Cited by 1,240Gastrointestinal motility and disordersAnalytical Chemistry and SensorsGastroesophageal reflux and treatments

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Open access

Evans, D F, Pye, G, Bramley, R, Clark, A G, Dyson, T J, Hardcastle, J D·1988·Gut

DOI 10.1136/gut.29.8.1035PMC PMC1433896

Open this paper in CoChat — free account Open PDF

Abstract

Gastrointestinal (GI) pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract. Signals were recorded with a portable solid state receiver and recording system, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit. Capsule position in the gut was monitored by surface location using a directional detector. Gastric pH was highly acidic (range 1.0-2.5) in all subjects. The mean pH in the proximal small intestine was 6.6 (0.5) for the first hour of intestinal recording. By comparison the mean pH in the terminal ileum was 7.5 (0.4) (p less than 0.001). In all subjects there was a sharp fall in pH to a mean of 6.4 (0.4) (p less than 0.001) as the capsule passed into the caecum. Values are means (SD). pH then rose progressively from the right to the left colon with a final mean value of 7.0 (0.7) (p less than 0.001).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gut.29.8.1035

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2
Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704
A Handbook on Biotelemetry and Radio Tracking
(1980) · Elsevier eBooks · doi:10.1016/c2013-0-05926-9 · Cited by 540
Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.
Reddy, B. S., Watanabe, K., Weisburger, J. H., & Wynder, E. L. (1977) · PubMed · Cited by 438
The geographical distribution of cancer.
Doll, R. (1969) · British Journal of Cancer · doi:10.1038/bjc.1969.1 · Cited by 251
Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device
Bown, R. L., Gibson, J., Sladen, G. E., Hicks, B. D., & Dawson, A. M. (1974) · Gut · doi:10.1136/gut.15.12.999 · Cited by 232
HIGH COLONIC pH PROMOTES COLORECTAL CANCER
THORNTON, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92244-3 · Cited by 220
The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)
Davis, S. S., Hardy, J. G., Taylor, M. J., WHALLEY, D. R., & WILSON, C. G. (1984) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(84)90191-1 · Cited by 132
pH profile of gut as measured by radiotelemetry capsule.
Watson, B. W., Meldrum, S. J., Riddle, H. C., Brown, R. L., & Sladen, G. E. (1972) · BMJ · doi:10.1136/bmj.2.5805.104 · Cited by 111
Colonic release of 5‐amino salicylic acid from an oral preparation in active ulcerative colitis.
Dew, M. J., Ryder, R. E. J., Evans, N., Evans, B. K., & Rhodes, J. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb04983.x · Cited by 111
Ambulatory monitoring of oesophageal pH in reflux oesophagitis using a portable radiotelemetry system.
Branicki, F. J., Evans, D. F., Ogilvie, A. L., Atkinson, M. A., & Hardcastle, J. D. (1982) · Gut · doi:10.1136/gut.23.11.992 · Cited by 107
Self-citation

Show all 23 references

Research works printed but not linked: 8

Pietrousti A, Caprilli R, Guilano M, Serrano S, Vita S. Faecal pH in co!orectal cancer. ItalJ Gastroenterol 1985; 17: 88-91.
Evans DF, Jones JA, Hardcastle JD. Ambulatory monitoring of gastrointestinal pH in man using a radiotelemetry capsule and a new solid state recorder. J Physiol 1985; 74: 4P.
Ford PH, Pike GH. Decce series 4 user guide. Nottingham: Nottingham University Press, 1986.
Da Cruz F. Kermit -A file transfer profile. Digital Press, 1984.
Walker ARP, Walker BF, Segal I. Faecal pH value and its modification in S. African black and white schoolchildren. S Afr Med J 1979; 55: 495-8.
Stower MJ, Hardcastle JD. Five year survival of 1,115 patients with colorectal cancer. J Clin Oncol 1985; 11: 119-23.
Evans DF, Pye G, Bramley RB, Dyson TJ, Balfour TW, Hardcastle JD. Is colonic pH important in colorectal cancer? [Abstract]. Gut 1986; 27: A1257.
Pye G, Crompton J, Evans DF, Clark AG, Hardcastle JD. The effect of dietary fibre supplementation on colonic pH in healthy volunteers. [Abstract] Gut 1987; 28: A 1366.

