The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Measurement of gastrointestinal pH profiles in normal ambulant human subjects
Open accessAbstract
Gastrointestinal (GI) pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract. Signals were recorded with a portable solid state receiver and recording system, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit. Capsule position in the gut was monitored by surface location using a directional detector. Gastric pH was highly acidic (range 1.0-2.5) in all subjects. The mean pH in the proximal small intestine was 6.6 (0.5) for the first hour of intestinal recording. By comparison the mean pH in the terminal ileum was 7.5 (0.4) (p less than 0.001). In all subjects there was a sharp fall in pH to a mean of 6.4 (0.4) (p less than 0.001) as the capsule passed into the caecum. Values are means (SD). pH then rose progressively from the right to the left colon with a final mean value of 7.0 (0.7) (p less than 0.001).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This suggests that aNFC/AP cryogels can generally protect acid-sensitive drugs in the gastric environment while achieving rapid release in the healthy small intestine, typically at a pH of 6.5–7.5 [52].”
From Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery (2025) · cites this paper as [52]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Narisawa, T., Magadia, N. E., Weisburger, J. H., & Wynder, E. L. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.4.1093 · Cited by 704
A Handbook on Biotelemetry and Radio Tracking
(1980) · Elsevier eBooks · doi:10.1016/c2013-0-05926-9 · Cited by 540
Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.
Reddy, B. S., Watanabe, K., Weisburger, J. H., & Wynder, E. L. (1977) · PubMed · Cited by 438
The geographical distribution of cancer.
Doll, R. (1969) · British Journal of Cancer · doi:10.1038/bjc.1969.1 · Cited by 251
Bown, R. L., Gibson, J., Sladen, G. E., Hicks, B. D., & Dawson, A. M. (1974) · Gut · doi:10.1136/gut.15.12.999 · Cited by 232
HIGH COLONIC pH PROMOTES COLORECTAL CANCER
THORNTON, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)92244-3 · Cited by 220
The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet)
Davis, S. S., Hardy, J. G., Taylor, M. J., WHALLEY, D. R., & WILSON, C. G. (1984) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(84)90191-1 · Cited by 132
pH profile of gut as measured by radiotelemetry capsule.
Watson, B. W., Meldrum, S. J., Riddle, H. C., Brown, R. L., & Sladen, G. E. (1972) · BMJ · doi:10.1136/bmj.2.5805.104 · Cited by 111
Colonic release of 5‐amino salicylic acid from an oral preparation in active ulcerative colitis.
Dew, M. J., Ryder, R. E. J., Evans, N., Evans, B. K., & Rhodes, J. (1983) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1983.tb04983.x · Cited by 111
Branicki, F. J., Evans, D. F., Ogilvie, A. L., Atkinson, M. A., & Hardcastle, J. D. (1982) · Gut · doi:10.1136/gut.23.11.992 · Cited by 107
Self-citation
Research works printed but not linked: 8
- Pietrousti A, Caprilli R, Guilano M, Serrano S, Vita S. Faecal pH in co!orectal cancer. ItalJ Gastroenterol 1985; 17: 88-91.
- Evans DF, Jones JA, Hardcastle JD. Ambulatory monitoring of gastrointestinal pH in man using a radiotelemetry capsule and a new solid state recorder. J Physiol 1985; 74: 4P.
- Ford PH, Pike GH. Decce series 4 user guide. Nottingham: Nottingham University Press, 1986.
- Da Cruz F. Kermit -A file transfer profile. Digital Press, 1984.
- Walker ARP, Walker BF, Segal I. Faecal pH value and its modification in S. African black and white schoolchildren. S Afr Med J 1979; 55: 495-8.
- Stower MJ, Hardcastle JD. Five year survival of 1,115 patients with colorectal cancer. J Clin Oncol 1985; 11: 119-23.
- Evans DF, Pye G, Bramley RB, Dyson TJ, Balfour TW, Hardcastle JD. Is colonic pH important in colorectal cancer? [Abstract]. Gut 1986; 27: A1257.
