The INternet ThERapy for deprESsion trial (INTEREST): protocol for a patient-preference, randomised controlled feasibility trial comparing iACT, iCBT and attention control among individuals with comorbid chronic pain and depression
Open accessAbstract
Introduction: Approximately one-third of adults with chronic pain also report clinically relevant levels of depression. Internet-delivered psychological therapies such as Cognitive Behavioural Therapy (iCBT) and Acceptance and Commitment Therapy (iACT) have been developed to overcome barriers of access to services and ensure the timely delivery of care. The objective of this trial is to collect data on feasibility, acceptability and range of probable effect sizes for iCBT and iACT interventions tailored towards the treatment of depression and chronic pain using a randomised controlled patient-preference design. Methods and analysis: Community dwelling adults with chronic non-cancer pain (CNCP) and major depression will be recruited from pain clinics and primary care providers in Newfoundland and Labrador, Canada. The study is a randomised controlled patient-preference trial. Eligible patients will be randomly assigned to a ‘preference’ or ‘no-preference’ arm during the first step of randomisation and to intervention or control in the second step of randomisation. Two interventions (ie, iCBT or iACT) will be evaluated relative to attention control. iCBT and iACT involve the completion of 7-weekly online modules augmented with one session of motivational enhancement and weekly therapy sessions. Primary outcomes include (1) feasibility and acceptability parameters and (2) change in symptoms of depression. Secondary outcomes include pain, physical function, emotional function and quality of life. We will recruit 60 participants and examine the range of effect sizes obtained from the trial but will not conduct significance testing as per recommendations for behavioural trial development. Ethics and dissemination: Ethics was approved by the provincial Health Research Ethics Board. Dissemination of results will be published in a peer-reviewed academic journal and presented at scientific conferences. Trial registration number: NCT04009135 .
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Bondesson, E., Jöud, A., Stigmar, K. G. E., Ringqvist, Å., Kraepelien, M., Kaldo, V., Wettermark, B., Forsell, Y., Petersson, I. F., & Schelin, M. E. C. (2021) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2021.101658 · Cited by 3 · see citing works
Virtual Acceptance and Commitment Therapy (vACT) For Youth with Chronic Illnesses: A Case Report
Mahrer, N. E., Sommer, V. S., Berman, D. I., Ngo, N. H., & Gold, J. I. (2023) · Medical Research Archives · doi:10.18103/mra.v11i6.3897
- Authors
- Bell, L. V., Cornish, P., Flusk, D., Garland, S. N., & Rash, J. A.
- Affiliations
- Memorial University of Newfoundland (CA)
- Corresponding author
- Rash, Joshua A
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2020-02
- Volume
- 10
- Issue
- 2
- Pages
- e033350
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC7050318
- OpenAlex
- W3008646058
- Cited by
- 5
- References
- 100
- Citations by year
- 2023: 2 · 2021: 3
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Memorial University of Newfoundland (Seed Grant / 213410-46316-2000)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- internet-based cognitive behavioral therapy, depression, chronic non-cancer pain, patient preferences, feasibility and acceptability, motivation enhancement, online psychological intervention, effect size estimation, quality of life, physical function
- MeSH terms
- Adult, Attention, Depression, Feasibility Studies, Humans, Newfoundland and Labrador, Quality of Life, Cognitive Behavioral Therapy, Randomized Controlled Trials as Topic, Treatment Outcome, Internet, Patient Preference, Chronic Pain, Acceptance and Commitment Therapy
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