Sorted by citations

Items 901–1,000 of 1,001

Novel gelling pectins from Zea mays husks’ agro-industrial residue and their interaction with calcium and iron (II)
Higuera-Coelho, R. A., Lizárraga, L., Ponce, N. M. A., Stortz, C. A., Rojas, A. M., Bernhardt, D. C., & Fissore, E. N. (2021) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2021.100273 · Cited by 7
In vitro release control of ketoprofen from pH-sensitive gels consisting of poly(acryloyl-l-proline methyl ester) and saturated fatty acid sodium salts
Negishi, M., Hiroki, A., Miyajima, M., Yoshida, M., Asano, M., & Katakai, R. (1999) · Radiation Physics and Chemistry · doi:10.1016/s0969-806x(98)00321-1 · Cited by 7
High-velocity delivery of biologics via the gastrointestinal tract by self-pressurized oral capsules
Palacios, J. I., Wood‐Yang, A. J., Klavohn, N., Friesenhahn, N., Raman, N., Baker, N. F., Ashby, G., & Prausnitz, M. R. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113963 · Cited by 6
Advances in drug release investigations: Trends and developments for dissolution test media
Kakuk, M., Farkas, D., Antal, I., & Kállai‐Szabó, N. (2020) · Acta Pharmaceutica Hungarica · doi:10.33892/aph.2020.90.155-169 · Cited by 6
Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline
Stamatopoulos, K., O’Farrell, C., Simmons, M. J. H., Batchelor, H. K., & Mistry, N. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030882 · Cited by 6
Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the Biopharmaceutical Performance of a Weak Base Drug Candidate
Zhang, W., Jia, W., Weitz, B. W., Ma, F., Chen, Y., Chiang, P., Hou, H. H., & Nagapudi, K. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00727 · Cited by 6
Characterization of novel endo-β-N-acetylglucosaminidases from intestinal Barnesiella intestinihominis that hydrolyze multi-branched complex-type N-glycans
Doi, K., Mitani, A., Nakakita, S., Higuchi, Y., & Takegawa, K. (2023) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2023.12.004 · Cited by 6
Assessing the utility of in silico tools in early drug development: The case of a pharmaceutically relevant formulation of the prodrug psilocybin
Richter, L. M., Al-Gousous, J., de Araújo, G. L. B., Davies, N. M., & Löbenberg, R. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105305 · Cited by 7
Toxoplasma-induced behavior changes - is microbial dysbiosis the missing link?
Prandovszky, E., Severance, E. G., Splan, V. W., Liu, H., Xiao, J., & Yolken, R. H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1415079 · Cited by 8
Polymeric Anti‐Antibiotic Microparticles to Prevent Antibiotic Resistance Evolution
Koshani, R., Yeh, S., He, Z., Narasimhalu, N., Steeg, L. G. V., Sim, D. G., Woods, R. J., Read, A. F., & Sheikhi, A. (2025) · Small · doi:10.1002/smll.202407549 · Cited by 6
Engineered Tissue Models to Decode Host–Microbiota Interactions
Adelfio, M., Callen, G. E., He, X., Paster, B. J., Hastürk, H., & Ghezzi, C. E. (2025) · Advanced Science · doi:10.1002/advs.202417687 · Cited by 6
PREPARATION AND EVALUATION OF KOLLIDON SR MATRIX TABLETS OF TINIDAZOLE FOR COLON SPECIFIC DRUG DELIVERY
Kirankumar, G. B., Annangi, V. K., & Ahamed, M. G. (2013) · Cited by 6
Reductive amination of oxidized hydroxypropyl cellulose with ω-aminoalkanoic acids as an efficient route to zwitterionic derivatives
Zhou, Y., Yao, Y., Zhai, Z., Mohamed, M. A., Mazzini, F., Qi, Q., Bortner, M. J., Taylor, L. S., & Edgar, K. J. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121699 · Cited by 6