- Pye G, Crompton J, Evans DF, Clark AG, Hardcastle JD. The effect of dietary fibre supplementation on colonic pH in healthy volunteers. [Abstract] Gut 1987; 28: A 1366.
Cited by
Sorted by citations
Items 101–200 of 1,001
Cellulose esters in drug delivery
Edgar, K. J. (2006) · Cellulose · doi:10.1007/s10570-006-9087-7 · Cited by 192
Rodrı́guez, M., Vila-Jato, J. L., & Torres, D. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00029-7 · Cited by 191
Lin, L., Chi, J., Yan, Y., Luo, R., Feng, X., Zheng, Y., Xian, D., Li, X., Quan, G., Liu, D., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.07.014 · Cited by 195
Bile salt hydrolase/aminoacyltransferase shapes the microbiome
Guzior, D., Okros, M., Hernandez, C. M., Shivel, M., Armwald, B., Hausinger, R., & Quinn, R. (2022) · doi:10.21203/rs.3.rs-2050406/v1 · Cited by 187
A Critical Look at Prebiotics Within the Dietary Fiber Concept
Verspreet, J., Damen, B., Broekaert, W. F., Verbeke, K., Delcour, J. A., & Courtin, C. M. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-081315-032749 · Cited by 194
Oral delayed-release system for colonic specific delivery
Gazzaniga, A., Iamartino, P., Maffione, G., & Sangalli, M. E. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90418-9 · Cited by 184
Liu, X., Dawei, C., Li-ping, X., & Rongqing, Z. (2003) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.08.019 · Cited by 184
Targeting Drugs to the Colon: Delivery Systems for Oral Administration
Ashford, M. B., & Fell, J. T. (1994) · Journal of drug targeting · doi:10.3109/10611869408996806 · Cited by 178
Lactose digestion from yogurt: mechanism and relevance
Savaiano, D. A. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.073023 · Cited by 177
Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans
Cezairliyan, B. O., Vinayavekhin, N., Lee, D. G., Yuen, G. J., Saghatelian, A., & Ausubel, F. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003101 · Cited by 177
Gastroretentive Delivery Systems: A Mini Review
Talukder, R. M., & Fassihi, R. (2004) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-200040239 · Cited by 176
Oral insulin delivery: existing barriers and current counter-strategies
Gedawy, A., Martinez, J., Al‐Salami, H., & Dass, C. R. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12852 · Cited by 177
Milojevic, S., Newton, J. M., Cummings, J. H., Gibson, G. R., Botham, R. L., Ring, S. G., Stockham, M. A., & Allwood, M. C. (1996) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00112-3 · Cited by 174
Intestinal and fecal pH in human health
Yamamura, R., Inoue, K. Y., Nishino, K., & Yamasaki, S. (2023) · Frontiers in Microbiomes · doi:10.3389/frmbi.2023.1192316 · Cited by 185
Zimmermann, T., Yeates, R. A., Laufen, H., Pfaff, G., & Wildfeuer, A. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00199879 · Cited by 172
Palm, K., Luthman, K., Ros, J., Gråsjö, J., & Artursson, P. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35123-7 · Cited by 172
Merchant, H. A., McConnell, E. L., Liu, F., Ramaswamy, C., Kulkarni, R. P., Basit, A. W., & Murdan, S. (2010) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2010.09.019 · Cited by 171
Friend, D. R. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90051-d · Cited by 171
The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer
Sui, Y., Wu, J., & Chen, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631552 · Cited by 175
Microbial Communities in the Human Small Intestine: Coupling Diversity to Metagenomics
