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Assessing the Variation within the Oral Microbiome of Healthy Adults
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Abstract
The human oral cavity is inhabited by a diverse community of microbes, known as the human oral microbiome. These microbes play a role in maintaining both oral and systemic health and, as such, have been proposed to be useful biomarkers of disease. However, to identify these biomarkers, we first need to determine the composition and variation of the healthy oral microbiome. In this report, we investigate the oral microbiome of 1,049 healthy individuals to determine which genera and amplicon sequence variants are commonly found between individual oral microbiomes. We then further investigate how lifestyle, anthropometric, and dietary choices impact overall microbiome composition. Interestingly, the results from this investigation showed that while many features were significantly associated with oral microbiome composition, no single biological factor explained a variation larger than 2%. These results indicate that future work on biomarker detection may be encouraged by the lack of strong confounding factors.
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“Many studies have explored the association between gender and salivary microbiome, and reported that there was gender-specific difference in the salivary microbiome [56,57].”
From Saliva microbiome alterations in dental fluorosis population (2023) · cites this paper as [57]
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“However, at present, research on the dental plaque microbiota of school-aged children with dental fluorosis remains limited.”
From Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis (2026) · cites this paper as [18]
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Sorted by citations
Di Stefano, M., Polizzi, A., Santonocito, S., Romano, A., Lombardi, T., & Isola, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095142 · Cited by 292
Identifying biases and their potential solutions in human microbiome studies
Nearing, J. T., Comeau, A. M., & Langille, M. G. I. (2021) · Microbiome · doi:10.1186/s40168-021-01059-0 · Cited by 240
Self-citationSaliva microbiome alterations in dental fluorosis population
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Xia, Y., Peng, S., Yu, J., Wang, Y., Ye, Y., Liu, M., Shang, L., Cui, X., Wang, P., & Ding, Z. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2714622
Metadata
- Authors
- Nearing, J. T., DeClercq, V., Van Limbergen, J., & Langille, M. G. I.
- Affiliations
- Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
- Population Cancer Research Program, Dalhousie University, Halifax, Nova Scotia, Canada
- Division of Pediatric Gastroenterology & Nutrition, Emma Children’s Hospital, Amsterdam University Medical Centers, Amsterdam, The Netherlands
- ORCID
- Nearing, Jacob T.
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2020-10-28
- Volume
- 5
- Issue
- 5
- ISSN
- 2379-5042
- PMC
- PMC7529435
- Cited by
- 117
- References
- 9
- Language
- en
- Funders
- Canadian Foundation of Innovation John R. Evans Leadership fund
- Nova Scotia Health Research Foundation
- Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (2016-05039)
- Gouvernement du Canada | Canadian Institutes of Health Research
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