Approaches to Rapid In Vivo Optimization of Hydrophilic Matrix Tablets
McDermott, J., Scholes, P., Lin, W., & Connor, A. L. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4939-1519-4_9 · Cited by 6
Colloidal phase behavior of pH-responsive, amphiphilic PEGylated poly(carboxylic acid)s and effect on kinetic solubility under acidic conditions
Adams, M. L., Rao, V. M., Thakur, A. B., & Hussain, M. A. (2009) · Pharmaceutical Development and Technology · doi:10.3109/10837450903170772 · Cited by 6
COLON SPECIFIC DRUG DELIVERY SYSTEMS: A REVIEW ON PRIMARY AND NOVEL APPROACHES Review Article
Challa, T., Vynala, V., Allam, K. V., & Padmavathi, T. (2011) · Cited by 6
COLON TARGETED DRUG DELIVERY SYSTEMS: A REVIEW
Prasad, K., Anilkumar, P., Ravisankar, B., Nirosha, M., & Hyndavi, M. (2011) · Cited by 6
The design, synthesis and in vivo biological evaluations of [V(IV)O(2,6-pyridine diacetatato) (H2O)2] (PDOV): Featuring its prolonged glucose lowering effect and non-toxic nature
Rambaran, V. H., Saumya, S. M., Roy, S., Sonu, K. P., Eswaramoorthy, M., & Peter, S. C. (2020) · Inorganica Chimica Acta · doi:10.1016/j.ica.2020.119448 · Cited by 6
Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs
Damoiseaux, D., Li, W., Martínez-Chávez, A., Beijnen, J. H., Schinkel, A. H., Huitema, A. D. R., & Dorlo, T. P. C. (2022) · Pharmaceuticals · doi:10.3390/ph15070860 · Cited by 6
The immunomodulatory functions of chromogranin A-derived peptide pancreastatin
Ioannidis, M., Mahata, S. K., & van den Bogaart, G. (2022) · Peptides · doi:10.1016/j.peptides.2022.170893 · Cited by 6
Positive effect of Bifidobacterium animalis subsp. lactis VHProbi YB11 in improving gastrointestinal movement of mice having constipation
Cui, H., Wang, Q., Feng, C., Guo, C., Zhang, J., Bu, X., & Duan, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1040371 · Cited by 6
Albumin microspheres for oral delivery of iron
Shivakumar, H. N., Vaka, S. R. K., & Murthy, S. N. (2009) · Journal of drug targeting · doi:10.3109/10611860903156393 · Cited by 6
FORMULATION DEVELOPMENT OF COLON TARGETED MESALAMINE PELLETS: IN VITRO-IN VIVO RELEASE STUDY
Bahekar, J., & Wadher, S. J. (2019) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2019v11i6.34920 · Cited by 6
„Targeted Delivery“ in den Gastrointestinaltrakt
Leopold, C. S. (1999) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/bf03042026 · Cited by 6
Circadian Cycle and Chronotherapeutics: Recent Trend for the Treatment of Various Biological Disorders
Singh, R., Sharma, P. K., & Malviya, R. (2012) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/187221112799219107 · Cited by 6
Systematic Delivery of Chloroquine and Promethazine Using pH-Sensitive Polymers
Attama, A. A., & Ezeamama, U. F. (2005) · Drug Delivery · doi:10.1080/10717540590921423 · Cited by 6
Acid Survival Mechanisms in Neutralophilic Bacteria
Pennacchietti, E., Giovannercole, F., & Biase, D. D. (2016) · Wiley eBooks · doi:10.1002/9781119004813.ch89 · Cited by 6
Drug Transport and Metabolism in Rat and Human Intestine
Berggren, S. (2006) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 6
Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery
Feng, S., Laurén, P., Zini, J., Gounani, Z., Bi, J., Yi, J., & Laaksonen, T. (2025) · Gels · doi:10.3390/gels11090700 · Cited by 5
“This suggests that aNFC/AP cryogels can generally protect acid-sensitive drugs in the gastric environment while achieving rapid release in the healthy small intestine, typically at a pH of 6.5–7.5 [52].”