Booijink, C. C., Zoetendal, E. G., Kleerebezem, M., & de Vos, W. M. (2007) · Future Microbiology · doi:10.2217/17460913.2.3.285 · Cited by 164
Core–Shell Chitosan Microcapsules for Programmed Sequential Drug Release
Yang, X., Ju, X., Mu, X.-T., Wang, W., Xie, R., Liu, Z., & Chu, L. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01277 · Cited by 164
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization
Schalper, K. A., Sánchez, H. A., Lee, S. C., Altenberg, G. A., Nathanson, M. H., & Sáez, J. C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00015.2010 · Cited by 163
Clinical translation of advanced colonic drug delivery technologies
Awad, A., Madla, C. M., McCoubrey, L. E., Ferraro, F., Gavins, F. K. H., Buanz, A. B. M., Gaisford, S., Orlu, M., Siepmann, F., Siepmann, J., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114076 · Cited by 171
Wang, Y., Mohammed, S. D., Farmer, A. D., Wang, D., Zárate-López, N., Hobson, A. R., Hellström, P. M., Semler, J. R., Kuo, B., Rao, S. S. C., et al. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13329 · Cited by 162
Oral Anticancer Drugs: Mechanisms of Low Bioavailability and Strategies for Improvement
Stuurman, F. E., Nuijen, B., Beijnen, J. H., & Schellens, J. H. M. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0040-2 · Cited by 164
Drug dissolution: significance of physicochemical properties and physiological conditions
Jambhekar, S. S., & Breen, P. J. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.08.013 · Cited by 162
Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel
Cremer, J., Šegota, I., Chih-Yu, Y., Arnoldini, M., Sauls, J. T., Zhang, Z., Gutierrez, E., Groisman, A., & Hwa, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601306113 · Cited by 166
In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents
Zhang, H., & Neau, S. H. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00011-x · Cited by 161
pH-Mediated Microbial and Metabolic Interactions in Fecal Enrichment Cultures
Ilhan, Z. E., Marcus, A. K., Kang, D., Rittmann, B. E., & Krajmalnik‐Brown, R. (2017) · mSphere · doi:10.1128/msphere.00047-17 · Cited by 168
Fleckenstein, B. T., Qiao, S., Larsen, M. R., Jung, G., Roepstorff, P., & Sollid, L. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310198200 · Cited by 157
Phage Therapy with a Focus on the Human Microbiota
Ganeshan, S. D., & Hosseinidoust, Z. (2019) · Antibiotics · doi:10.3390/antibiotics8030131 · Cited by 156
Zhou, S., Zhong, Q., Wang, Y., Hu, P., Zhong, W. H., Huang, C., Yu, Z., Ding, C., Liu, H., & Fu, J. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214309 · Cited by 157
Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
Potthoff, M. J., Potts, A., He, T., Duarte, J. A. G., Taussig, R., Mangelsdorf, D. J., Kliewer, S. A., & Burgess, S. C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00400.2012 · Cited by 158
Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale
das Neves, J., Bahia, M. F., Amiji, M. M., & Sarmento, B. F. C. C. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.586334 · Cited by 156
Secor, S. M. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00300 · Cited by 153
Ibekwe, V. C., Fadda, H. M., Parsons, G. E., & Basit, A. W. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.10.038 · Cited by 150
Jones, H. M., Parrott, N. J., Ohlenbusch, G., & Lav, T. (2006) · Clinical Pharmacokinetics · doi:10.2165/00003088-200645120-00006 · Cited by 150
Zhang, P., Zhu, B., Du, P., & Travaš‐Sejdić, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00392 · Cited by 150
