Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies
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OBJECTIVE: To investigate and quantify the potential dose-response association between egg consumption and risk of coronary heart disease and stroke. DESIGN: Dose-response meta-analysis of prospective cohort studies. DATA SOURCES: PubMed and Embase prior to June 2012 and references of relevant original papers and review articles. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Prospective cohort studies with relative risks and 95% confidence intervals of coronary heart disease or stroke for three or more categories of egg consumption. RESULTS: Eight articles with 17 reports (nine for coronary heart disease, eight for stroke) were eligible for inclusion in the meta-analysis (3,081,269 person years and 5847 incident cases for coronary heart disease, and 4,148,095 person years and 7579 incident cases for stroke). No evidence of a curve linear association was seen between egg consumption and risk of coronary heart disease or stroke (P=0.67 and P=0.27 for non-linearity, respectively). The summary relative risk of coronary heart disease for an increase of one egg consumed per day was 0.99 (95% confidence interval 0.85 to 1.15; P=0.88 for linear trend) without heterogeneity among studies (P=0.97, I(2)=0%). For stroke, the combined relative risk for an increase of one egg consumed per day was 0.91 (0.81 to 1.02; P=0.10 for linear trend) without heterogeneity among studies (P=0.46, I(2)=0%). In a subgroup analysis of diabetic populations, the relative risk of coronary heart disease comparing the highest with the lowest egg consumption was 1.54 (1.14 to 2.09; P=0.01). In addition, people with higher egg consumption had a 25% (0.57 to 0.99; P=0.04) lower risk of developing hemorrhagic stroke. CONCLUSIONS: Higher consumption of eggs (up to one egg per day) is not associated with increased risk of coronary heart disease or stroke. The increased risk of coronary heart disease among diabetic patients and reduced risk of hemorrhagic stroke associated with higher egg consumption in subgroup analyses warrant further studies.
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Egg consumption has no significant association with incident CVD in general populations.
“Egg consumption has no significant association with incident CVD in general populations (Figure 6).196, 197”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [196]
Higher egg consumption associates with lower risk of hemorrhagic stroke, potentially related to protective effects of dietary cholesterol on vascular fragility.
“On the other hand, higher egg consumption associates with lower risk of hemorrhagic stroke,196 potentially related to protective effects of dietary cholesterol on vascular fragility.198, 199”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [196]
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McNamara, D. J. (2014) · Proceedings of the Nutrition Society · doi:10.1017/s0029665113003844 · Cited by 30 · see citing works
- Authors
- Rong, Y., Chen, L., Zhu, T., Song, Y., Yu, M., Shan, Z., Sands, A., Hu, F. B., & Liu, L.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Harvard University (US)
- Corresponding author
- Liu, L.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2013-01-07
- Volume
- 346
- Issue
- jan07 2
- Pages
- e8539-e8539
- ISSN
- 1756-1833 (ISSN-L)
- PMC
- PMC3538567
- OpenAlex
- W2099311158
- Cited by
- 364
- References
- 76
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 17 · 2023: 11 · 2022: 30 · 2021: 19 · 2020: 26 · 2019: 38 · 2018: 38 · 2017: 42 · 2016: 28 · 2015: 45 · 2014: 32 · 2013: 18 · 2012: 1
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Natural Science Foundation of China (NSFC 81072291)
- National Key Research and Development Program of China (2009CB118803)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007703)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- egg consumption, coronary artery disease, stroke, hemorrhagic stroke, dose-response relationship, dietary cholesterol, diabetes mellitus, cardiovascular risk
- MeSH terms
- Cholesterol, Dietary, Coronary Disease, Diabetes Mellitus, Eggs, Humans, Prospective Studies, Practice Guidelines as Topic, Risk Assessment, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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