Influential
Microenvironmental pH-Modulated Dissolution of Albendazole Layered on Tartaric Acid Starter Pellet Cores
Vlahović, K., Lengyel, M., Fleck, C., Kállai‐Szabó, N., Balogh, E., Laki, A. J., & Antal, I. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17091133 · Cited by 5
Smart Sampling Capsule for Capture and Detection of Enteric Pathogens in the Small Intestine
Krishnakumar, A., Sarnaik, D., Gallina, N. L. F., McCain, R. R., Crain, C. J., Bhunia, A. K., & Rahimi, R. (2025) · Advanced Materials Technologies · doi:10.1002/admt.202500848 · Cited by 5
Unveiling the impact of colonic pH and pH-sensing receptors in blood pressure regulation
Dinakis, E., Xie, L., Vecchio, E. A., Mackay, C. R., & Marques, F. Z. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2656346 · Cited by 5
Natural Product – Drug Interactions and Their Evaluation Using a Caco-2 Cell Culture Model
Galkin, A., & Tammela, P. (2023) · Natural Product Communications · doi:10.1177/1934578x231207263 · Cited by 5
The current and future clinical applications of capsule endoscopy
Ho, A. H. Y., & Lui, R. N.-S. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16490 · Cited by 5
An Overview of Colon Specific Drug Delivery: Approaches and Evaluation Aspects
Siddiqui, M. A., Agrawal, N., Jaiswal, M., Gupta, S., & Lanjhiyana, S. K. (2025) · Current Drug Research Reviews · doi:10.2174/0125899775364358250124105814 · Cited by 5
Small molecule drug absorption in inflammatory bowel disease and current implementation in physiologically- based pharmacokinetic models
Langeraert, J., Gasthuys, E., & Vermeulen, A. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107095 · Cited by 5
Interaction of Nanomaterials with Biological Systems
Miguel, T. B. A. R., Pinheiro, S. K. D. P., & Miguel, E. D. C. (2021) · Materials horizons · doi:10.1007/978-981-33-6056-3_12 · Cited by 5
Inverse ISAsomes in Bio-Compatible Oils—Exploring Formulations in Squalane, Triolein and Olive Oil
Trummer, F., Glatter, O., & Chemelli, A. (2022) · Nanomaterials · doi:10.3390/nano12071133 · Cited by 5
Metabolomic monitoring of chicory during in vitro gastrointestinal digestion and correlation with bioactive properties
Pouille, C. L., Dugardin, C., Behra-Miellet, J., Tourret, M., Molinié, R., Fontaine, J., Mathiron, D., Palaric, C., Gagneul, D., Ravallec, R., et al. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142344 · Cited by 5
Paediatric Development: Gastrointestinal
Batchelor, H. K. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4899-8011-3_4 · Cited by 5
The evolutionary development in drug discovery and delivery
Ithnin, H., Hussein, M. Z., Tan, J. M., & Fakurazi, S. (2013) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(13)50031-1 · Cited by 5
RETRACTED ARTICLE: Synthesis of dispersed and stabilized silver nanoparticles in acidic media
Atta, A. M., Al‐Lohedan, H. A., Ezzat, A. O., & Issa, Z. A. (2014) · Polymer Science Series B · doi:10.1134/s1560090414060013 · Cited by 5
Retracted
Study on absorption sites of quinidine and methotrexate in rat intestine
Murakami, T., Yokooji, T., & Mori, N. (2010) · Die Pharmazie · doi:10.31083/ph.2010.0031r · Cited by 5
Urinary Excretion Levels of MMX-Mesalazine as a Tool to Assess Non- Adherence
Römkens, T. E. H., Salomon, J., & Peters, W. H. M. (2015) · Pharmaceutica Analytica Acta · doi:10.4172/2153-2435.1000443 · Cited by 5
The protein dynamics of bovine and caprine β-lactoglobulin differ as a function of pH