Ali, H., Weigmann, B., Neurath, M. F., Collnot, E. M., Windbergs, M., & Lehr, C. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.039 · Cited by 148
Sarosiek, I., Selover, K., KATZ, L. A., Semler, J. R., Wilding, G. E., Lackner, J. M., Sitrin, M. D., Kuo, B., Chey, W. D., Hasler, W. L., et al. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04162.x · Cited by 147
Sen, G., Mishra, S. K., Jha, U., & Pal, S. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.05.004 · Cited by 147
Diet-induced endogenous formation of nitroso compounds in the GI tract
Kuhnle, G. G. C., Story, G. W., Reda, T., Mani, A. R., Moore, K. P., Lunn, J. C., & Bingham, S. A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.011 · Cited by 146
McConnell, E. L., Short, M. B., & Basit, A. W. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.022 · Cited by 146
Mi, F., Wu, Y.-Y., Lin, Y.-H., Sonaje, K., Ho, Y., Chen, C.-T., Juang, J.-H., & Sung, H. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800076n · Cited by 146
Human Gut Microbiota: Toward an Ecology of Disease
Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 151
Quantitative determination of cesium binding to ferric hexacyanoferrate: Prussian blue
Faustino, P. J., Yang, Y., Progar, J. J., Brownell, C. R., Sadrieh, N. K., May, J. C., Leutzinger, E. E., Place, D. A., Duffy, E. P., Houn, F., et al. (2008) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.11.049 · Cited by 145
Bayat, A., Dorkoosh, F. A., Dehpour, A. R., Moezi, L., Larijani, B. A., Junginger, H. E., & Rafiee‐Tehrani, M. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.12.037 · Cited by 144
Lopez-Medina, E., Fan, D., Coughlin, L. A., Ho, E. X., Lamont, I. L., Reimmann, C., Hooper, L. V., & Koh, A. Y. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005129 · Cited by 143
Human metabolome variation along the upper intestinal tract
Folz, J., Culver, R. N., Morales, J. M., Grembi, J., Triadafilopoulos, G., Relman, D. A., Huang, K. C., Shalon, D., & Fiehn, O. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00777-z · Cited by 143
Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies
Boelsterli, U. A., Redinbo, M. R., & Saitta, K. S. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs310 · Cited by 143
Ringel‐Kulka, T., Choi, C. H., Temas, D., Kim, A., Maier, D. M., Scott, K. P., Galanko, J. A., & Ringel, Y. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.220 · Cited by 142
Abuhelwa, A. Y., Foster, D. J. R., & Upton, R. N. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9952-8 · Cited by 142
Bouhnik, Y., Raskine, L., Simoneau, G., Paineau, D., & Bornet, F. R. J. (2006) · Nutrition Journal · doi:10.1186/1475-2891-5-8 · Cited by 142
Giardia lamblia: The roles of bile, lactic acid, and pH in the completion of the life cycle in vitro
Gillin, F. D., Boucher, S., Rossi, S. S., & Reiner, D. S. (1989) · Experimental Parasitology · doi:10.1016/0014-4894(89)90185-9 · Cited by 140
Hayes, E. T., Wilks, J. C., Sanfilippo, P., Yohannes, E., Tate, D. P., Jones, B. D., Radmacher, M. D., BonDurant, S. S., & Slonczewski, J. L. (2006) · BMC Microbiology · doi:10.1186/1471-2180-6-89 · Cited by 140
In situ reprogramming of gut bacteria by oral delivery
Hsu, B. B., Plant, I. N., Lyon, L. G., Anastassacos, F. M., Way, J. C., & Silver, P. A. (2020) · Nature Communications · doi:10.1038/s41467-020-18614-2 · Cited by 138
Diakidou, A., Vertzoni, M., Goumas, K., Söderlind, E., Abrahamsson, B., Dressman, J., & Reppas, C. I. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9927-x · Cited by 143
