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Cited by 724

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years

Open access
Lithell, Hans O, McKeigue, Paul M, Berglund, Lars, Mohsen, Rawya, Lithell, Ulla-Britt, Leon, David A·1996·BMJ
DOI 10.1136/bmj.312.7028.406
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Abstract

Objective : To establish whether the relation between size at birth and non-insulin dependent diabetes is mediated through impaired β cell function or insulin resistance. Design : Cohort study. Setting : Uppsala, Sweden. Subjects : 1333 men whose birth records were traced from a cohort of 2322 men born during 1920-4 and resident in Uppsala in 1970. Main outcome measures : Intravenous glucose tolerance test at age 50 years and non-insulin dependent diabetes at age 60 years. Results : There was a weak inverse correlation (r=-0.07, P=0.03) between ponderal index at birth and 60 minute insulin concentrations in the intravenous glucose tolerance test at age 50 years. This association was stronger (r=-0.19, P=0.001) in the highest third of the distribution of body mass index than in the other two thirds (P=0.01 for the interaction between ponderal index and body mass index). Prevalence of diabetes at age 60 years was 8% in men whose birth weight was less than 3250 g compared with 5% in men with birth weight 3250 g or more (P=0.08; 95% confidence interval for difference −0.3% to 6.8%). There was a stronger association between diabetes and ponderal index: prevalence of diabetes was 12% in the lowest fifth of ponderal index compared with 4% in the other four fifths (P=0.001; 3.0% to 12.6%). Conclusion : These results confirm that reduced fetal growth is associated with increased risk of diabetes and suggest a specific association with thinness at birth. This relation seems to be mediated through insulin resistance rather than through impaired β cell function and to depend on an interaction with obesity in adult life.

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Metadata

Authors
Lithell, H. O., McKeigue, P. M., Berglund, L., Mohsen, R., Lithell, U.-B., & Leon, D. A.
Venue
BMJ
Publisher
BMJ
Published
1996-02-17
Volume
312
Issue
7028
Pages
406-410
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.312.7028.406
OpenAlex
W2021708142
Cited by
724
References
2
FWCI
41.99
Type
journal article
Language
en
Open access
green

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