McKerchar, H. J., Lento, C., Bennie, R. Z., Crowther, J. M., Dolamore, F., Dyer, J. M., Clerens, S., Mercadante, D., Wilson, D. J., & Dobson, R. C. J. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135229 · Cited by 5
Microbial Biocatalysis within Us: The Underexplored Xenobiotic Biotransformation Potential of the Urinary Tract Microbiota
Marti, T. D., Schärer, M. R., & Robinson, S. L. (2023) · CHIMIA International Journal for Chemistry · doi:10.2533/chimia.2023.424 · Cited by 5
Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital adrenal hyperplasia
Karunasena, N., Margetson, D. N., Neal, G., Whitaker, M. J., & Ross, R. J. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0948 · Cited by 5
Applications of Graft Copolymerization
Setia, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810462-0.00001-6 · Cited by 5
Colon Targeted Drug Delivery System – A Review.
., A. D., Nalawade, P., ., R. T., & ., S. K. (2018) · Journal of Current Pharma Research · doi:10.33786/jcpr.2018.v09i01.007 · Cited by 5
Efficacy and safety of prolonged release budesonide granules in mesalazine‐refractory ulcerative colitis: A multi‐centre Phase IIa study (TOPICAL‐1)
Fellermann, K., Schiefke, I., Rácz, I. A., Derova, J., Jonaitis, L. V., Wehrum, S., Nacak, T., & Greinwald, R. (2020) · United European Gastroenterology Journal · doi:10.1177/2050640620962632 · Cited by 5
Presumptive probiotic bacteria from traditionally fermented African food challenge the adhesion of enteroaggregative E. coli
Agbemavor, W. S. K., & Buys, E. M. (2021) · Journal of Food Safety · doi:10.1111/jfs.12905 · Cited by 5
Bridging the Gap Between Micro and Nanotechnology: Using Lab-on-a-Chip to Enable Nanosensors for Genomics, Proteomics, and Diagnostic Screening
Cooper, J. M., Johannessen, E. A., & Cumming, D. R. S. (2004) · Lecture notes in computer science · doi:10.1007/978-3-540-30141-7_75 · Cited by 5
Surface coating of l-glutamine solid microparticles for enteric delivery
Zhong, Q., & Shah, B. S. (2012) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2012.09.009 · Cited by 5
Influence of feeding regimens on rat gut fluids and colonic metabolism of diclofenac-β-cyclodextrin
Vieira, A. C. F., Murdan, S., Serra, A. C., Veiga, F., Gonsalves, A. M. D. R., & Basit, A. W. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.06.064 · Cited by 5
Species Similarities and Differences in Pharmacokinetics and Distribution of Antiretroviral Drugs
Owen, A., & Curley, P. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1655-9_28 · Cited by 5
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES
Nguyen, A., Schill, M. S., Jian, M., & LiWang, P. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071575 · Cited by 5
Applications of Polymers in Colon Drug Delivery
Bardoliwala, D., Baradia, D., Amrutiya, J., & Misra, A. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819659-5.00007-0 · Cited by 5
Effect of Olsalazine and Mesalazine on Intraluminal pH of the Duodenum and Proximal Jejunum in Healthy Humans
Falungborg, J., Christensen, L. A., Jacobsen, B. A., Ingeman‐Nielsen, M., Rasmussen, H. H., ABILDGAARD, K., & Rasmussen, S. N. (1994) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529409092461 · Cited by 5
Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial
Brodersen, K., Mose, M., Ramer Mikkelsen, U., Jørgensen, J. O. L., Festersen Nielsen, M., Møller, N., Wegeberg, A., Brock, C., Hartmann, B., Holst, J. J., et al. (2022) · Physiological Reports · doi:10.14814/phy2.15462 · Cited by 4
