Distinct microbial populations exist in the mucosa‐associated microbiota of sub‐groups of irritable bowel syndrome
Abstract
Background There is increasing evidence to support a role for the gastrointestinal microbiota in the etiology of irritable bowel syndrome (IBS). Given the evidence of an inflammatory component to IBS, the mucosa‐associated microbiota potentially play a key role in its pathogenesis. The objectives were to compare the mucosa‐associated microbiota between patients with diarrhea predominant IBS (IBS‐D), constipation predominant IBS (IBS‐C) and controls using fluorescent in situ hybridization and to correlate specific bacteria groups with individual IBS symptoms. Methods Forty‐seven patients with IBS (27 IBS‐D and 20 IBS‐C) and 26 healthy controls were recruited to the study. Snap‐frozen rectal biopsies were taken at colonoscopy and bacterial quantification performed by hybridizing frozen sections with bacterial‐group specific oligonucleotide probes. Key Results Patients with IBS had significantly greater numbers of total mucosa‐associated bacteria per mm of rectal epithelium than controls [median 218 (IQR – 209) vs 128 (121) P = 0.007], and this was chiefly comprised of bacteroides IBS [69 (67) vs 14 (41) P = 0.001] and Eubacterium rectale–Clostridium coccoides [52 (58) vs 25 (35) P = 0.03]. Analysis of IBS sub‐groups demonstrated that bifidobacteria were lower in the IBS‐D group than in the IBS‐C group and controls [24 (32) vs 54 (88) vs 32 (35) P = 0.011]. Finally, amongst patients with IBS, the maximum number of stools per day negatively correlated with the number of mucosa‐associated bifidobacteria (P < 0.001) and lactobacilli (P = 0.002). Conclusions & Inferences The mucosa‐associated microbiota in patients with IBS is significantly different from healthy controls with increases in bacteroides and clostridia and a reduction in bifidobacteria in patients with IBS‐D.
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Emerging data support the existence of dysbiosis in a subset of IBS: a decreased complexity in composition, temporary instability, and changes in the mucosa-associated microbiota, with an increase in Bacteroides and Clostridia and a reduction in Bifidobacterium.
“Nonetheless, emerging data support the existence of dysbiosis in a subset of IBS [59] : a decreased complexity in composition [60] , temporary instability [61] , and changes in the mucosa-associated microbiota, with an increase in Bacteroides and Clostridia and a reduction in Bifidobacterium [62] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [62]
Limited data suggest differences in intestinal microbiota between IBS subtypes.
“Limited data also suggest differences in mucosa-associated microbiota (32, 33, 86, 129), reduced stability over time (106, 107), rDNA, and differences between IBS subtypes (81, 104, 129, 142).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [129]
Limited data suggest differences in mucosa-associated microbiota in patients with IBS.
“Limited data also suggest differences in mucosa-associated microbiota (32, 33, 86, 129), reduced stability over time (106, 107), rDNA, and differences between IBS subtypes (81, 104, 129, 142).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [129]
The genus Blautia displays a high incidence in patients with IBD.
“Moreover, the genus Blautia, recently reorganized to refer to several misclassified species belonging to the Clostridium cluster XIVa, which according to our study is more abundant in women than in men under obesity condition, display a high incidence in patients with IBD [53, 54].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [53]
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- Authors
- Parkes, G. C., Rayment, N. B., Hudspith, B. N., Petrovska, L., Lomer, M. C., Brostoff, J., Whelan, K., & Sanderson, J. D.
- Affiliations
- King's College London (GB)
- Corresponding author
- Parkes, G. C.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2011-11-09
- Volume
- 24
- Issue
- 1
- Pages
- 31-39
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W1605188970
- Cited by
- 200
- References
- 48
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 22 · 2019: 17 · 2018: 17 · 2017: 18 · 2016: 19 · 2015: 14 · 2014: 23 · 2013: 13 · 2012: 12
- FWCI
- 15.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- irritable bowel syndrome, mucosa-associated microbiota, diarrhea-predominant irritable bowel syndrome, irritable bowel syndrome with constipation, rectal mucosa, Bacteroides, Bifidobacterium, lactobacilli, gut microbiota, IBS pathogenesis, fluorescence in situ hybridization, rectal biopsy
- MeSH terms
- Adult, Bacteria, Biopsy, Female, Humans, Intestinal Mucosa, Male, Rectum, Irritable Bowel Syndrome, Metagenome
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