Maurer, J. M., Schellekens, R. C. A., van Rieke, H. M., Wanke, C., Iordanov, V. P., Stellaard, F., Wutzke, K. D., Dijkstra, G. D. H., van der Zee, M., Woerdenbag, H. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129076 · Cited by 137
Cook, M. T., Tzortzis, G., Khutoryanskiy, V. V., & Charalampopoulos, D. (2012) · Journal of Materials Chemistry B · doi:10.1039/c2tb00126h · Cited by 137
Evaluation of guar gum as a compression coat for drug targeting to colon
Krishnaiah, Y. S. R., Satyanarayana, S., Prasad, Y. V. R., & Rao, S. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00172-0 · Cited by 137
Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms
Debotton, N., & Dahan, A. (2016) · Medicinal Research Reviews · doi:10.1002/med.21403 · Cited by 138
An in vivo investigation into the suitability of pH dependent polymers for colonic targeting
Ashford, M. B., Fell, J. T., Attwood, D., Sharma, H. L., & Woodhead, P. J. (1993) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(93)90406-6 · Cited by 134
Murray, M. J., & Schusser, G. F. (1993) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1993.tb02983.x · Cited by 133
Gramatté, T., Oertel, R., Terhaag, B., & Kirch, W. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90182-4 · Cited by 131
Overview and Future Potential of Buccal Mucoadhesive Films as Drug Delivery Systems for Biologics
Montenegro-Nicolini, M., & Morales, J. O. (2016) · AAPS PharmSciTech · doi:10.1208/s12249-016-0525-z · Cited by 129
Oral colon delivery of insulin with the aid of functional adjuvants
Maroni, A., Zema, L., Curto, M. D. D., Foppoli, A., & Gazzaniga, A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.10.006 · Cited by 127
Luo, Y., Lan, C., Li, H., Ouyang, Q., Kong, F., Wu, A., Ren, Z., Tian, G., Cai, J., Yu, B., et al. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00338-4 · Cited by 130
Hydrotropic polymer micelles containing acrylic acid moieties for oral delivery of paclitaxel
Kim, S., Kim, J. Y., Huh, K. M., Acharya, G. S., & Park, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.07.004 · Cited by 127
Macleod, G. S., Fell, J. T., Collett, J. H., Sharma, H. L., & Smith, A.-M. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00196-9 · Cited by 126
Ursodeoxycholic acid — adverse effects and drug interactions
Hempfling, W., Dilger, K., & Beuers, U. H. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01792.x · Cited by 127
Azoreductase activity of dye-decolorizing bacteria isolated from the human gut microbiota
Zahran, S. A., Ali‐Tammam, M., Hashem, A. M., Aziz, R. K., & Ali, A. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-41894-8 · Cited by 128
Liu, F., Merchant, H. A., Kulkarni, R. P., Alkademi, M., & Basit, A. W. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.01.001 · Cited by 124
Kloetzer, L., Chey, W. D., McCallum, R. W., Koch, K. L., Wo, J. M., Sitrin, M. D., katz, L. A., Lackner, J. M., Parkman, H. P., Wilding, G. E., et al. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01468.x · Cited by 125
Wang, Y., Liu, J., Li, Q., Wang, Y., & Wang, C. (2014) · Biotechnology Letters · doi:10.1007/s10529-014-1647-6 · Cited by 123
Lee, B.-H., Rose, D. R., Lin, A. H., Quezada‐Calvillo, R., Nichols, B. L., & Hamaker, B. R. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b01816 · Cited by 123
Fukui, E., Miyamura, N., Uemura, K., & Kobayashi, M. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00454-3 · Cited by 122
A technical review and clinical assessment of the wireless motility capsule.