“Anatomical landmarks were defined as previously described (Evans et al., 1988; Fallingborg et al., 1998; Sarosiek et al., 2010; Zarate et al., 2010).”
Method
Programmable Host–Guest Recognition for Shape-Shifting Supramolecular Nanostructure States
Su, B., Liu, D., Chi, T., Fan, B., Wang, K., Xian, S., Ye, Z., & Webber, M. J. (2025) · ACS Nano · doi:10.1021/acsnano.5c04357 · Cited by 4
Structure of the complete 14-subunit botulinum neurotoxin B complex reveals a unique anchoring through the narrow central pore of HA70
Krč, A., Košenina, S. P., Nowakowska, M. B., Masuyer, G., & Stenmark, P. (2025) · Science Advances · doi:10.1126/sciadv.adx5058 · Cited by 4
Oral (poly)peptide delivery: On the emulsifying properties of inverted lipid phases under gastrointestinal conditions
Ebert, M. L., Postina, A., Schmidt, M. R., Laffleur, F., Kali, G., & Bernkop‐Schnürch, A. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114508 · Cited by 4
Structural hijacking of FcRn by human astrovirus spikes reveals conserved epitopes for broad-spectrum antivirals
Agrawal, S., Jain, M., Marinelli, D., Cho, S. Y., Briney, B. S., & Wilson, I. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116679 · Cited by 4
Maintenance and Protection of Probiotics
Huckle, B. D., & Zhang, Z. (2011) · Microbiology monographs · doi:10.1007/978-3-642-20838-6_4 · Cited by 4
An Investigation into the Characteristics of Natural Polysaccharide: Polymer Metoprolol Succinate Tablets for Colonic Drug Delivery
Godge, G. R., & Hiremath, S. N. (2014) · Cited by 4
Nanopreparations for Oral Administration
Hubbard, D., Brayden, D. J., & Ghandehari, H. (2014) · Frontiers in nanobiomedical research · doi:10.1142/9789814520652_0022 · Cited by 4
IMPLICATIONS OF BIODEGRADABLE AND BIOADHESIVE SYSTEMS IN COLON DELIVERY
Kaushik, D., Sardana, S., & Mishra, D. N. (2009) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2009.010201 · Cited by 4
Applications of Polymers in Delivery of Biologics
Inamdar, N., & Mourya, V. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819659-5.00016-1 · Cited by 4
Design, Development, and Optimisation of Smart Linker Chemistry for Targeted Colonic Delivery—In Vitro Evaluation
Abd-Ellah, H. S., Mudududdla, R., Carter, G. P., & Baell, J. B. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010303 · Cited by 4
Environmental insults and compensative responses: when microbiome meets cancer
Nagpal, S., & Mande, S. S. (2023) · Discover Oncology · doi:10.1007/s12672-023-00745-9 · Cited by 4
The Effects of Food on Drug Bioavailability and Bioequivalence
DeHaven, W. I., & Conner, D. P. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4939-1252-0_4 · Cited by 5
Critical Illness and the Intestinal Microflora: pH as a Surrogate Marker
Fleming, I. D., DeFazio, J. R., Zaborina, O. Y., & Alverdy, J. C. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8503-2_116-1 · Cited by 4
A pH-sensitive hydrogel-based smart switch for GI-tract payload release
Jiang, H., Yu, W., Zhou, J., & Ziaie, B. (2017) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/memsys.2017.7863455 · Cited by 4
Fluorescent diagnostics of epithelial neoplasms of different colon parts
Korneva, Y. S., Ae, D., & Maryakhina, V. S. (2017) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22683 · Cited by 4
An in-vitro upper gut simulator for assessing continuous gas production: A proof-of-concept using milk digestion
Pillai, N. V., Berean, K. J., Brkljača, R., Greve, L. J., Kasapis, S., & Kalantar‐Zadeh, K. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.054 · Cited by 4
