Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
Abstract
Background Although postinfectious irritable bowel syndrome (PI-IBS) is a well-recognised complication of acute gastroenteritis, its prognosis remains poorly defined. The natural history of PI-IBS was assessed among participants in the Walkerton Health Study (WHS), which has followed the long-term effects of a large outbreak of acute gastroenteritis related to municipal water contamination in May 2000. Methods WHS participants were invited to return for annual assessment at a research clinic. Adult residents of Walkerton at the time of the outbreak who enrolled in 2002/2003 and returned for assessment in 2008 were eligible for a PI-IBS study cohort if they had no prior history of IBS or inflammatory bowel disease. A modified Bowel Disease Questionnaire was used to diagnose IBS by Rome I criteria and to identify IBS subtypes. Results Of 4561 WHS participants, 2451 returned for their 8 year assessment and 1166 were eligible for the PI-IBS study cohort (688 females, mean age 46.2 years). The prevalence of IBS among 742 eligible subjects who suffered acute gastroenteritis during the outbreak declined from 28.3% after 2-3 years to 15.4% after 8 years, but remained significantly increased compared with controls who did not have acute gastroenteritis (OR 3.12; 95% CI 1.99 to 5.04). Independent risk factors for PI-IBS at 8 years included female gender, younger age, prior anxiety/depression, and fever or weight loss during the acute enteric illness. IBS subtypes were not stable over t…
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In one longitudinal follow-up study, 15% of those with PI-IBS remained symptomatic 8 years later.
“in one longitudinal follow-up study, 15% of those with PI-IBS remained symptomatic 8 years later. 20”
From Irritable bowel syndrome (2020) · cites this paper as [20]
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- Authors
- Marshall, J. K., Thabane, M., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., & Walkerton Health Study Investigators
- Affiliations
- McMaster University Medical Centre (CA)
- McMaster University (CA)
- Western University (CA)
- Corresponding author
- Marshall, John K
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2010-04-28
- Volume
- 59
- Issue
- 5
- Pages
- 605-611
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2114058582
- Cited by
- 227
- References
- 3
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 3 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 11 · 2018: 19 · 2017: 21 · 2016: 28 · 2015: 20 · 2014: 24 · 2013: 12 · 2012: 19
- FWCI
- 16.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- post-infectious irritable bowel syndrome, acute gastroenteritis, long-term prognosis, IBS prevalence, IBS subtypes, risk factors, anxiety and depression, fever and weight loss, natural history (disease)
- MeSH terms
- Acute Disease, Adult, Disease Outbreaks, Dysentery, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Ontario, Prognosis, Water Microbiology, Water Supply, Irritable Bowel Syndrome
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