10.1038/35035124 · DOI
- 10.1186/1471-2121-4-4 · DOI
- 10.1016/S0960-9822(01)00290-1 · DOI · Paper page
- Takagi J., 2003, Nature, 424, 969, 10.1038/nature01873 · DOI
- 10.1038/35035117 · DOI · Paper page
- 10.1086/368277 · DOI · Paper page
- 10.1038/35035110 · DOI
- 10.1146/annurev.cellbio.14.1.59 · DOI
- 10.1074/jbc.274.43.30419 · DOI
- 10.1056/NEJM199606063342307 · DOI
Cited by
Sorted by citations
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
Li, X., Zhang, Y., Kang, H., Liu, W., Liu, P., Zhang, J., Harris, S. E., & Wu, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413274200 · Cited by 1,366
Self-citationSkeletal remodeling in health and disease
Zaidi, M. (2007) · Nature Medicine · doi:10.1038/nm1593 · Cited by 1,069
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
Semënov, M., Tamai, K., & He, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504308200 · Cited by 771
Sequential roles of Hedgehog and Wnt signaling in osteoblast development
Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005) · Development · doi:10.1242/dev.01564 · Cited by 682
The clinical utility of bone marker measurements in osteoporosis
Wheater, G., Elshahaly, M., Tuck, S. P., Datta, H. K., & van Laar, J. M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-201 · Cited by 322
Vlashi, R., Zhang, X., Wu, M., & Chen, G. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.07.011 · Cited by 165
Wnt signaling in bone and muscle
Rudnicki, M. A., & Williams, B. O. (2015) · Bone · doi:10.1016/j.bone.2015.02.009 · Cited by 132
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Li, Y., Chen, J., Lu, W., McCormick, L. M., Wang, J., & Bu, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02651 · Cited by 53
Metadata
- Authors
- Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S., & Wu, D.
- Affiliations
- Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut
- Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
- Department of Structure Biology, St Jude Hospital, Memphis, Tennessee
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2004-06-01
- Volume
- 24
- Issue
- 11
- Pages
- 4677-4684
- ISSN
- 1098-5549
- Cited by
- 142
- References
- 8
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review