Real-Time Tracking of a 3D-Printed Smart Capsule Using on-Board Near-Infrared Led Array
Jiang, H., Kim, A., Zhou, J., Rahimi, R., & Ziaie, B. (2019) · International Conference on Solid-State Sensors, Actuators and Microsystems · doi:10.1109/transducers.2019.8808508 · Cited by 4
Colon Specific Drug Delivery by pH Sensitive Polymers & Pulsatile Drug Delivery System
Kumar, A., Aggarwal, G., & Harikumar, S. L. (2015) · Indo Global Journal of Pharmaceutical Sciences · doi:10.35652/igjps.2015.18 · Cited by 4
Salmonella enterica serovar Typhi genomic regions involved in low pH resistance and in invasion and replication in human macrophages
Mendoza-Mejía, B. D., Medina-Aparicio, L., Serrano‐Fujarte, I., Vázquez, A., Calva, E., & Hernández-Lucas, I. (2021) · Annals of Microbiology · doi:10.1186/s13213-021-01629-5 · Cited by 4
Enabling rational gut microbiome manipulations by understanding gut ecology through experimentally-evidenced in silico models
Ortiz, J. P. M., McClure, D. D., Shanahan, E. R., Dehghani, F., Holmes, A. J., & Read, M. N. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1965698 · Cited by 4
Preformulation Studies with Phenylalanine Ammonia Lyase: Essential Prelude to a Microcapsule Formulation for the Management of Phenylketonuria
Besada, C., Hakami, A., Pillai, G. S., Yetsko, K., Truong, N., Little, T., Pantano, S., & D’mello, A. P. (2022) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2022.03.016 · Cited by 4
Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH
Tran, P., Crawford, T., Ragnarsson, L. K. N., Deuis, J. R., Mobli, M., Sharpe, S. J., Schroeder, C. I., & Vetter, I. (2023) · ACS Omega · doi:10.1021/acsomega.3c02664 · Cited by 4
Film Coatings Based on Aqueous Shellac Ammonium Salt “Swanlac® ASL 10” and Inulin for Colon Targeting
Strich, S., Azehaf, H., Neut, C., Lellouche-Jacob, Y., Medkour, N., Penning, M., & Karrout, Y. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02652-2 · Cited by 4
Synthetic polymers as biomaterials for the treatment of colon diseases
Chaurasia, S., & Mishra, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-14044-0.00018-1 · Cited by 4
Cyclic Voltammetry and Chronoamperometry Techniques in Description of the Surface-Active Phospholipid Bilayer Relative to Acid-Base Equilibria
Naumowicz, M. (2016) · Journal of The Electrochemical Society · doi:10.1149/2.0301609jes · Cited by 4
The Role of Polymers in Solid Oral Dosage Forms
Kendall, R. A., & Basit, A. W. (2006) · CRC Press eBooks · doi:10.1201/9781420021677.ch4 · Cited by 4
Development of Redox Nanomedicine for Gastrointestinal Complications via Oral Administration Route
Vong, L. B., & Nagasaki, Y. (2017) · ACS symposium series · doi:10.1021/bk-2017-1253.ch002 · Cited by 4
A novel colonic drug delivery system of ibuprofen
Gohel, M., & Nagori, S. (2009) · Asian Journal of Pharmaceutics · doi:10.4103/0973-8398.56304 · Cited by 4
Orally Administered Drug Delivery Systems to the Colon
Milabuer, M. N., Kam, Y., & Rubinstein, A. (2010) · Wiley eBooks · doi:10.1002/9780470640487.ch14 · Cited by 4
Modelling and simulation in bioequivalence
Silva, N. E. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 4
A multi-omic trip through the human gut
Quinn, R. A., Christian Martin, H., & Guzior, D. V. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00773-3 · Cited by 5
Targeted drug delivery using self-unrolling sheets in magnetically actuated capsules