Saad, R. J., & Hasler, W. L. (2011) · PubMed Central · Cited by 122
Bouhnik, Y., Neut, C., Raskine, L., Michel, C., Riottot, M., Andrieux, C., Guillemot, F., Dyard, F., & Flourié, B. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01918.x · Cited by 122
The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release
Macleod, G. S., Collett, J. H., & Fell, J. T. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00168-0 · Cited by 121
Implementation of Multichannel Sensors for Remote Biomedical Measurements in a Microsystems Format
Johannessen, E. A., Wang, L., Li, C., Tang, T. B., Ahmadian, M., Astaras, A., Reid, S. W. J., Yam, P. S., Murray, A. F., Flynn, B. W., et al. (2004) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2003.820370 · Cited by 121
The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles
García-Díaz, M., Birch, D., Wan, F., & Nielsen, H. M. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.11.002 · Cited by 123
Ling, K., Wu, H., Neish, A. S., & Champion, J. A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.017 · Cited by 119
Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets
HU, L., Liu, Y., TANG, X., & ZHANG, Q. (2006) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.04.004 · Cited by 119
Self‐Assembled pH‐Sensitive Nanoparticles: A Platform for Oral Delivery of Protein Drugs
Sonaje, K., Lin, K., Wang, J., Mi, F., Chen, C., Juang, J., & Sung, H. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201001014 · Cited by 118
Food, physiology and drug delivery
Varum, F., Hatton, G. B., & Basit, A. W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.04.034 · Cited by 121
Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions
Gala, U., Miller, D. A., & Williams, R. O. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.188319 · Cited by 123
Wani, S. U. D., Ali, M., Mehdi, S., Masoodi, M. H., Zargar, M. I., & Shakeel, F. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125875 · Cited by 117
Novel nanoparticles for oral insulin delivery via the paracellular pathway
Lin, Y.-H., Chen, C.-T., Liang, H., Kulkarni, A. R., Lee, P.-W., Chen, C., & Sung, H. (2007) · Nanotechnology · doi:10.1088/0957-4484/18/10/105102 · Cited by 115
Micro/nanofabricated platforms for oral drug delivery
Fox, C. B., Kim, J., Le, L. V., Nemeth, C. L., Chirra, H. D., & Desai, T. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.033 · Cited by 114
Drying technology strategies for colon-targeted oral delivery of biopharmaceuticals
Vass, P., Démuth, B., Hirsch, E., Nagy, B., Andersen, S. K., Vígh, T., Verreck, G., Csontos, I., Nagy, Z. K., & Marosi, G. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.023 · Cited by 119
Patel, D., Bertz, R., Ren, S., Boulton, D. W., & Någård, M. B. (2019) · Clinical Pharmacokinetics · doi:10.1007/s40262-019-00844-3 · Cited by 115
Tran, K. A., Brun, R., & Kuo, B. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12437874 · Cited by 112
Ibekwe, V. C., Liu, F., Fadda, H. M., Khela, M. K., Evans, D. F., Parsons, G. E., & Basit, A. W. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20742 · Cited by 111
Self-citationThomas, L. A., Veysey, M. J., Bathgate, T., King, A., French, G. L., Smeeton, N., Murphy, G. M., & Dowling, R. H. (2000) · Gastroenterology · doi:10.1053/gast.2000.16495 · Cited by 111
Gerloff, K., Pereira, D. I. A., Faria, N. R., Boots, A. W., Kolling, J., Förster, I., Albrecht, C., Powell, J. J., & Schins, R. P. F. (2012) · Nanotoxicology · doi:10.3109/17435390.2012.662249 · Cited by 110
Binders for colon specific drug delivery: an in vitro evaluation
Sinha, V. R., & Kumria, R. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00398-8 · Cited by 110
den Mooter, G. V. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.1.111 · Cited by 112
Akhgari, A., Garekani, H. A., Sadeghi, F., & Azimaie, M. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.08.025 · Cited by 110
Stimuli‐responsive delivery of therapeutics for diabetes treatment
Yu, J., Zhang, Y., Bomba, H. N., & Gu, Z. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10036 · Cited by 109
Ibekwe, V. C., Khela, M. K., Evans, D. F., & Basit, A. W. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03810.x · Cited by 109
Self-citation
Metadata
- Authors
- Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D.
- Affiliations
- Queen's Medical Centre (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1988-08
- Volume
- 29
- Issue
- 8
- Pages
- 1035-1041
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1433896
- OpenAlex
- W2089407496
- Cited by
- 1,240
- References
- 23
- Citations by year
- 2026: 38 · 2025: 74 · 2024: 52 · 2023: 67 · 2022: 70 · 2021: 84 · 2020: 67 · 2019: 58 · 2018: 47 · 2017: 55 · 2016: 49 · 2015: 59 · 2014: 67 · 2013: 43 · 2012: 56
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- gastrointestinal pH, gastric pH, terminal ileum, cecum, colon, ambulatory pH monitoring, gastrointestinal transit, normal subjects
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Gastrointestinal Contents, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Reference Values
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review