Lee, J., Park, S., Yoon, D., Murugan, C., Bang, S., & Park, S. (2025) · Device · doi:10.1016/j.device.2024.100654 · Cited by 3
Effects of Short-Chain Fatty Acid Combinations Relevant to the Healthy and Dysbiotic Gut upon Candida albicans
Hickey, E., Leaves, I., Pradhan, A., Ma, Q., Yuecel, R., Gow, N. A. R., Brown, G. D., & Brown, A. J. P. (2025) · Current Microbiology · doi:10.1007/s00284-025-04400-0 · Cited by 4
Exploring the prebiotic potential of dietary fibre concentrates from artichoke, red pepper, cucumber, and carrot by-products
Vaz, A. A., Odriozola‐Serrano, I., Oms‐Oliu, G., Martín‐Belloso, O., & Bellı́, G. (2025) · Food Hydrocolloids for Health · doi:10.1016/j.fhfh.2025.100257 · Cited by 3
Contrasting pH optima of β-lactamases CTX-M and CMY influence Escherichia coli fitness and resistance ecology
Anbo, M., Otani, S., Ivanova, M., Nielsen, H. N., Jensen, J. D., Svendsen, C. A., Pang, C., & Aarestrup, F. M. (2025) · Applied and Environmental Microbiology · doi:10.1128/aem.01775-25 · Cited by 3
Advances and prospects of microenvironment-targeted nanotherapeutics for ulcerative colitis: evolving paradigms in the precision gut microenvironment
Lu, H., Zhang, W., Wu, Z., Peng, Y., Liu, F., Gao, S., & Deng, L. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126546 · Cited by 3
Obesity-associated pathologies: Recent advances in stimuli-responsive nanocarriers for adipose tissue browning and beyond
Elsherbini, A. M., Mohamed, S. A., Zayed, A. M., Mouhamed, W. A., & Sabra, S. A. (2026) · OpenNano · doi:10.1016/j.onano.2026.100290 · Cited by 3
A smart ingestible capsule for real-time monitoring of stimuli-responsive polymer dissolution kinetics and oral drug release in the gastrointestinal tract
Srinivasan, P., Rana, M. M., Krishnakumar, A., Sarnaik, D., Ramesh, Y., McCain, R. R., & Rahimi, R. (2026) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2026.118715 · Cited by 3
Fabrication of a Dual-Triggered Natural Gum–Based Multi-Particulate Colon-Targeted Drug Delivery System of Budesonide Using the QbD Approach
Patel, J., Patel, K., & Shah, S. (2023) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-023-09764-z · Cited by 3
Bacillus subtilis var. natto promotes tobacco plant growth under normal conditions and in the presence of sodium bicarbonate
Cheah, B. H., CHEN, Y.-L., ZOU, X.-Y., Lee, K., Shih, Y.-H., & LIN, Y.-F. (2024) · Biologia Plantarum · doi:10.32615/bp.2023.024 · Cited by 3
Deciphering the spatiotemporal transcriptional landscape of intestinal diseases (Review)
Guo, Y., Ren, C., He, Y., Wu, Y., & Yang, X. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13281 · Cited by 3

Authors: Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D.
Affiliations: Queen's Medical Centre (GB)
Venue: Gut
Publisher: BMJ
Published: 1988-08
Volume: 29
Issue: 8
Pages: 1035-1041
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.29.8.1035
PMC: PMC1433896
OpenAlex: W2089407496
Cited by: 1,240
References: 23
Citations by year: 2026: 38 · 2025: 74 · 2024: 52 · 2023: 67 · 2022: 70 · 2021: 84 · 2020: 67 · 2019: 58 · 2018: 47 · 2017: 55 · 2016: 49 · 2015: 59 · 2014: 67 · 2013: 43 · 2012: 56
FWCI: 7.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords: gastrointestinal pH, gastric pH, terminal ileum, cecum, colon, ambulatory pH monitoring, gastrointestinal transit, normal subjects
MeSH terms: Adult, Aged, Aged, 80 and over, Female, Gastrointestinal Contents, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Reference Values

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks